scholarly journals Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons

2021 ◽  
Vol 11 (8) ◽  
pp. 1050
Author(s):  
Dmitry B. Zorov ◽  
Nadezda V. Andrianova ◽  
Valentina A. Babenko ◽  
Irina B. Pevzner ◽  
Vasily A. Popkov ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Oxidative Phosphorylation ◽  
Signaling Cascades ◽  
Negative Effects ◽  
Mitochondrial Uncoupling ◽  
Pros And Cons ◽  
Mild Uncoupling

There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. We provide a full set of positive and negative effects that should be taken into account when using uncouplers in experiments and clinical practice.

The Yin and Yang of smartphones: an interview study of smartphone use and its effects

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Naresh Kumar Agarwal ◽  
Wenqing Lu
Keyword(s):  
Negative Effects ◽  
Content Type ◽  
The Real ◽  
Uses And Gratification ◽  
Uses And Gratification Theory ◽  
Frequency Of Use ◽  
Yin Yang ◽  
Yin And Yang ◽  
Pros And Cons ◽  
Smartphone Use

Purpose The purpose of this paper is to study smartphone use and its positive and negative effects and to provide recommendations for balanced use. Design/methodology/approach To study phone use, this paper applies the uses and gratification theory and gathered interview data from 24 participants on the participants’ frequency of use, mode of communication, people contacted and the reasons for using their phones. This paper analyzes the pros and cons of using smartphones using the Yin-Yang worldview. Findings This paper finds that people use their smartphones for communication, entertainment and other specific functions. Ease of communication and multitasking are the key benefits, and overuse and disconnect from the real world are the detriments in smartphone use. Research limitations/implications The findings can enable future researchers and practitioners to view smartphones and their effects more holistically, rather than seeing it only from the negative or the positive lens. Practical implications The proposed framework can help the reader to consider their daily use of smartphones and their ways of balancing their presence in the virtual and the real worlds. Originality/value This paper proposes the Yin-Yang framework of smartphone use and provides recommendations for effective usage.

Pros and Cons of Integrating Non-Financial Services in Microfinance

2018 ◽  
pp. 171-199
Author(s):  
Nhung Thi Hong Vu
Keyword(s):  
Social Services ◽  
Financial Services ◽  
Poverty Reduction ◽  
Microfinance Institutions ◽  
Negative Effects ◽  
The Poor ◽  
Need Support ◽  
Microfinance Institution ◽  
Pros And Cons

Microfinance as argued in recent literature is not a panacea for poverty reduction as it was expected. The poor may need support from various ranges of non-financial services including business development services and social services alongside microfinance services. The main aim of this chapter is to provide policymakers and practitioners some discussions on the pros and cons of integrating non-financial services together with microfinance services. This chapter proposes a framework of both positive and negative effects of providing non-financial services on microfinance institutions and clients. A case study of offering non-financial services in a microfinance institution in Vietnam provides both quantitative and qualitative evidence of effects on the microfinance institution and its clients.

Systemwide Analysis of Freeway Improvements

1996 ◽  
Vol 1554 (1) ◽  
pp. 172-183 ◽  
Author(s):  
Sam Yagar ◽  
Richard Hui
Keyword(s):  
Negative Effects ◽  
Complicated Problem ◽  
Local Capacity ◽  
Pros And Cons

Determining where to restripe or widen freeway sections to strategically relieve bottlenecks is a far more complicated problem than simply estimating the local capacity effects of specific lane additions. The pros and cons of reducing lane and shoulder widths to obtain an extra travel lane are discussed, with an emphasis on the effects on the overall freeway system. This study describes how increasing capacity at an upstream location can overload a downstream bottleneck and cause flow breakdown. An evaluation of potential local improvements at a number of existing bottlenecks in the westbound Highway 401 corridor in Toronto is provided; it finds that in a systems context about one-half are worthwhile, and the others have net negative effects.

scholarly journals Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species

2020 ◽  
Vol 21 (6) ◽  
pp. 1936 ◽  
Author(s):  
Maura Calvani ◽  
Amada Pasha ◽  
Claudio Favre
Keyword(s):  
Well Being ◽  
Epidemiological Studies ◽  
Long Term Results ◽  
Negative Effects ◽  
Cell Growth Arrest ◽  
Host Interactions ◽  
Health And Disease ◽  
Pros And Cons ◽  
The Individual

In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient–organism interaction could define the balance between health and disease. Nutrients and dietary components influence epigenetic phenomena and modify drugs response; therefore, these food–host interactions can influence the individual predisposition to disease and its potential therapeutic response. Do nutraceuticals have positive or negative effects during chemotherapy? The use of nutraceutical supplements in cancer patients is a controversial debate without a definitive conclusion to date. During cancer treatment, patients take nutraceuticals to alleviate drug toxicity and improve long-term results. Some nutraceuticals may potentiate the effect of cytotoxic chemotherapy by inducing cell growth arrest, cell differentiation, and alteration of the redox state of cells, but in some cases, high levels of them may interfere with the effectiveness of chemotherapy, making cancer cells less reactive to chemotherapy. In this review, we highlighted the emerging opinions and data on the pros and cons on the use of nutraceutical supplements during chemotherapy.

SOX 404(b) exemption effects on auditor changes

2016 ◽  
Vol 31 (4/5) ◽  
pp. 387-402 ◽  
Author(s):  
Benjamin W. Hoffman ◽  
Albert L. Nagy
Keyword(s):  
Positive Association ◽  
Negative Effects ◽  
Significant Positive Association ◽  
Public Companies ◽  
Content Type ◽  
Sarbanes Oxley ◽  
Sensitivity Tests ◽  
Prior Literature ◽  
Pros And Cons ◽  
Practical Implications

Purpose This paper aims to investigate whether the Sarbanes-Oxley Act: Section 404(b) exemption caused an increase in auditor changes due to changes in expectations for both auditors and their clients. Design/methodology/approach This paper predicts that this exemption caused a significant amount of auditor changes post-exemption, due to a change in expected future economic rents (audit scope demands) for auditors (clients). Logistic regression analysis is used to examine whether auditor changes increased for non-accelerated filers (public companies with less than $75 million in public float), who were affected by this exemption, compared to auditor changes for accelerated filers (public companies with greater than $75 million in public float), who were not affected by this exemption. Findings The results show a significant positive association between the exemption and auditor dismissals for non-accelerated filers compared to that of accelerated filers. This finding is robust when sensitivity tests are used. Practical implications Prior literature finds that an increase in auditor changes can have various positive and negative effects on the affected companies. Thus, investors will be interested in the results of this paper when making their investment decisions with regard to non-accelerated filers. Social implications The results of this paper will aid policymakers as they consider the pros and cons of this exemption, as it pertains to the affected companies. Originality/value This paper is the first to study the effects of this exemption on auditor turnover for the affected companies.

scholarly journals Pros and cons of L-arginine supplementation in disease

2004 ◽  
Vol 17 (2) ◽  
pp. 193-210 ◽  
Author(s):  
Yvonne L. J. Vissers ◽  
Iris B. J. G. Debats ◽  
Yvette C. Luiking ◽  
Rajiv Jalan ◽  
René R. W. J. van der Hulst ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Practice ◽  
Amino Acid ◽  
Liver Failure ◽  
Essential Amino Acid ◽  
Alternative Hypothesis ◽  
Severe Illness ◽  
Pros And Cons ◽  
To Come ◽  
Arginine Supplementation

The amino acid arginine and one of its metabolites NO have gathered broad attention in the last decade. Although arginine is regarded as a conditionally essential amino acid in disease, L-arginine supplementation in severe illness has not found its way into clinical practice. This might be due to the invalid interpretation of results from studies with immune-enhancing diets containing L-arginine amongst other pharmaconutrients. However, not much attention is given to research using L-arginine as a monotherapy and the possibility of the alternative hypothesis: that L-arginine supplementation is beneficial in disease. The present review will discuss data from studies in healthy and diseased animals and patients with monotherapy of L-arginine to come to an objective overview of positive and negative aspects of L-arginine supplementation in disease with special emphasis on sepsis, cancer, liver failure and wound healing.

scholarly journals CRIME OF ABORTION STUDY IN INDONESIA

2017 ◽  
Vol 1 (2) ◽  
pp. 10
Author(s):  
Frans Simangunsong
Keyword(s):  
Domestic Violence ◽  
Sex Education ◽  
Social Institution ◽  
Criminal Code ◽  
Negative Effects ◽  
Positive Law ◽  
Illegal Abortion ◽  
Pros And Cons ◽  
The Law ◽  
Role Of Parents

<p>Abortion is a social phenomenon that is increasingly alarming. The concern is not without reason, because so far the behavior of abortion many negative effects both for themselves perpetrators and the community at large. In terms of positive law in Indonesia, there is still debate and opposition from the pros and cons about the perception or understanding of the laws that exist to this day. Neither of Health Law, the Law on medical practice, The Criminal Code (Penal Code), Law on the elimination of domestic violence (domestic violence), and the Law on Human Rights (HAM). Normative legal research(normative law research) using the product in the form of case studies of normative legal behavior. Factors that led to the crime of abortion is rampant in Indonesia, partly because the sex education curriculum(sex education)in schools has been less effective in tackling promiscuity among teenagers. Therefore, the role of parents is very important in instilling moral values, ethics, law and religion. Sexual promiscuity among teenagers Indonesia today is alarming. Efforts to tackle the crime of abortion in the study of law in Indonesia. As for things - things that must be done by governments, institutions, communities and families in tackling illegal abortions are: Government: Providing spectacle qualified educate and prohibit the spectacle that does not make sense and did not educate as patron wearing tight uniform, Soon follow-up of cases - cases of illegal abortion and impose penalties sufficient to deter; Society: Society as a social institution should be more sensitive control and participate on everything that exists within its territory, reinforcing the social control in society</p>

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