scholarly journals Large-Scale Production of Bioactive Terrein by Aspergillus terreus Strain S020 Isolated from the Saudi Coast of the Red Sea

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 480 ◽  
Author(s):  
Hani Z. Asfour ◽  
Zuhier A. Awan ◽  
Alaa A. Bagalagel ◽  
Mahmoud A. Elfaky ◽  
Reda F. A. Abdelhameed ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Crude Extract ◽  
Large Scale ◽  
Aspergillus Terreus ◽  
Antimicrobial Activities ◽  
Carcinoma Cells ◽  
Small Scale ◽  
Scale Production ◽  
Fungal Strains

The diversity of symbiotic fungi derived from two marine sponges and sediment collected off Obhur, Jeddah (Saudi Arabia), was investigated in the current study. A total of 23 isolates were purified using a culture-dependent approach. Using the morphological properties combined with internal transcribed spacer-rDNA (ITS-rDNA) sequences, 23 fungal strains (in the majority Penicillium and Aspergillus) were identified from these samples. The biological screening (cytotoxic and antimicrobial activities) of small-scale cultures of these fungi yielded several target fungal strains which produced bioactive secondary metabolites. Amongst these isolates, the crude extract of Aspergillus terreus strain S020, which was cultured in fermentation static broth, 21 L, for 40 days at room temperature on potato dextrose broth, displayed strong antimicrobial activities against Pseudomonas aeruginosa and Staphylococcus aureus and significant antiproliferative effects on human carcinoma cells. Chromatographic separation of the crude extract by silica gel column chromatography indicated that the S020 isolate could produce a series of chemical compounds. Among these, pure crystalline terrein was separated with a high yield of 537.26 ± 23.42 g/kg extract, which represents the highest fermentation production of terrein to date. Its chemical structure was elucidated on the basis of high-resolution electrospray ionization mass spectrometry (HRESIMS) or high-resolution mass spectrometry (HRMS), 1D, and 2D NMR spectroscopic analyses and by comparison with reported data. The compound showed strong cytotoxic activity against colorectal carcinoma cells (HCT-116) and hepatocellular carcinoma cells (HepG2), with IC50 values of 12.13 and 22.53 µM, respectively. Our study highlights the potential of A. terreus strain S020 for the industrial production of bioactive terrein on a large scale and the importance of future investigations of these strains to identify the bioactive leads in these fungal extracts.

AGRICULTURAL PRODUCTION OF CA DONG PEOPLE IN RESETTLEMENT AREA OF TRANH RIVER HYDROPOWER NUMBER 2: CURRENT SITUATION AND IMPACT FACTORS

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Bùi Thị Bích Lan
Keyword(s):  
Social Relations ◽  
Agricultural Production ◽  
Large Scale ◽  
Transition Process ◽  
Impact Factors ◽  
Small Scale ◽  
Scale Production ◽  
Technical Application ◽  
Production Models ◽  
Role Of The State

In Vietnam, the construction of hydropower projects has contributed significantly in the cause of industrialization and modernization of the country. The place where hydropower projects are built is mostly inhabited by ethnic minorities - communities that rely primarily on land, a very important source of livelihood security. In the context of the lack of common productive land in resettlement areas, the orientation for agricultural production is to promote indigenous knowledge combined with increasing scientific and technical application; shifting from small-scale production practices to large-scale commodity production. However, the research results of this article show that many obstacles in the transition process are being posed such as limitations on natural resources, traditional production thinking or the suitability and effectiveness of scientific - technical application models. When agricultural production does not ensure food security, a number of implications for people’s lives are increasingly evident, such as poverty, preserving cultural identity, social relations and resource protection. Since then, it has set the role of the State in researching and building appropriate agricultural production models to exploit local strengths and ensure sustainability.

scholarly journals Efficient and large-area all vacuum-deposited perovskite light-emitting diodes via spatial confinement

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Peipei Du ◽  
Jinghui Li ◽  
Liang Wang ◽  
Liang Sun ◽  
Xi Wang ◽  
...  
Keyword(s):  
High Resolution ◽  
Large Scale ◽  
High Efficiency ◽  
Light Emitting Diodes ◽  
Scale Production ◽  
Nonradiative Recombination ◽  
Large Area ◽  
Spatial Confinement ◽  
Light Emitting ◽  
Large Scale Production

AbstractWith rapid advances of perovskite light-emitting diodes (PeLEDs), the large-scale fabrication of patterned PeLEDs towards display panels is of increasing importance. However, most state-of-the-art PeLEDs are fabricated by solution-processed techniques, which are difficult to simultaneously achieve high-resolution pixels and large-scale production. To this end, we construct efficient CsPbBr3 PeLEDs employing a vacuum deposition technique, which has been demonstrated as the most successful route for commercial organic LED displays. By carefully controlling the strength of the spatial confinement in CsPbBr3 film, its radiative recombination is greatly enhanced while the nonradiative recombination is suppressed. As a result, the external quantum efficiency (EQE) of thermally evaporated PeLED reaches 8.0%, a record for vacuum processed PeLEDs. Benefitting from the excellent uniformity and scalability of the thermal evaporation, we demonstrate PeLED with a functional area up to 40.2 cm2 and a peak EQE of 7.1%, representing one of the most efficient large-area PeLEDs. We further achieve high-resolution patterned perovskite film with 100 μm pixels using fine metal masks, laying the foundation for potential display applications. We believe the strategy of confinement strength regulation in thermally evaporated perovskites provides an effective way to process high-efficiency and large-area PeLEDs towards commercial display panels.

scholarly journals Circum-nuclear molecular disks: Role in AGN fueling and feedback

2019 ◽  
Vol 15 (S359) ◽  
pp. 312-317
Author(s):  
Francoise Combes
Keyword(s):  
Black Hole ◽  
Angular Momentum ◽  
High Resolution ◽  
Large Scale ◽  
Active Galaxy ◽  
Small Scale ◽  
Massive Black Hole ◽  
Molecular Outflows ◽  
Molecular Outflow

AbstractGas fueling AGN (Active Galaxy Nuclei) is now traceable at high-resolution with ALMA (Atacama Large Millimeter Array) and NOEMA (NOrthern Extended Millimeter Array). Dynamical mechanisms are essential to exchange angular momentum and drive the gas to the super-massive black hole. While at 100pc scale, the gas is sometimes stalled in nuclear rings, recent observations reaching 10pc scale (50mas), may bring smoking gun evidence of fueling, within a randomly oriented nuclear gas disk. AGN feedback is also observed, in the form of narrow and collimated molecular outflows, which point towards the radio mode, or entrainment by a radio jet. Precession has been observed in a molecular outflow, indicating the precession of the radio jet. One of the best candidates for precession is the Bardeen-Petterson effect at small scale, which exerts a torque on the accreting material, and produces an extended disk warp. The misalignment between the inner and large-scale disk, enhances the coupling of the AGN feedback, since the jet sweeps a large part of the molecular disk.

scholarly journals Fabrication Techniques for Graphene Oxide-Based Molecular Separation Membranes: Towards Industrial Application

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 757
Author(s):  
Ohchan Kwon ◽  
Yunkyu Choi ◽  
Eunji Choi ◽  
Minsu Kim ◽  
Yun Chul Woo ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Large Scale ◽  
Spray Coating ◽  
Dip Coating ◽  
Small Scale ◽  
Scale Production ◽  
Separation Membranes ◽  
Current Review ◽  
Slot Die ◽  
Continuous Fabrication

Graphene oxide (GO) has been a prized material for fabricating separation membranes due to its immense potential and unique chemistry. Despite the academic focus on GO, the adoption of GO membranes in industry remains elusive. One of the challenges at hand for commercializing GO membranes lies with large-scale production techniques. Fortunately, emerging studies have acknowledged this issue, where many have aimed to deliver insights into scalable approaches showing potential to be employed in the commercial domain. The current review highlights eight physical methods for GO membrane fabrication. Based on batch-unit or continuous fabrication, we have further classified the techniques into five small-scale (vacuum filtration, pressure-assisted filtration, spin coating, dip coating, drop-casting) and three large-scale (spray coating, bar/doctor blade coating, slot die coating) approaches. The continuous nature of the large-scale approach implies that the GO membranes prepared by this method are less restricted by the equipment’s dimensions but rather the availability of the material, whereas membranes yielded by small-scale methods are predominately limited by the size of the fabrication device. The current review aims to serve as an initial reference to provide a technical overview of preparing GO membranes. We further aim to shift the focus of the audience towards scalable processes and their prospect, which will facilitate the commercialization of GO membranes.

scholarly journals Climate SPHINX: evaluating the impact of resolution and stochastic physics parameterisations in the EC-Earth global climate model

2017 ◽  
Vol 10 (3) ◽  
pp. 1383-1402 ◽  
Author(s):  
Paolo Davini ◽  
Jost von Hardenberg ◽  
Susanna Corti ◽  
Hannah M. Christensen ◽  
Stephan Juricke ◽  
...  
Keyword(s):  
High Resolution ◽  
Large Scale ◽  
Climate Model ◽  
Global Climate ◽  
Rainfall Variability ◽  
Global Climate Model ◽  
Small Scale ◽  
Low Resolution ◽  
The Impact ◽  
Stochastic Physics

Abstract. The Climate SPHINX (Stochastic Physics HIgh resolutioN eXperiments) project is a comprehensive set of ensemble simulations aimed at evaluating the sensitivity of present and future climate to model resolution and stochastic parameterisation. The EC-Earth Earth system model is used to explore the impact of stochastic physics in a large ensemble of 30-year climate integrations at five different atmospheric horizontal resolutions (from 125 up to 16 km). The project includes more than 120 simulations in both a historical scenario (1979–2008) and a climate change projection (2039–2068), together with coupled transient runs (1850–2100). A total of 20.4 million core hours have been used, made available from a single year grant from PRACE (the Partnership for Advanced Computing in Europe), and close to 1.5 PB of output data have been produced on SuperMUC IBM Petascale System at the Leibniz Supercomputing Centre (LRZ) in Garching, Germany. About 140 TB of post-processed data are stored on the CINECA supercomputing centre archives and are freely accessible to the community thanks to an EUDAT data pilot project. This paper presents the technical and scientific set-up of the experiments, including the details on the forcing used for the simulations performed, defining the SPHINX v1.0 protocol. In addition, an overview of preliminary results is given. An improvement in the simulation of Euro-Atlantic atmospheric blocking following resolution increase is observed. It is also shown that including stochastic parameterisation in the low-resolution runs helps to improve some aspects of the tropical climate – specifically the Madden–Julian Oscillation and the tropical rainfall variability. These findings show the importance of representing the impact of small-scale processes on the large-scale climate variability either explicitly (with high-resolution simulations) or stochastically (in low-resolution simulations).

scholarly journals Low-cost Large Scale Vermicompost Unit

2021 ◽  
Vol 2115 (1) ◽  
pp. 012026
Author(s):  
Sonam Solanki ◽  
Gunendra Mahore
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Small Scale ◽  
Scale Production ◽  
Key Innovation ◽  
Main Challenge ◽  
Long Run ◽  
Large Scale Production ◽  
Term Maintenance

Abstract In the current process of producing vermicompost on a large-scale, the main challenge is to keep the worms alive. This is achieved by maintaining temperature and moisture in their living medium. It is a difficult task to maintain these parameters throughout the process. Currently, this is achieved by building infrastructure but this method requires a large initial investment and long-run maintenance. Also, these methods are limited to small-scale production. For large-scale production, a unit is developed which utilises natural airflow with water and automation. The main aim of this unit is to provide favourable conditions to worms in large-scale production with very low investment and minimum maintenance in long term. The key innovation of this research is that the technology used in the unit should be practical and easy to adopt by small farmers. For long-term maintenance of the technology lesser number of parts are used.

scholarly journals Climate SPHINX: evaluating the impact of resolution and stochastic physics parameterisations in climate simulations

2016 ◽  
Author(s):  
Paolo Davini ◽  
Jost von Hardenberg ◽  
Susanna Corti ◽  
Hannah M. Christensen ◽  
Stephan Juricke ◽  
...  
Keyword(s):  
High Resolution ◽  
Large Scale ◽  
Rainfall Variability ◽  
Pilot Project ◽  
Small Scale ◽  
Low Resolution ◽  
Climate Simulations ◽  
Advanced Computing ◽  
The Impact ◽  
Stochastic Physics

Abstract. The Climate SPHINX (Stochastic Physics HIgh resolutioN eXperiments) project is a comprehensive set of ensemble simulations aimed at evaluating the sensitivity of present and future climate to model resolution and stochastic parameterisation. The EC-Earth Earth-System Model is used to explore the impact of stochastic physics in a large ensemble of 30-year climate integrations at five different atmospheric horizontal resolutions (from 125 km up to 16 km). The project includes more than 120 simulations in both a historical scenario (1979–2008) and a climate change projection (2039–2068), together with coupled transient runs (1850–2100). A total of 20.4 million core hours have been used, made available from a single year grant from PRACE (the Partnership for Advanced Computing in Europe), and close to 1.5 PBytes of output data have been produced on SuperMUC IBM Petascale System at the Leibniz Supercomputing Center (LRZ) in Garching, Germany. About 140 TBytes of post-processed data are stored on the CINECA supercomputing center archives and are freely accessible to the community thanks to an EUDAT Data Pilot project. This paper presents the technical and scientific setup of the experiments, including the details on the forcing used for the simulations performed, defining the SPHINX v1.0 protocol. In addition, an overview of preliminary results is given: an improvement in the simulation of Euro-Atlantic atmospheric blocking following resolution increases is observed. It is also shown that including stochastic parameterisation in the low resolution runs helps to improve some aspects of the tropical climate – specifically the Madden-Julian Oscillation and the tropical rainfall variability. These findings show the importance of representing the impact of small scale processes on the large scale climate variability either explicitly (with high resolution simulations) or stochastically (in low resolution simulations).

scholarly journals Dependence of Model Energy Spectra on Vertical Resolution

2016 ◽  
Vol 144 (4) ◽  
pp. 1407-1421 ◽  
Author(s):  
Michael L. Waite
Keyword(s):  
High Resolution ◽  
Large Scale ◽  
Vertical Mixing ◽  
Energy Spectra ◽  
Small Scale ◽  
Rossby Number ◽  
Vertical Resolution ◽  
Wide Range ◽  
Qualitative Shape ◽  
Vertical Grid

Abstract Many high-resolution atmospheric models can reproduce the qualitative shape of the atmospheric kinetic energy spectrum, which has a power-law slope of −3 at large horizontal scales that shallows to approximately −5/3 in the mesoscale. This paper investigates the possible dependence of model energy spectra on the vertical grid resolution. Idealized simulations forced by relaxation to a baroclinically unstable jet are performed for a wide range of vertical grid spacings Δz. Energy spectra are converged for Δz 200 m but are very sensitive to resolution with 500 m ≤ Δz ≤ 2 km. The nature of this sensitivity depends on the vertical mixing scheme. With no vertical mixing or with weak, stability-dependent mixing, the mesoscale spectra are artificially amplified by low resolution: they are shallower and extend to larger scales than in the converged simulations. By contrast, vertical hyperviscosity with fixed grid-scale damping rate has the opposite effect: underresolved spectra are spuriously steepened. High-resolution spectra are converged except for the stability-dependent mixing case, which are damped by excessive mixing due to enhanced shear over a wide range of horizontal scales. It is shown that converged spectra require resolution of all vertical scales associated with the resolved horizontal structures: these include quasigeostrophic scales for large-scale motions with small Rossby number and the buoyancy scale for small-scale motions at large Rossby number. It is speculated that some model energy spectra may be contaminated by low vertical resolution, and it is recommended that vertical-resolution sensitivity tests always be performed.

The Scalability of Wet Ball Milling for The Production of Nanosuspensions

2019 ◽  
Vol 7 (2) ◽  
pp. 147-161 ◽  
Author(s):  
Maria L.A.D. Lestari ◽  
Rainer H. Müller ◽  
Jan P. Möschwitzer
Keyword(s):  
Ball Milling ◽  
Large Scale ◽  
Milling Time ◽  
High Energy ◽  
Small Scale ◽  
Particle Sizes ◽  
Scale Production ◽  
Batch Mode ◽  
Pharmaceutical Ingredients ◽  
Large Scale Production

Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be performed on a large scale. Ideally, the information generated at small scale is predictive for large scale production. Objective: This study was aimed to investigate the scalability when producing nanosuspensions starting from a 10 g scale of nanosuspension using low energy wet ball milling up to production scales of 120 g nanosuspension and 2 kg nanosuspension by using a standard high energy wet ball milling operated in batch mode or recirculation mode, respectively. Methods: Two different active pharmaceutical ingredients, i.e. curcumin and hesperetin, have been used in this study. The investigated factors include the milling time, milling speed, and the type of mill. Results: Comparable particle sizes of about 151 nm to 190 nm were obtained for both active pharmaceutical ingredients at the same milling time and milling speed when the drugs were processed at 10 g using low energy wet ball milling or 120 g using high energy wet ball milling in batch mode, respectively. However, an adjustment of the milling speed was needed for the 2 kg scale produced using high energy wet ball milling in recirculation mode to obtain particle sizes comparable to the small scale process. Conclusion: These results confirm in general, the scalability of wet ball milling as well as the suitability of small scale processing in order to correctly identify the most suitable formulations for large scale production using high energy milling.

scholarly journals Solutions for changing production scale in the agricultural sector in Vietnam

2020 ◽  
Vol 175 ◽  
pp. 10008
Author(s):  
Thi Hoai Nguyen ◽  
Duc Luan Nguyen
Keyword(s):  
Labor Productivity ◽  
Agricultural Production ◽  
Large Scale ◽  
Agricultural Sector ◽  
Current Situation ◽  
Small Scale ◽  
Scale Production ◽  
Number Of Solutions ◽  
Production Scale ◽  
Large Scale Production

In this paper, the authors analyze the current situation of agricultural production in Vietnam and affirm that fragmentation is one of the basic causes leading to ineffective potentials and low labor productivity. Based on this, the authors propose a number of solutions to convert small-scale production to large-scale production in order to improve labor productivity and optimally exploit resources in the agricultural sector in Vietnam today.

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