scholarly journals Performance Comparison of Flow-Through Optofluidic Biosensor Designs

Biosensors ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 226
Author(s):  
Joel G. Wright ◽  
Md Nafiz Amin ◽  
Holger Schmidt ◽  
Aaron R. Hawkins

Optofluidic flow-through biosensors are being developed for single particle detection, particularly as a tool for pathogen diagnosis. The sensitivity of the biosensor chip depends on design parameters, illumination format (side vs. top), and flow configuration (parabolic, two- and three-dimensional hydrodynamic focused (2DHF and 3DHF)). We study the signal differences between various combinations of these design aspects. Our model is validated against a sample of physical devices. We find that side-illumination with 3DHF produces the strongest and consistent signal, but parabolic flow devices process a sample volume more quickly. Practical matters of optical alignment are also discussed, which may affect design choice.

Author(s):  
R. C. Schlaps ◽  
S. Shahpar ◽  
V. Gümmer

In order to increase the performance of a modern gas turbine, compressors are required to provide higher pressure ratio and avoid incurring higher losses. The tandem aerofoil has the potential to achieve a higher blade loading in combination with lower losses compared to single vanes. The main reason for this is due to the fact that a new boundary layer is generated on the second blade surface and the turning can be achieved with smaller separation occurring. The lift split between the two vanes with respect to the overall turning is an important design choice. In this paper an automated three-dimensional optimisation of a highly loaded compressor stator is presented. For optimisation a novel methodology based on the Multipoint Approximation Method (MAM) is used. MAM makes use of an automatic design of experiments, response surface modelling and a trust region to represent the design space. The CFD solutions are obtained with the high-fidelity 3D Navier-Stokes solver HYDRA. In order to increase the stage performance the 3D shape of the tandem vane is modified changing both the front and rear aerofoils. Moreover the relative location of the two aerofoils is controlled modifying the axial and tangential relative positions. It is shown that the novel optimisation methodology is able to cope with a large number of design parameters and produce designs which performs better than its single vane counterpart in terms of efficiency and numerical stall margin. One of the key challenges in producing an automatic optimisation process has been the automatic generation of high-fidelity computational meshes. The multi block-structured, high-fidelity meshing tool PADRAM is enhanced to cope with the tandem blade topologies. The wakes of each aerofoil is properly resolved and the interaction and the mixing of the front aerofoil wake and the second tandem vane are adequately resolved.


2009 ◽  
Author(s):  
Md. Faisal Kader ◽  
Yong-du Jun ◽  
Kum-bae Lee

In summer, the temperature of a parked automobile compartment increases extremely high under a sunny condition. Investigation of this fluid flow and heat transfer characteristics is very important for controlling the effect of major design parameters. This paper address the behavior of fluid flow through convection and air temperature inside a car parked in the sun. The numerical solution was done by a new and operation friendly CFD code – SC/Tetra with a full scale model of a SM3 car and turbulence was modeled by the standard k-ε equation. It can be seen that solar radiation is an important parameter to raise the compartment temperature above the ambient temperature during summer. Numerical analysis of the three-dimensional model predicts a detailed description of fluid flow and temperature distribution driven by the incoming solar radiation (insoaltion) in the passenger compartment.


2010 ◽  
Vol 163-167 ◽  
pp. 16-19
Author(s):  
Yong Jun He ◽  
Xu Hong Zhou ◽  
Jun Cheng Hu

Development of multi-story and high-rise steel three-dimensional (3D) garages is an effective way to solve the parking problem in modern cities. In this paper, several types of multi-story and high-rise steel 3D garages are presented. The structural configurations and design parameters of the 3D garages, such as structural planar layout, storey height and limit value of horizontal displacement, are analyzed. Then the economic performances of the steel 3D garages are compared and their suitable storey numbers are obtained.


Energies ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1430
Author(s):  
Aleksandr Viatkin ◽  
Riccardo Mandrioli ◽  
Manel Hammami ◽  
Mattia Ricco ◽  
Gabriele Grandi

This paper presents a comprehensive study of peak-to-peak and root-mean-square (RMS) values of AC current ripples with balanced and unbalanced fundamental currents in a generic case of three-phase four-leg converters with uncoupled AC interface inductors present in all three phases and in neutral. The AC current ripple characteristics were determined for both phase and neutral currents, considering the sinusoidal pulse-width modulation (SPWM) method. The derived expressions are simple, effective, and ready for accurate AC current ripple calculations in three- or four-leg converters. This is particularly handy in the converter design process, since there is no need for heavy numerical simulations to determine an optimal set of design parameters, such as switching frequency and line inductances, based on the grid code or load restrictions in terms of AC current ripple. Particular attention has been paid to the performance comparison between the conventional three-phase three-leg converter and its four-leg counterpart, with distinct line inductance values in the neutral wire. In addition to that, a design example was performed to demonstrate the power of the derived equations. Numerical simulations and extensive experimental tests were thoroughly verified the analytical developments.


Author(s):  
Irsalan Arif ◽  
Hassan Iftikhar ◽  
Ali Javed

In this article design and optimization scheme of a three-dimensional bump surface for a supersonic aircraft is presented. A baseline bump and inlet duct with forward cowl lip is initially modeled in accordance with an existing bump configuration on a supersonic jet aircraft. Various design parameters for bump surface of diverterless supersonic inlet systems are identified, and design space is established using sensitivity analysis to identify the uncertainty associated with each design parameter by the one-factor-at-a-time approach. Subsequently, the designed configurations are selected by performing a three-level design of experiments using the Box–Behnken method and the numerical simulations. Surrogate modeling is carried out by the least square regression method to identify the fitness function, and optimization is performed using genetic algorithm based on pressure recovery as the objective function. The resultant optimized bump configuration demonstrates significant improvement in pressure recovery and flow characteristics as compared to baseline configuration at both supersonic and subsonic flow conditions and at design and off-design conditions. The proposed design and optimization methodology can be applied for optimizing the bump surface design of any diverterless supersonic inlet system for maximizing the intake performance.


2017 ◽  
Vol 2017 ◽  
pp. 1-13
Author(s):  
Xin Wan ◽  
Ximing Liu ◽  
Jichen Miao ◽  
Peng Cong ◽  
Yuai Zhang ◽  
...  

Pebble dynamics is important for the safe operation of pebble-bed high temperature gas-cooled reactors and is a complicated problem of great concern. To investigate it more authentically, a computed tomography pebble flow detecting (CT-PFD) system has been constructed, in which a three-dimensional model is simulated according to the ratio of 1 : 5 with the core of HTR-PM. A multislice helical CT is utilized to acquire the reconstructed cross-sectional images of simulated pebbles, among which special tracer pebbles are designed to indicate pebble flow. Tracer pebbles can be recognized from many other background pebbles because of their heavy kernels that can be resolved in CT images. The detecting principle and design parameters of the system were demonstrated by a verification experiment on an existing CT system in this paper. Algorithms to automatically locate the three-dimensional coordinates of tracer pebbles and to rebuild the trajectory of each tracer pebble were presented and verified. The proposed pebble-detecting and tracking technique described in this paper will be implemented in the near future.


Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 295
Author(s):  
Pao-Hsiung Wang ◽  
Yu-Wei Huang ◽  
Kuo-Ning Chiang

The development of fan-out packaging technology for fine-pitch and high-pin-count applications is a hot topic in semiconductor research. To reduce the package footprint and improve system performance, many applications have adopted packaging-on-packaging (PoP) architecture. Given its inherent characteristics, glass is a good material for high-speed transmission applications. Therefore, this study proposes a fan-out wafer-level packaging (FO-WLP) with glass substrate-type PoP. The reliability life of the proposed FO-WLP was evaluated under thermal cycling conditions through finite element simulations and empirical calculations. Considering the simulation processing time and consistency with the experimentally obtained mean time to failure (MTTF) of the packaging, both two- and three-dimensional finite element models were developed with appropriate mechanical theories, and were verified to have similar MTTFs. Next, the FO-WLP structure was optimized by simulating various design parameters. The coefficient of thermal expansion of the glass substrate exerted the strongest effect on the reliability life under thermal cycling loading. In addition, the upper and lower pad thicknesses and the buffer layer thickness significantly affected the reliability life of both the FO-WLP and the FO-WLP-type PoP.


2020 ◽  
Vol 319 ◽  
pp. 02004
Author(s):  
Muhammad Akif Rahman ◽  
Md Badrath Tamam ◽  
Md Sadman Faruque ◽  
A.K.M. Monjur Morshed

In this paper a numerical analysis of three-dimensional laminar flow through rectangular channel heat sinks of different geometric configuration is presented and a comparison of thermal performance among the heat sinks is discussed. Liquid water was used as coolant in the aluminum made heat sink with a glass cover above it. The aspect ratio (section height to width) of rectangular channels of the mini-channel heat sink was 0.33. A heat flux of 20 W/cm2 was continuously applied at the bottom of the channel with different inlet velocity for Reynold’s number ranging from 150 to 1044. Interconnectors and obstacles at different positions and numbers inside the channel were introduced in order to enhance the thermal performance. These modifications cause secondary flow between the parallel channels and the obstacles disrupt the boundary layer formation of the flow inside the channel which leads to the increase in heat transfer rate. Finally, Nusselt number, overall thermal resistance and maximum temperature of the heat sink were calculated to compare the performances of the modified heat sinks with the conventional mini channel heat sink and it was observed that the heat sink with both interconnectors and obstacles enhanced the thermal performance more significantly than other configurations. A maximum of 36% increase in Nusselt number was observed (for Re =1044).


2011 ◽  
Vol 121-126 ◽  
pp. 1744-1748
Author(s):  
Xiang Yang Jin ◽  
Tie Feng Zhang ◽  
Li Li Zhao ◽  
He Teng Wang ◽  
Xiang Yi Guan

To determine the efficiency, load-bearing capacity and fatigue life of beveloid gears with intersecting axes, we design a mechanical gear test bed with closed power flow. To test the quality of its structure and predict its overall performance, we establish a three-dimensional solid model for various components based on the design parameters and adopt the technology of virtual prototyping simulation to conduct kinematics simulation on it. Then observe and verify the interactive kinematic situation of each component. Moreover, the finite element method is also utilized to carry out structural mechanics and dynamics analysis on some key components. The results indicate that the test bed can achieve the desired functionality, and the static and dynamic performance of some key components can also satisfy us.


Author(s):  
Michelle Priante ◽  
David Tyrell ◽  
Benjamin Perlman

In train collisions, multi-level rail passenger vehicles can deform in modes that are different from the behavior of single level cars. The deformation in single level cars usually occurs at the front end during a collision. In one particular incident, a cab car buckled laterally near the back end of the car. The buckling of the car caused both lateral and vertical accelerations, which led to unanticipated injuries to the occupants. A three-dimensional collision dynamics model of a multi-level passenger train has been developed to study the influence of multi-level design parameters and possible train configuration variations on the reactions of a multi-level car in a collision. This model can run multiple scenarios of a train collision. This paper investigates two hypotheses that could account for the unexpected mode of deformation. The first hypothesis emphasizes the non-symmetric resistance of a multi-level car to longitudinal loads. The structure is irregular since the stairwells, supports for tanks, and draglinks vary from side to side and end to end. Since one side is less strong, that side can crush more during a collision. The second hypothesis uses characteristics that are nearly symmetric on each side. Initial imperfections in train geometry induce eccentric loads on the vehicles. For both hypotheses, the deformation modes depend on the closing speed of the collision. When the characteristics are non-symmetric, and the load is applied in-line, two modes of deformation are seen. At low speeds, the couplers crush, and the cars saw-tooth buckle. At high speeds, the front end of the cab car crushes, and the cars remain in-line. If an offset load is applied, the back stairwell of the first coach car crushes unevenly, and the cars saw-tooth buckle. For the second hypothesis, the characteristics are symmetric. At low speeds, the couplers crush, and the cars remain in-line. At higher speeds, the front end crushes, and the cars remain in-line. If an offset load is applied to a car with symmetric characteristics, the cars will saw-tooth buckle.


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