Oxidative Stress and Bipolar Mood Disorder: An Important Yet Ambiguous Relationship

Journal of Pharmaceutical Care ◽

10.18502/jpc.v9i4.8225 ◽

2022 ◽

Author(s):

Sara Rahsepar ◽

Amirhooshang Mohammadpour

Keyword(s):

Oxidative Stress ◽

Bipolar Disorder ◽

Thiobarbituric Acid ◽

Bipolar Mood Disorder ◽

Oxidative Markers ◽

Stress Oxidative ◽

Bipolar Patients ◽

The Relationship ◽

And Oxidative Stress

Bipolar disorder is a chronic psychological condition that disturbs many patients' lives around the world. The exact pathophysiology of bipolar disorder is yet unknown, but there are several hypotheses to explain this condition. One of the most challenging theories is the role of oxidative stress in the progression of bipolar disorder. Here, we conducted a narrative review to gather the studies that investigated the relationship between bipolar disorder and oxidative stress. We searched PubMed, Scopus, Web of science, and google scholar databases using the following keywords: “bipolar disorder,” “oxidative stress,” “oxidative markers,” and “bipolar patients.” A majority of studies showed that oxidative markers such as Thiobarbituric acid reactive substances are significantly higher in bipolar patients compared to healthy subjects. Based on the included articles, bipolar disorder is associated with oxidative stress. Nevertheless, further well-established Cohorts are required to support these results.

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High BDNF serum levels are associated to good cognitive functioning in bipolar disorder

European Psychiatry ◽

10.1016/j.eurpsy.2019.02.006 ◽

2019 ◽

Vol 60 ◽

pp. 97-107 ◽

Cited By ~ 11

Author(s):

Ester Mora ◽

Maria J. Portella ◽

Gerard Piñol-Ripoll ◽

Ricard López ◽

Daniel Cuadras ◽

...

Keyword(s):

Oxidative Stress ◽

Bipolar Disorder ◽

Cognitive Functioning ◽

Verbal Memory ◽

Cognitive Outcome ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Bipolar Patients ◽

And Oxidative Stress

AbstractBackground:Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. To date, there is a lack of studies linking the cognitive impairment observed in BD with these neurobiological mechanisms. This study aimed to investigate the role of these neurobiological factors in clinical and cognitive outcomes in a sample of bipolar individuals.Methods:We measured serum BDNF, cytokines and oxidative stress markers in a sample of 133 individuals: 52 euthymic bipolar patients, 32 manic patients and 49 healthy controls. They were all assessed with a comprehensive cognitive battery. Sociodemographic and clinical data were collected. Multiple linear regression models were built to study associations of neurotrophins and inflammatory and oxidative measures with cognitive functioning.Results:BDNF levels were decreased in euthymic (p = 0.039) and manic (p < 0.001) individuals. Conversely, inflammatory (interleukin 6 (IL-6)) (p = 0.019) and oxidative stress (p = 0.003) measures were increased in bipolar individuals compared to controls. BDNF levels were associated with executive functioning (β = 0.01, p = 0.02) and verbal memory (β = 0.013, p = 0.005), together with other demographic variables. In particular, verbal memory was also associated with obesity (β=-0.04, p = 0.005). Neither inflammatory markers, oxidative stress markers nor other relevant clinical variables showed any association with cognitive outcome.Conclusions:Of all the peripheral neurobiological factors analysed, BDNF was the only one significantly associated with cognitive dysfunction in bipolar disorder individuals. This study emphasizes the role of BDNF not only across mood phases but also in cognitive functioning.

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Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

Antioxidants ◽

10.3390/antiox11010091 ◽

2021 ◽

Vol 11 (1) ◽

pp. 91

Author(s):

Yuanqiang Ma ◽

Gyurim Lee ◽

Su-Young Heo ◽

Yoon-Seok Roh

Keyword(s):

Oxidative Stress ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Therapeutic Agents ◽

Nonalcoholic Fatty Liver ◽

Stress Oxidative ◽

The Relationship

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.

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Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes

International Journal of Molecular Sciences ◽

10.3390/ijms21103653 ◽

2020 ◽

Vol 21 (10) ◽

pp. 3653

Author(s):

Sara Cheleschi ◽

Marcella Barbarino ◽

Ines Gallo ◽

Sara Tenti ◽

Maria Bottaro ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Enzymes ◽

Hydrostatic Pressure ◽

B Cell Lymphoma ◽

Type Ii Collagen ◽

Mrna Levels ◽

Osteoarthritic Chondrocytes ◽

The Relationship ◽

And Oxidative Stress

Hydrostatic pressure (HP) modulates chondrocytes metabolism, however, its ability to regulate oxidative stress and microRNAs (miRNA) has not been clarified. The aim of this study was to investigate the role of miR-34a, miR-146a, and miR-181a as possible mediators of HP effects on oxidative stress in human osteoarthritis (OA) chondrocytes. Chondrocytes were exposed to cyclic low HP (1–5 MPa) and continuous static HP (10 MPa) for 3~h. Metalloproteinases (MMPs), disintegrin and metalloproteinase with thrombospondin motif (ADAMTS)-5, type II collagen (Col2a1), miR-34a, miR-146a, miR-181a, antioxidant enzymes, and B-cell lymphoma 2 (BCL2) were evaluated by quantitative real-time polymerase chain reaction qRT-PCR, apoptosis and reactive oxygen species ROS production by cytometry, and β-catenin by immunofluorescence. The relationship among HP, the studied miRNA, and oxidative stress was assessed by transfection with miRNA specific inhibitors. Low cyclical HP significantly reduced apoptosis, the gene expression of MMP-13, ADAMTS5, miRNA, the production of superoxide anion, and mRNA levels of antioxidant enzymes. Conversely, an increased Col2a1 and BCL2 genes was observed. β-catenin protein expression was reduced in cells exposed to HP 1–5 MPa. Opposite results were obtained following continuous static HP application. Finally, miRNA silencing enhanced low HP and suppressed continuous HP-induced effects. Our data suggest miRNA as one of the mechanisms by which HP regulates chondrocyte metabolism and oxidative stress, via Wnt/β-catenin pathway.

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“Cumulative Stress”: The Effects of Maternal and Neonatal Oxidative Stress and Oxidative Stress-Inducible Genes on Programming of Atopy

Oxidative Medicine and Cellular Longevity ◽

10.1155/2016/8651820 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Sara Manti ◽

Lucia Marseglia ◽

Gabriella D’Angelo ◽

Caterina Cuppari ◽

Erika Cusumano ◽

...

Keyword(s):

Oxidative Stress ◽

Dna Sequences ◽

Allergic Diseases ◽

Atopic Diseases ◽

Cumulative Stress ◽

Inducible Genes ◽

The Relationship ◽

And Oxidative Stress ◽

Epigenetic Pattern

Although extensive epidemiological and laboratory studies have been performed to identify the environmental and immunological causes of atopy, genetic predisposition seems to be the biggest risk factor for allergic diseases. The onset of atopic diseases may be the result of heritable changes of gene expression, without any alteration in DNA sequences occurring in response to early environmental stimuli. Findings suggest that the establishment of a peculiar epigenetic pattern may also be generated by oxidative stress (OS) and perpetuated by the activation of OS-related genes. Analyzing the role of maternal and neonatal oxidative stress and oxidative stress-inducible genes, the purpose of this review was to summarize what is known about the relationship between maternal and neonatal OS-related genes and the development of atopic diseases.

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Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis: Emerging Role of Gamma-Glutamyltransferase

Advances in Pharmacological Sciences ◽

10.1155/2012/465634 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Etienne Mokondjimobe ◽

Benjamin Longo-Mbenza ◽

Jean Akiana ◽

Ulrich Oswald Ndalla ◽

Regis Dossou-Yovo ◽

...

Keyword(s):

Oxidative Stress ◽

Pulmonary Tuberculosis ◽

Oxidative Markers ◽

Tb Treatment ◽

Normal Ranges ◽

Independent Association ◽

Design And Methods ◽

The Impact ◽

The Relationship

Background. The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT.Design and Methods. A prospective followup of 40 adults (21 males; mean age of34.7±5.8years) with active PTB on initial phase and continuation phase anti-TB.Results. Only 3% (n=1) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0–day 60, there was a significant, negative, and independent association between GGT and AST.Conclusion. The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR.

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The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/3232869 ◽

2020 ◽

Vol 2020 ◽

pp. 1-17

Author(s):

Xiaoyu Wang ◽

Yunxiang Zhou ◽

Qiannan Gao ◽

Dongnan Ping ◽

Yali Wang ◽

...

Keyword(s):

Oxidative Stress ◽

Neurodegenerative Diseases ◽

Cell Communication ◽

Irreversible Damage ◽

Exosomal Mirnas ◽

A Cell ◽

Physiological Pathways ◽

The Relationship ◽

And Oxidative Stress

Neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease are aging-associated diseases with irreversible damage of brain tissue. Oxidative stress is commonly detected in neurodegenerative diseases and related to neuronal injury and pathological progress. Exosome, one of the extracellular vesicles, is demonstrated to carry microRNAs (miRNAs) and build up a cell-cell communication in neurons. Recent research has found that exosomal miRNAs regulate the activity of multiple physiological pathways, including the oxidative stress response, in neurodegenerative diseases. Here, we review the role of exosomal miRNAs and oxidative stress in neurodegenerative diseases. Firstly, we explore the relationship between oxidative stress and neurodegenerative diseases. Secondly, we introduce the characteristics of exosomes and roles of exosome-related miRNAs. Thirdly, we summarized the crosstalk between exosomal miRNAs and oxidative stress in neurodegenerative diseases. Fourthly, we discuss the potential of exosomes to be a biomarker in neurodegenerative diseases. Finally, we summarize the advantages of exosome-based delivery and present situation of research on exosome-based delivery of therapeutic miRNA. Our work is aimed at probing and reinforcing the recognition of the pathomechanism of neurodegenerative diseases and providing the basis for novel strategies of clinical diagnosis and treatment.

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Inter-Relationship between Platelet-Derived Microparticles and Oxidative Stress in Patients with Venous Thromboembolism

Antioxidants ◽

10.3390/antiox9121217 ◽

2020 ◽

Vol 9 (12) ◽

pp. 1217

Author(s):

Salvatore Santo Signorelli ◽

Gea Oliveri Conti ◽

Maria Fiore ◽

Maria Grazia Elfio ◽

Antonio Cristaldi ◽

...

Keyword(s):

Oxidative Stress ◽

Venous Thromboembolism ◽

Potential Role ◽

Thiobarbituric Acid ◽

Thiobarbituric Acid Reactive Substances ◽

Circulating Microparticles ◽

Galectin 3 ◽

And Oxidative Stress ◽

Control Study

Background: Hypercoagulative conditions play a key role in venous thromboembolism (VTE). Inflammation is currently linked to VTE, but the potential role of circulating microparticles and oxidative stress (OxS) must be elucidated. The aim of this study was to evaluate platelet-derived microparticles and surrogate OxS biomarkers in patients diagnosed with VTE through a case–control study. Methods: Platelet-derived microparticles (MPs), pro-thrombinase-induced clotting time assay (PiCT), phospholipids (PLPs), malondialdehyde (MDA), 4-hydroxynonenale (4-HNE), thiobarbituric acid reactive substances (TBARs), superoxide dismutase (SOD), and galectin-3 (Gal-3) were measured in VTE patients and in healthy controls. Results: PLPs, 4-HNE, TBARs, and Gal-3 were higher in VTE patients compared to controls; conversely, SOD was lower. A significant non-linear regression between OxS biomarkers and the markers of platelet degranulation was found. Conclusion: Our results suggest that OxS and platelet degranulation are concomitant pathophysiological mechanisms in VTE.

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Biomarkers and staging of bipolar disorder: a systematic review

Trends in Psychiatry and Psychotherapy ◽

10.1590/2237-6089-2014-0002 ◽

2014 ◽

Vol 37 (1) ◽

pp. 03-11 ◽

Cited By ~ 23

Author(s):

Ângela Roda ◽

Inês Chendo ◽

Mauricio Kunz

Keyword(s):

Oxidative Stress ◽

Bipolar Disorder ◽

Neurotrophic Factors ◽

Grey Matter ◽

Progressive Disease ◽

Treatment Algorithms ◽

Treatment Regimens ◽

Control Disease ◽

The Relationship ◽

And Oxidative Stress

INTRODUCTION: A growing body of evidence suggests that bipolar disorder (BD) is a progressive disease according to clinical, biochemical and neuroimaging findings. This study reviewed the literature on the relationship between specific biomarkers and BD stages.METHODS: A comprehensive literature search of MEDLINE and PubMed was conducted to identify studies in English and Portuguese using the keywords biomarker, neurotrophic factors, inflammation, oxidative stress, neuroprogression and staging models cross-referenced with bipolar disorder.RESULTS: Morphometric studies of patients with BD found neuroanatomic abnormalities, such as ventricular enlargement, grey matter loss in the hippocampus and cerebellum, volume decreases in the prefrontal cortex and variations in the size of the amygdala. Other studies demonstrated that serum concentrations of neurotrophic factors, inflammatory mediators and oxidative stress may be used as BD biomarkers.CONCLUSIONS: The analysis of neurobiological changes associated with BD progression and activity may confirm the existence of BD biomarkers, which may be then included in staging models that will lead to improvements in treatment algorithms and more effective, individually tailored treatment regimens. Biomarkers may also be used to define early interventions to control disease progression.

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Role of oxidative stress in the pathogenesis of postmenopausal osteoporosis (literature review)

Terapevt (General Physician) ◽

10.33920/med-12-2010-03 ◽

2020 ◽

pp. 29-42

Author(s):

S. V. Bulgakova ◽

A. V. Melikova

Keyword(s):

Oxidative Stress ◽

Literature Review ◽

Postmenopausal Osteoporosis ◽

Redox Homeostasis ◽

Large Body ◽

World Population ◽

Social Significance ◽

The Relationship ◽

And Oxidative Stress

Postmenopausal osteoporosis is a disease of great medical and social significance for the world population. At the same time, the underlying pathogenesis of this pathology is not fully understood. A large body of research suggests that endocrine changes associated with postmenopause can lead to disruption of redox homeostasis and oxidative stress that affects bone metabolism. This literature review analyzes the relationship between hypoestrogenemia, oxidative stress and postmenopausal osteoporosis, as well as methods for the prevention and treatment of these conditions.

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