scholarly journals Potentials of Raspberry Ketone as a Natural Antioxidant

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 482
Author(s):  
Sung Ho Lim ◽  
Chang-Ik Choi
Keyword(s):  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Experimental Models ◽  
Functional Health ◽  
Health Food ◽  
Pharmacological Activities ◽  
Raspberry Ketone ◽  
Effective Antioxidant ◽  
Total Antioxidant ◽  
Underlying Mechanisms

Oxidative stress is closely linked to various diseases, and many studies have been conducted to determine how to reduce this stress. In particular, efforts are being made to find potential antioxidants from natural products. Studies have shown that raspberry ketone (RK; 4-(4-hydroxyphenyl)-2-butanone) has various pharmacological activities. This review summarizes the antioxidant activities of RK and their underlying mechanisms. In several experimental models, it was proven that RK exhibits antioxidant properties through increasing total antioxidant capacity (TAC); upregulating antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT); and improving lipid peroxidation. In conclusion, research about RK’s antioxidant activities is directly or indirectly related to its other various physiological activities. Further studies at the clinical level will be able to verify the value of RK as an effective antioxidant, functional health food, and therapeutic agent.

Antioxidant Properties of Ethanolic Extract from Ramulus mori (Sangzhi)

2009 ◽  
Vol 15 (5) ◽  
pp. 435-444 ◽  
Author(s):  
Zuofa Zhang ◽  
Jie Jin ◽  
Liangen Shi
Keyword(s):  
Antioxidant Activity ◽  
Superoxide Radical ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Reducing Power ◽  
Ethanolic Extract ◽  
Experimental Models ◽  
Hplc Method ◽  
Total Phenolic ◽  
Dependent Manner

The antioxidant properties and total phenolic contents of four fractions of ethanolic extract from Ramulus mori were examined. Various experimental models including superoxide radical, hydroxyl radical, 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) scavenging activity, metal chelating activity, and reducing power were used for characterization of their antioxidant activity. The four fractions showed various degrees of efficacy in each assay in a dose-dependent manner. The third fraction with the highest amount of total phenolics was the most potent antioxidant in all assays used. In addition, the most powerful compound (oxyresveratrol) was isolated and identified followed by on-line HPLC method and characterized by different spectral analysis. Oxyresveratrol exhibited impressive antioxidant activities in scavenging the superoxide radical, hydroxide radical, and DPPH. On the basis of the results obtained, Ramulus mori may serve as a potential source of natural antioxidant due to its significant antioxidant activity and oxyresveratrol may be the most powerful antioxidant in ethanolic extracts of Ramulus mori.

scholarly journals Myocardial Protection from Ischemia-Reperfusion Damage by the Antioxidant Effect ofHibiscus sabdariffa Linnaeuson Metabolic Syndrome Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Israel Pérez-Torres ◽  
Juan Carlos Torres-Narváez ◽  
Verónica Guarner-Lans ◽  
Eulises Díaz-Díaz ◽  
Mario Perezpeña-Diazconti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antioxidant Capacity ◽  
Myocardial Protection ◽  
Mechanical Performance ◽  
Antioxidant Activities ◽  
Ischemia Reperfusion ◽  
Antioxidant Properties ◽  
Antioxidant Effect ◽  
Total Antioxidant ◽  
Copper Zinc Superoxide Dismutases

Cardiovascular diseases (CVD) constitute one of the most prevalent health problems worldwide, being strongly associated with metabolic syndrome (MS). Oxidative stress (OS) is present in both CVD and MS. Infusions ofHibiscus sabdariffa Linnaeus(HSL) have antioxidant properties and could therefore decrease the presence of OS in these diseases. The aim of this study was to evaluate myocardial protection during ischemia/reperfusion due to the antioxidant effect of HSL infusion (3%) on a MS rat model induced by the administration of 30% sucrose in drinking water. We determined in control, MS, andMS+HSLrat hearts (n=6per group) cardiac mechanical performance (CMP), coronary vascular resistance (CVR), and activities of manganese and copper/zinc superoxide dismutases (Mn and Cu/Zn-SOD), peroxidases, glutathione peroxidase (GPx), catalase (CAT), glutathione s-transferase (GST), glutathione reductase (GR), and glutathione (GSH). We also determined lipoperoxidation (LPO), total antioxidant capacity (TAC), and the nitrate/nitrite ratio (NO3-/NO2-). The treatment with the HSL infusion restored the CMP (p=0.01) and CVR (p=0.04) and increased the Mn- (p=0.02), Cu/Zn-SOD (p=0.05), peroxidases (p=0.04), GST (p=0.02) activity, GHS (p=0.02), TAC (p=0.04), and NO3-/NO2-(p=0.01) and decreased the LPO (p=0.02) in the heart of MS rats undergoing ischemia/reperfusion. The results suggest that the treatment with an infusion from HSL calices protects the cardiac function from damage by ischemia and reperfusion through the antioxidant activities of the substances it possesses. It favors antioxidant enzymatic activities and nonenzymatic antioxidant capacity.

scholarly journals Proximate and antioxidant activities of bio-preserved ogi flour with garlic and ginger

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1936 ◽  
Author(s):  
Abiola F. Olaniran ◽  
Sumbo H. Abiose
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Titratable Acidity ◽  
Total Phenolic ◽  
Health Food ◽  
Mineral Contents ◽  
Antioxidants Activity ◽  
Total Antioxidant ◽  
Ginger Powder

Background: Ogi from locally available cereals remains a relatively affordable complementary food in West Africa, but has a tendency to spoil due it high moisture content. This study explored effects of garlic and ginger as biopreservatives in ogi flour. Methods: Ogi flour was prepared from sorghum and quality protein maize grains with different concentrations of garlic and ginger powder (2 and 4% w/w) by fermentation technique. These samples were stored for 16 weeks during which the total titratable acidity, pH, proximate composition, mineral content and total antioxidant activities were determined. Results: The proximate compositions of bio-preserved ogi samples were relatively stable throughout storage. The addition of garlic and ginger slightly increased the ash (0.04%), crude protein and mineral contents (mg/ 100g) of the samples.  Magnesium (10.85-13.13 and 5.17-9.72); zinc (1.37-1.78 and 7.01-8.50), manganese (1.30-1.71 and 0.45-0.86) and iron (1.53-1.77 and 0.68-2.77) contents increased on addition (of garlic and ginger) to maize ogi and sorghum ogi flours respectively. The free radical scavenging activity; total phenolic and flavonoid contents increased correspondingly with the antioxidants activity. Conclusion: Although not well known to ogi consumer, the bio-preserved ogi flours showed better nutritional values and have potential as a health food.

Cardioprotection by ginseng: experimental and clinical evidence and underlying mechanisms

2018 ◽  
Vol 96 (9) ◽  
pp. 859-868 ◽  
Author(s):  
Xiaohong Tracey Gan ◽  
Morris Karmazyn
Keyword(s):  
Animal Studies ◽  
Large Scale ◽  
Clinical Evidence ◽  
Artery Bypass ◽  
Antioxidant Properties ◽  
Experimental Models ◽  
Therapeutic Effects ◽  
Ischemic And Reperfusion Injury ◽  
Underlying Mechanisms ◽  
The Many

Protection of the ischemic and reperfused myocardium represents a major therapeutic challenge. Translating results from animal studies to the clinical setting has been disappointing, yet the need for effective intervention, particularly to limit heart damage following infarction or surgical procedures such as coronary artery bypass grafting, is substantial. Among the many compounds touted as cardioprotective agents is ginseng, a medicinal herb belonging to the genus Panax, which has been used as a medicinal agent for thousands of years, particularly in Asian societies. The biological actions of ginseng are very complex and reflect composition of many bioactive components, although many of the biological and therapeutic effects of ginseng have been attributed to the presence of steroid-like saponins termed ginsenosides. Both ginseng and many ginsenosides have been shown to exert cardioprotective properties in experimental models. There is also clinical evidence that traditional Chinese medications containing ginseng exert cardioprotective properties, although such clinical evidence is less robust primarily owing to the paucity of large-scale clinical trials. Here, we discuss the experimental and clinical evidence for ginseng, ginsenosides, and ginseng-containing formulations as cardioprotective agents against ischemic and reperfusion injury. We further discuss potential mechanisms, particularly as these relate to antioxidant properties.

scholarly journals Kefir fermentation as a bioprocess to improve lentils antioxidant properties: is it worthwhile?

2020 ◽  
Vol 23 ◽  
Author(s):  
Iuri Magalhães de Alencar Oliveira ◽  
Ruann Janser Soares de Castro
Keyword(s):  
Incubation Temperature ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Bioactive Molecules ◽  
Percentage Increase ◽  
Total Antioxidant ◽  
Dpph Radical Scavenging ◽  
Lactic Bacteria ◽  
Fermented Products

Abstract Kefir, a consortium of acetic and lactic bacteria and yeasts, is versatile for biotransformation of vegetable substrates and may improve their bioactive properties. Lentil is a legume rich in vitamins, minerals, complex carbohydrates and proteins, making it an excellent substrate for fermentation and obtaining bioactive molecules. We report the effect of different process variables on antioxidant properties of lentil extracts obtained using kefir as a biotransformation agent and experimental design. The results showed that the factors agitation (rpm) and incubation temperature exerted significant effects. Incubation temperature of 28 °C and agitation of 75 rpm were the most suitable conditions for kefir fermentation and maximizing the antioxidant properties of the fermented lentils. The highest antioxidant activities for fermented products were 4128.39, 35.87 and 23.20 μmol of Trolox equivalents per gram of sample (μmoL TE g-1) measured by Total Antioxidant Capacity, FRAP and DPPH-radical scavenging methods, respectively. Additionally, we detected that the initial fermentation times (in the first six hours) were enough to positively affect the antioxidant properties of the lentil extracts, reaching a percentage increase of up to 270% in the antioxidant activity of the fermented products in relation to those non-fermented samples.

A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds

2019 ◽  
Vol 15 ◽  
Author(s):  
Aleksandra Kładna ◽  
Paweł Berczyński ◽  
Oya Bozdağ Dündar ◽  
Irena Kruk ◽  
Beyza Torun ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Antioxidant Activities ◽  
Wide Spectrum ◽  
Antioxidant Properties ◽  
Butylated Hydroxytoluene ◽  
Hydroxyl Group ◽  
Antioxidant Power ◽  
Total Antioxidant

Background: Stilbene phytalexis (1,2-diphenyloethylen) and benzamide are beneficial for human health. To increase the stilbene ring activity, a new series of its derivatives containing benzamide structure was synthesized and evaluated for their in vitro antioxidant power. Methods: 1H nuclear magnetic resonance, mass spectroscopy, and chromatographic analyses were used to confirm the successful synthesis. The antioxidant properties were determined by the elimination of , HO , DPPH , ABTS+ radicals, total antioxidant status (TAS) and the ferric reducing antioxidant activities (TAC) measurements. Results: Stilbenebenzamide compounds showed a wide spectrum of antioxidant ability, however their total antioxidant power was weaker than those of butylated hydroxytoluene (BHT), ascorbic acid, and resveratrol. The highest antiradical activity towards and HO was shown by the compounds with structures containing amine group (SBEBA, SBA) ( : 37.7 – 38.0% and 40.8 – 43.5%, HO : 29.8%, 28.7% inhibition, respectively) at1.25 mM concentration. The antiradical power of SBEBA (0.29) in DPPH assay was lower than those of resveratrol (1.83), ascorbic acid (3.63) and BHT (4.09). The TAS values of the synthesized compounds ranged from 152.9±5.3 to 240.2±6.7µM trolox equivalent/gram (TE/g) and were much lower than those of BHT (1304±43.0), reservatrol (1360±29.0) and ascorbic acid (2782±39.7) µM TE/g. Similarly, the TAC values ranging from 29.7±0.9 to 41.5±1.6 µM TE were weaker than that of resveratrol (239.2 ±6.7 µM TE/g). Conclusion: The results suggest that the presence of hydroxyl group in stilbene ring should be considered in further design of stilbenebenzamide compounds to enhance their antioxidant activity.

scholarly journals Nutrient profiles, functional compositions, and antioxidant activities of seven types of grain fermented with Sanghuangporus sanghuang fungus

2020 ◽  
Author(s):  
Tingting Song ◽  
Zuofa Zhang ◽  
Qunli Jin ◽  
Weilin Feng ◽  
Yingyue Shen ◽  
...  
Keyword(s):  
Crude Protein ◽  
Antioxidant Activities ◽  
Soluble Sugar ◽  
Antioxidant Properties ◽  
Principal Component ◽  
Health Food ◽  
Coix Seed ◽  
Solid Substrates ◽  
Nutrient Profiles ◽  
Fermentation Substrate

Abstract Sanghuangporus sanghuang (SS) is a rare medicinal polypore fungus that grows solely on Morus trees. In this study, seven grains (oats, barley, millet, rice, buckwheat, corn, and coix seed) were used as solid substrates for SS fermentation and characterized in their nutrition, functional composition, and antioxidant activities. After fermentation, the nutrient compositions of crude protein (F1,41 = 111.1, P < 0.01), soluble protein (F1,41 = 595.7, P < 0.01), soluble sugar (F1,41 = 51.4, P < 0.01) and ash (F1,41 = 227.3, P < 0.01) increased significantly. Oats were one of the best grains for SS fermentation, SS-Oat produced 6.23 mg QE/g polyphenols, 21.8 mg rutin/g flavonoids, and 2.3% triterpene. In addition, the antioxidant capacities of the seven grains all increased. Principal component analysis analysis shows that the antioxidant properties of the grains were similar after SS fermentation. The changes of antioxidant activity due to SS fermentation were corrected with corresponding grain and remarked as ΔT-AOC/ABTS+/DPPH/DNAp, that was correlated to part of changes in polyphenol, carotenoid, triterpenoids, and flavonoid contents. In summary, oats have the greatest potential for use as a fermentation substrate for health food development.

scholarly journals Antioxidant Potential of the Polyherbal Formulation “ImmuPlus”: A Nutritional Supplement for Horses

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Stefano Cecchini ◽  
Mariateresa Paciolla ◽  
Anna Rocchina Caputo ◽  
Alfonso Bavoso
Keyword(s):  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Reducing Power ◽  
Nutritional Supplement ◽  
Antioxidant Potential ◽  
Tinospora Cordifolia ◽  
Beneficial Effects ◽  
Polyherbal Formulation ◽  
Total Antioxidant

In order to counteract harmful effects of oxidative stress due to pathological conditions or physical exercise, horses are often administered dietary supplements having supposed high antioxidant activities. The aim of the present study was to identify thein vitroantioxidant potential of “ImmuPlus”, a polyherbal formulation (Global Herbs LTD, Chichester, West Sussex, Great Britain), containing three medicinal plants (Withania somnifera, Tinospora cordifolia,andEmblica officinalis), known in Ayurveda for their use in human disease treatment. Extracts obtained by different solvents (water, methanol, ethanol, acetone, and hexane) were tested for total antioxidant capacity, total reducing power, scavenging activity against DPPH radical, and total polyphenol and flavonoid contents. Our results showed that, except as regards hexane, all the used solvents are able to extract compounds having high antioxidant activity, even when compared to ascorbic acid. Regression analysis showed significant correlations between antioxidant properties and polyphenol/flavonoid contents, indicating the latter, known for their beneficial effects on health of human and animal beings, as major components responsible for the strong antioxidant capacities. Moreover, obtained results suggest the effective role of the polyherbal mixture as good source of antioxidants in horses.

scholarly journals Proximate and antioxidant activities of bio-preserved ogi flour with garlic and ginger

F1000Research ◽  
2019 ◽  
Vol 7 ◽  
pp. 1936
Author(s):  
Abiola F. Olaniran ◽  
Sumbo H. Abiose
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Titratable Acidity ◽  
Total Phenolic ◽  
Health Food ◽  
Mineral Contents ◽  
Antioxidants Activity ◽  
Total Antioxidant ◽  
Ginger Powder

Background: Ogi from locally available cereals remains a relatively affordable complementary food in West Africa, but has a tendency to spoil due it high moisture content. This study explored effects of garlic and ginger as biopreservatives in ogi flour. Methods: Ogi flour was prepared from sorghum and quality protein maize grains with different concentrations of garlic and ginger powder (2 and 4% w/w) by fermentation technique. These samples were stored for 16 weeks during which the total titratable acidity, pH, proximate composition, mineral content and total antioxidant activities were determined. Results: The proximate compositions of bio-preserved ogi samples were relatively stable throughout storage. The addition of garlic and ginger slightly increased the ash (0.04%), crude protein and mineral contents (mg/ 100g) of the samples.  Magnesium (10.85-13.13 and 5.17-9.72); zinc (1.37-1.78 and 7.01-8.50), manganese (1.30-1.71 and 0.45-0.86) and iron (1.53-1.77 and 0.68-2.77) contents increased on addition (of garlic and ginger) to maize ogi and sorghum ogi flours respectively. The free radical scavenging activity; total phenolic and flavonoid contents increased correspondingly with the antioxidants activity. Conclusion: Although not well known to ogi consumer, the bio-preserved ogi flours showed better nutritional values and have potential as a health food.

Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Stephen Adeniyi Adefegha ◽  
Ganiyu Oboh ◽  
Bathlomew Maduka Okeke
Keyword(s):  
Neurological Disorders ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Complementary Therapy ◽  
Inhibitory Effect ◽  
Distilled Water ◽  
Underlying Mechanisms ◽  
Reducing Properties

Abstract Objectives This study examined effect of berberine and piperine on neuroprotective potential of neostigmine in the management of neurological disorders. Methods Berberine and neostigmine were weighed (30 g), dissolved in distilled water (30 mL) separately, while, 30 mg piperine was dissolved in ethanol (0.45 mL), made up to 30 mL with distilled water. Antioxidant activities in 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH), 2, 2-azinobis (3-ethylbenzothiazoline-6-sulfonate) radical (ABTS), Fe-chelation, ferric reducing properties (FRAP), nitric oxide (NO) and hydroxyl (OH) radical scavenging abilities and Fe2+, cisplatin and sodium nitroprusside (SNP) induced lipid peroxidation (LPO), and acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and monoamine oxidase (MAO) activities were assessed in vitro. Results The result revealed that tested compounds inhibited enzymes activities dose-dependently. However, berberine (IC50=0.17 mg/mL) had slight higher AChE inhibitory effect than piperine and neostigmine (p<0.05). Also, berberine had the highest BChE inhibitory effect (IC50=0.16 mg/mL) while piperine exhibited the highest MAO inhibitory effect (IC50=0.21 mg/mL). Berberine, piperine and neostigmine exhibited high antioxidant properties and inhibited Fe2+, cisplatin and SNP induced LPO. Conclusions Both alkaloids demonstrated antiradical scavenging ability comparable to neostigmine action against Alzheimer’s disease (AD). The modulatory and antioxidant berberine and piperine properties on these enzymes (AChE, BChE and MAO) could be possible underlying mechanisms in employing these compounds as a complementary therapy in neurodegenerative diseases (NDDs) management.

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