scholarly journals Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 822
Author(s):  
Firzan Nainu ◽  
Ayu Masyita ◽  
Muh. Akbar Bahar ◽  
Muhammad Raihan ◽  
Shajuthi Rahman Prova ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Royal Jelly ◽  
Chemical Compounds ◽  
Special Focus ◽  
Bioactive Components ◽  
Long Run ◽  
Alternative Approach ◽  
Traditional Healing Practices ◽  
Viral Proliferation ◽  
Insight Into

Bee products have long been used in traditional healing practices to treat many types of disorders, including cancer and microbial-related diseases. Indeed, several chemical compounds found in bee products have been demonstrated to display anticancer, antibacterial, antiviral, and antiparasitic properties. With the improvement of research tools and in view of recent advances related to bee products, this review aims to provide broad yet detailed insight into the pharmaceutical prospects of bee products such as honey, propolis, bee pollen, royal jelly, bee bread, beeswax, and bee venom, in the domain of cancer and infectious disease management. Available literature confirms the efficacy of these bee products in the alleviation of cancer progression, inhibition of bacterial and viral proliferation, and mitigation of parasitic-related symptoms. With such potentials, bioactive components isolated from the bee products can be used as an alternative approach in the long-run effort to improve humans’ health at a personal and community level.

Speed vs. comfort: Testing the efficacy of a single question for predicting transit users’ route choices

2019 ◽  
Author(s):  
Joseph John Pyne Simons ◽  
Ilya Farber
Keyword(s):  
Data Collection ◽  
Efficient Method ◽  
Choice Task ◽  
The Self ◽  
Self Report ◽  
Model Parameters ◽  
Single Item ◽  
Alternative Approach ◽  
Single Question ◽  
Insight Into

Not all transit users have the same preferences when making route decisions. Understanding the factors driving this heterogeneity enables better tailoring of policies, interventions, and messaging. However, existing methods for assessing these factors require extensive data collection. Here we present an alternative approach - an easily-administered single item measure of overall preference for speed versus comfort. Scores on the self-report item predict decisions in a choice task and account for a proportion of the differences in model parameters between people (n=298). This single item can easily be included on existing travel surveys, and provides an efficient method to both anticipate the choices of users and gain more general insight into their preferences.

Kinase Phosphorylation-based Mechanisms of PARP Inhibitor Resistance During Synthetic Lethal Oncotherapy

2020 ◽  
Vol 15 (1) ◽  
pp. 12-23
Author(s):  
Eriko Osaki ◽  
Shinya Mizuno
Keyword(s):  
Cancer Progression ◽  
Catalytic Domain ◽  
Synthetic Lethality ◽  
Excision Repair ◽  
Parp Inhibitor ◽  
Clinical Importance ◽  
Parp Inhibition ◽  
Special Focus ◽  
Driver Genes ◽  
Kinase Phosphorylation

Background: Poly-(ADP-Ribose) Polymerase (PARP) plays a central role in recovery from single-strand DNA (ssDNA) damage via base excision repair. When PARP activity is inhibited by a NAD+ mimetic analog, ssDNA is converted into a Double-Strand Break (DSB) during the S-phase in a cell cycle. However, the DSB site is repaired in a process of Homologous Recombination (HR) that is derived by genes such as BRCA1/2, PALB2, and RAD51. Under conditions of HR dysfunction, including mutations of BRCA1/2 (called BRCAness), PARP inhibitor (PARPi) induces “synthetic lethality” in BRCAness-specific cancer cells. Indeed, clinical trials using forms of PARPi that include olaparib, veliparib and rucaparib, have revealed that PARP inhibition produces a dramatic effect that actually arrests cancer progression. Its clinical efficiency is limited, however, due to the acquisition of PARPi resistance during long-term use of this inhibitor. Thus, it is important to elucidate the mechanisms of PARPi resistance. Methods: We searched the scientific literature published in PubMed, with a special focus on kinase phosphorylation that is involved in acquiring PARPi resistance. We also summarized the possible molecular events for recovering HR system, a key event for acquiring PARPi resistance. Results: CDK1 is a critical kinase for 5’-3’ DNA end resection, which is important for generating ssDNA for recruiting HR-priming factors. CDK12 is necessary for the transcription of HR-driver genes, such as BRCA1, BRCA2, RAD51 and ATR via the phosphorylation of RNA Pol-II. PLK-1 participates in driving HR via the phosphorylation of RAD51. The PI3K-AKT-mTOR signaling cascade is involved in BRCA1 induction via an ETS1 transcriptional pathway. Even under ATMdeficient conditions, the ATR-CHK1 axis compensates for loss in the DNA damage response, which results in HR recovery. The HGF receptor Met tyrosine kinase is responsible for promoting DNA repair by activating the PARP catalytic domain. Conclusion: These kinase-based signaling pathways are biologically important for understanding the compensatory system of HR, whereas inactivation of these kinases has shown promise for the release of PARPi resistance. Several lines of preclinical studies have demonstrated the potential use of kinase inhibitors to enhance PARPi sensitivity. We emphasize the clinical importance of chemical inhibitors as adjuvant drugs to block critical kinase activities and prevent the possible PARPi resistance.

scholarly journals LOXL2 Inhibitors and Breast Cancer Progression

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 312
Author(s):  
Sandra Ferreira ◽  
Nuno Saraiva ◽  
Patrícia Rijo ◽  
Ana S. Fernandes
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Cancer Biology ◽  
Breast Cancer Cells ◽  
Lysyl Oxidase ◽  
Breast Cancer Progression ◽  
Special Focus ◽  
Amine Oxidases ◽  
Cross Link ◽  
Promising Strategy

LOX (lysyl oxidase) and lysyl oxidase like-1–4 (LOXL 1–4) are amine oxidases, which catalyze cross-linking reactions of elastin and collagen in the connective tissue. These amine oxidases also allow the cross-link of collagen and elastin in the extracellular matrix of tumors, facilitating the process of cell migration and the formation of metastases. LOXL2 is of particular interest in cancer biology as it is highly expressed in some tumors. This protein also promotes oncogenic transformation and affects the proliferation of breast cancer cells. LOX and LOXL2 inhibition have thus been suggested as a promising strategy to prevent metastasis and invasion of breast cancer. BAPN (β-aminopropionitrile) was the first compound described as a LOX inhibitor and was obtained from a natural source. However, novel synthetic compounds that act as LOX/LOXL2 selective inhibitors or as dual LOX/LOX-L inhibitors have been recently developed. In this review, we describe LOX enzymes and their role in promoting cancer development and metastases, with a special focus on LOXL2 and breast cancer progression. Moreover, the recent advances in the development of LOXL2 inhibitors are also addressed. Overall, this work contextualizes and explores the importance of LOXL2 inhibition as a promising novel complementary and effective therapeutic approach for breast cancer treatment.

scholarly journals Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3770
Author(s):  
Željka Peršurić ◽  
Sandra Kraljević Pavelić
Keyword(s):  
Mass Spectrometry ◽  
Wound Healing ◽  
Chemical Composition ◽  
Extracellular Vesicles ◽  
Royal Jelly ◽  
Geographical Origin ◽  
Bioactive Components ◽  
Animal Cells ◽  
Health Promoting ◽  
High Diversity

In recent years, interest has surged among researchers to determine compounds from bee products such as honey, royal jelly, propolis and bee pollen, which are beneficial to human health. Mass spectrometry techniques have shown that bee products contain a number of proven health-promoting compounds but also revealed rather high diversity in the chemical composition of bee products depending on several factors, such as for example botanical sources and geographical origin. In the present paper, we present recent scientific advances in the field of major bioactive compounds from bee products and corresponding regenerative properties. We also discuss extracellular vesicles from bee products as a potential novel bioactive nutraceutical component. Extracellular vesicles are cell-derived membranous structures that show promising potential in various therapeutic areas. It has been extensively reported that the use of vesicles, which are naturally formed in plant and animal cells, as delivery agents have many advantages. Whether the use of extracellular vesicles from bee products represents a new solution for wound healing remains still to be elucidated. However, promising results in specific applications of the bee products in wound healing and tissue regenerative properties of extracellular vesicles provide a good rationale to further explore this idea.

Determination of Bioactive Components of 60°С Volatiles from Cinnamomum camphora Branches by TD-GC/MS

2011 ◽  
Vol 230-232 ◽  
pp. 852-856
Author(s):  
Qing Li ◽  
Dang Quan Zhang ◽  
Qi Mei Liu ◽  
Kuan Peng
Keyword(s):  
Chemical Compounds ◽  
Chemical Components ◽  
Cinnamomum Camphora ◽  
Bioactive Components ◽  
Industrial Materials ◽  
Analytical Result ◽  
Main Components

The chemical components of helium volatiles from the fresh branches of Cinnamomum camphora were studied by TD-GC/MS. The analytical result by 60°С-based TD-GC/MS showed that 55 peaks were obtained from the helium volatiles from the fresh branches of Cinnamomum camphora and 53 chemical compounds were identified. The results showed that the main components were as: Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)- (15.4328%), 1,3-Benzodioxole, 5-(2-propenyl)- (14.881%), Tricyclo[2.2.1.0(2,6)]heptane, 1,7-dimethyl-7-(4-methyl-3-pentenyl)-, (-)- (12.694%), p-menth-1-en-8-ol (9.832%), Bicyclo[2.2.1]heptane, 2-methyl-3-methylene-2-(4-methyl-3- pentenyl)-, (1S-exo)- (6.143%), 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl- (5.365%), Bicyclo[3.1.1] hept-2-ene, 2,6-dimethyl-6-(4-methyl-3-pentenyl)- (4.527%), Naphthalene, 1,2,3,5,6,8a- hexahydro-4,7-dimethyl-1-(1-methylethyl)-, (1S-cis)- (4.129%), 3-Cyclohexen-1-ol, 4-methyl-1- (1-methylethyl)- (2.965%), Borneol (2.627%), Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, (1S-endo)- (2.586%), Copaene (2.534%), 1,6,10-Dodecatriene, 7,11-dimethyl-3-methylene-, (Z)- (1.612%), (-)-Isosativene (1.121%), etc. The analytical result suggested that the helium volatiles from the fresh branches of Cinnamomum camphora could be used as industrial materials of biomedicines and spicery.

scholarly journals Human Milk Microbiota and Oligosaccharides: A Glimpse into Benefits, Diversity and Correlations

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1123
Author(s):  
Carole Ayoub Moubareck
Keyword(s):  
Human Milk ◽  
Maternal Diet ◽  
Geographical Location ◽  
Intestinal Barrier ◽  
Bioactive Components ◽  
Bioactive Constituents ◽  
Ongoing Research ◽  
Genetic Significance ◽  
The Rich ◽  
Insight Into

Human milk represents a cornerstone for growth and development of infants, with extensive array of benefits. In addition to exceptionally nutritive and bioactive components, human milk encompasses a complex community of signature bacteria that helps establish infant gut microbiota, contributes to maturation of infant immune system, and competitively interferes with pathogens. Among bioactive constituents of milk, human milk oligosaccharides (HMOs) are particularly significant. These are non-digestible carbohydrates forming the third largest solid component in human milk. Valuable effects of HMOs include shaping intestinal microbiota, imparting antimicrobial effects, developing intestinal barrier, and modulating immune response. Moreover, recent investigations suggest correlations between HMOs and milk microbiota, with complex links possibly existing with environmental factors, genetics, geographical location, and other factors. In this review, and from a physiological and health implications perspective, milk benefits for newborns and mothers are highlighted. From a microbiological perspective, a focused insight into milk microbiota, including origins, diversity, benefits, and effect of maternal diet is presented. From a metabolic perspective, biochemical, physiological, and genetic significance of HMOs, and their probable relations to milk microbiota, are addressed. Ongoing research into mechanistic processes through which the rich biological assets of milk promote development, shaping of microbiota, and immunity is tackled.

Market Influence Analytics in a Digital Ecosystem

2012 ◽  
Vol 2 (4) ◽  
pp. 42-53 ◽  
Author(s):  
Vandana Ahuja
Keyword(s):  
Negative Impact ◽  
Information Age ◽  
Product Positioning ◽  
Careful Evaluation ◽  
Digital Ecosystem ◽  
New Business ◽  
Marketing Intelligence ◽  
Micro Level ◽  
Viral Proliferation ◽  
Insight Into

The internet provides opportunities for marketing which extend from the micro level of electronic contacts to the macro level of new business opportunities. As the democratisation of consumer expression leads to a viral proliferation of information online, the new age communication ecosystem has prompted the need for a careful evaluation of the potential of what is being called Consumer Generated internet content, creating new challenges for Marketing Intelligence. These offerings of the Information age have garnered adequate potential to engineer business transformations. Consumer Generated Media (CGM) comprises the content generated by consumers within online venues such as Internet forums, Blogs, Wikis, discussion lists, etc. Leveraging CGM and channelizing it appropriately has become critical for organisations for understanding and managing market performance, product positioning, and driving brand reputations. The biggest challenge in front of organizations now is to harvest CGM to help marketers gain insight into the online market conversations taking place. Efforts are on by marketing in organizations to track the volume, origin, flow, and trajectory of the conversations in real time as they evolve, study the domain of Individual Internet Worth and map the scope, reach and influence of the same on topics that might have a positive or negative impact on a company’s products, promotions, and reputation.

scholarly journals GUIDELINES FOR DESIGNING SAND NOURISHMENT ON LOW TO VERY EXPOSED COASTS

2020 ◽  
pp. 5
Author(s):  
Henrik Vinge Karlsson ◽  
Britt Gadesboll Larsen ◽  
Per Sorensen
Keyword(s):  
Natural Variation ◽  
Primary Objective ◽  
Coastal Protection ◽  
Special Focus ◽  
Protection Scheme ◽  
Coastal Cliff ◽  
Sand Nourishment ◽  
The Impact ◽  
Privately Owned ◽  
Insight Into

Danish law establishes a common right of passage on foot along the Danish shoreline, even though beaches are often privately owned. The law also states that coastal protection must not hinder this. Therefore, sand nourishment should be part of every coastal protection scheme against erosion. Sand nourishments can be designed in numerous ways depending on their objectives. As part of the European Interreg project, Building With Nature (BWN), guidelines will be developed by the Danish Coastal Authority (DCA) in end-2020. This abstract presents these guidelines with special focus on the coasts of Denmark. Special emphasis will be on insight into the natural variation of the coasts, as this is vital both when designing effective coastal protection schemes and when evaluating the impact of the nourishment. In this project, the pathway along which sediment is being transported spans from offshore at the outer bar to the coastal cliff. The aim is to be able to determine the along- and cross-shore paths, along which the nourishment sand is transported, the diffusion velocity of the nourishment and the impact on the surrounding coasts. Based on the results of the multiple analysis, the primary objective is to produce guidelines on how to use sand nourishment to counteract erosion in a sustainable and socioeconomic way.Recorded Presentation from the vICCE (YouTube Link): https://youtu.be/nIrFFmH98V8

scholarly journals Is Customer Satisfaction Driving Revenue A Longitudinal Analysis With Evidence From The Banking Industry

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Gerhard Winkler ◽  
Markus S. Schwaiger
Keyword(s):  
Customer Satisfaction ◽  
Banking Industry ◽  
Positive Impact ◽  
Time Lag ◽  
Retail Banking ◽  
Long Run ◽  
Long Term Impact ◽  
Insight Into ◽  
Longitudinal Dataset

The connection between customer satisfaction and the financial performance of companies has been under academic scrutiny for quite some time. Evidence regarding the long term impact of customer satisfaction is however relatively scarce. Furthermore, research has so far often neglected potential industry idiosyncrasies in estimating the consequences of changes in customer satisfaction. We provide an insight into the overall long run impact of customer satisfaction on operating revenues based on a longitudinal dataset for the Austrian retail banking industry. Our results corroborate the intuition of a positive long run effect of satisfaction on revenues. We can show, that a time lag of 1,5 years has to elapse for satisfaction to have a positive impact on sales.

Spotlight: 21st Century Skills in Latin America and the Caribbean

2021 ◽  
Author(s):  
Christopher Petrie ◽  
Clara García-Millán ◽  
María Mercedes Mateo-Berganza Díaz
Keyword(s):  
Latin America ◽  
21St Century ◽  
21St Century Skills ◽  
Economic Conditions ◽  
Development Bank ◽  
Learning Context ◽  
Long Run ◽  
The World ◽  
The Caribbean ◽  
Insight Into

There is a wealth of conversation around the world today on the future of the workplace and the skills required for children to thrive in that future. Without certain core abilities, even extreme knowledge or job-specific skills will not be worth much in the long run. To address these issues, the Inter-American Development Bank (IDB) and HundrED conducted this Spotlight project with the goal of identifying and researching leading innovations that focus on 21st Century Skills in Latin America and the Caribbean. The Spotlight program was supported by J.P. Morgan. The purpose of this project is to shine a spotlight, and make globally visible, leading education innovations from Latin America and the Caribbean doing exceptional work on developing 21st Century Skills for all students, teachers, and leaders in schools today. The main aims of this Spotlight are to: Discover the leading innovations cultivating 21st century skills in students globally; understand how schools or organizations can implement these innovations; gain insight into any required social or economic conditions for these innovations to be effectively introduced into a learning context; celebrate and broadcast these innovations to help them spread to new countries. All the findings of the Spotlight in 21st Century Skills are included in this report.

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