The Willingness of Community Psychiatric Management Physicians to Preferentially Recommend Long-Acting Injections in Beijing

Background: Severe mental disorders (SMD) impose a heavy burden on individuals, society, and the country. Under the background of deinstitutionalization, more and more patients return to the community, and the community psychiatric management physicians (CPMP) play an essential role in this process. Long-acting injection (LAI) is an important way to improve compliance and reduce re-hospitalization. Some districts in Beijing have implemented the policy of free LAI. This article aims to find out the willingness of CPMP to preferentially recommend LAI and provide suggestions for follow-up promotion.Methods: All CPMP in 16 districts of Beijing were surveyed. A self-made electronic questionnaire was used to investigate the willingness to recommend LAI in priority. Descriptive statistics, Chi-square test, and logistic regression were used to analyze the data.Results: The willingness of CPMP to preferentially recommend LAI is up to 80%. Participants aged 40–49, female, with higher self-evaluation of psychiatric management knowledge, managing patients who have used LAI in the past, and working in communities with the free LAI policy have higher willingness to recommend LAI in priority.Conclusion: CPMP in Beijing have a positive attitude toward LAI, and most of them have the willingness to recommend LAI to the patients in priority. The recommendation willingness is the basis of prescription decision-making. Therefore, the coverage of free LAI policy should be further expanded in the future to improve the recommendation willingness and thus improve the injection rate of LAI.

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PROGNOSTIC FACTORS OF RENAL TUMOR RECURRENCE AFTER RADICAL NEPHRECTOMY

British Journal of Surgery ◽

10.1093/bjs/znab160.044 ◽

2021 ◽

Vol 108 (Supplement_3) ◽

Author(s):

G Martínez Izquierdo ◽

A R Arnaiz Pérez ◽

E Escolano Fernández ◽

M Merayo Álvarez ◽

B Carrasco Aguilera ◽

...

Keyword(s):

Multivariate Analysis ◽

Prognostic Factors ◽

Radical Nephrectomy ◽

Univariate Analysis ◽

Malignant Neoplasms ◽

Histopathological Analysis ◽

Chi Square ◽

Renal Sinus ◽

Chi Square Test

Abstract INTRODUCTION Renal cell carcinoma (RCC) represents 3% of overall malignant neoplasms in adults. However, its aetiology has not been clearly established. Although surgery represents the cornerstone in treatment, recurrence postoperative rates are around 20-30%, what implies prognostic factors search must be mandatory in order to help to plan de follow-up and the different adjuvant therapy possibilities available in case they were necessary. MATERIAL AND METHODS A retrospective observational study was carried out in 110 patients who underwent radical nephrectomy between 2004 and 2018, with the aim of identifying possible prognostic factors of recurrence of RCC after these surgeries. Preoperative data (epidemiological, comorbidities and laboratory tests), surgical, pathological and variables related to follow-up were taken into account. A univariate and multivariate analysis were performed, using chi-square test and logistic regression, respectively. RESULTS The median follow-up time was 53.5 months (SD = 35.8), time in which 19 patients had a recurrence of RCC after radical nephrectomy (17.2%). Histopathological items such as the surgical piece size, the nodal and microvascular invasion, the renal sinus invasion and the presence of necrosis in the surgical piece were associated with RCC recurrence in the univariate analysis, while only the presence of necrosis in the surgical piece showed a significant result in the multivariate analysis (p = 0.004). CONCLUSIONS Histopathological analysis, highlighting the presence of necrosis in the histological sample, was proved to be the main risk factor of RCC recurrence.

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Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China

BMC Cancer ◽

10.1186/s12885-021-08531-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Mei-Zhen Dai ◽

Yi Qiu ◽

Xing-Hong Di ◽

Wei-Wu Shi ◽

Hui-Hui Xu

Keyword(s):

Cervical Cancer ◽

Cervical Carcinogenesis ◽

Chi Square ◽

Major Health Problem ◽

Hpv16 E6 ◽

Exact Test ◽

Chi Square Test ◽

E6 And E7

Abstract Background Human papillomavirus (HPV) type 16 accounts for a larger share of cervical cancer and has been a major health problem worldwide for decades. The progression of initial infection to cervical cancer has been linked to viral sequence properties; however, the role of HPV16 variants in the risk of cervical carcinogenesis, especially with longitudinal follow-up, is not fully understood in China. Methods We aimed to investigate the genetic variability of HPV16 E6 and E7 oncogenes in isolates from cervical exfoliated cells. Between December 2012 and December 2014, a total of 310 single HPV16-positive samples were selected from women living in the Taizhou area, China. Sequences of all E6 and E7 oncogenes were analysed by PCR-sequencing assay. Detailed sequence comparison, genetic heterogeneity analyses and maximum-likelihood phylogenetic tree construction were performed with BioEdit Sequence Alignment Editor and MEGA X software. Data for cytology tests and histological diagnoses were obtained from our Taizhou Area Study with longitudinal follow-up for at least 5 years. The relationship between HPV16 variants and cervical carcinogenesis risk was analysed by the chi-square test or Fisher’s exact test. Results In this study, we obtained 64 distinct variation patterns with the accession GenBank numbers MT681266-MT681329. Phylogenetic analysis revealed that 98.3% of HPV16 variants belong to lineage A, in which the A4 (Asian) sublineage was dominant (64.8%), followed by A2 (12.1%), A1 (11.4%), and A3 (10.0%). The A4 (Asian) sublineage had a higher risk of CIN2+ than the A1–3 (European) sublineages (OR = 2.69, 95% CI = 1.04–6.97, P < 0.05). Furthermore, nucleotide variation in HPV16 E6 T178G is associated with the development of cervical cancer. Conclusion These data could provide novel insights into the role of HPV16 variants in cervical carcinogenesis risk in China.

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Evaluation of laboratory markers of progression of HIV disease to death

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86822011005000062 ◽

2011 ◽

Vol 44 (6) ◽

pp. 657-660 ◽

Cited By ~ 1

Author(s):

Graça Maria de Castro Viana ◽

Maria do Desterro Soares Brandão Nascimento ◽

Aila de Menezes Ferreira ◽

Érica Milena Fernandes Rabelo ◽

João Arnaud Diniz Neto ◽

...

Keyword(s):

Viral Load ◽

Hiv Disease ◽

Significant Relation ◽

Chi Square ◽

Laboratory Markers ◽

Cd4 Lymphocyte Count ◽

Chi Square Test ◽

Cd4 Lymphocyte ◽

Hiv Aids

INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

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Risk Factors for Dysphagia After Anterior Cervical Discectomy and Fusion With the Zero-P Implant System: a Retrospective Study With Minimum of 2 Years Follow-up

10.21203/rs.3.rs-138933/v1 ◽

2021 ◽

Author(s):

Rong Xue ◽

Ningdao Li ◽

Zhurong Ji ◽

Xingdong Cheng ◽

Zhuqiu Zhang ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Operation Time ◽

Anterior Cervical Discectomy ◽

Postoperative Dysphagia ◽

Chi Square ◽

Chi Square Test ◽

Implant System ◽

Segmental Angle

Abstract Background: Dysphagia is one of the most common complications after anterior cervical spine surgery. The study aimed to evaluate the risk factors for dysphagia after anterior cervical discectomy and fusion (ACDF) with the Zero-P Implant System by multidimensional analysis and investigated the predictive values of these risk factors for dysphagia. Methods: A retrospective analysis of 260 patients who underwent ACDF with the Zero-P Implant System and had at least 2 year of follow-up ware performed. All patients were divided into a non-dysphagia group and a dysphagia group. Sex, age, body mass index (BMI), intraoperative time, estimated blood loss, diabetes mellitus, hypertension, smoking, alcohol consumption, prevertebral soft-tissue thickness, the levels of surgery, O-C2 angle, C2–7 angle, T1 slope and segmental angle were analyzed. Chi-square test and logistic regression were performed to analyze the predictive value of each dimension for dysphagia. Results: In total, the non-dysphagia group comprised 170 patients and the dysphagia group comprised 90 patients. Chi-square test results indicated that number of operated levels, operation time dT1 slope, dO-C2 angle, dC2–7 angle, segmental angle and dPSTT were associated with a high incidence of dysphagia. Multivariate logistic regression analysis showed that number of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia.Conclusions: Number of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia. In additionally, sufficient preoperative preparation, evaluation combining with proficient and precise treatment measures are suggested to reduce the incidence of postoperative dysphagia when ACDF is performed.

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Beban Keluarga Berhubungan dengan Kemampuan Keluarga dalam Merawat Pasien Halusinasi

Jurnal Keperawatan Jiwa ◽

10.26714/jkj.8.1.2020.97-102 ◽

2020 ◽

Vol 8 (1) ◽

pp. 97

Author(s):

Cucu Rokayah ◽

Fahmi Dwi Novian ◽

Supriyadi Supriyadi

Keyword(s):

Univariate Analysis ◽

Psychiatric Hospitals ◽

Sampling Technique ◽

P Value ◽

West Java ◽

Chi Square ◽

Hospital Outpatient ◽

The Family ◽

Chi Square Test ◽

Heavy Burden

Skizofrenia merupakan suatu gangguan mental yang menyebabkan timbulnya pikiran, persepsi, emosi, gerakan, perilaku yang aneh dan terganggu.Penderita skizofrenia 70% diantaranya mengalami halusinasi.Dampak terberat yang dirasakan oleh keluarga dalam merawat pasien dengan halusinasi adalah dampak pada psikologis, terutama stress atau beban yang dirasakan oleh keluarga. Tujuan penelitian ini adalah untuk mengetahui Hubungan Beban Keluarga dengan Kemampuan Keluarga Dalam Merawat Pasien Halusinasi di InstalasI Rawat Jalan Rumah Sakit Jiwa Provinsi Jawa Barat. Metode penelitian ini menggunakan deskriptif korelasional dengan tehnik purposive samplingterhadap 69 responden dari populasi 996 responden di Instalasi Rawat Jalan Rumah Sakit Jiwa Provinsi Jawa Barat. instrumen yang digunakan dalam penelitian ini adalah kuesioner beban keluarga dan kemampuan keluarga yang terdiri dari kognitif dan psikomotor. Analisa univariat dalam penelitian ini menggunakan distribusi frekuensi dan analisa bivariat pada penelitian ini menggunakan uji chi square hasil penelitian menunjukan beban berat yaitu 35 responden (50,7 %), sedangkan untuk kemampuan keluarga baik 46 responden (42 %). kesimpulannya bahwa ada hubungan antara beban keluarga dengan kemampuan keluarga dalam merawat pasien halusinasi di Instalasi Rawat Jalan Rumah Sakit Jiwa Provinsi Jawa Barat dengan nilai p value (0,001) < (0,005). Kata kunci: halusinasi, beban keluarga, kemampuan keluarga FAMILY BURDEN CONNECTED WITH FAMILY ABILITY TO TREAT HALLUCINATORY PATIENTS ABSTRACTSchizophrenia is a mental disorder that causes the onset of thought, perception, emotion, movement, strange and disturbing behavior. Schizophrenia 70% of them have hallucinations.The toughest impact the family feels in treating patients with hallucinations is its impact on the psychological, especially the stress or burden felt by the family.The purpose of this research is to know the family's burden relationship with the ability of the family to treat hallucinative patients in the installation of hospital outpatient in West Java province.This method of study uses descriptive correlation with purposive sampling technique against 69 respondents from the population of 996 respondents in an outpatient installation of psychiatric hospitals in West Java province. The instruments used in this reseacrh used family load questionnaires and family skills questionnaires comprising cognitive and psychomotor. Univariate analysis in this research using frequency distribution and bivariat analysis of this study using chi square test. the results showed a heavy burden of 35 respondents (50.7%), while for family ability of either 46 respondents (42%).in conclusion that there is a connection between the burden of the family with the ability of families to treat hallucinatory patients in the hospital outpatient installation in the psychiatric province of West Java with a value of P (0.001) < (0.005). Keywords: hallucinations, family load, abillity family

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More focus on atypical glandular cells in cervical screening: Risk of significant abnormalities and low histological follow-up rate

CytoJournal ◽

10.25259/cytojournal_77_2019 ◽

2020 ◽

Vol 17 ◽

pp. 22

Author(s):

Pingping Zhong ◽

Chenghong Yin ◽

Yulan Jin ◽

Tianbao Chen ◽

Yang Zhan ◽

...

Keyword(s):

Statistical Significance ◽

Cervical Screening ◽

Close Relation ◽

Prior History ◽

Pap Smears ◽

Chi Square ◽

Glandular Cells ◽

Atypical Glandular Cells ◽

Chi Square Test

Objectives: Atypical glandular cells (AGC) detected by Papanicolaou (Pap) smears are in close relation with adenocarcinoma and precursors detected by histopathology. Yet, sometimes the cytological diagnosis of AGC has been neglected. With increase of adenocarcinoma and precursors, we need more focus on glandular abnormalities. Material and Methods: Clinicopathological data of patients who had AGC on Pap smears between April 2015 and October 2018 and underwent histological follow-up were retrieved from the computerized database of Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Patients with a prior history of cancer were excluded from the study. Statistical analyses were performed using Pearson’s Chi-square test in SPSS software version 23. P < 0.05 (two sided) was considered as statistical significance. Results: Liquid-based cytological examination of the uterine cervix was carried out in 164,080 women. Five hundred and twenty-five women were diagnosed with AGC, 314 with not otherwise specified (AGC-NOS), and 211 with favor neoplastic (AGC-FN). Only 310 cases had histological follow-up, 168 women (168/314, 53.5%) originally with AGC-NOS on Pap smears, and 142 (142/211, 67.3%) with AGC-FN. The median age of histological significant abnormalities was 46.7 years, and 126 women (126/162, 77.8%) were postmenopausal. Sixty-six cases (66/168, 39.3%) of AGC-NOS had significant abnormalities (96/142, 67.6%, AGC-FN). One hundred and sixty-two cases of significant abnormalities included 40 high-grade squamous abnormalities and 122 glandular abnormalities. AGC-FN was more likely to be associated with a clinically significant abnormalities (P < 0.001) compared to AGC-NOS. Conclusions: Patients with AGC on Pap smears are in close relation with significant abnormalities, especially with significant glandular abnormalities on histopathology slices. AGC should be evaluated vigilantly with histological workup, especially if patients are diagnosed with AGC-FN and are aged 41–60 years. We need more focus on AGC.

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Evaluation of crestal bone resorption around cylindrical and conical implants following 6 months of loading: A randomized clinical trial

European Journal of Dentistry ◽

10.4103/ejd.ejd_38_17 ◽

2017 ◽

Vol 11 (03) ◽

pp. 317-322 ◽

Cited By ~ 1

Author(s):

Naser Sargolzaie ◽

Hamid Reza Arab ◽

Marzieh Mohammadi Moghaddam

Keyword(s):

Bone Loss ◽

Chi Square ◽

Pocket Depth ◽

Significance Level ◽

Crestal Bone Loss ◽

Significant Difference ◽

Chi Square Test ◽

Male Patients ◽

Maxilla And Mandible

ABSTRACT Objective: The purpose of this clinical study was to evaluate the effect of implant body form (cylindrical and conical implants) on crestal bone levels during 6 months' follow-up after loading. Materials and Methods: A total of 32 SPI implants (19 conical implants/13 cylindrical implants) were randomly placed in 12 male patients using a submerged approach. None of the patients had compromising medical conditions or parafunctional habits. Periapical radiographs using the parallel technique were taken after clinical loading and 6 months later. Clinical indices including pocket depth and bleeding on probing (BOP) were recorded on 6-month follow-up. Data were analyzed by independent samples t-test and Chi-square test with a significance level of 0.05. Results: Six months after loading, crestal bone loss was 0.84 (±0.29) mm around the cylindrical implants and 0.73 (±0.62) mm around the conical types, which was not significantly different (P = 0.54). Pocket depth around the cylindrical and conical implants was 2.61 (±0.45) mm and 2.36 (±0.44) mm, respectively (P = 0.13). BOP was observed among 53.8% and 47.4% of the cylindrical implants and conical (P = 0.13). Bone loss and pocket depth in the maxilla and mandible had no significant difference (P = 0.46 and P = 0.09, respectively). Conclusion: In this study, although bone loss and clinical parameters were slightly higher in the cylindrical implants, there was no significant difference between the conical- and cylindrical-shaped implants.

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Gamma knife surgery for dural arteriovenous shunts: 25 years of experience

Journal of Neurosurgery ◽

10.3171/jns.2006.104.6.867 ◽

2006 ◽

Vol 104 (6) ◽

pp. 867-875 ◽

Cited By ~ 79

Author(s):

Michael Söderman ◽

Göran Edner ◽

Kaj Ericson ◽

Bengt Karlsson ◽

Tiit Rähn ◽

...

Keyword(s):

Gamma Knife ◽

Intracranial Hemorrhage ◽

Venous Drainage ◽

Gamma Knife Surgery ◽

Chi Square ◽

Arteriovenous Shunts ◽

Chi Square Test ◽

Dural Arteriovenous Shunts ◽

Cortical Venous Drainage

Object The aim of this study was to assess the clinical efficacy of gamma knife surgery (GKS) in the treatment of dural arteriovenous shunts (DAVSs). Methods From a database of more than 1600 patients with intracranial arteriovenous shunts that had been treated with GKS, the authors retrospectively and prospectively identified 53 patients with 58 DAVSs from the period between 1978 and 2003. Four patients were lost to follow-up evaluation and were excluded from the series. Thus, this study is based on the remaining 49 patients with 52 DAVSs. Thirty-six of the shunts drained into the cortical venous system, either directly or indirectly, and 22 of these were associated with intracranial hemorrhage on patient presentation. The mean prescription radiation dose was 22 Gy (range 10–28 Gy). All patients underwent a clinical follow-up examination. In 41 cases of DAVS a follow-up angiography study was performed. At the 2-year follow-up visit, 28 cases (68%) had angiographically proven obliteration of the shunt and in another 10 cases (24%) there was significant flow regression. Three shunts remained unchanged. There was one immediate minor complication related to the administration of radiation. Furthermore, one patient had a radiation-induced complication 10 years after treatment, although she recovered completely. There was one posterior fossa bleed 2 months after radiosurgery; a hematoma, as well as a lesion, was evacuated, and the patient recovered uneventfully. A second patient had an asymptomatic occipital hemorrhage approximately 6 months postradiosurgery. The clinical outcome after GKS was significantly better than that in patients with naturally progressing shunts (p < 0.01, chi-square test); figures on the latter have been reported previously. Conclusions Gamma knife surgery is an effective treatment for DAVSs, with a low risk of complications. Major disadvantages of this therapy include the time elapsed before obliteration and the possibility that not all shunts will be obliterated. Cortical venous drainage from a DAVS, a risk factor for intracranial hemorrhage, is therefore a relative contraindication. Consequently, GKS can be used in the treatment of both benign DAVSs with subjectively intolerable bruit and aggressive DAVSs not responsive to endovascular treatment or surgery.

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Dental trauma and itssequelae in deciduous and permanent teeth - Longitudinal study

Acta Scientiarum Health Sciences ◽

10.4025/actascihealthsci.v41i1.34030 ◽

2019 ◽

Vol 41 (1) ◽

pp. 34030

Author(s):

Graziele Martioli ◽

Helena Sandrini Venante ◽

Gabriela Cristina Santin ◽

Carlos Luiz Fernandes de Salles ◽

Sandra Mara Maciel ◽

...

Keyword(s):

Root Resorption ◽

Tissue Injury ◽

Dental Trauma ◽

Permanent Teeth ◽

Deciduous Teeth ◽

Chi Square ◽

Elapsed Time ◽

Chi Square Test ◽

Type Of Injury

Objective: This study evaluated the prevalence, clinical management and sequelae in deciduous teeth involved and permanent successors in 150 children (256 deciduous teeth. Of these, 63.3% were male, 24-35 months of age at the time of the trauma (37.9%) and the falls (78.1%) represented the major etiological factor. In relation to the type of injury, 24.6% was enamel fracture; 62.5% showed support tissue injury (lateral luxation, 22.3%). In the first and second assessments (T1 and T2), the average follow-up time was 14.5 and 26 months (256 and 131 teeth).We diagnosed clinical and radiographic sequels including discoloration of the crown (T1-15.6; T2-13.7%), inflammatory root resorption (T1-7.0; T2-8.4%); and in permanent successors, enamel hypoplasia (T1-1.2; T2-2.3%), eruption disturbances (T1-2.0; T2-1.5%).The chi-square test evidenced association, in T1, between injuries to the supporting tissues and clinical (p = 0.003) and radiographic (p = 0.004) sequelae in permanent successors; and between clinical sequelae and age at the time of trauma (p = 0.005). In T2, radiological sequelae in deciduous teeth with injuries to the tooth and supporting tissue (p = 0.035); as well as clinical sequelae with elapsed time of trauma in permanent teeth (p = 0.005). It is concluded that the follow-up of traumatized deciduous teeth is essential to prevent sequelae.

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Profile and follow-up of patients with tuberculosis in a priority city in Brazil

Revista de Saúde Pública ◽

10.1590/s0034-8910.2015049005304 ◽

2015 ◽

Vol 49 (0) ◽

Cited By ~ 2

Author(s):

Jisleny da Cruz Pereira ◽

Marcio Roberto Silva ◽

Ronaldo Rodrigues da Costa ◽

Mark Drew Crosland Guimarães ◽

Isabel Cristina Gonçalves Leite

Keyword(s):

Surveillance System ◽

Reporting System ◽

Southeastern Brazil ◽

Chi Square ◽

Significance Level ◽

Treatment Default ◽

Chi Square Test ◽

Return Visits ◽

The Impact

OBJECTIVE To analyze the cases of tuberculosis and the impact of direct follow-up on the assessment of treatment outcomes.METHODS This open prospective cohort study evaluated 504 cases of tuberculosis reported in the Sistema de Informação de Agravos de Notificação (SINAN – Notifiable Diseases Information System) in Juiz de Fora, MG, Southeastern Brazil, between 2008 and 2009. The incidence of treatment outcomes was compared between a group of patients diagnosed with tuberculosis and directly followed up by monthly consultations during return visits (287) and a patient group for which the information was indirectly collected (217) through the city’s surveillance system. The Chi-square test was used to compare the percentages, with a significance level of 0.05. The relative risk (RR) was used to evaluate the differences in the incidence rate of each type of treatment outcome between the two groups.RESULTS Of the outcomes directly and indirectly evaluated, 18.5% and 3.2% corresponded to treatment default and 3.8% and 0.5% corresponded to treatment failure, respectively. The incidence of treatment default and failure was higher in the group with direct follow-up (p < 0.05) (RR = 5.72, 95%CI 2.65;12.34, and RR = 8.31, 95%CI 1.08;63.92, respectively).CONCLUSIONS A higher incidence of treatment default and failure was observed in the directly followed up group, and most of these cases were neglected by the disease reporting system. Therefore, effective measures are needed to improve the control of tuberculosis and data quality.

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