scholarly journals Current View on Green Tea Catechins Formulations, Their Interactions with Selected Drugs, and Prospective Applications for Various Health Conditions

2021 ◽  
Vol 11 (11) ◽  
pp. 4905
Author(s):  
Magdalena Cerbin-Koczorowska ◽  
Magdalena Waszyk-Nowaczyk ◽  
Paweł Bakun ◽  
Tomasz Goslinski ◽  
Tomasz Koczorowski
Keyword(s):  
Dietary Supplements ◽  
Green Tea ◽  
The Elderly ◽  
Human Organism ◽  
Current View ◽  
Limiting Factor ◽  
Published Data ◽  
Channel Blockers ◽  
Tea Extract ◽  
The Impact

Green tea extract (GTE) is one of the most popular beverages globally, traditionally prepared from Camelia sinensis leaves. Therefore, it is beneficial to define the impact of GTE and its ingredients on the human organism. Epigallocatechin-3-O-gallate (EGCG) is the most abundant catechin in green tea leaves, belonging to the group of tannins and flavonoids, demonstrating pharmacological activity, but so far, it has not been applied as a drug. This is because EGCG does not present sufficient stability and quickly decomposes through epimerization or autooxidation mechanisms under the influence of light, temperature, changes in pH, or the presence of oxygen. Another limiting factor is EGCG’s low bioavailability after oral administration. Nevertheless, the growing market of dietary supplements together with increasing growing consumption of green tea extracts should prompt us to pay more attention to the safety of both EGCG itself, as well as its influence on other simultaneously used drugs. Previously published data confirm the relationship between healthcare professionals’ access to professional knowledge and their willingness to engage in patient education. For this reason, in this review article, we report the formulations of EGCG and GTE, discuss the data on the safety of EGCG and its possible interactions with drugs, as well as gather various recommendations from medical specialists. Particular attention should be paid to the consumption of green tea during pregnancy and breastfeeding, as well as in the elderly. Patients taking clozapine, digoxin, and warfarin should avoid consuming GTE extracts and dietary supplements containing EGCG. Professional consultation seems especially important for patients treated with statins, calcium channel blockers, or sildenafil.

scholarly journals Ingredient-Dependent Extent of Lipid Oxidation in Margarine

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 105
Author(s):  
Sarah Fruehwirth ◽  
Sandra Egger ◽  
Dennis Kurzbach ◽  
Jakob Windisch ◽  
Franz Jirsa ◽  
...  
Keyword(s):  
Citric Acid ◽  
Lipid Oxidation ◽  
Oxidative Stability ◽  
Green Tea ◽  
Acyl Chain ◽  
Green Tea Extract ◽  
Tocopheryl Acetate ◽  
Tea Extract ◽  
The Impact ◽  
Β Carotene

This study reports the impact of margarine-representative ingredients on its oxidative stability and green tea extract as a promising antioxidant in margarine. Oil-in-water emulsions received much attention regarding factors that influence their oxidative stability, however, water-in-oil emulsions have only been scarcely investigated. Margarine, a widely consumed water-in-oil emulsion, consists of 80–90% fat and is thermally treated when used for baking. As different types of margarine contain varying additives, their impact on the oxidative stability of margarine during processing is of pressing importance. Thus, the influence of different ingredients, such as emulsifiers, antioxidants, citric acid, β-carotene and NaCl on the oxidative stability of margarine, heated at 80 °C for 1 h to accelerate lipid oxidation, was analyzed by the peroxide value and oxidation induction time. We found that monoglycerides influenced lipid oxidation depending on their fatty acyl chain. α-Tocopheryl acetate promoted lipid oxidation, while rosemary and green tea extract led to the opposite. Whereas green tea extract alone showed the most prominent antioxidant effect, combinations of green tea extract with citric acid, β-carotene or NaCl increased lipid oxidation in margarine. Complementary, NMR data suggested that polyphenols in green tea extracts might decrease lipid mobility at the surface of the water droplets, which might lead to chelating of transition metals at the interface and decreasing lipid oxidation.

scholarly journals Bio-Based Packaging Materials Containing Substances Derived from Coffee and Tea Plants

Materials ◽  
2020 ◽  
Vol 13 (24) ◽  
pp. 5719
Author(s):  
Olga Olejnik ◽  
Anna Masek
Keyword(s):  
Mechanical Properties ◽  
Caffeic Acid ◽  
Green Tea ◽  
Chemical Structure ◽  
Green Tea Extract ◽  
Packaging Materials ◽  
Scanning Calorimetry ◽  
Spectra Analysis ◽  
Tea Extract ◽  
The Impact

The aim of the research was to obtain intelligent and eco-friendly packaging materials by incorporating innovative additives of plant origin. For this purpose, natural substances, including green tea extract (polyphenon 60) and caffeic acid, were added to two types of biodegradable thermoplastics (Ingeo™ Biopolymer PLA 4043D and Bioplast GS 2189). The main techniques used to assess the impact of phytocompounds on materials’ thermal properties were differential scanning calorimetry (DSC) and thermogravimetry (TGA), which confirmed the improved resistance to thermo-oxidation. Moreover, in order to assess the activity of applied antioxidants, the samples were aged using a UV aging chamber and a weathering device, then retested in terms of dynamic mechanical properties (DMA), colour changing, Vicat softening temperature, and chemical structure, as studied using FT-IR spectra analysis. The results revealed that different types of aging did not cause significant differences in thermo-mechanical properties and chemical structure of the samples with natural antioxidants but induced colour changing. The obtained results indicate that polylactide (PLA) and Bioplast GS 2189, the plasticizer free thermoplastic biomaterial containing polylactide and starch (referred to as sPLA in the present article), both with added caffeic acid and green tea extract, can be applied as smart and eco-friendly packaging materials. The composites reveal better thermo-oxidative stability with reference to pure materials and are able to change colour as a result of the oxidation process, especially after UV exposure, providing information about the degree of material degradation.

scholarly journals THE IMPACT OF DENTURES ON THE NUTRITIONAL HEALTH OF THE ELDERLY

2015 ◽  
pp. 1-4
Author(s):  
M. Cafaro Gellar ◽  
D. Alter
Keyword(s):  
Older Adult ◽  
Health Care Providers ◽  
Disease Process ◽  
The Elderly ◽  
Published Data ◽  
Care Providers ◽  
Physiological Factors ◽  
Factors Affecting ◽  
Loss Of Appetite ◽  
The Impact

Objective: There are many factors that can affect appetite in the older adult. Physiological factors affecting appetite can include cardiovascular disease, pulmonary disease, renal disease, mental health issues, and even side effects of medications. Decreased ability to ambulate due to joint issues or pain can also negatively impact an older adult’s appetite. But perhaps one significant factor that is commonly overlooked is the ill fitting partial or complete denture. According to the American Dental Association, there are approximately 57% of people ages 65 to 74 wearing some form of denture. Due to this large number of denture wearers, it becomes imperative that health care providers learn to incorporate an oral assessment into their plan of care each time an older adult patient is examined. This assessment can assist providers to identify and differentiate unintentional weight loss and loss of appetite as being either part of a disease process or as a symptom of denture issues. Only then can the overall health of the elderly be holistically viewed and treated. The aim of this paper is to provide a summary of published data expressing the nutritional issues that occur in the elderly due to either being edentulous or from wearing improperly fitting dentures.

scholarly journals Changes in pain following an interaction period of resistance training and green tea extract consumption in sedentary hypertensive women: impact of blood pressure swings

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Hamid Arazi ◽  
Behzad Taati ◽  
Jalal Kheirkhah ◽  
Samaneh Ramezanpour
Keyword(s):  
Blood Pressure ◽  
Resistance Training ◽  
Green Tea ◽  
Pain Threshold ◽  
Pain Perception ◽  
Green Tea Extract ◽  
Controlled Study ◽  
Training Groups ◽  
Tea Extract ◽  
The Impact

Abstract Background Changes in blood pressure (BP) may affect pain. However, the interaction effect of resistance training and green tea on BP and pain has not been studied. The primary aim of this study was to evaluate the impact of resistance training and green tea extract (GTE) on pain variables in hypertensive patients. Secondary aim included determining the effects of BP alterations on pain responses. Methods In a randomized, double-blind, placebo-controlled study, 30 middle-aged sedentary women were randomly divided into resistance training and green tea extract (GR, n = 8), resistance training (R, n = 8), green tea (G, n = 7), and control groups (C, n = 7). The study period consisted of 3 weeks of GTE (~ 245 mg total polyphenols) consumption twice a day followed by 6 weeks of interaction with resistance training. GR and R groups performed two circuits of training with ten repetitions at 50% of 1RM 2 days a week while other two groups had no any regular exercise training. R and C groups also received placebo capsules (maltodextrin) with the same timing. Pain threshold and perception, BP, and heart rate were recorded following the first and last session of training at rest and 5th and 15th minute. Results Pain perception of training groups after the last session was significantly higher than control conditions, and at this time, the magnitude of BP responses was lower in training groups. In proportion to pain threshold, there were no significant differences between groups. Conclusion It seems that training-induced hypotension can alter pain perception in hypertensive women through changes in baroreceptor activation.

scholarly journals Study and evaluation antioxidant activity of dietary supplements with green tea extract

2021 ◽  
Vol 14 (2) ◽  
pp. 215-219
Author(s):  
O. Yu. Maslov ◽  
S. V. Kolisnyk ◽  
M. A. Komisarenko ◽  
A. A. Altukhov ◽  
K. V. Dynnyk ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dietary Supplements ◽  
Green Tea ◽  
Platinum Electrode ◽  
Green Tea Extract ◽  
Natural Sources ◽  
Low Level ◽  
A Value ◽  
Potentiometric Measurements ◽  
Tea Extract

The aim of the work is to determine and evaluate the antioxidant activity of dietary supplements with green tea extract, as well as to introduce conditional terms of the level of AOA. Materials and methods. The object of the study was dietary supplements of different manufactures: “Green Tea Extract” of Natural Sources, USA (DS1), “Extract of green tea” of Elit-Pharm, Ukraine (DS2) and “Green tea” of Pharmakom, Ukraine (DS3). Potentiometric measurements were conducted by pH meter Hanna 2550 (Germany) with a combined platinum electrode EZDO 5010. Epigallocatechin-3-O-gallate ˃98.0 % (Sigma Aldrich), K3[Fe(CN)6], K4[Fe(CN)6], NaHPO4, KH2PO4 were analytical grade. Results. It was established that a value of the antioxidant activity of DS1 was 36.51 mmol/tab, DS2 – 29.78 mmol/tab, and DS3 – 16.67 mmol/tab. DS1 had the highest value of the antioxidant activity, which correlated with the content of catechins (r2 = 0.9314). According to the proposed conditional terms of antioxidant activity dietary supplements, DS1 and DS2 possessed a low level of antioxidant activity, whereas DS3 corresponded to very low level of antioxidant activity. Conclusions. It was found that the studied dietary supplements with green tea extract have antioxidant activity, which correlates with the content of catechins.

An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC‐QTOF‐MS method

2018 ◽  
pp. e4469 ◽  
Author(s):  
David Paul ◽  
Shruthi Surendran ◽  
Patheparapu Chandrakala ◽  
Nanjappan Satheeshkumar
Keyword(s):  
Green Tea ◽  
Green Tea Extract ◽  
Tea Extract ◽  
The Impact

scholarly journals Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo

2015 ◽  
Vol 65 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Hana Bártíková ◽  
Lenka Skálová ◽  
Kateřina Valentová ◽  
Petra Matoušková ◽  
Barbora Szotáková ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Small Intestine ◽  
Antioxidant Enzymes ◽  
Dietary Supplements ◽  
Green Tea ◽  
Thioredoxin Reductase ◽  
Oxidative Stress Status ◽  
Tea Extract

Abstract Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase

scholarly journals COVID-19 scenarios for comparing the effectiveness of age-specific vaccination regimes, exemplified for the city of Aschaffenburg (Germany)

2021 ◽  
Author(s):  
Tobias Krebs ◽  
Holger von Jouanne-Diedrich ◽  
Michael J Moeckel
Keyword(s):  
Local Population ◽  
Age Groups ◽  
The Elderly ◽  
Strong Increase ◽  
Published Data ◽  
Model Parameters ◽  
Agent Based ◽  
The Past ◽  
The Impact ◽  
The City

Purpose of this report: The purpose of this rapid communication is to illustrate the effectiveness of different vaccination regimes for controlling the number of severe and critical COVID-19 cases in the city of Aschaffenburg, Germany. Our results show that, despite numerous vaccinations in the past, further vaccinations are necessary to immunize the population and to keep the number of severe and critical cases low in the coming months. Considering that not all people can or want to receive vaccination, we compare different age-specific vaccination approaches. Applied Methods: We use the agent-based epidemiological simulator Covasim for discussing the impact of different vaccination strategies. We calibrate it to reproduce the historical course of the COVID-19 pandemic in the city of Aschaffenburg, Germany; for this, we model and integrate numerous public health interventions imposed on the local population. As for some of the political actions rigorous quantification is currently not available, we fit those unknown (free) model parameters to published data on the measured epidemiological dynamics. Then we calculate the state of immunization of the population, gained through infections and vaccinations, at any time in the past, including models for time-dependent immunity decay that have been made available in Covasim. Finally, we define and compare scenar-ios of different vaccination regimes, especially with regard to vaccinating adolescents and providing booster vaccinations to the elderly. Key message: Without further vaccinations, we expect a strong increase in severe and critical cases. In order to restrict their growth our simulations suggest that in all considered cases vaccinations of unvaccinated people is more effective than booster vaccinations for already fully vaccinated people. This applies even to vaccinations of young people who are not themselves at high risk of developing severe or critical illness. We attribute this observation to the fact that immunization of adolescents indirectly protects vulnerable age groups by preventing the spread of the virus more ef-fectively than further immunizing other age groups. This indicates that with the pandemic ongoing, strategies focussed on minimizing individual health risks by vaccinations may no longer coincide with those needed to minimize the num-ber of severe and critical cases.

The Impact of Hemoglobin on Total Mortality in Elderly Asian-American Men: The Honolulu Heart Program.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 587-587
Author(s):  
Beatriz L. Rodriguez ◽  
Robert D. Abbott ◽  
Samir H. Mody ◽  
Kamal Masaki ◽  
Bradley Willcox ◽  
...  
Keyword(s):  
Asian American ◽  
Independent Predictor ◽  
The Elderly ◽  
Published Data ◽  
Elderly Persons ◽  
Asian American Men ◽  
The Impact ◽  
Fold Excess ◽  
Prevalence Of Anemia

Abstract Anemia in the elderly is frequently unrecognized and untreated. Anemia prevalence increases with age and has been reported to occur in >20% of elderly persons. Anemia has also been shown to be a significant and independent predictor of mortality. There are no published data, however, regarding prevalence of anemia or its association with mortality in an elderly Asian-American population. In this study, we examined the relationship between hemoglobin (Hb) and mortality in elderly Asian-American men in the Honolulu Heart Program (HHP). The HHP began in 1965 following a cohort of 8006 Asian-American men aged 45-68 living on Oahu, Hawaii. These men have been followed for over 40 years(y). The present analysis is based on 14 years of follow-up for mortality events beginning at examinations that were given from 1991–1993 when the men were aged 71-93y. Anemia (Hb<13g/dL) and borderline anemia (Hb:13-13.9 g/dL) were defined using WHO criteria. Age-adjusted mortality rates in person-years(y) of follow-up were calculated across ranges of Hb using logistic regression and standard analysis of covariance methods. Statistical tests for an association between Hb and mortality were based on proportional hazards regression models with adjustments for age, total cholesterol, alcohol intake, HDL cholesterol, fibrinogen, BMI, forced expiratory volume, physical activity, diabetes, hypertension, cigarette smoking, and a history of cancer and CVD. Linear and nonlinear relationships were examined along with efforts to identify ranges of Hb that were associated with the lowest incidence of mortality. In the latter instance, differential calculus yielded a combination of regression coefficients that resulted in a single Hb value that was associated with the lowest mortality. Bootstrap sampling further provided a corresponding 95% CI. Of the total subjects, 9.1% had anemia with 14.7% having borderline anemia. Anemia prevalence increased from 4.3% in men 71-75y to 27.2% in those ≥86y (p<0.001). In 14 years of follow-up, there were 2,311 deaths (6.7/100 person-y). The mortality rate in those with anemia was 11.8/100 person-y vs 6.4/100 person-y in those without anemia (p<0.001). The association persisted for men with and without cancer and cardiovascular disease, across age strata, for deaths that occurred <1y, 1-5y and >5y and after adjustment for other risk factors. There was a significant (p<0.001) inversed J-shaped relationship with a minimum in mortality incidence occurring when Hb was 15.5g/dL. The corresponding 95% CI (15–15.9g/dL) was used as a reference for comparing rates of mortality with other Hb ranges. Compared to this latter group, there was a 2.4-fold excess in mortality (95% CI, 1.8–3.1) in men with a Hb<12g/dL (p<0.001). For men with Hb ≥17g/dL, there was a 1.3–fold excess (95% CI, 1.2–1.6). The latter, however, was not significant after excluding former and current smokers. These results are the first to describe prevalence of anemia in elderly Asian-American men. These findings indicate anemia is a strong independent predictor of mortality in this elderly population with the risk similar to that reported from other studies of the elderly.

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