Effects of Ibuprofen Use on Lymphocyte Count and Oxidative Stress in Elite Paralympic Powerlifting

Background: Paralympic Powerlifting (PP) training tends to promote fatigue and oxidative stress. Objective: To analyze the effects of ibuprofen use on performance and oxidative stress in post-training PP athletes. Methodology: Ten national level PP athletes (age: 27.13 ± 5.57) were analyzed for oxidative stress in post-training. The study was carried out in three weeks, (1) familiarization and (2 and 3) evaluated the recovery with the use of a placebo (PLA) and ibuprofen (IBU), 800 mg. The Peak Torque (PT), Torque Development Rate (TDR), Fatigue Index (FI), reactive substances to thiobarbituric acid (TBARS) and sulfhydryl groups (SH) were evaluated. The training consisted of five sets of five repetitions (80–90%) 1-Repetition Maximum (1-RM) in the bench press. Results: The IBU showed a higher PT (24 and 48 h, p = 0.04, ɳ2 p = 0.39), a lower FI (24 h, p = 0.01, ɳ2p = 0.74) and an increased lymphocyte count (p < 0.001; ɳ2p = 4.36). There was no change in oxidative stress. Conclusions: The use of IBU provided improvements in strength and did not protect against oxidative stress.

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Patients Undergoing Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation Exhibit Depleted Vitamin C Status in Association with Febrile Neutropenia

Nutrients ◽

10.3390/nu12061879 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1879 ◽

Cited By ~ 1

Author(s):

Anitra C. Carr ◽

Emma Spencer ◽

Andrew Das ◽

Natalie Meijer ◽

Carolyn Lauren ◽

...

Keyword(s):

Oxidative Stress ◽

Febrile Neutropenia ◽

Vitamin C ◽

Thiobarbituric Acid ◽

Thiobarbituric Acid Reactive Substances ◽

C Reactive Protein ◽

Hematopoietic Stem ◽

Reactive Protein ◽

Myeloablative Chemotherapy ◽

And Oxidative Stress

Patients undergoing myeloablative chemotherapy and hematopoietic stem cell transplantation (HSCT) experience profound neutropenia and vulnerability to infection. Previous research has indicated that patients with infections have depleted vitamin C status. In this study, we recruited 38 patients with hematopoietic cancer who were undergoing conditioning chemotherapy and HSCT. Blood samples were collected prior to transplantation, at one week, two weeks and four weeks following transplantation. Vitamin C status and biomarkers of inflammation (C-reactive protein) and oxidative stress (protein carbonyls and thiobarbituric acid reactive substances) were assessed in association with febrile neutropenia. The vitamin C status of the study participants decreased from 44 ± 7 µmol/L to 29 ± 5 µmol/L by week one (p = 0.001) and 19 ± 6 µmol/L by week two (p < 0.001), by which time all of the participants had undergone a febrile episode. By week four, vitamin C status had increased to 37 ± 10 µmol/L (p = 0.1). Pre-transplantation, the cohort comprised 19% with hypovitaminosis C (i.e., <23 µmol/L) and 8% with deficiency (i.e., <11 µmol/L). At week one, those with hypovitaminosis C had increased to 38%, and at week two, 72% had hypovitaminosis C, and 34% had outright deficiency. C-reactive protein concentrations increased from 3.5 ± 1.8 mg/L to 20 ± 11 mg/L at week one (p = 0.002), and 119 ± 25 mg/L at week two (p < 0.001), corresponding to the development of febrile neutropenia in the patients. By week four, these values had dropped to 17 ± 8 mg/L (p < 0.001). There was a significant inverse correlation between C-reactive protein concentrations and vitamin C status (r = −0.424, p < 0.001). Lipid oxidation (thiobarbituric acid reactive substances (TBARS)) increased significantly from 2.0 ± 0.3 µmol/L at baseline to 3.3 ± 0.6 µmol/L by week one (p < 0.001), and remained elevated at week two (p = 0.003), returning to baseline concentrations by week four (p = 0.3). Overall, the lowest mean vitamin C values (recorded at week two) corresponded with the highest mean C-reactive protein values and lowest mean neutrophil counts. Thus, depleted vitamin C status in the HSCT patients coincides with febrile neutropenia and elevated inflammation and oxidative stress.

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Effect of progesterone on phosphamidon-induced impairment of memory and oxidative stress in rats

Human & Experimental Toxicology ◽

10.1177/0960327110396522 ◽

2011 ◽

Vol 30 (10) ◽

pp. 1626-1634 ◽

Cited By ~ 6

Author(s):

Amit K Sharma ◽

Swapan K Bhattacharya ◽

Naresh Khanna ◽

Ashok K Tripathi ◽

Tarun Arora ◽

...

Keyword(s):

Oxidative Stress ◽

Cognitive Function ◽

Organophosphorus Pesticides ◽

Thiobarbituric Acid ◽

Treated Group ◽

Control Group ◽

Protein Thiols ◽

Acute And Chronic Exposure ◽

The Brain ◽

And Oxidative Stress

Progesterone (a neurosteroid) is an important modulator of the nervous system functioning. Organophosphorus pesticides like phosphamidon have been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present study was therefore designed to investigate the effects of progesterone (PROG) on phosphamidon-induced modulation of cognitive function and oxidative stress in rats. Cognitive function was assessed using step-down latency (SDL) on a passive avoidance apparatus and transfer latency (TL) on an elevated plus maze. Oxidative stress was assessed by examining the levels of thiobarbituric acid reactive species (TBARS) and non-protein thiols (NP-SH) in isolated homogenized whole brain samples. The results showed a significant reduction in SDL and prolongation of TL in the phosphamidon (1.74 mg/kg/d; p.o.) treated group at weeks 6 and 8 as compared to the control group. Two weeks treatment with PROG (15 mg/kg/d; i.p.) antagonized the effect of phosphamidon on SDL as well as TL. Phosphamidon alone produced a significant increase in the brain TBARS levels and decrease in the brain NP-SH levels. Treatment with PROG (15 mg/kg/d; i.p.) attenuated the effect of phosphamidon on oxidative stress. Together, the results showed that progesterone attenuated the cognitive dysfunction and increased oxidative stress induced by phosphamidon in the brain.

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The Effects of Yellow Soybean, Black Soybean, and Sword Bean on Lipid Levels and Oxidative Stress in Ovariectomized Rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000010 ◽

2010 ◽

Vol 80 (2) ◽

pp. 97-106 ◽

Cited By ~ 23

Author(s):

Jae Soon Byun ◽

Young Sun Han ◽

Sang Sun Lee

Keyword(s):

Oxidative Stress ◽

Postmenopausal Women ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Thiobarbituric Acid ◽

Female Rats ◽

Ovariectomized Rats ◽

Lipid Levels ◽

Black Soybean ◽

And Oxidative Stress

Soy isoflavones have been reported to decrease the risk of atherosclerosis in postmenopausal women. However, the effects of dietary consumption of soybean have not been explored. In this study, we evaluated the effects of consuming yellow soybeans, black soybeans (Glycine max), or sword beans (Canavalia gladiate) on lipid and oxidative stress levels in an ovariectomized rat model. Forty-seven nine-week-old female rats were ovariectomized, randomly divided into four groups, and fed one of the following diets for 10 weeks: a diet supplemented with casein (NC, n = 12), a diet supplemented with yellow soybean (YS, n = 12), a diet supplemented with black soybean (BS, n = 12), or a diet supplemented with sword bean (SB, n = 11). Plasma triglyceride (TG) levels in the BS and SB groups were significantly lower than that in the NC group. Notably, the BS group had significantly lower plasma total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels than the other groups. Hepatic total lipid levels were significantly lower in the YS and SB groups, and cholesterol levels were significantly lower in the SB group than in the NC group. Superoxide dismutase (SOD) and catalase (CAT) activities were significantly higher in the groups fed beans compared to the NC group. Hepatic thiobarbituric acid reactive substances (TBARS) levels were also significantly lower in the BS and SB groups than the NC group. In conclusion, our results suggest that consumption of various types of beans may inhibit oxidative stress in postmenopausal women by increasing antioxidant activity and improving lipid profiles. Notably, intake of black soybean resulted in the greatest improvement in risk factors associated with cardiovascular disease.

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Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues

Anais da Academia Brasileira de Ciências ◽

10.1590/s0001-37652012005000056 ◽

2012 ◽

Vol 84 (4) ◽

pp. 1121-1126 ◽

Cited By ~ 11

Author(s):

Seyed M. Nabavi ◽

Seyed F. Nabavi ◽

Akbar H. Moghaddam ◽

William N. Setzer ◽

Morteza Mirzaei

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Sodium Fluoride ◽

Biochemical Parameters ◽

Reduced Glutathione ◽

Thiobarbituric Acid ◽

Glutathione Level ◽

Thiobarbituric Acid Reactive Substances ◽

Cardiac Tissues ◽

And Oxidative Stress

This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.

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Beta-alanine Supplementation Neither Reduce the Oxidative Stress nor Improve Physical Performance of Volleyball Athletes

10.31236/osf.io/zs9qk ◽

2019 ◽

Author(s):

Jean Carlos Silvestre ◽

Rodrigo Gianoni ◽

Gilmar Esteves ◽

Rafael Lambertucci ◽

Alessandro de Moura Zagatto ◽

...

Keyword(s):

Oxidative Stress ◽

Uric Acid ◽

Thiobarbituric Acid ◽

Thiobarbituric Acid Reactive Substances ◽

Countermovement Jump ◽

Internal Load ◽

Stress Indices ◽

Beta Alanine ◽

Upper Respiratory ◽

And Oxidative Stress

This study analyzed whether the Beta-Alanine (BA) supplementation improves performance and oxidative stress indices during the tapering period. We assessed eleven volleyball athletes over 8-week. The performance was evaluated through the countermovement jump (CMJ). We evaluated Internal Training Load (ITL), questionnaires (Wisconsin Upper Respiratory Symp-tom Survey 21 – WURSS 21) and oxidative stress (Thiobarbituric acid reactive substances - TBARS, uric acid and nitrite). Athletes supplemented with BA or dextrose (PL) at doses of 6.4 g/day. Beta-alanine (BA) supplementation does not modulate the performance (CMJ). Along the treatment period, the internal load of the PL group remained higher than the BA group (P=0.011). The uric acid and nitrite were neither modulated by training nor treatment. Howev-er, the TBARS was lower at post moment than pre, without difference between groups. Thus, BA supplementation neither increased the performance nor decreased oxidative stress in vol-leyball athletes after a period of training intensification.

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Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure

Clinical Science ◽

10.1042/cs20130789 ◽

2014 ◽

Vol 127 (10) ◽

pp. 589-602 ◽

Cited By ~ 11

Author(s):

Tzu-Pin Weng ◽

Tieh-Cheng Fu ◽

Chao-Hung Wang ◽

Chih-Chin Hsu ◽

Jong-Shyan Wang

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Aerobic Capacity ◽

Lymphocyte Count ◽

Sympathetic Activation ◽

Inflammatory Status ◽

Patients With Heart Failure ◽

And Oxidative Stress ◽

Disease Specific

Increased sympathetic activation and oxidative stress/pro-inflammatory status cause lymphocytopenia by activating programmed lymphocyte death in patients with HF. Moreover, a low lymphocyte count correlates with reduced haemodynamics and aerobic capacity, which reflects poor generic/disease-specific QoL in the HF patients.

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The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males

Antioxidants ◽

10.3390/antiox10060866 ◽

2021 ◽

Vol 10 (6) ◽

pp. 866

Author(s):

Takaki Tominaga ◽

Tsukasa Ikemura ◽

Koichi Yada ◽

Kazue Kanda ◽

Kaoru Sugama ◽

...

Keyword(s):

Oxidative Stress ◽

Thiobarbituric Acid ◽

Organ Damage ◽

Exhaustive Exercise ◽

Strenuous Exercise ◽

Intestinal Damage ◽

Urine Biomarkers ◽

Exercise Induced ◽

And Oxidative Stress ◽

Healthy Males

Strenuous exercise induces organ damage, inflammation and oxidative stress. To prevent exercise-induced organ damage, inflammation and oxidative stress, rehydrating may be an effective strategy. In the present study, we aimed to examine whether beverage intake after exhaustive exercise to recover from dehydration prevents such disorders. Thirteen male volunteers performed incremental cycling exercise until exhaustion. Immediately after exercise, the subjects drank an electrolyte containing water (rehydrate trial: REH) or did not drink any beverage (control trial: CON). Blood samples were collected before (Pre), immediately (Post), 1 h and 2 h after exercise. Urine samples were also collected before (Pre) and 2 h after exercise. We measured biomarkers of organ damage, inflammation and oxidative stress in blood and urine. Biomarkers of muscle, renal and intestinal damage and inflammation increased in the blood and urine after exercise. However, changes in biomarkers of organ damage and inflammation did not differ between trials (p > 0.05). The biomarker of oxidative stress, thiobarbituric acid reactive substances (TBARS), in plasma, showed different changes between trials (p = 0.027). One hour after exercise, plasma TBARS concentration in REH had a higher trend than that in CON (p = 0.052), but there were no significant differences between Pre and the other time points in each trial. These results suggest that beverage intake after exercise does not attenuate exercise-induced organ damage, inflammation or oxidative stress in healthy males. However, rehydration restores exercise-induced oxidative stress more quickly.

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Oxidative Stress and Bipolar Mood Disorder: An Important Yet Ambiguous Relationship

Journal of Pharmaceutical Care ◽

10.18502/jpc.v9i4.8225 ◽

2022 ◽

Author(s):

Sara Rahsepar ◽

Amirhooshang Mohammadpour

Keyword(s):

Oxidative Stress ◽

Bipolar Disorder ◽

Thiobarbituric Acid ◽

Bipolar Mood Disorder ◽

Oxidative Markers ◽

Stress Oxidative ◽

Bipolar Patients ◽

The Relationship ◽

And Oxidative Stress

Bipolar disorder is a chronic psychological condition that disturbs many patients' lives around the world. The exact pathophysiology of bipolar disorder is yet unknown, but there are several hypotheses to explain this condition. One of the most challenging theories is the role of oxidative stress in the progression of bipolar disorder. Here, we conducted a narrative review to gather the studies that investigated the relationship between bipolar disorder and oxidative stress. We searched PubMed, Scopus, Web of science, and google scholar databases using the following keywords: “bipolar disorder,” “oxidative stress,” “oxidative markers,” and “bipolar patients.” A majority of studies showed that oxidative markers such as Thiobarbituric acid reactive substances are significantly higher in bipolar patients compared to healthy subjects. Based on the included articles, bipolar disorder is associated with oxidative stress. Nevertheless, further well-established Cohorts are required to support these results.

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Can Creatine Supplementation Interfere with Muscle Strength and Fatigue in Brazilian National Level Paralympic Powerlifting?

Nutrients ◽

10.3390/nu12092492 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2492

Author(s):

Carlos Rodrigo Soares Freitas Sampaio ◽

Felipe J. Aidar ◽

Alexandre R. P. Ferreira ◽

Jymmys Lopes dos Santos ◽

Anderson Carlos Marçal ◽

...

Keyword(s):

Muscle Strength ◽

Isometric Force ◽

National Level ◽

Creatine Supplementation ◽

Peak Torque ◽

Fatigue Index ◽

Force Peak ◽

Maximum Isometric Force ◽

Force Time ◽

Blind Manner

The aim of the present study was to analyze the effect of creatine (Cr) supplementation on peak torque (PT) and fatigue rate in Paralympic weightlifting athletes. Eight Paralympic powerlifting athletes participated in the study, with 25.40 ± 3.30 years and 70.30 ± 12.15 kg. The measurements of muscle strength, fatigue index (FI), peak torque (PT), force (kgf), force (N), rate of force development (RFD), and time to maximum isometric force (time) were determined by a Musclelab load cell. The study was performed in a single-blind manner, with subjects conducting the experiments first with placebo supplementation and then, following a 7-day washout period, beginning the same protocol with creatine supplementation for 7 days. This sequence was chosen because of the lengthy washout of creatine. Regarding the comparison between conditions, Cr supplementation did not show effects on the variables of muscle force, peak torque, RFD, and time to maximum isometric force (p > 0.05). However, when comparing the results of the moments with the use of Cr and placebo, a difference was observed for the FI after seven days (U3: 1.12; 95% CI: (0.03, 2.27); p = 0.02); therefore, the FI was higher for placebo. Creatine supplementation has a positive effect on the performance of Paralympic powerlifting athletes, reducing fatigue index, and keeping the force levels as well as PT.

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Inter-Relationship between Platelet-Derived Microparticles and Oxidative Stress in Patients with Venous Thromboembolism

Antioxidants ◽

10.3390/antiox9121217 ◽

2020 ◽

Vol 9 (12) ◽

pp. 1217

Author(s):

Salvatore Santo Signorelli ◽

Gea Oliveri Conti ◽

Maria Fiore ◽

Maria Grazia Elfio ◽

Antonio Cristaldi ◽

...

Keyword(s):

Oxidative Stress ◽

Venous Thromboembolism ◽

Potential Role ◽

Thiobarbituric Acid ◽

Thiobarbituric Acid Reactive Substances ◽

Circulating Microparticles ◽

Galectin 3 ◽

And Oxidative Stress ◽

Control Study

Background: Hypercoagulative conditions play a key role in venous thromboembolism (VTE). Inflammation is currently linked to VTE, but the potential role of circulating microparticles and oxidative stress (OxS) must be elucidated. The aim of this study was to evaluate platelet-derived microparticles and surrogate OxS biomarkers in patients diagnosed with VTE through a case–control study. Methods: Platelet-derived microparticles (MPs), pro-thrombinase-induced clotting time assay (PiCT), phospholipids (PLPs), malondialdehyde (MDA), 4-hydroxynonenale (4-HNE), thiobarbituric acid reactive substances (TBARs), superoxide dismutase (SOD), and galectin-3 (Gal-3) were measured in VTE patients and in healthy controls. Results: PLPs, 4-HNE, TBARs, and Gal-3 were higher in VTE patients compared to controls; conversely, SOD was lower. A significant non-linear regression between OxS biomarkers and the markers of platelet degranulation was found. Conclusion: Our results suggest that OxS and platelet degranulation are concomitant pathophysiological mechanisms in VTE.

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