scholarly journals Endothelial Cell Distribution After Flow Exposure With Two Stent Struts Placed in Different Angles

2022 ◽  
Vol 12 ◽  
Author(s):  
Zi Wang ◽  
Narendra Kurnia Putra ◽  
Hitomi Anzai ◽  
Makoto Ohta

Stent implantation has been a primary treatment for stenosis and other intravascular diseases. However, the struts expansion procedure might cause endothelium lesion and the structure of the struts could disturb the blood flow environment near the wall of the blood vessel. These changes could damage the vascular innermost endothelial cell (EC) layer and pose risks of restenosis and post-deployment thrombosis. This research aims to investigate the effect of flow alterations on EC distribution in the presence of gap between two struts within the parallel flow chamber. To study how the gap presence impacts EC migration and the endothelialization effect on the surface of the struts, two struts were placed with specific orientations and positions on the EC layer in the flow chamber. After a 24-h exposure under wall shear stress (WSS), we observed the EC distribution conditons especially in the gap area. We also conducted computational fluid dynamics (CFD) simulations to calculate the WSS distribution. High EC-concentration areas on the bottom plate corresponded to the high WSS by the presence of gap between the two struts. To find the relation between the WSS and EC distributions on the fluorescence images, WSS condition by CFD simulation could be helpful for the EC distribution. The endothelialization rate, represented by EC density, on the downstream sides of both struts was higher than that on the upstream sides. These observations were made in the flow recirculation at the gap area between two struts. On two side surfaces between the gaps, meaning the downstream at the first and the upstream at the second struts, EC density differences on the downstream surfaces of the first strut were higher than on the upstream surfaces of the second strut. Finally, EC density varied along the struts when the struts were placed at tilted angles. These results indicate that, by the presence of gap between the struts, ECs distribution could be predicted in both perpendicular and tiled positions. And tiled placement affect ECs distribution on the strut side surfaces.

2020 ◽  
Vol 92 (10) ◽  
pp. 1459-1468
Author(s):  
Aleksander Olejnik ◽  
Adam Dziubiński ◽  
Łukasz Kiszkowiak

Purpose This study aims to create 6-degree of freedom (SDOF) for computational fluid dynamics (CFD) simulations of body movement, and to validate using the experimental data for empty tank separation from I-22 Iryda jet trainer. The procedure has an ability to be modified or extended, to simulate, for example, a sequential release from the joints. Design/methodology/approach A set of CFD simulations are calculated. Both the SDOF procedure and the CFD simulation settings are validated using the wind tunnel data available for the aircraft. Findings The simulation using designed procedure gives predictable results, but offers availability to be modified to represent external forces, i.e. from body interaction or control system without necessity to model the control surfaces. Practical implications The procedure could be used to model the separation of external stores and design the deployment of anti-radar chaff, flares or ejection seats. Originality/value The work presents original work, caused by insufficient abilities of original SDOF procedure in ANSYS code. Additional value is the ability of the procedure to be easily modified.


2018 ◽  
Vol 240 ◽  
pp. 05005
Author(s):  
Milind Devle ◽  
Ankur Garg ◽  
Darci Cavali

In general a multi-door refrigerator machine compartment comprises of fan, condenser, compressor, control box, drain tray, and drain tubes. The performance of machine compartment depends upon the efficiency of heat extraction or heat exchange from heat generating components such as condenser and compressor. The efficiency of heat exchange can be improved by addressing two major factors, namely (1) Air bypass and (2) Hot air recirculation. The hot air recirculation in the machine compartment for builtin multi-door refrigerator configuration is the focus of this study. The results from Computational Fluid Dynamics (CFD) simulations show that efficiency of heat exchange for built-in application is lower than that for free-standing configuration. Recirculation of hot air and reduction in airflow are the two major factors which contribute towards the variation in machine compartment performance. The CFD simulations were coupled with Partial Factorial Design of Experiment (DoE) approach to systematically investigate the effect of variables such as (a) side gap and top gap between kitchen cabinetry and the refrigerator, (b) the baffle/flap (i.e. back and bottom of machine compartment) on the performance effectiveness of machine compartment. The results of the simulation provided critical design improvement directions resulting in performance improvement. Furthermore, the CFD simulation results were also compared to test data and the results compared favourably.


Author(s):  
Brian Dotson ◽  
Kent Eshenberg ◽  
Chris Guenther ◽  
Thomas O’Brien

The design of high-efficiency lower-emission coal-fed power plants is facilitated by the extensive use of computational fluid dynamics (CFD) simulations. This paper describes work conducted at the National Energy Technology Laboratory (NETL) and Pittsburgh Supercomputing Center (PSC) to provide an environment for the immersive three-dimensional visualization of CFD simulation results. A low-cost high-resolution projection system has been developed in the visualization lab at NETL. This multi-wall system consists of four projection screens, three of which are tiled into four quadrants. The graphics for the multi-wall system are rendered using a cluster of eight personal computers. A high-level visualization interface named Mavis has also been developed to combine the powerful 3D modules of OpenDX with methods developed at NETL for studying multiphase CFD data. With Python, a completely new OpenDX user interface was built that extends and simplifies the features of a basic graphics library.


Author(s):  
Siyeong Ju ◽  
Linxia Gu

Stenosis or narrowing of arteries induces a turbulent flow region downstream. Multiple stenosis may lead to flow interference and further disturb the blood flow. This has important clinical implications [1], such as disturbed blood flow and flow recirculation which were correlated with the development of atherosclerosis by upregulating the endothelial cells genes and proteins that cause atherogenesis [2]. Numerical simulation of concentric stenoses by Lee et al [3] have shown that the recirculation zone following the first concentric stenosis affected the flow field at the downstream of the second one, which was dependent on the spacing ratio and degree of stenosis. However, the majority of stenosis is eccentric [2] and the detailed fluid dynamics of multiple stenoses with eccentric constrictions is lacking. The aim of this study is to investigate the interactions between double stenoses with eccentricity using computational fluid dynamics (CFD) simulation. The role of spacing ratio on the recirculation zone and turbulence intensity (TI) were characterized and also compared to concentric cases.


Author(s):  
Pál Schmitt ◽  
Christian Windt ◽  
Josh Davidson ◽  
John V. Ringwood ◽  
Trevor Whittaker

Computational Fluid Dynamics (CFD) simulations, based on Reynolds Averaged Navier Stokes (RANS) models, are a useful tool for a wide range of coastal and offshore applications, providing a high fidelity representation of the underlying hydrodynamic processes. Generating input waves in the CFD simulation is performed by a numerical wavemaker (NWM), with a variety of different NWM methods existing for this task. While NWMs, based on impulse source methods, have been widely applied for wave generation in depth averaged, shallow water models, they have not seen the same level of adoption in the more general RANS based CFD simulations, due to difficulties in relating the required impulse source function to the resulting free surface elevation for non-shallow water cases. This paper presents an implementation of an impulse source wavemaker, which is able to self-calibrate the impulse source function to produce a desired wave series in deep or shallow water at a specific point in time and space. Example applications are presented, for a numerical wave tank (NWT), based on the opensource CFD software OpenFOAM, for wave packets in deep and shallow water, highlighting the correct calibration of phase and amplitude. Also, the suitability for cases requiring very low reflection from NWT boundaries is demonstrated. Possible issues in the use of the method are discussed and guidance for good application is given.


Author(s):  
Mobina Mohammadikharkeshi ◽  
Mazdak Parsi ◽  
Ramin Dabirian ◽  
Ram S. Mohan ◽  
Ovadia Shoham

Abstract Slug flow, which commonly occurs in the petroleum industry, is not always a desired flow pattern due to production operation problems it may cause in pipelines and processing facilities. To mitigate these problems, flow conditioning devices such as multiphase flow manifolds and slug catchers are used, where dissipation of slugs occurs in downward flow or in larger diameter pipe sections. Tee-junctions are important parts of these flow conditioning devices. In this work, Computational Fluid Dynamics (CFD) simulations are conducted using ANSYS/FLUENT 17.2 to investigate slug dissipation in an Enlarged Impacting Tee-Junction (EIT). An Eulerian–Eulerian MultiFluid VOF transient model in conjunction with the standard k-ε turbulent model is used to simulate slug dissipation in an EIT geometry. The EIT consists of a 0.05 m ID 10 m long inlet, which is connected to the center of a 0.074 m ID 5.5 m long section that forms the EIT branches. Moreover, experimental data are acquired on slug dissipation lengths in a horizontal EIT with a similar geometry as in the CFD simulations. The CFD results include the mean void fraction and cross-sectionally averaged void fraction time series in the EIT for different gas and liquid velocities. These results provide the inlet slug length and dissipation length in the EIT branches. The CFD results are evaluated against the experimental data demonstrating that the slug dissipation occurring in EIT branches can be predicted by simulation.


2005 ◽  
Author(s):  
Zuoxin Hao

Segregation in particulate multiphase flow with binary solid mixture has extensive applications in industrial separation processes. Up to now there have been few attempts towards numerical simulation of segregation in particulate multiphase flow with binary mixture due to complexity of the problem. In view of this, the primary objective of present work is to simulate the problem by computational fluid dynamics (CFD) and to validate by comparison with experimental measurements. Eulerian-Eulerian approach, incorporating the granular temperature, an essential ingredient in the solids pressure and solids viscosity formulation, was used to model the flow field of multiphase flow and was solved by Fluent 6.0. The CFD simulation results have been validated by experiments of liquid fluidization of binary solid mixtures. Validation results show that CFD simulation predict segregation and solid volume fraction profile precisely, and in addition, it can supply a more realistic prediction of other hydrodynamic features of the multiphase flow, such as velocity vector of all phases and pressure drop. The success of such CFD simulations opens doors for many potential studies.


Author(s):  
S. S. Borges

Abstract This work presents an analysis of the aerodynamic performance of a centrifugal fan with forward curved blades (Sirocco) applied to electric motors. In this analysis were carried out computational fluid dynamics (CFD) simulations and experimental tests for comparison of results. The focus of this analysis is the performance comparison among three different models of general connection interface that are required for the connection between the grids of the rotating and stationary domains of CFD simulation, considering the method adopted by the Ansys CFX, software used as computational tool. Thereby, Frozen Rotor, Stage, and Transient Rotor-Stator were the interface models evaluated. For comparison reference, the experimental data were used to evaluate the performance of each interface models for overall operating range of the fan.


2014 ◽  
Vol 2014 ◽  
pp. 1-12
Author(s):  
Ren Xiaoguang ◽  
Xu Xinhai

Computational fluid dynamics (CFD) simulation often needs to periodically output intermediate results to files in the form of snapshots for visualization or restart, which seriously impacts the performance. In this paper, we present asynchronous pipeline I/O (AP-IO) optimization scheme for the periodically snapshot output on the basis of asynchronous I/O and CFD application characteristics. InAP-IO, dedicated background I/O processes or threads are in charge of handling the file write in pipeline mode, therefore the write overhead can be hidden with more calculation than classic asynchronous I/O. We design the framework ofAP-IOand implement it in OpenFOAM, providing CFD users with a user-friendly interface. Experimental results on theTianhe-2supercomputer demonstrate thatAP-IOcan achieve a good optimization effect for the periodical snapshot output in CFD application, and the effect is especially better for massively parallel CFD simulations, which can reduce the total execution time up to about 40%.


2019 ◽  
Vol 3 (4) ◽  
pp. 41-57
Author(s):  
Xiaoyu Wang ◽  
Jinzhu Meng ◽  
Tianwei Zhu ◽  
Jingyu Zhang

AbstractTo protect heritage buildings better, a method exploiting computational fluid dynamics (CFD) was developed for the analysis of wind erosion at a heritage site. Over a two-year period, we collected measurements of hourly weather data at Xinbin County to obtain statistics of wind speeds and directions for the Yongling Mausoleum. Subsequent results from CFD simulations show that before greening, with wind speeds reaching 10 m/s, certain structures (southwest-facing corners, doors and windows on open sides, places where swirling winds develop, and eaves of sloping roofs) of four heritage buildings were eroded more severely. With appropriate greening, plants may exert their unique ecological presence to better protect heritage buildings and their historical environments. After greening, the severity of damage to these vulnerable structures by wind was reduced. With wind speeds reaching 10 m/s, the average pressure on the structures of each building was 0.41–27.85 Pa, representing a reduction of 2.4%–75.6% from pressures before greening. We also constructed a 1:500-scale model to verify in experiments the correctness of CFD simulation qualitatively. The CFD simulations were found to provide an effective method to investigate and predict wind erosion of the heritage site.


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