Analysis and Comparison of Electromagnetic Microrobotic Platforms for Biomedical Applications

Magnetic microrobotics is a promising technology for improving minimally invasive surgery (MIS) with the ambition of enhancing patient care and comfort. The potential benefits include limited incisions, less hemorrhaging and postoperative pain, and faster recovery time. To achieve this, a key issue relies on the design of a proper electromagnetic actuation (EMA) setup which is based on the use of magnetic sources. The magnetic field and its gradient generated by the EMA platform is then used to induce magnetic torque and force for microrobot manipulations inside the human body. Like any control systems, the EMA system must be adapted to the given controlled microrobot and customized for the application. With great research efforts on magnetic manipulating of microrobots, the EMA systems are approaching commercial applications, and their configurations are becoming more suitable to be employed in real medical surgeries. However, most of the proposed designs have not followed any specific rule allowing to take into account the biomedical applications constraints. Through reviewing the different proposed EMA systems in the literature, their various specifications and configurations are comprehensively discussed and analyzed. This study focus on EMA platforms that use electromagnets. From this review and based on the biomedical application specifications, the appropriate EMA system can be determined efficiently.

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Cellular Uptake and Magneto-Hyperthermia Induced Cytotoxicity using Photoluminescent Fe3O4 Nanoparticle/Si Quantum Dot Hybrids

10.26434/chemrxiv.13138427 ◽

2020 ◽

Author(s):

Morteza Javadi ◽

Van A. Ortega ◽

Alyxandra Thiessen ◽

Maryam Aghajamali ◽

Muhammad Amirul Islam ◽

...

Keyword(s):

Radio Frequency ◽

Biomedical Applications ◽

Short Term ◽

Water Dispersible ◽

Optical Responses ◽

Si Quantum Dot ◽

Real World Applications ◽

Potential Benefits ◽

Low Toxicity ◽

Si Quantum Dots

The design and fabrication of Si-based multi-functional nanomaterials for biological and biomedical applications is an active area of research. The potential benefits of using Si-based nanomaterials are not only due to their size/surface-dependent optical responses but also the high biocompatibility and low-toxicity of silicon itself. Combining these characteristics with the magnetic properties of Fe3O4 nanoparticles (NPs) multiplies the options available for real-world applications. In the current study, biocompatible magnetofluorescent nano-hybrids have been prepared by covalent linking of Si quantum dots to water-dispersible Fe3O4 NPs via dicyclohexylcarbodiimide (DCC) coupling. We explore some of the properties of these magnetofluorescent nano-hybrids as well as evaluate uptake, the potential for cellular toxicity, and the induction of acute cellular oxidative stress in a mast cells-like cell line (RBL-2H3) by heat induction through short-term radio frequency modulation (10 min @ 156 kHz, 500 A). We found that the NPs were internalized readily by the cells and also penetrated the nuclear membrane. Radio frequency activated nano-hybrids also had significantly increased cell death where > 50% of the RBL-2H3 cells were found to be in an apoptotic or necrotic state, and that this was attributable to increased triggering of oxidative cell stress mechanisms.

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Формирование изображений электрических сигналов преобразователя магнитного поля при гистерезисной интерференции для контроля металлов в импульсных магнитных полях

Дефектоскопия ◽

10.31857/s0130308220110044 ◽

2020 ◽

pp. 38-45

Author(s):

В.В. Павлюченко ◽

Е.С. Дорошевич

Keyword(s):

Magnetic Field ◽

Aluminum Plate ◽

Thickness Variation ◽

Magnetic Carrier ◽

Electric Voltage ◽

Total Strength ◽

Magnetic Field Transducer ◽

The Given ◽

The Magnetic Field

Based on the developed methods of hysteresis interference, the calculated dependences U(x) of the electric voltage taken from the magnetic field transducer on the x coordinate were obtained. A magnetic carrier with an arctangent characteristic was exposed to a series of bipolar pulses of the magnetic field of a linear inductor of one, two, three, four, five and fifteen pulses. An algorithm is presented for the sequence of changes in the magnitude of the total strength of the magnetic field pulses on the surface of an aluminum plate, which provides the same amplitude of hysteresis oscillations of the electric voltage and makes it possible to obtain a linear difference dependence U(x) for wedge-shaped and flat aluminum samples. The results obtained make it possible to increase the accuracy and efficiency of control of the thickness of the object and its thickness variation in the given directions, as well as the defects of the object.

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Graphene and Graphene-Based Materials in Biomedical Applications

Current Medicinal Chemistry ◽

10.2174/0929867326666190705155854 ◽

2019 ◽

Vol 26 (38) ◽

pp. 6834-6850 ◽

Cited By ~ 5

Author(s):

Mohammad Omaish Ansari ◽

Kalamegam Gauthaman ◽

Abdurahman Essa ◽

Sidi A. Bencherif ◽

Adnan Memic

Keyword(s):

Tissue Engineering ◽

Thermal Properties ◽

Gene Delivery ◽

Regenerative Medicine ◽

Biomedical Research ◽

Biomedical Applications ◽

Biomedical Application ◽

Two Dimensional ◽

Drug And Gene Delivery ◽

Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

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Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

Current Medicinal Chemistry ◽

10.2174/0929867327666200303102859 ◽

2020 ◽

Vol 27 (28) ◽

pp. 4622-4646 ◽

Cited By ~ 1

Author(s):

Huayu Liu ◽

Kun Liu ◽

Xiao Han ◽

Hongxiang Xie ◽

Chuanling Si ◽

...

Keyword(s):

Mechanical Properties ◽

Metal Ion ◽

Biomedical Applications ◽

Biomedical Application ◽

Cellulose Nanofibrils ◽

Wound Dressings ◽

Preparation Methods ◽

Tissue Scaffold ◽

Surface Areas ◽

Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

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Biomedical Applications and Patents on Metallic Nanoparticles

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681210999200430005827 ◽

2020 ◽

Vol 10 ◽

Author(s):

Geetanjali Singh ◽

Pramod Kumar Sharma ◽

Rishabha Malviya

Keyword(s):

Metallic Nanoparticles ◽

Biomedical Applications ◽

Size Range ◽

Biomedical Application ◽

Chemical Reduction ◽

Chemical Methods ◽

Future Challenges ◽

Biological Methods ◽

Cancer Diagnosis And Therapy ◽

Physical And Chemical

Aim/Objective: The author writes the manuscript by reviewing the literatures related to the biomedical application of metallic nanoparticles. The term metal nanoparticles are used to describe the nanosized metals with the dimension within the size range of 1-100 nm. Methods: The preparation of metallic nanoparticles and their application is an influential area for research. Among various physical and chemical methods (viz. chemical reduction, thermal decomposition, etc.) for synthesizing silver nanoparticles, biological methods have been suggested as possible eco-friendly alternatives. The synthesis of metallic nanoparticles is having many problems inclusive of solvent toxicity, the formation of hazardous byproducts and consumption of energy. So it is important to design eco-friendly benign procedures for the synthesis of metallic nanoparticles. Results: From the literature survey, we concluded that metallic nanoparticles have applications in the treatment of different diseases. Metallic nanoparticles are having a great advantage in the detection of cancer, diagnosis, and therapy. And it can also have properties such as antifungal, antibacterial, anti-inflammatory, antiviral and anti-angiogenic. Conclusion: In this review, recent upcoming advancement of biomedical application of nanotechnology and their future challenges has been discussed.

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Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

Pharmaceutics ◽

10.3390/pharmaceutics13020261 ◽

2021 ◽

Vol 13 (2) ◽

pp. 261

Author(s):

Orlando Donoso-González ◽

Lucas Lodeiro ◽

Álvaro E. Aliaga ◽

Miguel A. Laguna-Bercero ◽

Soledad Bollo ◽

...

Keyword(s):

Biomedical Applications ◽

Colloidal Stability ◽

Biomedical Application ◽

Drug Loading ◽

Gold Nanostars ◽

Raman Optical Activity ◽

Cationic Group ◽

Low Cytotoxicity ◽

Stability Limits ◽

Zeta Potential Analysis

Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.

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Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Nano-Micro Letters ◽

10.1007/s40820-021-00619-1 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Jiang Ouyang ◽

Ling Zhang ◽

Leijiao Li ◽

Wei Chen ◽

Zhongmin Tang ◽

...

Keyword(s):

Biomedical Applications ◽

Density Functional ◽

Biomedical Application ◽

Density Functional Theory Calculations ◽

Free Electrons ◽

Functional Theory ◽

New Approach ◽

New Type ◽

Average Size ◽

Cancer Theranostics

Abstract Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.

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Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽

10.3390/polym12122896 ◽

2020 ◽

Vol 12 (12) ◽

pp. 2896

Author(s):

Sara Ferraris ◽

Silvia Spriano ◽

Alessandro Calogero Scalia ◽

Andrea Cochis ◽

Lia Rimondini ◽

...

Keyword(s):

Surface Modification ◽

Biomedical Applications ◽

Biomedical Application ◽

Electrospun Fibers ◽

Natural Polymers ◽

Polymeric Fibers ◽

Biological Phenomena ◽

Proper Design ◽

Synthetic And Natural Polymers ◽

Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

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Coplanar waveguide-fed ISM band implantable crossed-type triangular slot antenna for biomedical applications

International Journal of Microwave and Wireless Technologies ◽

10.1017/s1759078713000883 ◽

2013 ◽

Vol 6 (2) ◽

pp. 167-172 ◽

Cited By ~ 10

Author(s):

Srinivasan Ashok Kumar ◽

Thangavelu Shanmuganantham

Keyword(s):

Biomedical Applications ◽

Biomedical Application ◽

Coplanar Waveguide ◽

Impedance Matching ◽

High Gain ◽

Slot Antenna ◽

Center Frequency ◽

Ism Band ◽

High Data ◽

Implantable Antenna

A novel coplanar waveguide fed Industrial, Scientific, and Medical (ISM) band implantable crossed-type triangular slot antenna is proposed for biomedical applications. The antenna operates at the center frequency of 2450 MHz, which is in ISM band, to support GHz wideband communication for high-data rate implantable biomedical application. The size of the antenna is 78 mm3 (10 mm × 12 mm × 0.65 mm). The simulated and measured bandwidths are 7.9 and 8.2% at the resonant frequency of 2.45 GHz. The specific absorption rate distribution induced by the implantable antenna inside a human body tissue model is evaluated. The communication between the implanted antenna and external device is also examined. The proposed antenna has substantial merits such as miniaturization, lower return loss, better impedance matching, and high gain over other implanted antennas.

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Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

10.1101/317115 ◽

2018 ◽

Author(s):

Mahendran Subramanian ◽

Arkadiusz Miaskowski ◽

Stuart Iain Jenkins ◽

Jenson Lim ◽

Jon Dobson

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Field Gradient ◽

Biomedical Applications ◽

Magnetic Field Gradient ◽

Field Source ◽

Remote Manipulation ◽

Cancer Cell Death ◽

The Magnetic Field

AbstractThe manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary focus of this study is on understanding the manipulation of MNPs by a time-varying static magnetic field and how this can be used, at different frequencies and displacement, to manipulate cellular function. Here we explore, using numerical modeling, the physical mechanism which underlies this kind of manipulation, and we discuss potential improvements which would enhance such manipulation with its use in biomedical applications, i.e., increasing the MNP response by improving the field parameters. From our observations and other related studies, we infer that such manipulation depends mostly on the magnetic field gradient, the magnetic susceptibility and size of the MNPs, the magnet array oscillating frequency, the viscosity of the medium surrounding MNPs, and the distance between the magnetic field source and the MNPs. Additionally, we demonstrate cytotoxicity in neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells in vitro. This was induced by incubation with MNPs, followed by exposure to a magnetic field gradient, physically oscillating at various frequencies and displacement amplitudes. Even though this technique reliably produces MNP endocytosis and/or cytotoxicity, a better biophysical understanding is required to develop the mechanism used for this precision manipulation of MNPs, in vitro.

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