scholarly journals Effect of Maternal Water Restriction on Sexual Behavior, Reproductive Performance, and Reproductive Hormones of Male Rat Offspring

Animals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 379
Author(s):  
Ja’far Al-Khaza’leh ◽  
Rami Kridli ◽  
Belal Obeidat ◽  
Shahera Zaitoun ◽  
Anas Abdelqader
Keyword(s):  
Sexual Behavior ◽  
Reproductive Performance ◽  
Negative Impact ◽  
Sperm Count ◽  
Reproductive Hormones ◽  
Female Rats ◽  
Male Rat ◽  
Water Restriction ◽  
Rat Offspring ◽  
Intromission Latency

The present study aimed to investigate the effect of maternal water restriction on sexual behavior, reproductive performance, and reproductive hormones of male rat offspring. Forty pregnant female rats were divided into two equal groups: Control (C) and water-restricted (WR). Control dams had ad libitum water access throughout pregnancy, while dams in the WR group were subjected to 50% water-restriction from day 10 of pregnancy onwards. The maternal water restriction provoked a significant reduction (p < 0.05) in body weight of dams before delivery and at birth and litter body weights of offspring at birth. Maternal water restriction did not affect relative weights of reproductive and body organs of male rat offspring. All hormonal concentrations, sperm count, and vitality in male rat offspring were not significantly affected by maternal water restriction. Maternal water restriction exposure induced significant (p < 0.05) reduction in intromission latency, intromission frequency, and post-ejaculation interval in male rat offspring while a significant (p < 0.05) increase in the ejaculation latency was detected in maternal WR group. In conclusion, this study suggests that maternal water restriction had a negative impact on some reproductive characteristics but did not severely affect reproductive performance and reproductive hormones of male rat offspring.

Sexual Behavior is Enhanced by Regular, Repeated Mating from Young Adulthood to Middle Age in Female Long-Evans Rats

2020 ◽  
Vol 13 (2) ◽  
pp. 169-177
Author(s):  
Fay A. Guarraci ◽  
Chantal M.F. Gonzalez ◽  
Devon Lucero ◽  
Lourdes K. Davis ◽  
Sarah H. Meerts
Keyword(s):  
Sexual Behavior ◽  
Mating Behavior ◽  
Preference Test ◽  
Sexual History ◽  
Female Rats ◽  
Male Rat ◽  
Female Rat ◽  
Repeated Mating ◽  
First Time ◽  
Mating Tests

Background: Aging is associated neuroendocrine changes in women. Animals can be used to model these changes, as well as changes in reproductive behavior. Objective: The current study was designed to characterize mating behavior across age and assess the effects of age and sexual history on mating behavior. Methods: Sexual motivation was assessed using the partner-preference test, in which a female rat is given the choice to interact with a same-sex conspecific or a sexually-vigorous male rat, with which she can mate. Results: Across repeated mating tests (2-12 months of age), female rats spent more time with the male, displayed more solicitation behaviors, were less likely to leave the male after mounts, but visited both stimulus animals less frequently. Comparing a separate group of age-matched, hormoneyoked female rats mated for the first time at 12 months of age to female rats mated for the first time at 2 months of age showed that the 12 month rats visited both stimulus animals less, were less likely to leave the male after mounts, took longer to return to the male after mounts, and displayed fewer solicitation behaviors than their younger counterparts. Relative to middle-aged female rats once they were sexually experienced, 12 month naïve rats spent less time with the male, were more likely to leave the male after mounts, and displayed fewer solicitation behaviors. Furthermore, 12 month naïve rats failed to discriminate between the stimulus animals, visiting both stimulus animals at the same rate unlike 2 month naïve or 12 month experienced rats. Conclusion: Taken together, these results suggest that aging affects some measures of sexual behavior, but most effects of age can be mitigated by regular, repeated mating.

scholarly journals EFFECT OF YOHIMBINE ON CLOMIPRAMINE-INDUCED SEXUAL DYSFUNCTION IN MALE RATS

2017 ◽  
Vol 10 (2) ◽  
pp. 92
Author(s):  
Devangam Sheshadri Shekar
Keyword(s):  
Sexual Behavior ◽  
Sexual Dysfunction ◽  
Histopathological Examination ◽  
Red Light ◽  
Female Rats ◽  
Male Rats ◽  
Male Rat ◽  
Testicular Damage

Object: The present investigation has been carried out to find out the effect of yohimbine on clomipramine-induced sexual dysfunction in male rats.Methods: The male rats were treated with clomipramine and yohimbine simultaneously for 60 days. During the treatment, all the male rats werechallenged with the female rats which are in estrous phase and their sexual behavior was observed under dim red light. Half of the animals in each group and remaining on 60 day were sacrificed, blood was collected and serum separated. Testis was collected and preserved in 10% formalin forsubsequent histopathological examination. thResults: The study reveals that yohimbine failed to antagonize the clomipramine-induced sexual dysfunction in male rats in all aspects, except thepartial improvement in the sexual behavior.Conclusion: Yohimbine a well-known aphrodisiac failed to antagonize the clomipramine-induced sexual dysfunction in male rats. The decrease intestosterone levels, a decrease in spermatozoa count were continued even in the presence of yohimbine except improvement in the sexual behaviorparameters. Hence, yohimbine could not be a safe antidote against clomipramine-induced sexual dysfunction in male rats.Keywords: Yohimbine, Clomipramine, Testosterone, Male rat sexual competence, Testicular damage.

scholarly journals Investigation Into Effect Of Crude Mixture Of Abrus Precatorius Seed On Hypothalamopituitary Gonadal Axis And Development Of Antifertility In Male Rats

1970 ◽  
Vol 36 (1) ◽  
pp. 103-109 ◽  
Author(s):  
S Talukder ◽  
MA Hossain ◽  
S Sarker ◽  
MAH Khan
Keyword(s):  
Negative Impact ◽  
Sperm Count ◽  
Sharp Decrease ◽  
Serum Levels ◽  
Serum Biochemistry ◽  
Male Rats ◽  
Male Rat ◽  
Control Group ◽  
Abrus Precatorius ◽  
Crude Mixture

To evaluate the antifertility effect of crude mixture of A. precatorius seeds at the dose level of 50 mg/kg body weight in adult male rats, after oral administration to male rats for 40 days, the rats were sacrificed and hormonal profiles, serum biochemistry, sperm count and histological changes were recorded. A sharp decrease in the serum levels of testosterone (0.70 ± 0.17 ng/ml), FSH (0.70 ± 0.22 lU/L), and LH (0.87 ± 0.35 IU/L) was detected compared to control (FSH, LH and testosterone levels 0.93 ± 0.15 ng/ml, 0.76 ± 0.28 IU/L, 1.44 ± .011 IU/L, respectively). A significant reduction of epididymal sperm count (2.34 million/mL) was noted in treated rats as compared to control group (7.87 million/mL). Histology of testes showed marked atrophy of the testes, which was characterized by disruption of the seminiferous epithelium and atrophy of the Leydig cells. Crude mixture of A. precatorius seed has a negative impact on male reproductive functions. It might be suggested that crude mixture of A. precatorius seeds might have antifertility property for male rats.   Keywords: Abrus precatorius; antifertility; male rat; testosterone. DOI: http://dx.doi.org/10.3329/bjar.v36i1.9234 BJAR 2011; 36(1): 103-109

Dietary Administration of Colesevelam Hydrochloride Does Not Affect Fertility or Reproductive Performance in Rats

2004 ◽  
Vol 23 (6) ◽  
pp. 357-367 ◽  
Author(s):  
Judith K. Marquis ◽  
Rafif Dagher ◽  
Michael R. Jones
Keyword(s):  
Reproductive Performance ◽  
Sperm Count ◽  
Embryo Implantation ◽  
Sperm Concentration ◽  
Study Groups ◽  
Female Rats ◽  
Corpora Lutea ◽  
Sprague Dawley ◽  
Total Percentage ◽  
Male And Female Rats

Colesevelam hydrochloride (HCl) (WelChol; Sankyo Pharma) is a novel, highly potent, bile acid-binding polymer used for the treatment of hypercholesterolemia. The primary aim of this study was to determine the effects of dietarily administered colesevelam HCl on fertility and reproductive performance parameters. To assess these effects, sexually mature Sprague-Dawley rats were randomized to one of five treatment groups: feed alone, feed plus control article (SigmaCell), or feed plus colesevelam HCl 200, 1000, or 2000 mg/kg/day. Male and female rats were administered the appropriate group agent for 28 and 15 days, respectively, and were subsequently paired together for cohabitation and mating. Females continued to receive the test agent in their dietary formulation through presumed gestation day (GD) 7. Presumed pregnant females underwent cesarean section on GD 20. Food consumption rate, body weight, gross necropsy, and standard preclinical tests for reproduction and fertility were performed for each test animal. No statistically significant differences were found between control and drug-treated groups for any tested endpoints of reproduction. All animals placed in cohabitation successfully mated. Uterine and litter end points were unaffected by dosages of colesevelam HCl as high as 2000 mg/kg/day. There were no significant differences between treatment group litter averages in the number of corpora lutea, implantation sites, litter size, live fetuses, body weights, early/late resorptions, and the number of dams with viable fetuses. In addition, no external alterations of fetal morphology were attributable to treatment with colesevelam HCl when administered up to the embryo implantation stage. In male animals, no significant differences were found between the colesevelam HCl and control study groups in the average caudal epididymal sperm count or sperm concentration, total number of motile and nonmotile sperm, and the total percentage of motile sperm. Based on these data, colesevelam HCl does not have any significant adverse reproductive or fertility effects in rats, even when administered at doses approximately 30 times greater than the approved clinical dose.

Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring

2017 ◽  
Vol 8 (1) ◽  
pp. 3-7 ◽  
Author(s):  
S. Lecoutre ◽  
L. Marousez ◽  
A. Drougard ◽  
C. Knauf ◽  
C. Guinez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Adult Male ◽  
Messenger Rna ◽  
Leptin Receptor ◽  
Female Rats ◽  
Male Rat ◽  
Mrna Levels ◽  
Maternal Undernutrition ◽  
Rat Offspring ◽  
Adult Male Rat

Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone adult male rat offspring displayed hyperleptinemia with modifications in leptin and leptin receptor messenger RNA (mRNA) levels in white adipose tissue (WAT). Apelin is a member of the adipokine family that regulates various aspects of energy metabolism and WAT functionality. We investigated whether apelin and its receptor APJ could be a target of maternal undernutrition. Adult male rat offspring from FR30 dams showed increased plasma apelin levels and apelin gene expression in WAT. Post-weaning high-fat diet led to marked increase in APJ mRNA and protein levels in offspring’s WAT. We demonstrate that maternal undernutrition and post-weaning diet have long-term consequences on the apelinergic system of adult male rat offspring.

Maternal exposure to picrotoxin modifies the response of the GABAA receptor during sexual behavior of adult male rat offspring

2012 ◽  
Vol 23 (7) ◽  
pp. 703-709 ◽  
Author(s):  
Maria M. Bernardi ◽  
Thiago B. Kirsten ◽  
Elizabeth Teodorov ◽  
Ana C.Z. Baso ◽  
Fabio C. Prosdocimi ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Gabaa Receptor ◽  
Adult Male ◽  
Maternal Exposure ◽  
Male Rat ◽  
Rat Offspring ◽  
Adult Male Rat

scholarly journals Gestational Diabetes Adversely Affects Pancreatic Islet Architecture and Function in the Male Rat Offspring

Endocrinology ◽  
2019 ◽  
Vol 160 (8) ◽  
pp. 1907-1925 ◽  
Author(s):  
Prasoon Agarwal ◽  
Navdeep Brar ◽  
Taylor S Morriseau ◽  
Stephanie M Kereliuk ◽  
Mario A Fonseca ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gestational Diabetes ◽  
Ribosomal Proteins ◽  
Female Rats ◽  
Whole Body ◽  
Male Rat ◽  
Islet Function ◽  
Adult Rat ◽  
Rat Offspring ◽  
Glucose Stimulated Insulin Secretion

Abstract Fetal exposure to gestational diabetes mellitus (GDM) and poor postnatal diet are strong risk factors for type 2 diabetes development later in life, but the mechanisms connecting GDM exposure to offspring metabolic health remains unclear. In this study, we aimed to determine how GDM interacts with the postnatal diet to affect islet function in the offspring as well as characterize the gene expression changes in the islets. GDM was induced in female rats using a high-fat, high-sucrose (HFS) diet, and litters from lean or GDM dams were weaned onto a low-fat (LF) or HFS diet. Compared with the lean control offspring, GDM exposure reduced glucose-stimulated insulin secretion in islets isolated from 15-week-old offspring, which was additively worsened when GDM exposure was combined with postnatal HFS diet consumption. In the HFS diet–fed offspring of lean dams, islet size and number increased, an adaptation that was not observed in the HFS diet–fed offspring of GDM dams. Islet gene expression in the offspring of GDM dams was altered in such categories as inflammation (e.g., Il1b, Ccl2), mitochondrial function/oxidative stress resistance (e.g., Atp5f1, Sod2), and ribosomal proteins (e.g., Rps6, Rps14). These results demonstrate that GDM exposure induced marked changes in gene expression in the male young adult rat offspring that cumulatively interact to worsen islet function, whole-body glucose homeostasis, and adaptations to HFS diets.

scholarly journals Assessment of the Protective Impact of Vitamin E on Sex Hormones and Sperm Parameters of Formaldehyde-treated Male Rats: A Preliminary Investigation

2017 ◽  
Vol 6 (4) ◽  
pp. 330-337
Author(s):  
Hassan Moladoust ◽  
Ebrahim Nasiri ◽  
Rouhollah Gazor ◽  
Tolue Mahdavi ◽  
Reza Ghorbani ◽  
...  
Keyword(s):  
Vitamin E ◽  
Adult Male ◽  
Reproductive System ◽  
Corn Oil ◽  
Negative Impact ◽  
Sperm Count ◽  
Reproductive Hormones ◽  
Sperm Parameters ◽  
Male Rats ◽  
The Impact

Background: Lifestyle factors, including environmental and occupational exposure, have a key role in reproductive health status and may impact fertility. Formaldehyde (FA) is a suspected reproductive toxicant, which may cause significant adverse effects on the reproductive system. This study was aimed at detecting the impact of FA and the possible protective role of vitamin E on the male reproductive system in rats. Materials and Methods: Thirty-two adult male Wistar rats were randomly divided into four groups: control rats, rats treated with vehicle (corn-oil), rats treated with 10 mg/kg/day FA (FAt), and rats treated with FA plus 30 mg/kg/day vitamin E plus vehicle (FAt+ vitamin E) for two weeks. After treatment, sex hor­mone levels were examined using ELISA. Moreover the count, morphology, and motility of sperm, were observed. Results: The sperm count and the percentage of rapid progressive sperm were significantly decreased in rats in the FAt-treated group compared with those in the control and vehicle-treated groups (p<0.05). Vitamin E treatment significantly improved the parame­ters examined in the FAt+ vitamin E group (29.85±8.62 vs. 10.04±4.79 for sperm count and 60.50±5.67 vs. 42.19±8.02 for sperm motility). Moreover, serum follicle-stimulating hormone (FSH) levels mildly decreased in the FA exposure group, although the difference was not statis­tically significant (p>0.05). Conclusion: The findings of this study revealed that FA exposure had a negative impact on sperm parameters and some reproductive hormones in rats and vita­min E attenuated the deleterious impact of FA on the reproductive system of adult male rats. [GMJ.2017;6(4):330-7] DOI: 10.22086/gmj.v6i4.904

scholarly journals Association between high-fat diet feeding and male fertility in high reproductive performance mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
M. D. Gómez-Elías ◽  
T. S. Rainero Cáceres ◽  
M. M. Giaccagli ◽  
V. A. Guazzone ◽  
G. N. Dalton ◽  
...  
Keyword(s):  
Reproductive Performance ◽  
High Fat Diet ◽  
Male Fertility ◽  
Negative Impact ◽  
Sperm Count ◽  
Male Mice ◽  
High Fat ◽  
Hybrid Male ◽  
Testicular Weight

AbstractThe increasing worldwide prevalence of metabolic syndrome (MetS), especially in younger populations, is a risk factor for fertility disorders. However, a direct correlation of MetS with male infertility still remains unclear. In this work, we evaluated whether MetS has a negative impact on fertility of hybrid male mice with high reproductive performance. To induce a MetS-like condition, (C57BL/6xBALB/c) F1 male mice were fed a high-fat diet (HFD, 30% fat) for 19 weeks, while controls received a normal-fat diet (NFD, 6% fat). HFD-fed animals exhibited increased body weight, hypercholesterolemia, hyperglycemia and glucose intolerance. In vivo fertilisation assays performed along the treatment period showed no differences in fertilisation nor in vitro embryo development rates between groups. While testicular weight and morphology were similar in both groups, HFD-fed mice presented lighter epididymides and higher amounts of gonadal fat. Moreover, sperm count was lower in HFD-fed mice, despite normal sperm viability, morphology, motility or acrosome reaction. Finally, no differences were observed in in vitro fertilisation rates between groups. In summary, although HFD feeding altered some reproductive parameters, it did not impair male fertility in high performance breeders suggesting the possibility that a fertility impairment could be the result of the cumulative combination of environmental and/or genetic factors.

scholarly journals Leaf-Methanolic Extract of Pseudopanax arboreus (Araliaceae) (L. F. Phillipson) Reverses Amitriptyline-Induced Sexual Dysfunction in Male Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Egbe B. Besong ◽  
G. Ateufack ◽  
Smith B. Babiaka ◽  
Albert Kamanyi
Keyword(s):  
Sexual Behavior ◽  
Sexual Dysfunction ◽  
Methanolic Extract ◽  
Relative Weight ◽  
Hormonal Treatment ◽  
Female Rats ◽  
Male Rats ◽  
Normal Male ◽  
Intromission Latency ◽  
Group 2

The people of the Bayangi tribe (Manyu Division) of Cameroon have used the leaves of Pseudopanax arboreus (Araliaceae) traditionally for decades as an aphrodisiac. In order to scientifically investigate this folk claim, we evaluated the effects of the leaf-aqueous extract of P. arboreus on the sexual behavior of normal male rats. The present study was designed to assess the effects of the leaf-methanolic extract of P. arboreus on amitriptyline-induced sexual dysfunction in male rats. Sexually impaired male rats were randomly divided into 4 groups of 8 rats each. Group 1 received 10 ml/kg distilled water, while group 2 was given 6 mg/kg Viagra. Groups 3 and 4 received 46.5 and 93 mg/kg of the leaf-methanolic extract, respectively. Female rats were made receptive by ovariectomy and subsequent hormonal treatment. Sexual behavior parameters were monitored on days 1, 7, 14, and 21 by pairing each male to a receptive female. The extract-treated rats registered significant decrease in mount latency (ML) and intromission latency (IL); nonsignificant increase in mount frequency (MF), intromission frequency (IF), and penile licking (PL); significant decrease in postejaculatory interval (PEI); contrasting effects in ejaculation latency (EL); and mean intromission interval (MII). Both doses of the extract also provoked a significant increase in relative weight of testes, but had no significant effect on the plasma hormonal profile. These findings are similar to those obtained with normal male rats and show that the leaf-methanolic extract of P. arboreus could constitute a potential solution to male sexual impairment.

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