scholarly journals Epidermal Club Cells in Fishes: A Case for Ecoimmunological Analysis

2021 ◽  
Vol 22 (3) ◽  
pp. 1440
Author(s):  
Sumali Pandey ◽  
Craig A. Stockwell ◽  
Madison R. Snider ◽  
Brian D. Wisenden
Keyword(s):  
Warning System ◽  
Life History Evolution ◽  
Metabolic Cost ◽  
Immune Functions ◽  
Food Ration ◽  
Immune Stress ◽  
Chemical Alarm Cues ◽  
Club Cells ◽  
Fitness Benefits

Epidermal club cells (ECCs), along with mucus cells, are present in the skin of many fishes, particularly in the well-studied Ostariophysan family Cyprinidae. Most ECC-associated literature has focused on the potential role of ECCs as a component of chemical alarm cues released passively when a predator damages the skin of its prey, alerting nearby prey to the presence of an active predator. Because this warning system is maintained by receiver-side selection (senders are eaten), there is want of a mechanism to confer fitness benefits to the individual that invests in ECCs to explain their evolutionary origin and maintenance in this speciose group of fishes. In an attempt to understand the fitness benefits that accrue from investment in ECCs, we reviewed the phylogenetic distribution of ECCs and their histochemical properties. ECCs are found in various forms in all teleost superorders and in the chondrostei inferring either early or multiple independent origins over evolutionary time. We noted that ECCs respond to several environmental stressors/immunomodulators including parasites and pathogens, are suppressed by immunomodulators such as testosterone and cortisol, and their density covaries with food ration, demonstrating a dynamic metabolic cost to maintaining these cells. ECC density varies widely among and within fish populations, suggesting that ECCs may be a convenient tool with which to assay ecoimmunological tradeoffs between immune stress and foraging activity, reproductive state, and predator–prey interactions. Here, we review the case for ECC immune function, immune functions in fishes generally, and encourage future work describing the precise role of ECCs in the immune system and life history evolution in fishes.

scholarly journals Biologia futura: embryo–maternal communication via progesterone-induced blocking factor (PIBF) positive embryo-derived extracellular vesicles. Their role in maternal immunomodulation

2021 ◽  
Author(s):  
Julia Szekeres-Bartho ◽  
Timea Csabai ◽  
Eva Gorgey
Keyword(s):  
Extracellular Vesicles ◽  
Cell Function ◽  
Nk Cell ◽  
Immune Functions ◽  
Transplantation Immunity ◽  
Blocking Factor ◽  
Cytokine Balance ◽  
Favourable Environment ◽  
Normal Gestation

AbstractPaternal antigens expressed by the foetus are recognized as foreign. Therefore,—according to the rules of transplantation immunity—the foetus ought to be “rejected”. However, during normal gestation, maternal immune functions are re-adjusted, in order to create a favourable environment for the developing foetus. Some of the mechanisms that contribute to the altered immunological environment, for example, the cytokine balance and NK cell function, with special emphasis on the role of progesterone and the progesterone-induced blocking factor (PIBF) will be reviewed.

scholarly journals Dual Role of Interleukin-10 in Murine NZB/W F1 Lupus

2021 ◽  
Vol 22 (3) ◽  
pp. 1347
Author(s):  
Anaïs Amend ◽  
Natalie Wickli ◽  
Anna-Lena Schäfer ◽  
Dalina T. L. Sprenger ◽  
Rudolf A. Manz ◽  
...  
Keyword(s):  
B Cell ◽  
Disease Model ◽  
Interleukin 10 ◽  
Immune Functions ◽  
Murine Lupus ◽  
Anti Inflammatory ◽  
In Vivo Effects

As a key anti-inflammatory cytokine, IL-10 is crucial in preventing inflammatory and autoimmune diseases. However, in human and murine lupus, its role remains controversial. Our aim was to understand regulation and immunologic effects of IL-10 on different immune functions in the setting of lupus. This was explored in lupus-prone NZB/W F1 mice in vitro and vivo to understand IL-10 effects on individual immune cells as well as in the complex in vivo setting. We found pleiotropic IL-10 expression that largely increased with progressing lupus, while IL-10 receptor (IL-10R) levels remained relatively stable. In vitro experiments revealed pro- and anti-inflammatory IL-10 effects. Particularly, IL-10 decreased pro-inflammatory cytokines and slowed B cell proliferation, thereby triggering plasma cell differentiation. The frequent co-expression of ICOS, IL-21 and cMAF suggests that IL-10-producing CD4 T cells are important B cell helpers in this context. In vitro and in vivo effects of IL-10 were not fully concordant. In vivo IL-10R blockade slightly accelerated clinical lupus manifestations and immune dysregulation. Altogether, our side-by-side in vitro and in vivo comparison of the influence of IL-10 on different aspects of immunity shows that IL-10 has dual effects. Our results further reveal that the overall outcome may depend on the interplay of different factors such as target cell, inflammatory and stimulatory microenvironment, disease model and state. A comprehensive understanding of such influences is important to exploit IL-10 as a therapeutic target.

Leptin Functioning in Eating Disorders

CNS Spectrums ◽  
2004 ◽  
Vol 9 (7) ◽  
pp. 523-529 ◽  
Author(s):  
Palmiero Monteleone ◽  
Antonio DiLieto ◽  
Eloisa Castaldo ◽  
Mario Maj
Keyword(s):  
Physical Activity ◽  
Eating Disorders ◽  
Body Weight ◽  
Eating Behaviors ◽  
Clinical Manifestations ◽  
Immune Functions ◽  
Abnormal Eating ◽  
The Brain

AbstractLeptin is an adipocyte-derived hormone, which is involved predominantly in the long-term regulation of body weight and energy balance by acting as a hunger suppressant signal to the brain. Leptin is also involved in the modulation of reproduction, immune function, physical activity, and some endogenous endocrine axes. Since anorexia nervosa (AN) and bulimia nervosa (BN) are characterized by abnormal eating behaviors, dysregulation of endogenous endocrine axes, alterations of reproductive and immune functions, and increased physical activity, extensive research has been carried out in the last decade in order to ascertain a role of this hormone in the pathophysiology of these syndromes. In this article, we review the available data on leptin physiology in patients with eating disorders. These data support the idea that leptin is not directly involved in the etiology of AN or BN. However, malnutrition-induced alterations in its physiology may contribute to the genesis and/or the maintenance of some clinical manifestations of AN and BN and may have an impact on the prognosis of AN.

scholarly journals Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age

Blood ◽  
1988 ◽  
Vol 71 (6) ◽  
pp. 1726-1730
Author(s):  
KA Melez ◽  
LF Fries ◽  
BS Bender ◽  
T Quinn ◽  
MM Frank
Keyword(s):  
Aging Process ◽  
Elderly Population ◽  
The Elderly ◽  
Older Individuals ◽  
Immune Functions ◽  
Macrophage Function ◽  
Normal Volunteers ◽  
Age Related ◽  
Male Subjects

Decreased immune functions have been suggested as a cause for the increased incidence of autoimmunity, malignancy, and infection in the elderly population. To assess the possible role of changes in macrophage function in the aging process we studied the Fc receptor- mediated clearance of IgG-coated erythrocytes in 56 healthy normal volunteers by following the removal of radiolabeled autologous erythrocytes. An age-related decrease in Fc-mediated clearance rates in both female and male subjects was found, which suggests a physiological decline of this macrophage function in older individuals.

scholarly journals A review of the reasons for high prevalence and rapid progression of COVID-19 in men

2021 ◽  
Vol 7 (1) ◽  
pp. e03-e03
Author(s):  
Neda Taghizabet ◽  
Fatemeh Rezaei-Tazangi ◽  
Hossein Roghani‐Shahraki
Keyword(s):  
Transmembrane Protein ◽  
Rapid Progression ◽  
Acute Type ◽  
Converting Enzyme ◽  
Immune Functions ◽  
Male And Female ◽  
Angiotensin Converting Enzyme 2 ◽  
High Prevalence ◽  
Hormonal Levels

Previous studies have demonstrated a relationship between gender and COVID-19 outcomes. In addition, this is confirmed that men have more danger of progressing an acute type of the illness than women, specifies the significance of miscellaneous data related to male and female patients with COVID-19. In other words, some factors like hormonal levels and immune function may interact with each other. A perception of the fundamental reasons for gender diversities in COVID-19 patients can beget a chance for disease prevention and faster treatment. The present study evaluates the role of gender in the incidence and progression of the COVID-19 disease. It has been explained that how gender affects angiotensin-converting enzyme 2 (ACE2), which is a basic factor for the COVID-19 pathogenesis introducing the sex diversities in platelet function, immune reactions and how sex hormones affect immune functions, also the effect of androgens on transmembrane protein serine protease 2 (TMPRSS2) receptor in COVID-19 patients was investigated.

scholarly journals KELAYAKAN SISTEM EVAKUASI KAWASAN RAWAN BENCANA LETUSAN GUNUNG MERAPI DI KABUPATEN SLEMAN

Arsitektura ◽  
2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Dicky Setya Adi W ◽  
Kusumastuti Kusumastuti ◽  
Isti Andini
Keyword(s):  
Early Warning ◽  
Early Warning System ◽  
Quantitative Method ◽  
Warning System ◽  
Average Score ◽  
Qualitative And Quantitative ◽  
Meeting Point ◽  
Evacuation Route ◽  
Evacuation System

<em>Evacuation system in Mount Merapi eruption area consist of evacuation component, such early warning system, meeting point, evacuation lane, evacuation route, barrack, communication and transportation. The role of the goverment is to give services for refugees who live in scenario evacuation area. But there are some constrains, for example damaged road, evacuation lane crossover the bridge, people don’t heard the early warning system and high density of barracks. Based on those phenomenons, this research objected is to measure the feasibility of Mount Merapi evacuation system in Sleman district by using qualitative and quantitative method. The results of this research, some of evacuation systems don’t have perfect score. Early warning system has score 49%,  meeting point score 96,2%, evacuation lane 88,7%, evacuation route 100%, barracks 60,7%, transportation and communication 51,8%. From that components, the average score is 75% which means the system of evacuation in Mount Merapi Eruption Area not feasible yet.</em>

scholarly journals The Role of the Immune System from an Evolutionary Perspective

2019 ◽  
pp. 198-209
Author(s):  
Carsten Schradin ◽  
Rainer H. Straub
Keyword(s):  
Evolutionary Medicine ◽  
Future Generations ◽  
Lifetime Reproductive Success ◽  
Life History Stage ◽  
Evolutionary Perspective ◽  
Lifetime Fitness ◽  
Fitness Consequences ◽  
Reproductive Life ◽  
Fitness Benefits

“Nothing in Biology makes sense, except in the light of evolution.” This famous citation of Theodosius Dobzhansky also underlies the integrative field of evolutionary medicine, which faces the challenge to combine (patho-)physiological mechanisms with evolutionary function. Here we introduce a concept from the study of animal behavior, which are the four questions of Tinbergen that consider: 1. the ontogeny of an individual describing its development, 2. its physiological machinery, which 3. has fitness consequences influencing 4. the evolutionary history (phylogeny) of future generations. It is shown how this concept can be applied to infectious disease and to chronic inflammatory systemic diseases. Evolutionary medicine takes lifetime reproductive success into account. The hypothesis to be tested is that mechanisms underlying a disease in old age might have higher fitness benefits in the pre-reproductive and/or reproductive life history stage, leading to an overall increased lifetime fitness.

scholarly journals Analisis Strategi Forum Kewaspadaan Dini Masyarakat (FKDM) atas Cegah Dini dalam Penanganan Konflik Sosial di Provinsi Dki Jakarta Tahun 2019

2020 ◽  
Vol 3 (2) ◽  
pp. 205-209
Author(s):  
Dwi Agustina ◽  
Edy Mulyadi
Keyword(s):  
Government Regulation ◽  
Swot Analysis ◽  
Social Conflict ◽  
Warning System ◽  
Security Threats ◽  
Security Threat ◽  
National Unity ◽  
Conflict Handling ◽  
The Government

The community is responsible for the implementation of the community early awareness, meanwhile the government is obliged to facilitate it. A good role of the Community Early Awareness Forum or Forum Kewaspadaan Dini Masyarakat (FKDM) followed up by the government can save the community from security threat or disaster and minimize losses by anticipating the security threats and disaster. This research uses qualitative approach. Concept operationalization in this research refers to the used strategy, the SWOT analysis. The FKDM strategies in social conflict early prevention are: 1) inserting early warning system by increasing institutional capacities which include three elements; government, private sector, community through dialogue, 2) National Unity and Politics Agency or Badan Kesatuan Bangsa dan Politik (Kesbangpol) of DKI Jakarta actively making dialogue persuasively and finding solution, 3) budgeting of conflict handling according to the Government Regulation gives opportunity to strengthen community resilience to protect the community, encourage community participation, handle social conflict, and preserve local wisdom to maintain peace.

scholarly journals Contributions of metabolic and temporal costs to human gait selection

2018 ◽  
Vol 15 (143) ◽  
pp. 20180197 ◽  
Author(s):  
Erik M. Summerside ◽  
Rodger Kram ◽  
Alaa A. Ahmed
Keyword(s):  
Movement Time ◽  
Metabolic Cost ◽  
Metabolic Energy ◽  
Human Gait ◽  
Cost Of Transport ◽  
Relative Value ◽  
Weighted Combination

Humans naturally select several parameters within a gait that correspond with minimizing metabolic cost. Much less is understood about the role of metabolic cost in selecting between gaits. Here, we asked participants to decide between walking or running out and back to different gait specific markers. The distance of the walking marker was adjusted after each decision to identify relative distances where individuals switched gait preferences. We found that neither minimizing solely metabolic energy nor minimizing solely movement time could predict how the group decided between gaits. Of our twenty participants, six behaved in a way that tended towards minimizing metabolic energy, while eight favoured strategies that tended more towards minimizing movement time. The remaining six participants could not be explained by minimizing a single cost. We provide evidence that humans consider not just a single movement cost, but instead a weighted combination of these conflicting costs with their relative contributions varying across participants. Individuals who placed a higher relative value on time ran faster than individuals who placed a higher relative value on metabolic energy. Sensitivity to temporal costs also explained variability in an individual's preferred velocity as a function of increasing running distance. Interestingly, these differences in velocity both within and across participants were absent in walking, possibly due to a steeper metabolic cost of transport curve. We conclude that metabolic cost plays an essential, but not exclusive role in gait decisions.

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