scholarly journals Three-Dimensional Segmentation and in silico Comparison of Equine Deep Digital Flexor Tendon Pathology in Horses Undergoing Repeated MRI Examination

2021 ◽  
Vol 8 ◽  
Author(s):  
Kimberly D. Trolinger-Meadows ◽  
Adam H. Biedrzycki ◽  
Hongjia He ◽  
Natasha Werpy

The use of magnetic resonance imaging (MRI) has led to increased clinical and research applications using 3D segmentation and reconstructed volumetric data in musculoskeletal imaging. Lesions of the deep digital flexor tendon (DDFT) are a common pathology in horses undergoing MRI. Three-dimensional MRI reconstruction performed for volumetric tendon analysis in horses has not previously been documented. The aim of this proof-of-concept study was to evaluate the 3D segmentation of horses undergoing repeated MRI at several time points and to perform an analysis of the segmented DDFTs across time. MRI DICOM files were acquired from six horses undergoing repeated MRI examination of the foot for DDFT injury. Once segmented, volumetric tendon surface tessellation language (STL) files were created. Thickness and volumetric data were acquired for each tendon in addition to a tendon comparison across timepoints within each horse. Pearson correlation coefficients were calculated for comparison of MRI reports to computer analysis. There was a significant and positive correlation between MRI and medial record reports of clinical improvement or deterioration and computer analysis (r = 0.56, p = 0.01). The lower end range limit for tendon thickness varied between 0.16 and 1.74 mm. The upper end range limit for DDFT thickness varied between 4.6 and 23.6 mm. During tendon part comparison, changes in DDFT were reported between −3.0 and + 14.3 mm. Changes in DDFT size were non-uniform and demonstrated fluctuations throughout the tendon. The study was successful in establishing the volumetric appearance and thickness of the DDFT as it courses in the foot and tracking this over time. We encountered difficulties in accurate segmentation of the distal insertion of the DDFT as it blends with the distal phalanx. The data demonstrated that the DDFT can be segmented and volumetric studies based on size and shape can be performed using an in silico approach.

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Zhe Li ◽  
Guanzhi Liu ◽  
Run Tian ◽  
Ning Kong ◽  
Yue Li ◽  
...  

Abstract Background Our objective was to obtain normal patellofemoral measurements to analyse sex and individual differences. In addition, the absolute values and indices of tibial tuberosity-trochlear groove (TT-TG) distances are still controversial in clinical application. A better method to enable precise prediction is still needed. Methods Seventy-eight knees of 78 participants without knee pathologies were included in this cross-sectional study. A CT scan was conducted for all participants and three-dimensional knee models were constructed using Mimics and SolidWorks software. We measured and analysed 19 parameters including the TT-TG distance and dimensions and shapes of the patella, femur, tibia, and trochlea. LASSO regression was used to predict the normal TT-TG distances. Results The dimensional parameters, TT-TG distance, and femoral aspect ratio of the men were significantly larger than those of women (all p values < 0.05). However, after controlling for the bias from age, height, and weight, there were no significant differences in TT-TG distances and anterior-posterior dimensions between the sexes (all p values > 0.05). The Pearson correlation coefficients between the anterior femoral offset and other indexes were consistently below 0.3, indicating no relationship or a weak relationship. Similar results were observed for the sulcus angle and the Wiberg index. Using LASSO regression, we obtained four parameters to predict the TT-TG distance (R2 = 0.5612, p < 0.01) to achieve the optimal accuracy and convenience. Conclusions Normative data of patellofemoral morphology were provided for the Chinese population. The anterior-posterior dimensions of the women were thicker than those of men for the same medial-lateral dimensions. More attention should be paid to not only sex differences but also individual differences, especially the anterior condyle and trochlea. In addition, this study provided a new method to predict TT-TG distances accurately.


Author(s):  
Maxwell L. Albiero ◽  
Wesley Kokott ◽  
Cody Dziuk ◽  
Janelle A. Cross

Abstract Context: Inadequate hip active range of motion (AROM) may stifle the energy flow through the kinematic chain and decrease pitching performance while increasing the risk for pitcher injury. Objective: To examine the relationship of hip AROM and pitching biomechanics during a fastball pitch in adolescent baseball pitchers. Design: Cross-Sectional study. Setting: Biomechanics laboratory. Participants: A voluntary sample of 21 adolescent baseball pitchers (16.1 ± 0.8 yrs.; 183.9 ± 5.2 cm; 77.9 ± 8.3 kg). Main Outcome Measure (s): Bilateral hip internal rotation (IR), external rotation (ER), flexion, extension, and abduction AROM were measured. Three-dimensional biomechanics were assessed as participants threw from an indoor pitching mound to a strike zone net at regulation distance. Pearson correlation coefficients were used to determine correlations between hip AROM and biomechanical metrics. Results: Statistically significant negative correlations were found at foot contact between back hip ER AROM and back hip abduction angle (p=0.030, r=−0.474), back hip ER AROM and torso rotation angle (p=0.032, r=−0.468),and back hip abduction AROM and lead hip abduction angle (p=0.037, r=−0.458). Back hip extension AROM was positively correlated with increased stride length (p=0.043, r=0.446). Lead hip abduction AROM was also positively correlated with normalized elbow varus torque (p=0.034, r=0.464). Conclusions: There were several relationships between hip AROM and biomechanical variables during the pitching motion. The findings support the influence hip AROM can have on pitching biomechanics. Overall, greater movement at the hips allows for the kinematic chain to work at its maximal efficiency, increasing pitch velocity potential.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaodan Jiang ◽  
Hongwei Deng ◽  
Chun Lung ◽  
Fanyin Wang ◽  
Shuang Li ◽  
...  

Abstract Background Highly myopic eyes differ in morphology from emmetropic eyes, and the correct estimation of the vitreous volume is difficult. To explore an effective method to estimate ocular volume using refractive factors in children. Methods This is a retrospective study of children with high myopia who visited the Shenzhen Shekou People’s Hospital (July-December 2018) before undergoing posterior scleral reinforcement surgery. Data on refractive factors and ocular 3D reconstruction imaging based on high-end CT were collected for linear correlation and linear regression analyses. Results Ten patients (20 eyes) were included. There are nine males and one female. They were 4 to 12 years of age. The spherical equivalent ranges from + 0.25 to -20.00 D. The cylindrical equivalent ranges from − 0.50 to -6.25 D. The AL(axial length, AL) ranges from 21.78 to 33.90 mm. The corneal curvature (mean) ranges from 42.44 to 46.75. The 3D reconstruction of the CT images shows that the ocular volume ranges from 4.591 to 10.988 ml. The ocular volume of the 20 eyes decreases with the increase of diopter and total curvature, both presenting a linear trend, with the Pearson correlation coefficients being − 0.776 (P < 0.001) and − 0.633 (P = 0.003), respectively. The ocular volume of the 20 eyes increases with the increasing AL, also presenting a linear trend, with the Pearson correlation coefficient being 0.939 (P < 0.001). Conclusions In children, the ocular volume is negatively and linearly correlated with the diopter and curvature, and positively and linearly correlated with the AL.


2020 ◽  
pp. 193229682097465
Author(s):  
Joel Willem Johan Lasschuit ◽  
Jill Featherston ◽  
Katherine Thuy Trang Tonks

Background: In an era of increasing technology and telehealth utilization, three-dimensional (3D) wound cameras promise reliable, rapid, and touch-free ulceration measurements. However, reliability data for commercially available devices in the diabetes foot service setting is lacking. We aimed to evaluate the reliability of diabetes-related foot ulceration measurement using a 3D wound camera in comparison to the routinely used ruler and probe. Method: Participants were prospectively recruited from a tertiary interdisciplinary diabetes foot service. Ulcerations were measured at each visit by two blinded observers, first by ruler and probe, and then using a 3D wound camera twice. Reliability was evaluated using intraclass correlation coefficients (ICC). Measurement methods were compared by Pearson correlation. Results: Sixty-three ulcerations affecting 38 participants were measured over 122 visits. Interobserver reliability of ruler measurement was excellent for estimated area (ICC 0.98, 95% CI 0.97-0.98) and depth (ICC 0.93, 95% CI 0.90-0.95). Intraobserver and interobserver reliability of the 3D wound camera area was excellent (ICC 0.96, 95%CI 0.95-0.97 and 0.97 95% CI 0.96-0.98, respectively). Depth was unrecordable in over half of 3D wound camera measurements, and reliability was inferior to probe measurement. Area correlation between methods was good ( R = 0.88 and 0.94 per observer); however, depth correlation was poor ( R = 0.49 and 0.65). Conclusions: 3D wound cameras offer practical advantages over ruler-based measurement. In diabetes-related foot ulceration, the reliability and comparability of area measurement was excellent across both methods, although depth was more reliably obtained by the probe. These limitations, together with cost, are important considerations if implementing this technology in diabetes foot care.


2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Yang Qiao ◽  
Hong-Yue Tao ◽  
Kui Ma ◽  
Zi-Ying Wu ◽  
Jian-Xun Qu ◽  
...  

Objective. To compareT2⁎value of healthy and diseased Achilles tendons (AT) with a recently introduced three-dimensional ultrashort echo time (3D-UTE) sequence and analyze the correlation betweenT2⁎value and clinical scores.Methods. Ten patients with symptomatic Achilles tendon and ten healthy volunteers were investigated with 3D-UTE sequence on a 3T magnetic resonance (MR) scanner.T2⁎values of four regions in Achilles tendons were calculated. The clinical outcomes of patients were evaluated according to the American Orthopaedic Foot and Ankle Society (AOFAS) score and Achilles Tendon Rupture Score (ATRS). An independent samplet-test was used to compare the differences ofT2⁎value and clinical scores between two groups. The Pearson correlation coefficient between clinical scores andT2⁎values was assessed.Results. TheT2⁎values of Achilles tendon were statistically significantly different between patients and volunteers. The Pearson correlation coefficients betweenT2⁎and AOFAS or ATRS scores of patients werer=-0.733andr=-0.634, respectively.Conclusion. The variability ofT2⁎in healthy and pathologic AT can be quantified by UTE-T2⁎.T2⁎may be a promising marker to detect and diagnose AT tendinopathy. UTE-T2⁎could give a precise guidance to clinical outcome.


2016 ◽  
Vol 85 (4) ◽  
Author(s):  
Urška Barbič ◽  
Ivan Verdenik ◽  
Maja Marolt Mušič ◽  
Nataša Ihan Hren

Abstract: Background: The purpose of this study was to find a three - dimensional (3D) ultrasound technique for tongue volume estimation, to compare male and female groups and to find the correlation between tongue volume and body characteristics.Methods: 3D ultrasound was performed within a group of 14 men and a group of 18 women with norm-occlusion. The collected data were analysed by annexed software and the tongue volume was estimated. The repeatability as well as intra- and inter-rater agreement was determined by calculating intra-class correlation coefficient. The Student t-test was used to determine if there were significant differences in tongue volume and body characteristics between the male and the female groups. Pearson correlation coefficients were used to assess the relationship between tongue volume and body characteristics.Results: The 3D ultrasound estimation of tongue volume was highly repeatable in terms of good intraclass correlation coefficients of repeatability (ICC: 0,997) as well as intra- and inter-rater reliabilities (ICC: 0,998 and 0,993 respectively). The male group were significantly taller, heavier and with higher BMI than the female group, and had significantly larger tongue volumes (mean of 89.2 cm3 in males vs. 67.2 cm3 in females). Only the body weights and BMIs in the male group correlated with the tongue volume.Conclusion: This study did demonstrate a valid and reproducible 3D ultrasound technique for tongue volume assessment.


2011 ◽  
Vol 101 (3) ◽  
pp. 198-207 ◽  
Author(s):  
Sophie De Mits ◽  
Pascal Coorevits ◽  
Dirk De Clercq ◽  
Dirk Elewaut ◽  
James Woodburn ◽  
...  

Background: Abnormal foot posture and deformities are identified as important features in rheumatoid arthritis. There is still no consensus regarding the optimum technique(s) for quantifying these features; hence, a foot digitizer might be used as an objective measurement tool. We sought to assess the validity and reliability of the INFOOT digitizer. Methods: To investigate the validity of the INFOOT digitizer compared with clinical measurements, we calculated Pearson correlation coefficients. To investigate the reliability of the INFOOT digitizer, we calculated intraclass correlation coefficients, SEMs, smallest detectable differences, and smallest detectable difference percentages. Results: Most of the 38 parameters showed good intraclass correlation coefficients, with values greater than 0.9 for 30 parameters and greater than 0.8 for seven parameters. The left heel bone angle expressed a moderate correlation, with a value of 0.609. The SEM values varied between 0.31 and 3.51 mm for the length and width measures, between 0.74 and 5.58 mm for the height data, between 0.75 and 5.9 mm for the circumferences, and between 0.78° and 2.98° for the angles. The smallest detectable difference values ranged from 0.86 to 16.36 mm for length, width, height, and circumference measures and from 2.17° to 8.26° for the angle measures. For the validity of the INFOOT three-dimensional foot digitizer, Pearson correlation coefficients varied between 0.750 and 0.997. Conclusions: In this rheumatoid arthritis population, good validity was demonstrated compared with clinical measurements, and most of the obtained parameters proved to be reliable. (J Am Podiatr Med Assoc 101(3): 198–207, 2011)


2020 ◽  
Author(s):  
Zhe Li ◽  
Guanzhi Liu ◽  
Run Tian ◽  
Ning Kong ◽  
Yue Li ◽  
...  

Abstract Our objective was to obtain normal patellofemoral measurements so as to provide a reference for prosthetic design. Besides, the absolute values and indices of TT-TG distances are still controversial in clinical application. A better method to enable precise clinical applications is still needed.Methods:78 knees of 78 subjects without knee pathologies were included in this cross-sectional study. A CT scan was obtained from all subjects and three-dimensional knee models were constructed using Mimics and SolidWorks software. We measured and analyzed 19 parameters including TT-TG distance and dimensions and shapes of patella, femur, tibia, and trochlea. LASSO regression was used to predict the normal TT-TG distances.Results:The dimensional indexes, TT-TG distance, and femoral aspect ratio of the males were significantly larger than those of females (all P values <0.05). However, after controlling the bias from age, height, and weight, there were no significant differences in TT-TG distances, PAL, and anterior-posterior dimensions between genders (all P values >0.05). The Pearson correlation coefficients between the AFO and other indexes were consistently below 0.3, indicating a none or weak relationship. Similar results were observed for the SA and the Wiberg index. Using LASSO regression, we obtained four parameters to predict TT-TG distance (R2=0.5612, P<0.01) to achieve the optimal accuracy and convenience. Conclusion:The anterior-posterior dimensions of the females were thicker than those of males for the same medial-lateral dimensions. More attention should be paid to not only gender differences but individual differences, especially the anterior condyle and trochlea. Besides, this study provided a new method of predicting TT-TG distance to enable precise clinical diagnoses and guide the medial transfer of the tibial tuberosity.


2020 ◽  
Vol 29 (3) ◽  
pp. 429-435
Author(s):  
Patricia C. Mancini ◽  
Richard S. Tyler ◽  
Hyung Jin Jun ◽  
Tang-Chuan Wang ◽  
Helena Ji ◽  
...  

Purpose The minimum masking level (MML) is the minimum intensity of a stimulus required to just totally mask the tinnitus. Treatments aimed at reducing the tinnitus itself should attempt to measure the magnitude of the tinnitus. The objective of this study was to evaluate the reliability of the MML. Method Sample consisted of 59 tinnitus patients who reported stable tinnitus. We obtained MML measures on two visits, separated by about 2–3 weeks. We used two noise types: speech-shaped noise and high-frequency emphasis noise. We also investigated the relationship between the MML and tinnitus loudness estimates and the Tinnitus Handicap Questionnaire (THQ). Results There were differences across the different noise types. The within-session standard deviation averaged across subjects varied between 1.3 and 1.8 dB. Across the two sessions, the Pearson correlation coefficients, range was r = .84. There was a weak relationship between the dB SL MML and loudness, and between the MML and the THQ. A moderate correlation ( r = .44) was found between the THQ and loudness estimates. Conclusions We conclude that the dB SL MML can be a reliable estimate of tinnitus magnitude, with expected standard deviations in trained subjects of about 1.5 dB. It appears that the dB SL MML and loudness estimates are not closely related.


2020 ◽  
Vol 4 (1) ◽  
pp. 51-63
Author(s):  
Peter Neuhaus ◽  
Chris Jumonville ◽  
Rachel A. Perry ◽  
Roman Edwards ◽  
Jake L. Martin ◽  
...  

AbstractTo assess the comparative similarity of squat data collected as they wore a robotic exoskeleton, female athletes (n=14) did two exercise bouts spaced 14 days apart. Data from their exoskeleton workout was compared to a session they did with free weights. Each squat workout entailed a four-set, four-repetition paradigm with 60-second rest periods. Sets for each workout involved progressively heavier (22.5, 34, 45.5, 57 kg) loads. The same physiological, perceptual, and exercise performance dependent variables were measured and collected from both workouts. Per dependent variable, Pearson correlation coefficients, t-tests, and Cohen's d effect size compared the degree of similarity between values obtained from the exoskeleton and free weight workouts. Results show peak O2, heart rate, and peak force data produced the least variability. In contrast, far more inter-workout variability was noted for peak velocity, peak power, and electromyography (EMG) values. Overall, an insufficient amount of comparative similarity exists for data collected from both workouts. Due to the limited data similarity, the exoskeleton does not exhibit an acceptable degree of validity. Likely the cause for the limited similarity was due to the brief amount of familiarization subjects had to the exoskeleton prior to actual data collection. A familiarization session that accustomed subjects to squats done with the exoskeleton prior to actual data collection may have considerably improved the validity of data obtained from that device.


Sign in / Sign up

Export Citation Format

Share Document