scholarly journals Biologically Active Compounds in Mustard Seeds: A Toxicological Perspective

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2089
Author(s):  
Julika Lietzow
Keyword(s):  
Edible Oils ◽  
Biologically Active ◽  
Human Consumption ◽  
Active Components ◽  
Potential Health ◽  
Yellow Mustard ◽  
Beverage Industry ◽  
Wide Range ◽  
Food And Beverage ◽  
Mustard Seeds

Mustard plants have been widely cultivated and used as spice, medicine and as source of edible oils. Currently, the use of the seeds of the mustard species Sinapis alba (white mustard or yellow mustard), Brassica juncea (brown mustard) and Brassica nigra (black mustard) in the food and beverage industry is immensely growing due to their nutritional and functional properties. The seeds serve as a source for a wide range of biologically active components including isothiocyanates that are responsible for the specific flavor of mustard, and tend to reveal conflicting results regarding possible health effects. Other potentially undesirable or toxic compounds, such as bisphenol F, erucic acid or allergens, may also occur in the seeds and in mustard products intended for human consumption. The aim of this article is to provide comprehensive information about potentially harmful compounds in mustard seeds and to evaluate potential health risks as an increasing use of mustard seeds is expected in the upcoming years.

Chinese Herbal Medicine-Based Cancer Therapy: Novel Anticancer Agents Targeting MicroRNAs to Regulate Tumor Growth and Metastasis

2019 ◽  
Vol 47 (08) ◽  
pp. 1711-1735 ◽  
Author(s):  
Fu Peng ◽  
Xiaofang Xie ◽  
Cheng Peng
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Anticancer Agents ◽  
Biologically Active ◽  
Active Components ◽  
Rna Molecules ◽  
Chinese Herbal ◽  
Non Coding Rna ◽  
Wide Range ◽  
Tumor Growth And Metastasis

MicroRNAs, small non-coding RNA molecules, have gained a reputation of the most substantial regulators in gene network with the ability to down-regulate their targets. Accumulating evidence shifted insight toward microRNAs regulation as the key element of cancer initiation, development, and aggression. Recent studies have attached the importance of traditional Chinese medicine (TCM) to the treatment of various cancers, and the functional natural compounds have been considered as novel anticancer agents to directly inhibit tumor progression. In more recent decades, a wide range of biologically active components of TCM has gained increasing attention to their applications in the modulation of microRNAs. This review is on the purpose of demonstrating the significance of TCM bioactive ingredients in microRNAs regulation for cancer treatment according to the reports mainly in the recent six years, providing the evidence of efficient Chinese herbal medicine-based therapy and effective pro-diagnosis focusing on microRNAs expression of cancer patients.

scholarly journals Subclinical hypothyroidism: do you always need hormone replacement therapy? A modern view of the problem

2021 ◽  
Vol 17 (5) ◽  
pp. 418-421
Author(s):  
N.O. Kravchun ◽  
I.P. Dunaeva
Keyword(s):  
Trace Elements ◽  
Subclinical Hypothyroidism ◽  
Elderly Women ◽  
Clinical Symptoms ◽  
Hormone Replacement ◽  
Biologically Active ◽  
Rhodiola Rosea ◽  
Active Components ◽  
Stage Of Development ◽  
Wide Range

Subclinical hypothyroidism is the initial stage of development of hypothyroidism, in which there are no clear clinical symptoms and there is a slow decline in thyroid function. It is known that subclinical hypothyroidism occurs in the population much more often than overt one, its prevalence depends on gender, age of patients and it is much more often diagnosed in elderly women. The literature review considers the effectiveness of the combined herbal preparation to improve the quality of life in hypothyroidism — Endomar, which contains 50 % of Potentilla alba, 25 % of Skutellaria baicalensis and 25 % of Rhodiola rosea. All three components of Endomar are synergistic in hypothyroidism. This multicomponent herbal product has a wide range of therapeutic properties and can be recommended for subclinical forms of thyroid hypofunction. Potentilla alba has been used in medical practice since ancient times. Biologically active components of Potentilla alba extract are flavonoids that regulate the permeability and elasticity of blood vessel walls, thereby neutralizing free radi-cals, phenolcarboxylic acids having antimutagenic and diuretic properties, saponin glycosides, which have a cardiotonic, neurotropic effect, hypocholesterolemic, adaptogenic, sedative action. Rhodiola rosea, an extract of the roots and rhizomes of this plant, is an adaptogen that increases the body’s resistance to stress, exhaustion, fatigue. Rhodiola rosea includes the following active substances: phenols and their derivatives aurol, salidroside; flavonoids: kaempferol, rhodiolin, rhodionin, rhodiosine, trace elements. Endomar includes Skutellaria baicalensis, which has unique properties. This plant contains flavonoid baicalin, which has a neuroprotective and neotropic effect, flavonoids scutellarin and vagonin that maintain normal vascular tone. In general, all components have an antioxidant, antispasmodic, antiinflammatory effect, they are also adaptogens and include trace elements such as magnesium, zinc, selenium.

scholarly journals Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2099
Author(s):  
Lenka Sochorova ◽  
Mojmir Baron ◽  
Katerina Dadakova ◽  
Tomas Kasparovsky ◽  
Jiri Sochor
Keyword(s):  
Free Radicals ◽  
Biochemical Markers ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
The Body ◽  
Biologically Active ◽  
Active Components ◽  
Grapevine Cultivar ◽  
Wide Range

Cadmium (Cd) is a heavy metal that occurs in all areas of the environment, including the food chain. In the body, it causes oxidative stress by producing free radicals that are harmful to the cells. Grape seed extract (GSE) contains a wide range of biologically active components that help to neutralize the adverse effects of free radicals. In this study, the effects of GSE prepared form semi-resistant grapevine cultivar Cerason, which is rich in phenolics, on biochemical markers of brown rats exposed to the effects of cadmium were monitored. GSE increased the plasma antioxidant activity and, in the kidneys and the liver, Cd content was significantly lowered by GSE co-administration. Accordingly, the increase in creatinine content and alanine aminotransferase activity and the decrease of catalase and superoxide dismutase activities caused by cadmium were slowed down by GSE co-administration. The results of this work reveal that grape seed extract offers a protective effect against the intake of heavy metals into the organism.

scholarly journals Antibacterial activity of different fractional extracts of cerastium glomeratum

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Himayat Ullah ◽  
Muhammad Hubaib ◽  
Muhammad Israr ◽  
Muhammad Mushtaq ◽  
Muhammad Zeeshan ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Water Extract ◽  
Inhibition Zone ◽  
Biologically Active ◽  
Active Components ◽  
Gram Positive ◽  
Gram Negative ◽  
Soxhlet Apparatus ◽  
Wide Range

Every plant available in the universe is not produced to be the part of biodiversity, but is also produced to obtain medicinal purposes. The medicinal value of the plant is due to the availability of various chemical compounds [1]. Since prehistoric time, the crude extract of plant is used to cure various diseases, although the biologically active components of the plant were unidentified [2]. In the present study the antibacterial activity is performed for various extracts of cerastium glomeratum. The plant cerastium glomeratum was collected from near kalpani river Mardan, Pakistan and was identified by lecturer Israr department of botany GPGC Mardan, Pakistan. The plant was dried under shade and grinded into powder form. The extraction process was done by using soxhlet apparatus, reflux condenser and maceration process using ethanol as a solvent. The extract was divided into different fractions of n-hexane, DCM, ethyl acetate and water. These four extracts were tested against gram positive (staphylococcus aureus) and gram negative (E.coli) bacteria using well diffusion technique. The water extract show a wide range inhibition zone against both gram positive and gram negative bacteria while n-hexane, DCM and ethyl acetate fractions show no zone of inhibition against bacteria. In effort to find new antibacterial compounds cerastium glomeratum seems to be a good plant for additional phytochemical studies.

scholarly journals Characterization of sodium alginate extracted from brown seaweeds growing on Veraval coast, Gujarat

2021 ◽  
Vol 8 (1) ◽  
pp. 45-48
Author(s):  
Kiran Dangar ◽  
Vaishali Varsani ◽  
Suhas Vyas
Keyword(s):  
Sodium Alginate ◽  
Functional Materials ◽  
Biochemical Properties ◽  
Biologically Active ◽  
Marine Macroalgae ◽  
Human Consumption ◽  
Brown Seaweeds ◽  
Suitable Material ◽  
Wide Range ◽  
Sargassum Tenerrimum

Marine environment is a major potential source of functional materials, including polysaccharides, vitamins, enzymes, oils, antioxidants and peptides. All these materials are extracted from different marine living organisms including microbes, plants and animals. Among these seaweeds or marine macroalgae are one of the important sources and they are a part of staple diet from time immemorial in the orient as they are nutritionally rich materials. Those species that adapted to these pressures will expand their living boundaries and higher potential of row material availability in industry like pharmaceutical market, textile, fertilizer and for animal and human consumption. The present study concerns about the specific brown seaweeds, which is suitable material for alginate and growing abundantly at seacoast of Gujarat. Out of many species of seaweeds growing on the coastline of Veraval, four species viz., Sargassum tenerrimum, Dictyota dichotoma, Spathoglossum asperum, Iyengaria stellata were selected for alginate extraction. The focus of this study is to utilize natural resources as alternatives and sustainability of human health to use sodium alginate as novel polymer and which is also biodegradable. It may be associated to other biologically active molecules and has a wide range of physicochemical and biochemical properties. Because of amazing properties, alginate and its salts are used in drug delivery system.

scholarly journals Thermal fields of the Ebeko volcano (Paramushir Island, Kuril Islands) and their recreational and tourist potential

2020 ◽  
Vol 4 (4) ◽  
pp. 514-525
Author(s):  
R.V. Zharkov ◽  
Keyword(s):  
Chemical Properties ◽  
Thermal Spring ◽  
Kuril Islands ◽  
Biologically Active ◽  
Thermal Waters ◽  
Active Components ◽  
The North ◽  
Treatment And Prevention ◽  
Mineralized Water ◽  
Wide Range

The paper provides with the research results of physicochemical and balneological properties of thermal waters and hydrothermal mud of the Ebeko volcano (Paramushir Island, Kuril Islands). To assess recreational and tourist potential, we sample the most intensive thermal waters outputs. Ultra-acidic spring no. 1 of the Verkhne-Yuryeva group has a temperature of 88 °C, its mineralized (M – 13 g/l) chloride-sulfate waters contain biologically active elements in elevated concentrations (Si, B, Br, Fe2 +). Thermal waters of the Verkhne-Yuryeva springs can be roughly attributed to the Gaisky type of the acid water group and recommended for external use in the treatment and prevention of a wide range of diseases. Given the complexity of the route to the springs, the real development of this territory is considered not as a balneotherapy complex, but as an object of recreational and tourist activities. A similar situation is with an ultra-acidic sulfate thermal spring in the North-Eastern solfataric field. In addition to hydrotherms, it contains thin deposits of hydrothermal mud , which is almost impossible to use as a therapeutic due to its insufficiently good physical indicators and relatively small volume. The most promising deep hydrotherms for recreation and balneotherapy are opened by a well P-2 in the area of Severo-Kurilsk. In 2014, the hydrotherms temperature was 82 °C, mineralized water (M – 8.6 g/l) chloride-hydrocarbonate sodium, slightly alkaline (pH 7.6), with an elevated content of biologically active components (Si, B, Br). According to the physical and chemical properties, the thermal waters of well P-2 can be tentatively attributed to the Lazarevsky hydrochemical type of therapeutic drinking water of chloride-hydrocarbonate sodium group, and as an external (balneological) use, they are tentatively close to the Kuldur type of siliceous thermal waters of various ion composition.

scholarly journals Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Muhammad Farrukh Nisar ◽  
Mahnoor Khadim ◽  
Muhammad Rafiq ◽  
Jinyin Chen ◽  
Yali Yang ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Health Benefits ◽  
Antimicrobial Properties ◽  
Industrial Applications ◽  
Biologically Active ◽  
World Health ◽  
Potential Health ◽  
Naturally Occurring ◽  
Wide Range ◽  
Health Organization

The biologically active phytochemicals are sourced from edible and medicinally important plants and are important molecules being used for the formulation of thousands of drugs. These phytochemicals have great benefits against many ailments particularly the inflammatory diseases or oxidative stress-mediated chronic diseases. Eugenol (EUG) is a versatile naturally occurring molecule as phenolic monoterpenoid and frequently found in essential oils in a wide range of plant species. EUG bears huge industrial applications particularly in pharmaceutics, dentistry, flavoring of foods, agriculture, and cosmeceutics. It is being focused recently due to its great potential in preventing several chronic conditions. The World Health Organization (WHO) has declared EUG as a nonmutant and generally recognized as safe (GRAS) molecule. The available literature about pharmacological activities of EUG shows remarkable anti-inflammatory, antioxidant, analgesic, and antimicrobial properties and has a significant effect on human health. The current manuscript summarizes the pharmacological characteristics of EUG and its potential health benefits.

scholarly journals Impact of Propolis on the Oral Health

2019 ◽  
Vol 23 (1) ◽  
pp. 1-9
Author(s):  
Marizela Šabanović ◽  
Semir Saltović ◽  
Azra Avdić Mujkić ◽  
Midhat Jašić ◽  
Zerina Bahić
Keyword(s):  
Chemical Composition ◽  
Oral Cavity ◽  
Health Impact ◽  
Biologically Active ◽  
Restorative Dentistry ◽  
Active Components ◽  
Wide Range ◽  
Bad Breath ◽  
Therapeutic Properties ◽  
And Control

SummaryPropolis is a natural resinous substance collected by honey bees from buds and exudates of plant species, mixed with bee enzymes, pollen and wax. It has a complex composition with a wide range of effects, including antibacterial, antiviral, antifungal, antiflogistic, antioxidant, hepatoprotective, carcinostatic and immunomodulatory properties. It is often applied in the treatment of diseases involving the oral cavity and gums. The aim of this paper is to describe the therapeutic properties of propolis, chemical composition and its application in the oral cavity. Literature and systematic information on the composition and the effects of propolis on health were collected, with particular reference to the use in the treatment of oral cavity diseases. The chemical composition of propolis is very complex. The health impact depends on the biologically active components it contains. A particularly important application is in the treatment of diseases of the oral cavity. Studies show that propolis can help prevent dental caries and control gingivitis and plaque. It reduces halithosis (bad breath) and symptoms of periodontosis. It is also effective in fighting viruses. It can have significant application in orthodontics and restorative dentistry. A wide range of effects allows the multiple uses of propolis-based products. Recent research has been increasingly focused on diseases of the oral cavity. The development of novel propolis-based pharmaceutical forms could significantly reduce the use of antibiotics in conventional treatment of diseases of the oral cavity.

Solid State Kinetics and Antimicrobial Studies for Copper (II) Sesame and Copper (II) Groundnut Complexes with Substituted Benzothiazole Ligand

2020 ◽  
Vol 17 ◽  
Author(s):  
Asha Meena ◽  
Vandana Sukhadia ◽  
Rashmi Sharma
Keyword(s):  
Solid State ◽  
Thermal Degradation ◽  
Edible Oils ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Antimicrobial Studies ◽  
Solid State Kinetics ◽  
New Findings ◽  
Wide Range

: The aim of this manuscript is to give an overview of new findings in the field of thermal degradation and antimicrobial studies for copper (II) sesame and copper (II) groundnut complexes with substituted benzothiazole ligand. Solid state kinetics and thermal degradation has attracted the attention of scientific community not only due to its numerous applications in environment, energy, waste water treatment, pollution control and green chemistry but also due to their wide range of biological activities. This work aims to explore the study of chemical steps of the investigated degradation and the evaluation of the kinetic and thermodynamic parameters of the newly synthesized biologically active complexes (CSBe and CGBe) derived from two different edible oils i.e. sesame and groundnut and ligand containing nitrogen, oxygen and sulphur atoms i.e. 2-amino-6- ethoxy benzothiazole. The studies include Coats-Redfern equation (CRE), Horowitz-Metzger equation (HME), Broido equation (BE) and PiloyanNovikova equation (PNE) for analysis of the degradation and energetic for each step using kinetic data. The observation suggests that CGBe takes longer time and higher temperature to decompose completely than CSBe. Antimicrobial activities against Staphylococus aureus of these compounds also have been analysed which may provide an important account of information about their industrial utilization. The TGA study reveals that CSBe and CGBe complexes undergoes stepwise thermal degradation of ligand-soap bond of complex and saturated and unsaturated fatty acid components of edible oils i.e. sesame and groundnut. The order of antimicrobial activities of the two complexes studied is – CSBe > CGBe These results reveals that nature of different nitrogen, oxygen and sulphur containing ligands coordinated with copper ion play a significant role in the inhibition activity.

scholarly journals Genomic insights into the glutathione metabolism of the non-conventional wine yeast Starmerella bacillaris

OENO One ◽  
2021 ◽  
Vol 55 (1) ◽  
Author(s):  
Wilson José Fernandes Lemos Junior ◽  
Laura Treu ◽  
Chiara Nadai ◽  
Vinícius Da Silva Duarte ◽  
Stefano Campanaro ◽  
...  
Keyword(s):  
Wine Yeast ◽  
Redox Balance ◽  
Glutathione Metabolism ◽  
Wine Quality ◽  
Mixed Fermentation ◽  
Beverage Industry ◽  
Food And Beverage Industry ◽  
Wide Range ◽  
Food And Beverage ◽  
Gsh Metabolism

Glutathione (GSH) is an antioxidant molecule of great technological interest due to its wide range of applications in the food and beverage industry. In winemaking, although glutathione is produced during fermentation, its addition is possible for the control of oxidative spoilage of wine. Recently, to improve wine quality, mixed fermentation has been proposed by introducing a selection of non-Saccharomyces yeasts as complementary starters to the oenological species S. cerevisiae. Among them, Starmerella bacillaris, an osmophilic and high glycerol producer yeast, has been extensively studied. In the present study, the genomes of two S. bacillaris strains were compared with S. cerevisiae to identify the GSH metabolic pathway. The results showed that GSH biosynthesis includes the GSH1 and GSH2 genes in both species. The identification of a new transcription factor which binds sites in the promoter region of these genes underlined differences in the transcriptional regulation of both species. Additionally, between S. bacillaris strains, a high number of polymorphisms was found in genes involved in GSH redox balance. Preliminary laboratory scale fermentations revealed marked differences in the cell glutathione content of the two S. bacillaris strains. By comparing genomes, it was possible to gain a better understanding of the genes involved in the GSH metabolism pathway in S. bacillaris.

Sign in / Sign up

Export Citation Format

Share Document