scholarly journals Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging

Cells ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 159
Author(s):  
Mengping Liu ◽  
Lin Wang ◽  
Young Lo ◽  
Simon Chi-Chin Shiu ◽  
Andrew B. Kinghorn ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Physicochemical Properties ◽  
Drug Targeting ◽  
Recent Progress ◽  
Biomedical Application ◽  
Therapeutic Targeting ◽  
Anti Cancer ◽  
Diagnostic Applications ◽  
Theranostic Applications

A wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. There is a critical need for further components which can facilitate therapeutic targeting, augment their physicochemical properties, or broaden their theranostic applications. Aptamers are single-stranded nucleic acids which have been selected or evolved to bind specifically to molecules, surfaces, or cells. Aptamers can also act as direct biologic therapeutics, or in imaging and diagnostics. There is a rich field of discovery at the interdisciplinary interface between nanomaterials and aptamer science that has significant potential across biomedicine. Herein, we review recent progress in aptamer-enabled materials and discuss pending challenges for their future biomedical application.

scholarly journals RECENT PROGRESS OF DENDRIMERS IN DRUG DELIVERY FOR CANCER THERAPY

2018 ◽  
Vol 10 (5) ◽  
pp. 34 ◽  
Author(s):  
P. Anitha ◽  
J. Bhargavi ◽  
G. Sravani ◽  
B. Aruna ◽  
Ramkanth S.
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Targeting ◽  
Therapeutic Agent ◽  
Conventional Chemotherapy ◽  
Passive Targeting ◽  
Recent Advances ◽  
Anti Cancer ◽  
Diagnostic Applications ◽  
High Level

With the recent advances of nanotechnology, dendrimers are emerging as a highly attractive class of drug delivery vectors for cancer therapy. Dendrimers are multifunctional smart Nanocarriers to deliver one or more therapeutic agent safely and selectively to cancer cells. The high level of control over the synthesis of dendritic architecture makes dendrimers a nearly perfect (spherical) nanocarrier for site-specific drug delivery. The presence of functional groups in the dendrimers exterior also permits the addition of other moieties that can actively target certain diseases which are now widely used as tumor targeting strategies. Drug encapsulation, solubilization and passive targeting also equally contribute to the therapeutic use of dendrimers. Dendrimers are ideal carrier vehicles on cytotoxicity, blood plasma retention time, biodistribution and tumor uptake. In this review we highlight the advantages of dendrimers over conventional chemotherapy, toxicity and its management, following anti-cancer drugs delivered by using dendrimers and recent advances in drug delivery by various types of dendrimers as well as its diagnostic applications.

scholarly journals Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 890
Author(s):  
Shanmugavel Chinnathambi ◽  
Fuyuhiko Tamanoi
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Biomedical Application ◽  
The Body ◽  
Functional Surface ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Anti Cancer ◽  
Porous Nanomaterials

Porous nanomaterials can be used to load various anti-cancer drugs efficiently and deliver them to a particular location in the body with minimal toxicity. Biodegradable periodic mesoporous organosilica nanoparticles (BPMOs) have recently emerged as promising candidates for disease targeting and drug delivery. They have a large functional surface and well-defined pores with a biodegradable organic group framework. Multiple biodegradation methods have been explored, such as the use of redox, pH, enzymatic activity, and light. Various drug delivery systems using BPMO have been developed. This review describes recent advances in the biomedical application of BPMOs.

scholarly journals Recent progress on nanoparticle-based drug delivery systems for cancer therapy

2017 ◽  
Vol 14 (3) ◽  
pp. 228 ◽  
Author(s):  
Yanru Xin ◽  
Mingming Yin ◽  
Liyuan Zhao ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Recent Progress ◽  
Delivery Systems

scholarly journals Frontiers in Bioengineering and Biotechnology: Plant Nanoparticles for Anti-Cancer Therapy

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 830
Author(s):  
Erum Shoeb ◽  
Uzma Badar ◽  
Srividhya Venkataraman ◽  
Kathleen Hefferon
Keyword(s):  
Drug Delivery ◽  
Cancer Research ◽  
Cancer Therapy ◽  
Plant Virus ◽  
Biomedical Applications ◽  
Plant Viruses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Stimuli Response

Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. The following review describes how plant virus architecture facilitates the use of VNPs for imaging and a variety of therapeutic applications, with particular emphasis on cancer. Examples of plant viruses which have been engineered to carry drugs and diagnostic agents for specific types of cancer are provided. The drug delivery system in response to the internal conditions is known as stimuli response, recently becoming more applicable using plant viruses based VNPs. The review concludes with a perspective of the future of plant VNPs and plant virus-like particles (VLPs) in cancer research and therapy.

scholarly journals A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3859 ◽  
Author(s):  
Min Kim ◽  
Seung-Hae Kwon ◽  
Jung Choi ◽  
Aeju Lee
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Research Area ◽  
Delivery Systems ◽  
Cancer Therapies ◽  
Smart Systems ◽  
Tumor Microenvironments ◽  
Anti Cancer

Designing new drug delivery systems (DDSs) for safer cancer therapy during pre-clinical and clinical applications still constitutes a considerable challenge, despite advances made in related fields. Lipid-based drug delivery systems (LBDDSs) have emerged as biocompatible candidates that overcome many biological obstacles. In particular, a combination of the merits of lipid carriers and functional polymers has maximized drug delivery efficiency. Functionalization of LBDDSs enables the accumulation of anti-cancer drugs at target destinations, which means they are more effective at controlled drug release in tumor microenvironments (TMEs). This review highlights the various types of ligands used to achieve tumor-specific delivery and discusses the strategies used to achieve the effective release of drugs in TMEs and not into healthy tissues. Moreover, innovative recent designs of LBDDSs are also described. These smart systems offer great potential for more advanced cancer therapies that address the challenges posed in this research area.

Optical Properties and Antibacterial Bioactivity of ZnO Nanopowder Annealed in Different Ambient

2012 ◽  
Vol 626 ◽  
pp. 324-328 ◽  
Author(s):  
Chuo Ann Ling ◽  
Shahrom Mahmud ◽  
Khadijah Mohd Bakhori Siti ◽  
Sirelkhatim Amna ◽  
Mohamad Dasmawati ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Cancer Therapy ◽  
Biomedical Research ◽  
Cell Imaging ◽  
Biomedical Application ◽  
Biological Properties ◽  
Physical Chemical ◽  
Zno Nanopowder ◽  
Nanoparticle Drug Delivery

Nanomaterials have attracted much attention for their unique properties and promising performance compared to macroscopic materials. Nanotechnology refer to the cutting-edge approach of synthesis and modification of nanomaterials whose structures exhibit novel and improved physical, chemical, biological properties and functionality due to their nanoscaled size [1-2]. The ongoing revolution of the technology has imposed significant impact into several areas of biomedical research and engineering applications. Among the biomedical application include nanoparticle drug delivery, cell imaging, and cancer therapy.

RECENT ADVANCES IN GRAPHENE-BASED NANOMATERIALS FOR BIOMEDICAL APPLICATIONS

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1230001 ◽  
Author(s):  
HONGQIAN BAO ◽  
YONGZHENG PAN ◽  
LIN LI
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Cancer Therapies ◽  
Two Dimensional ◽  
Potential Applications ◽  
First Time ◽  
Potential Cancer

Graphene, a two-dimensional nanomaterial reported for the first time in 2004, has been widely investigated for its novel physicochemical properties and potential applications. This review selectively summarizes the recent progress in using graphene-based nanomaterials for various biomedical applications. In particular, graphene-based sensors and biosensors, which are classified according to different sensing mechanisms and targets, are thoroughly discussed. Next, the utilization of graphene as nanocarriers for drug delivery, gene delivery and nanomedicine are demonstrated for potential cancer therapies. Finally, other graphene-based matrices, nanoscaffolds, and composites, which are used in bioapplications, are presented, followed by conclusions and perspective.

scholarly journals Bioinspired Membrane-Coated Nanoplatform for Targeted Tumor Immunotherapy

2022 ◽  
Vol 11 ◽  
Author(s):  
Dan Mu ◽  
Pan He ◽  
Yesi Shi ◽  
Lai Jiang ◽  
Gang Liu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Tumor Targeting ◽  
Recent Progress ◽  
Tumor Immunotherapy ◽  
Immune Microenvironment ◽  
Research Directions ◽  
Tumor Immune Microenvironment ◽  
New Research

Immunotherapy can effectively activate the immune system and reshape the tumor immune microenvironment, which has been an alternative method in cancer therapy besides surgery, radiotherapy, and chemotherapy. However, the current clinical outcomes are not satisfied due to the lack of targeting of the treatment with some unexpected damages to the human body. Recently, cell membrane-based bioinspired nanoparticles for tumor immunotherapy have attracted much attention because of their superior immune regulating, drug delivery, excellent tumor targeting, and biocompatibility. Together, the article reviews the recent progress of cell membrane-based bioinspired nanoparticles for immunotherapy in cancer treatment. We also evaluate the prospect of bioinspired nanoparticles in immunotherapy for cancer. This strategy may open up new research directions for cancer therapy.

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