scholarly journals Physical Training Increases Erythroferrone Levels in Men

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1215
Author(s):  
Inga Dziembowska ◽  
Małgorzata Wójcik ◽  
Jakub Bukowski ◽  
Ewa Żekanowska

Intense physical activity contributes to an increased demand for red blood cells, which transport oxygen to working muscles. The purpose of this study was to assess the concentration of erythroferrone (ERFE), the novel marker of erythroid activity in athletes, during the beginning of their training season. The study group consisted of 39 athletes aged 23.24 ± 3.77 years. The study was carried out during the athletes’ preparatory period of the training cycle. The control group consisted of 34 healthy men aged 22.33 ± 2.77 years. The erythropoietic activity was evaluated by determining athletes’ concentrations of erythropoietin (EPO) and erythroferrone (ERFE). The level of physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). In the athletes’ group, we observed higher concentrations of EPO (Me = 12.65 mIU/mL) and ERFE (40.00 pg/mL) compared to the control group (EPO: Me = 5.74 mIU/ml, p = 0.001; ERFE: Me = 25.50 pg/mL, p = 0.0034). The average intensity of physical exercise significantly differentiated the participants as far as EPO and ERFE concentrations. These results suggest that intense physical activity, at least at the beginning of the training season, may stimulate EPO production, which increases ERFE release. This seems to be an adaptative mechanism that provides adequate iron for enhanced erythropoiesis.

2006 ◽  
Vol 9 (2) ◽  
pp. 258-265 ◽  
Author(s):  
Ulf Ekelund ◽  
Hanna Sepp ◽  
Sören Brage ◽  
Wulf Becker ◽  
Rupert Jakes ◽  
...  

AbstractObjectiveTo examine the validity of the short, last 7-day, self-administered form of the International Physical Activity Questionnaire (IPAQ).DesignAll subjects wore an accelerometer for seven consecutive days and completed the IPAQ questionnaire on the eighth day. Criterion validity was assessed by linear regression analysis and by modified Bland–Altman analysis. Specificity and sensitivity were calculated for classifying respondents according to the physical activity guidelines of the American College of Sports Medicine/Centers for Disease Control and Prevention.SettingWorkplaces in Uppsala, Sweden.SubjectsOne hundred and eighty-five (87 males) participants, aged 20 to 69 years.ResultsTotal self-reported physical activity (PA) (MET-min day−1) was significantly correlated with average intensity of activity (counts min−1) from accelerometry (r=0.34, P<0.001). Gender, age, education and body mass index did not affect this relationship. Further, subcomponents of self-reported PA (time spent sitting, time in PA, time in moderate and vigorous activity (MVPA)) were significantly correlated with objectively measured PA (P<0.05). Self-reported time in PA was significantly different from time measured by accelerometry (mean difference: −25.9 min day−1; 95% limits of agreement: −172 to 120 min day−1; P<0.001). IPAQ identified 77% (specificity) of those who met the current PA guidelines of accumulating more than 30 min day−1 in MVPA as determined by accelerometry, whereas only 45% (sensitivity) of those not meeting the guidelines were classified correctly.ConclusionsOur results indicate that the short, last 7-days version of the IPAQ has acceptable criterion validity for use in Swedish adults. However, the IPAQ instrument significantly overestimated self-reported time spent in PA. The specificity to correctly classify people achieving current PA guidelines was acceptable, whereas the sensitivity was low.


2020 ◽  
Vol 57 (2) ◽  
pp. 161-166
Author(s):  
Daniela Carolina Barizon TEZA ◽  
Érika Cristina FERREIRA ◽  
Mônica Lúcia GOMES

ABSTRACT BACKGROUND: Intestinal constipation (IC) in patients with the digestive form of Chagas disease is one of the main reasons for seeking medical care. Population data indicate that the practice of physical activity improves gastrointestinal motility. OBJECTIVE: This study evaluated the bowel frequency and symptoms of constipation and their relationship with the level of physical activity in patients with and without Chagas disease. METHODS: Patients (n=120) of both genres, aged between 35 and 84 years, in which 50% (n=60) were in the Chagas group and 50% (n=60) were in the control group, were evaluated regarding the level of IC using the Constipation Assessment Scale (CAS) and regarding the level of physical activity using the International Physical Activity Questionnaire (IPAQ). RESULTS - Patients in the Chagas group classified as active (IPAQ 2) had higher proportion (P=0.0235) of moderate IC with severe abdominal distension (P=0.0159) and decreased evacuation frequency (P=0.0281) than the patients in the control group, considered to be very active (IPAQ 1). The sedentary lifestyle was greater (P=0.0051) in the Chagas group with duration, intensity and frequency of physical activity lower than the control group. The health perception in the Chagas group was regular for 46.7% (P=0.0035) and poor for 8.3% (P=0.0244). CONCLUSION: There is a lower risk of developing intestinal constipation in more active individuals, evidencing that the level of physical activity interferes with bowel frequency and symptoms of constipation in patients with and without Chagas disease. The level of physical activity and health perception were worse in the Chagas group, reinforcing the disease stigma, which should be modified by the training of health professionals who routinely attend these patients.


Author(s):  
S.P. Nakonechna

Objective of the study: to assess the effectiveness of the correction of the motor stereotype in young people (students) with postural disorders, flat feet and obesity by means of physical therapy. Material and methods. Surveyed 110 first-year students. The control group consisted of students with normal body weight, normal posture and no signs of flat feet. The comparison group consisted of students with obesity, impaired posture in the sagittal plane and flat feet. They were divided into two groups: group 1 - students who expressed a desire to correct diagnosed violations on their own and / or in independently selected rehabilitation institutions and / or during classroom physical education. Group 2 consisted of students undergoing rehabilitation using the developed program of physical therapy, which lasted 6 months and included kinesiоtherapy, massage, kinesiological taping, nutritional modification, behavioral psychocorrection. The movement stereotype of students was assessed by the Functional Movement Screen, the level of physical activity - by the International Physical Activity Questionnaire. Results. Students with poor posture, flat feet and obesity showed violations of the motor stereotype, which was confirmed on the basis of the worst results of all Functional Movement Screen tests (p <0.05), as well as a lower level of general motor activity (according to the levels of weekly energy consumption, determined by the International Physical Activity Questionnaire) (p <0.05) relative to the indicators of their healthy peers. Analyzing the gender difference in the test results, it was found that the guys were easier to perform exercises related to the implementation of strength (6, 7 tests), and the girls - flexibility (2, 5 tests). The developed program of physical therapy with the use of functional training on the Prosedos platform, massage, kinesiological taping, nutrition modification, behavioral psychocorrection showed a statistically significantly better effect on all characteristics of the movement pattern and the level of physical activity of students compared to the results of individuals who did non-specialized programs (p <0.05). Findings. During their studies in higher educational institutions, students with disabilities in health require increased attention in the context of identifying and correcting pathological changes, is a consequence of chronic diseases, if possible - non-drug means, in particular, physical therapy.


2015 ◽  
Vol 4 (1) ◽  
pp. 62-70
Author(s):  
Daniati Ristia Ayu ◽  
Martha Irene Kartasurya

Latar Belakang : Hipertensi merupakan faktor risiko terjadinya penyakit jantung koroner, stroke, infark miokardia, gagal jantung dan penyakit ginjal. Tomat mengandung likopen yang mempunyai aktivitas antioksidan sehingga dapat menurunkan tekanan darah. Minyak zaitun meningkatkan absorbsi likopen dari tomat dan mengandung asam oleat yang dapat menurunkan tekanan darah. Tujuan: Menganalisis pengaruh penambahan minyak zaitun terhadap tekanan darah sistolik penderita hipertensi yang diberi jus tomat.Metode : Jenis penelitian adalah true experiment dengan rancangan pre –post test with control group design. Subjek penelitian adalah wanita menopause dengan tekanan darah sistolik 140 ­– 159 mmHg yang dibagi menjadi dua kelompok, 12 pada kelompok perlakuan dan 12 pada kontrol. Intervensi dilakukan selama 7 hari. Tekanan darah sistolik diukur menggunakan Sphygmomanometer air raksa. Asupan makanan diukur menggunakan metode food recall 2x24 jam dan dianalisis menggunakan nutrisurvey. Aktivitas fisik dianalisis menggunakan International Physical Activity Questionnaire (IPAQ). Analisis statistik menggunakan uji paired t-test, Wilcoxon, independent t-test dan Mann Whitney.Hasil : Ada penurunan tekanan darah sistolik pada kelompok perlakuan dari 150,9±1,7 mmHg menjadi 136,4±4,5 mmHg (p=0,002) dan pada kelompok kontrol dari 148,5±4,5 mmHg menjadi 138,4±5,5 mmHg (p=0,0001). Rerata penurunan tekanan darah sistolik pada kelompok perlakuan 14,5±4,7 mmHg, lebih besar daripada kelompok kontrol 10,1±2,3 mmHg (p=0,007)Kesimpulan : Jus tomat dengan minyak zaitun sebanyak 10ml selama 7 hari menurunkan tekanan darah sistolik lebih banyak daripada jus tomat saja.


2015 ◽  
Vol 4 (2) ◽  
pp. 133-140
Author(s):  
Teguh Ady Nur Cahyo ◽  
Martha Irene Kartasurya

Latar Belakang : Dislipidemia merupakan kelainan metabolisme lipid yang ditandai dengan peningkatan maupun penurunan profil lemak dalam darah dan berakibat terjadinya penyakit kardiovaskular (CVD). Kandungan utama kacang merah seperti isoflavon, proantosianidin dan serat berperan dalam menurunkan kolesterol LDL. Bakteri Asam Laktat (BAL) pada yoghurt kacang merah dapat mengaktifkan isoflavon menjadi aglikon sehingga menurunkan kolesterol LDL.Tujuan: Menganalisis pengaruh pemberian yoghurt kacang merah terhadap kadar kolesterol LDL pada wanita dislipidemia.Metode : Jenis penelitian adalah true experiment dengan rancangan pre-post test with control group. Subjek penelitian adalah 37 wanita dengan kadar kolesterol LDL ≥130 mg/dL yang dibagi menjadi dua kelompok, kelompok kontrol dan perlakuan (225 ml yoghurt kacang merah/hari). Intervensi dilakukan selama 15 hari. Kadar kolesterol LDL dihitung dengan kolesterol total - kadar kolesterol HDL-1/5 kadar trigliserida. Asupan makanan selama intervensi diukur menggunakan metode food recall 24 jam dan dianalisis menggunakan program nutrisurvey. Aktivitas fisik dianalisis menggunakan International Physical Activity Questionnaire (IPAQ). Uji normalitas menggunakan Shapiro Wilk. Analisis statistik menggunakan uji dependent t-test, Wilcoxon, independent t-test dan Mann Whitney.Hasil : Tidak terdapat perbedaan kolesterol LDL awal antara kedua kelompok. Ada penurunan kolesterol LDL pada kelompok perlakuan dari 174,67 mg/dL menjadi 158,7 mg/dL. Ada penurunan kolesterol LDL pada kelompok kontrol dari 162,96 mg/dL menjadi 155,49 mg/dL. Pada kelompok perlakuan lebih besar daripada kelompok Kontrol (p=0,001). Penurunan kadar kolesterol LDL pada kelompok perlakuan dan kontrol masing-masing sebesar 15,97 mg/dL (9,4%) dan 7,47 mg/dL (4,6%). Simpulan : Konsumsi yoghurt kacang merah dengan dosis 225ml/hari selama 15 hari menurunkan kadar kolesterol LDL pada wanita dislipidemia.


2016 ◽  
Vol 42 (04) ◽  
pp. 329-335
Author(s):  
M. Acar ◽  
E. Tonga ◽  
A. Daskapan ◽  
M. Karataş ◽  
A. Tekindal

Abstract Objectives: The aim of this study was to evaluate levels of physical activity in patients with rheumatoid arthritis, osteoarthritis and fibromyalgia and to compare the results with both healthy subjects and each other. Methods: A group of 50 rheumatoid arthritis patients, 95 osteoarthritis patients, 82 fibromyalgia patients and 110 healthy subjects were included in this study. Physical activity levels were assessed by the International Physical Activity Questionnaire (IPAQ). Results: There were significant differences in walking and total physical activity scores in IPAQ between the rheumatoid arthritis (RA), osteoarthritis (OA), fibromyalgia (FMS) patients and the control group (p<0.05). 36.6% of the fibromyalgia group, 28.4% of the osteoarthritis group, 38% of the rheumatoid arthritis group and 22.7% of the healthy subjects were found to be inactive. 45.1% of the fibromyalgia group, 42.1% of the osteoarthritis group, 46% of the rheumatoid arthritis group and 36.4% of the healthy subjects were found to be insufficiently active. Conclusion: As a result, when compared to healthy people, physical activity levels were significantly decreased in patients with rheumatoid arthritis, osteoarthritis, fibromyalgia. The decreases in the physical activity levels were clearer in patients with rheumatoid arthritis than in patients with osteoarthritis and fibromyalgia. Recommending regular physical activity should be integral to rheumatic disease management and walking offers a potentially accessible, inexpensive, and acceptable physical activity intervention.


2020 ◽  
Author(s):  
Ewelina Matusiak-Wieczorek ◽  
Anna Lipert ◽  
Ewa Kochan ◽  
Anna Jegier

Abstract Background: The problem of spending most of the day in a sitting position concerns all people, regardless of their age. Unfortunately, this trend is more and more often observed among young people. The aim of the study was to assess self-reported physical activity and time spent sitting among students of different fields of health related faculty.Methods: The study group included 216 students (22.3±1.8 years of age) of the Medical University of Lodz: physiotherapy students (n=101), pharmacy students (n=73), and dietetics students (n=42). The time spent sitting and physical activity level were assessed based on the International Physical Activity Questionnaire-long version. Results: The time spent sitting among health related faculty students was on average more than 46 hours a week (2781.8±1238.5 MET-minutes/week). Regarding all the students the pharmacy students spent most time sitting (3086.0±1032.1 MET-minutes/week), while the dietetics students spent the least (2215.7±1230.1 MET-minutes/week). Taking into account the physical activity level almost 65% of all the students were in a high category (mainly physiotherapy students). Only 1.4% of all the surveyed students were classified as the low physical activity category. Statistical analysis showed no significant differences ( P = 0.6880) between the time spent sitting and level of physical activity among all students.Conclusions: Students of medical universities spend too much hours on sitting, mostly 5-8 hours a day. Despite this, they undertake various activities due to which their level of physical activity is moderate or even high. Therefore, it cannot be unequivocally stated that there is a relationship between the time spent sitting and physical activity level.


2021 ◽  
Vol 13 (2) ◽  
pp. 446
Author(s):  
Anna Rutkowska ◽  
Katarzyna Kacperak ◽  
Sebastian Rutkowski ◽  
Luisa Cacciante ◽  
Pawel Kiper ◽  
...  

The lockdown with a prohibition of free mobility introduced in many countries has affected restrictions in physical activity (PA). The purpose of the study was to compare PA during restrictions and the “unfreezing” stage. The study group consisted of 89 healthy adult students. To assess the level of PA, a long version of the International Physical Activity Questionnaire (IPAQ) was used. The first evaluation was carried out in the period from 16 to 20 April 2020 at the time of the lockdown and the second in the period from 11 to 14 May 2020 during the so-called “unfreezing”. The average total PA rate during the first measurement was 8640 metabolic equivalent (MET)-min/week and in the second, 10,560 MET-min/week. The analysis of total energy expenditure showed a statistically significant difference (p < 0.029). The establishment of “unfreezing” laws for sport and recreation and the reduction of restrictions have significantly contributed to an increase in the overall level of PA. Based on our outcomes, we recommend students follow the scientific guidelines for undertaking PA (i.e., WHO) during the pandemic in order to maintain an appropriate pro-healthy dose of exercise.


2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1183.2-1184
Author(s):  
R. Izzo ◽  
S. Colafrancesco ◽  
A. Pinto ◽  
A. Gattamelata ◽  
F. Giardina ◽  
...  

Background:The Mediterranean Diet (MD) has anti-inflammatory and immunomodulatory effects1,2 suggesting a protective role in rheumatic diseases. There is limited knowledge about the eating habits and the nutritional state in patients with isolated Sjögren Syndrome (SS) living within the Mediterranean area.Objectives:assessment of adherence to the MD and analysis of the nutritional state in women with SS and their correlations with the clinical, laboratory and histological data of the disease.Methods:patients classified as isolated SS according to AECG criteria 20023 who had undergone to minor salivary gland biopsy during the previous twelve months were consecutively enrolled during follow-up visits. The adherence to the MD was assessed by the Med Diet (MDiet)4 which includes eleven groups of foods; to each group is assigned a value ranging between 0 and 5 based on the frequency of monthly intake. The total score spans from 0 (poor adherence) to 55 (maximum adherence). The level of physical activity was measured by the 6-minutes walking test (6MWT) and by the International Physical Activity Questionnaire (IPAQ). Systemic disease activity was evaluated with the EULAR SS disease activity index (ESSDAI); EULAR SS patient-reported index (ESSPRI) was calculated as well. A subgroup of patients was asked to fill a daily food diary processed with FOOD CONS software which allows to study in detail their eating habits. Nutritional state, muscle strength and basal metabolic rate were assessed. Alcoholism or drug abuse, diabetes mellitus, specific dietary models, treatment with drugs and/or food supplements with anti-inflammatory and/or antioxidant activity were considered exclusion criteria. Multivariate linear regression was performed with R project for Statistical Computing.Results:N= 40 N= 26Age, median (range) 53 (25-80) 33 (25-71)BMI, median (range) 21 (19-29.3) 25.1 (19-33.7)MedDiet score, median (range) 33 (26-43) 33 (23-40)ESSDAI, median (range) 2 (0-16) 1 (0-16)ESSPRI, median (range) 6 (0-8.6) 5.3 (1.6-9)ESSPRI dryness, median (range) 6 (0-10) 6 (2-10)Focus score, median (range) 2.5 (0-9.6) 1.7 (0.8-6.24)ASM kg, median (range) - 16.8 (13.3-21.7)IPAQ meters, median (range) - 1386 (99-11865)6MWT meters, median (range) - 595 (536-680)BMI, body mass index; ASM appendicular skeletal mass; IPAQ International Physical Activity Questionnaire; 6MWT, six minute walking test.MDiet was administered to 40 female SS outpatients. Even if not reaching significativity, patients with a higher focus score in their MSG have a lower value of MDiet score (p = 0.058, r = -1.00). The MDiet score is not associated with ESSDAI (p = 0.85, r 0.02), but only with lower serum levels of C3 (p = 0.004, r = - 0.08).In 26 patients, daily food questionnaire shows that their diet consists of 43% of carbohydrates while fats represent 40% of total energy intake, the remaining 17% daily energy comes from proteins. Fat consumption is higher compared to the levels of energy and nutrient intake for the Italian population5. Six patients had a reduction in muscle mass; sarcopenia is not associated to ESSDAI (p = 0.610).The MDiet score and the amount eaten of polyunsaturated fatty acids (PUFA) were reduced in patients with high value of subscale dryness of ESSPRI (p = 0.057, r -1.21; p =0.610, r -1.00).Conclusion:This study highlights a lower degree of glandular lymphocytic infiltration (expressed as focus score) in minor salivary glands in patients following MD, so its anti-inflammatory role of seems to be confirmed. SS patients have an unbalanced diet because of a higher intake of fat foods, likely for their lubricating effect. Despite the absence of correlation with objective parameters, the increased dryness in patients with a reduced intake of PUFA arouses our interest in a future study including omega-3 supplementation.References:[1]Schwingshackl L et al., Nutr Metab Cardiovasc Dis 2014[2]Mena MP et al., Am J Clin Nutr. 2009[3]Vitali C et al, ARD 2002[4]Panagiotakos D et al., J Med Food 2007[5]LARN 2014Disclosure of Interests:None declared


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