scholarly journals The Role of MMP8 in Cancer: A Systematic Review

2019 ◽  
Vol 20 (18) ◽  
pp. 4506 ◽  
Author(s):  
Juurikka ◽  
Butler ◽  
Salo ◽  
Nyberg ◽  
Åström
Keyword(s):  
Systematic Review ◽  
Prognostic Factor ◽  
Molecular Mechanisms ◽  
Tongue Cancer ◽  
Genetic Alterations ◽  
Bioactive Molecules ◽  
Extracellular Matrix Components ◽  
Oral Tongue Cancer ◽  
Important Regulator

Matrix metalloproteinases (MMPs) have traditionally been considered as tumor promoting enzymes as they degrade extracellular matrix components, thus increasing the invasion of cancer cells. It has become evident, however, that MMPs can also cleave and alter the function of various non-matrix bioactive molecules, leading to both tumor promoting and suppressive effects. We applied systematic review guidelines to study MMP8 in cancer including the use of MMP8 as a prognostic factor or as a target/anti-target in cancer treatment, and its molecular mechanisms. A total of 171 articles met the inclusion criteria. The collective evidence reveals that in breast, skin and oral tongue cancer, MMP8 inhibits cancer cell invasion and proliferation, and protects patients from metastasis via cleavage of non-structural substrates. Conversely, in liver and gastric cancers, high levels of MMP8 worsen the prognosis. Expression and genetic alterations of MMP8 can be used as a prognostic factor by examination of the tumor and serum/plasma. We conclude, that MMP8 has differing effects on cancers depending on their tissue of origin. The use of MMP8 as a prognostic factor alone, or with other factors, seems to have potential. The molecular mechanisms of MMP8 in cancer further emphasize its role as an important regulator of bioactive molecules.

scholarly journals A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

2021 ◽  
Author(s):  
Marta Tagliabue ◽  
Pietro Belloni ◽  
Rita De Berardinis ◽  
Sara Gandini ◽  
Francesco Chu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Tongue Cancer ◽  
Meta Analysis ◽  
Oral Tongue ◽  
Prognostic Role ◽  
Oral Tongue Cancer

scholarly journals Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis

2003 ◽  
Vol 89 (1) ◽  
pp. 55-64 ◽  
Author(s):  
B Martin ◽  
M Paesmans ◽  
T Berghmans ◽  
F Branle ◽  
L Ghisdal ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Prognostic Factor ◽  
Meta Analysis ◽  
Review Of The Literature

scholarly journals Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Tengjiao Zhu ◽  
Yingtong Chen ◽  
Shuyuan Min ◽  
Fang Li ◽  
Yun Tian
Keyword(s):  
Expression Patterns ◽  
B Cell Lymphoma ◽  
Genetic Alterations ◽  
Sphingolipid Metabolism ◽  
Migration And Invasion ◽  
Normal Tissues ◽  
Tumor Tissues ◽  
Important Regulator ◽  
Coexpressed Genes

The mammalian orosomucoid-like gene family (ORMDL), containing ORMDL1, ORMDL2, and ORMDL3, is the important regulator of sphingolipid metabolism, which is relevant to cell growth, proliferation, migration, and invasion. Since the role of ORMDL1 in cancers remained unclear, the main purpose of our study was to explore the expression patterns and prognostic values of ORMDL1 in different tumors, especially in cholangiocarcinoma (CHOL), lymphoid neoplasm diffuse large B cell lymphoma (DLBCL), acute myeloid leukemia (LAML), and thymoma (THYM). Bioinformatics tools including GEPIA, CCLE, LinkedOmics, cBioPortal, and TIMER databases were used. As a result, the expression levels of ORMDL1 in tumor tissues and normal tissues varied in different cancers, especially significantly upregulated in CHOL, DLBCL, LAML, and THYM. Moreover, ORMDL1 mRNA was also highly expressed in cell lines of DLBCL and LAML. Further studies showed that ORMDL1 overexpression was associated with poor prognosis in DLBCL, but not significant in CHOL, LAML, and THYM. Consistently, there were genetic alterations of ORMDL1 in DLBCL, and patients with genetic alterations indicated worse survival. Coexpressed genes and related biological events with ORMDL1 in DLBCL were found via LinkedOmics, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The relationship between ORMDL1 and cancer immune cells was investigated, and ORMDL1 expression was positively correlated with infiltrating levels of B cells. In conclusion, ORMDL1 is suggested to be a tumorigenic factor and considered as the potential therapeutic target and prognostic biomarker in DLBCL.

scholarly journals The effect of certain autophagy proteins (LC3b and Beclin) and apotosis (Casp8 and Bcl-2) on the clinical course of ovarian cancer

2021 ◽  
Vol 67 (4) ◽  
pp. 474-479
Author(s):  
Aliia Gafiullina ◽  
Zinaida Afanaseva ◽  
Karim Garipov ◽  
Zinaida Abramova
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Drug Therapy ◽  
Molecular Mechanisms ◽  
Clinical Course ◽  
Molecular Targets ◽  
Cochrane Library ◽  
Search For Information ◽  
New Molecular Targets

Treatment of ovarian cancer remains an important problem in practical oncology due to the increase in morbidity and mortality from this disease. The aim is to summarize the available literature data on the molecular mechanisms of the participation of various proteins of autophagy and apoptosis in the development, progression, formation of chemoresistance and in the assessment of the prognosis of epithelial ovarian cancer. Materials and methods. The search for information was carried out in the materials of the databases Medline, Cochrane Library, Elibrary, NCBI, RSCI, instructions for the medical use of drugs, using keywords in the title. Used 39 articles to write this systematic review. Results. The review examines the molecular mechanisms of autophagy and apoptosis involved in the progression of ovarian cancer and in the formation of resistance to anticancer drug therapy. It has been shown that modulation of autophagy and apoptosis can change the effectiveness of drug treatment for this tumor. Conclusion. Considering the literature data on the ambiguous role of autophagy and apoptosis in the course of ovarian cancer and the formation of resistance to antitumor treatment, further study is required and the search for new molecular targets for their modulation is required.

scholarly journals Nitric Oxide: Exploring the Contextual Link with Alzheimer’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Nicholas Asiimwe ◽  
Seung Geun Yeo ◽  
Min-Sik Kim ◽  
Junyang Jung ◽  
Na Young Jeong
Keyword(s):  
Nitric Oxide ◽  
Molecular Mechanisms ◽  
Neurodegenerative Disorder ◽  
The Body ◽  
Bioactive Molecules ◽  
Therapeutic Approaches ◽  
Cellular Debris ◽  
And Oxidative Stress ◽  
Proinflammatory Factors

Neuronal inflammation is a systematically organized physiological step often triggered to counteract an invading pathogen or to rid the body of damaged and/or dead cellular debris. At the crux of this inflammatory response is the deployment of nonneuronal cells: microglia, astrocytes, and blood-derived macrophages. Glial cells secrete a host of bioactive molecules, which include proinflammatory factors and nitric oxide (NO). From immunomodulation to neuromodulation, NO is a renowned modulator of vast physiological systems. It essentially mediates these physiological effects by interacting with cyclic GMP (cGMP) leading to the regulation of intracellular calcium ions. NO regulates the release of proinflammatory molecules, interacts with ROS leading to the formation of reactive nitrogen species (RNS), and targets vital organelles such as mitochondria, ultimately causing cellular death, a hallmark of many neurodegenerative diseases. AD is an enervating neurodegenerative disorder with an obscure etiology. Because of accumulating experimental data continually highlighting the role of NO in neuroinflammation and AD progression, we explore the most recent data to highlight in detail newly investigated molecular mechanisms in which NO becomes relevant in neuronal inflammation and oxidative stress-associated neurodegeneration in the CNS as well as lay down up-to-date knowledge regarding therapeutic approaches targeting NO.

scholarly journals New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 31 ◽  
Author(s):  
Giuseppe Ercolano ◽  
Paola De Cicco ◽  
Angela Ianaro
Keyword(s):  
Molecular Mechanisms ◽  
Human Cancer ◽  
Biological Activities ◽  
Mitochondrial Pathway ◽  
Marine Organisms ◽  
New Drugs ◽  
Bioactive Molecules ◽  
Bioactive Metabolites ◽  
Apoptotic Activity

Natural compounds derived from marine organisms exhibit a wide variety of biological activities. Over the last decades, a great interest has been focused on the anti-tumour role of sponges and algae that constitute the major source of these bioactive metabolites. A substantial number of chemically different structures from different species have demonstrated inhibition of tumour growth and progression by inducing apoptosis in several types of human cancer. The molecular mechanisms by which marine natural products activate apoptosis mainly include (1) a dysregulation of the mitochondrial pathway; (2) the activation of caspases; and/or (3) increase of death signals through transmembrane death receptors. This great variety of mechanisms of action may help to overcome the multitude of resistances exhibited by different tumour specimens. Therefore, products from marine organisms and their synthetic derivates might represent promising sources for new anticancer drugs, both as single agents or as co-adjuvants with other chemotherapeutics. This review will focus on some selected bioactive molecules from sponges and algae with pro-apoptotic potential in tumour cells.

scholarly journals Prognosis of Patients less than 40 Years of Age with Squamous Cell Cancer of the Oral Tongue

2015 ◽  
Vol 6 (2) ◽  
pp. 53-56 ◽  
Author(s):  
Khalid Al-Qahtani ◽  
Tahera Islam ◽  
Valérie Brousseau
Keyword(s):  
Prognostic Factor ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Tongue Cancer ◽  
Cell Cancer ◽  
Significant Prognostic Factor ◽  
Tumor Differentiation ◽  
Oral Tongue ◽  
Significant Difference ◽  
Oral Tongue Cancer

ABSTRACT Introduction Controversy exists about the prognosis of squamous cell carcinoma of the tongue between young and older patients. Our objective was to evaluate age as a prognostic factor in oral tongue cancer. Materials and methods A retrospective study was conducted by reviewing charts of 61 patients. They were divided into two age groups, below 40 years and above 40 years. Data regarding epidemiology pathology report, tumor differentiation, staging, treatment and outcome were obtained. The length of survival and disease recurrence was calculated and compared in this two age group. Statistical analysis was performed using student, t-test. Results The result showed no significant difference in prognosis, tumor differentiation or staging related to age in oral tongue cancer. Conclusion Although age is not a significant prognostic factor in oral tongue cancer, the disease etiology is likely different, we recommend prompt and aggressive treatment of young patients. How to cite this article Al-Qahtani K, Brousseau V, Islam T. prognosis of patients less than 40 Years of Age with Squamous Cell Cancer of the Oral Tongue. Int J Head Neck Surg 2015;6(2): 53-56.

scholarly journals Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

2020 ◽  
Vol 21 (13) ◽  
pp. 4760 ◽  
Author(s):  
Karol Kaiser ◽  
Vitezslav Bryja
Keyword(s):  
Choroid Plexus ◽  
Long Range ◽  
Bioactive Molecules ◽  
Important Regulator ◽  
Cns Activity ◽  
Broad Variety ◽  
The Brain ◽  
Extracellular Signalling ◽  
Extracellular Environment

Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only a mechanical brain protection but also a rich source of signalling factors modulating diverse processes during brain development and adulthood. The choroid plexus (CP) is a major source of CSF and as such it has recently emerged as an important mediator of extracellular signalling within the brain. Growing interest in the CP revealed its capacity to release a broad variety of bioactive molecules that, via CSF, regulate processes across the whole central nervous system (CNS). Moreover, CP has been also recognized as a sensor, responding to altered composition of CSF associated with changes in the patterns of CNS activity. In this review, we summarize the recent advances in our understanding of the CP as a signalling centre that mediates long-range communication in the CNS. By providing a detailed account of the CP secretory repertoire, we describe how the CP contributes to the regulation of the extracellular environment—in the context of both the embryonal as well as the adult CNS. We highlight the role of the CP as an important regulator of CNS function that acts via CSF-mediated signalling. Further studies of CP–CSF signalling hold the potential to provide key insights into the biology of the CNS, with implications for better understanding and treatment of neuropathological conditions.

Sign in / Sign up

Export Citation Format

Share Document