scholarly journals GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise

Genes ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 570 ◽  
Author(s):  
Isabel Espinosa-Salinas ◽  
Rocio de la Iglesia ◽  
Gonzalo Colmenarejo ◽  
Susana Molina ◽  
Guillermo Reglero ◽  
...  

Exercise performance is influenced by genetics. However, there is a lack of knowledge about the role played by genetic variability in the frequency of physical exercise practice. The objective was to identify genetic variants that modulate the commitment of people to perform physical exercise and to detect those subjects with a lower frequency practice. A total of 451 subjects were genotyped for 64 genetic variants related to inflammation, circadian rhythms, vascular function as well as energy, lipid and carbohydrate metabolism. Physical exercise frequency question and a Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) were used to qualitatively and quantitatively measure the average amount of physical exercise. Dietary intake and energy expenditure due to physical activity were also studied. Differences between genotypes were analyzed using linear and logistic models adjusted for Bonferroni. A significant association between GCKR rs780094 and the times the individuals performed physical exercise was observed (p = 0.004). The carriers of the minor allele showed a greater frequency of physical exercise in comparison to the major homozygous genotype carriers (OR: 1.86, 95% CI: 1.36–2.56). The analysis of the GCKR rs780094 variant suggests a possible association with the subjects that present lower frequency of physical exercise. Nevertheless, future studies are needed to confirm these findings.

2020 ◽  
Vol 77 (5) ◽  
pp. 309-315
Author(s):  
Aviroop Biswas ◽  
Kathleen G Dobson ◽  
Monique A M Gignac ◽  
Claire de Oliveira ◽  
Peter M Smith

ObjectivesThere is a paucity of longitudinal population-based studies examining whether changes in work factors are associated with concurrent changes in leisure time physical activity (LTPA). This study examines this issue using 12 years of longitudinal survey data.MethodsData were drawn from the Canadian National Population Health Survey. The initial analytical sample in 1994 of 6407 working individuals was followed every 2 years from 2000 to 2010. Seven work factors were measured as independent variables: skill discretion, decision authority, psychological demands, physical exertion, number of jobs, hours at work and shift schedule. LTPA was categorised as inactive, moderately active or active based on metabolic equivalent task values. Fixed-effects multinomial logistic models were used to examine associations between work factors and LTPA controlling for time-invariant effects and adjusted for covariates.ResultsWorkers with lower skill discretion (OR=0.96; 95% CI 0.92 to 0.99), higher psychological demands (OR=0.95; 95% CI 0.92 to 0.99), higher physical exertion (OR=0.93; 95% CI 0.88 to 0.99) and longer work hours (OR=0.97; 95% CI 0.95 to 098) were associated with a lower odds of transitioning from inactive to active and moderately active. There was no evidence of effect modification by age or sex.ConclusionResults suggest that as participants’ skill discretion decreased, and their physical and psychological demands, and work hours increased, their likelihood of becoming more active and moderately active also decreased, supporting the value of targeting improvements in these work factors for physical activity interventions.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Miao Cai ◽  
Bin Zhang ◽  
Rong Yang ◽  
Tongzhang Zheng ◽  
Guanghui Dong ◽  
...  

Abstract Background China had the second largest proportion of preterm birth (PTB) internationally. However, only 11% of pregnant women in China meet international guidelines for maternal physical activity, a significantly lower proportion than that in Western countries. This study aims to examine the association between outdoor physical exercise during pregnancy and PTB among Chinese women in Wuhan, China. Methods A case-control study was conducted among 6656 pregnant women (2393 cases and 4263 controls) in Wuhan, China from June 2011 to June 2013. Self-reported measures of maternal physical exercise (frequency per week and per day in minutes) were collected. Adjusted odds ratios were estimated using Bayesian hierarchical logistic regression and a generalized additive mixed model (GAMM). Results Compared to women not involved in any physical activity, those who participated in physical exercise 1–2 times, 3–4 times, and over five times per week had 20% (aOR: 0.80, 95% credible interval [95% CI]: 0.68–0.92), 30% (aOR: 0.70, 95% CI: 0.60–0.82), and 32% (aOR: 0.68, 95% CI: 0.59–0.78) lower odds of PTB, respectively. The Bayesian GAMM showed that increasing physical exercise per day was associated with lower risk of PTB when exercise was less than 150 min per day; however, this direction of association is reversed when physical exercise was more than 150 min per day. Conclusion Maternal physical exercise, at a moderate amount and intensity, is associated with lower PTB risk. More data from pregnant women with high participation in physical exercise are needed to confirm the reported U-shape association between the physical exercise and risk of preterm birth.


2004 ◽  
Vol 20 (4) ◽  
pp. 1103-1109 ◽  
Author(s):  
Luis Fernando Gómez ◽  
Julio Cesar Mateus ◽  
Gustavo Cabrera

This study measured the prevalence of leisure-time physical activity in women from 18 to 69 years of age and identified correlated social factors in the neighborhood of Santafe, Bogotá, Colombia. Levels of physical activity were calculated through a population survey (n = 1,045). Logistic regression modeling identified factors associated with inactivity. Some 79.1% of respondents reported being inactive; 15.7% practiced physical exercise irregularly; and 5.2% regularly practiced physical exercise. After adjustment of covariates, physical inactivity was associated with not participating in recreational weekend activities on Sundays and not planning to lose weight. The results of this study show the high proportion of physically inactive women in a community in Bogotá Intervention strategies should be developed to reinforce recreational weekend activities on promoted by the Municipality.


2017 ◽  
Vol 51 (0) ◽  
Author(s):  
Evelyn Helena Corgosinho Ribeiro ◽  
Leandro Martin Totaro Garcia ◽  
Emanuel Péricles Salvador ◽  
Evelyn Fabiana Costa ◽  
Douglas Roque Andrade ◽  
...  

ABSTRACT OBJECTIVE To assess the effect of interventions on the levels of physical activity of healthy adults, users of the Brazilian Unified Health System and attended by the Family Health Strategy. METHODS Non-randomized experimental study with 157 adults allocated in three groups: 1) physical exercise classes (n = 54), 2) health education (n = 54), 3) control (n = 49). The study lasted for18 months, with 12 months of interventions and six months of follow-up after intervention. Assessments took place at the beginning, in the 12 months, and in the 18 months of study. Physical activity has been assessed by questionnaires and accelerometry. For the analyses, we have used the intention-to-treat principle and generalized estimating equations. RESULTS After 12 months, both intervention groups have increased the minutes of weekly leisure time physical activity and annual scores of physical exercise, leisure and transport-related physical activity. The exercise class group has obtained the highest average annual physical exercises score when compared to the other groups (p < 0.001). In the follow-up period, the exercise class group reduced its annual score (average: -0.3; 95%CI -0.5–-0.1), while the health education group increased this score (average: 0.2; 95%CI 0.1–0.4). There have been no differences in the levels of physical activity measured by accelerometry. CONCLUSIONS The interventions have been effective in increasing the practice of physical activity. However, we have observed that the health education intervention was more effective for maintaining the practice of physical activity in the period after intervention. We recommend the use of both interventions to promote physical activity in the Brazilian Unified Health System, according to the local reality of professionals, facilities, and team objectives.


2018 ◽  
Vol 38 (4) ◽  
pp. 179-186 ◽  
Author(s):  
John C. Spence ◽  
Guy Faulkner ◽  
Eun-Young Lee ◽  
Tanya Berry ◽  
Christine Cameron ◽  
...  

Introduction In this cross-sectional follow-up study, we explored Canadian’s awareness of ParticipACTION and their levels of physical activity (PA) after seven years of campaigns. Methods A population-based survey was conducted with 7282 adults over a period of 14 months from February 2014 to May 2015. The survey consisted of questions on the 2014-2015 Physical Activity Monitor relating to awareness and knowledge of ParticipACTION. Weighted logistic models were constructed to examine whether awareness was associated with PA-related beliefs, intentions, and leisure time physical activity (LTPA). Results Approximately 20% of Canadians reported unprompted awareness of ParticipACTION and 82% reported prompted awareness. Education, income, and having children were significant correlates of awareness among Canadians. The adjusted odds of people being aware of ParticipACTION (prompted and unprompted) were greater if they were more educated (OR = 1.57, 95% CI: 1.04–2.39; OR = 2.00, 95% CI: 1.24–3.24), reported higher income (OR = 3.92, 95% CI: 2.35–6.53; OR = 2.29, 95% CI: 1.44–3.62), and had children (OR = 1.93, 95% CI: 1.40–2.66; OR = 1.70, 95% CI: 1.26–2.30). Furthermore, awareness of ParticipACTION was positively associated with outcome expectations and self-efficacy, and negatively associated with LTPA status. Conclusion Levels of unprompted awareness of ParticipACTION are higher than previously reported and, in comparison to active Canadians, inactive Canadians are more likely to be aware of the organization. Given that it had primarily targeted parents of inactive children over the past seven years, it appears the organization has been partially effective in achieving its communication goals.


2021 ◽  
Author(s):  
Yunxia Ding ◽  
Song Ding ◽  
Jiali Niu

Abstract Background: We aimed to conduct a meta-analysis to assess the impact of coronavirus disease 2019 (COVID-19) on college students’ physical activity.Methods: All cohort studies, comparing college students undertaking physical exercise at school before the COVID-19 pandemic and physical exercise at home during the COVID-19 pandemic will be included in this review. We will use index words related to college students, physical exercise and COVID-19 to perform literature searches in PubMed, Medline, Embase and CNKI databases, to include articles indexed as of June 20, 2021 in English and Chinese language. Two reviewers will independently select trials for inclusion, assess trial quality and extract information for each included trials. Primary outcomes are exercise frequency, duration and intensity and associated factors. Based on Cochrane assessment tool, we will evaluate the risk of bias of the included studies. Revman 5.3 will be used for heterogeneity assessment, data synthesis, subgroup analysis, sensitivity analysis and generating funnel-plots.Discussion: The stronger evidence about the impact of COVID-19 on college students’ physical activity will be provided, so as to better guide teaching practice.Systematic review registration: PROSPERO CRD42021262390.


2019 ◽  
Vol 8 ◽  
pp. 1549
Author(s):  
Babak Pezeshki ◽  
Ehsan Bahramali ◽  
Amir Ansari ◽  
Aliasghar Karimi ◽  
Mojtaba Frajam ◽  
...  

Background: Diabetes mellitus (DM) is a common metabolic disease worldwide and has many complications. The vascular events are the major complication of DM that have an important effect on mortality and disability. The physical activity (PA) enhances the vascular function by several pathways. The aim of this study was to evaluation of the relationship between PA and vascular diseases in patients with DM.Materials and Methods: This research was performed as the case-control study that was extracted from a prospective epidemiological research study in Iran (PERSIAN). The patients with type 2 DM more than six months defined as case group and the non-DM subjects in control group with ratio 1:2, and both groups were matched in the term of age and sex. The MET score was used to evaluate the level of PA and blood glucose, lipid profile, body mass index, overweight, dyslipidemia, glomerular filtration rate, myocardial infarction (MI), unstable angina, and stroke.Results: Overall, 1242 patients with DM were extracted, and 2484 non-diabetic subjects were investigated. In the case group, 355(28.6 %) and 887(71.4%) were men and women, respectively, the and 710 (28.6%) men and 1774(71.4%) women in control group. The mean MET score was 30 and 40.97 in the DM and non-DM groups, respectively (P˂0.001). The frequency of MI, stroke, and cardiac ischemia were 44 (3.5%), 37 (3%), and 267 (21.5%), respectively in DM group, and 54 (2.2%), 43 (1.7%), and 389 (15.7%), respectively in non-DM group.Conclusion: The incidence of vascular events associated with PA level in patients with DM and adherence to regular PA reduce the vascular events and DM complications. [GMJ.2019;inpress:e1549]


2020 ◽  
Author(s):  
Shao-Wei Yeh ◽  
Chun-Yan Yuan ◽  
Yu-Feng Wu ◽  
Rui Shen

BACKGROUND Promoting physical activity for adolescence is a global challenge in public health. Physical inactivity and sedentary behaviors have been regarded to cause harmful chronic diseases to adolescent lifespan. However, high engagement in mobile technology for students may provide opportunities to help change adolescent unhealthy behaviors. Therefore, school sectors may play an important key role, such as implementing mobile health (mHealth) intervention to change students’ unhealthy behaviors and promote regular physical exercise behaviors, especially during the transition from adolescence to young adult. OBJECTIVE This study aimed to explore university students’ daily exercise patterns upon intervention of school-based mHealth project. METHODS Students’ physical exercise participation was recorded with students’ mobile application. With 4152 university freshmen (1476 males, 2676 females) and 335898 of their exercise records were analyzed (mean frequency of 38.2 ±16.10 in males, 45.1±10.81 in females) during the semester. RESULTS Under the school intervention project, students that exercised on Friday and Saturday was lower than that on other days, which indicated that the participation in exercise were more active on weekdays than on weekends. Among the participants who completed the requirement set by the school intervention project, both males and females used weekends to do exercise. On the other hand, overweight male university students participated in physical activity more than the requirement of the school intervention project and their exercise duration were found to be significantly higher than other participants. CONCLUSIONS Understanding a week of daily exercise patterns among youth upon the school mHealth Apps intervention can benefit in developing efficient and flexible projects to promote physical health and improve regular exercise participation in youth.


Sign in / Sign up

Export Citation Format

Share Document