Performance Comparison of Flow-Through Optofluidic Biosensor Designs
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Optofluidic flow-through biosensors are being developed for single particle detection, particularly as a tool for pathogen diagnosis. The sensitivity of the biosensor chip depends on design parameters, illumination format (side vs. top), and flow configuration (parabolic, two- and three-dimensional hydrodynamic focused (2DHF and 3DHF)). We study the signal differences between various combinations of these design aspects. Our model is validated against a sample of physical devices. We find that side-illumination with 3DHF produces the strongest and consistent signal, but parabolic flow devices process a sample volume more quickly. Practical matters of optical alignment are also discussed, which may affect design choice.
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2010 ◽
Vol 163-167
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pp. 16-19
2021 ◽
pp. 095441002110029
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2011 ◽
Vol 121-126
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pp. 1744-1748