scholarly journals Platelet Innate Immune Receptors and TLRs: A Double-Edged Sword

2021 ◽  
Vol 22 (15) ◽  
pp. 7894
Author(s):  
Théo Ebermeyer ◽  
Fabrice Cognasse ◽  
Philippe Berthelot ◽  
Patrick Mismetti ◽  
Olivier Garraud ◽  
...  
Keyword(s):  
The Body ◽  
Innate Immune ◽  
Main Function ◽  
Vascular Integrity ◽  
Immune Receptors ◽  
Functional Capabilities ◽  
Wide Range ◽  
Long Time ◽  
Stress Signals ◽  
Platelet Functions

Platelets are hematopoietic cells whose main function has for a long time been considered to be the maintenance of vascular integrity. They have an essential role in the hemostatic response, but they also have functional capabilities that go far beyond it. This review will provide an overview of platelet functions. Indeed, stress signals may induce platelet apoptosis through proapoptotis or hemostasis receptors, necrosis, and even autophagy. Platelets also interact with immune cells and modulate immune responses in terms of activation, maturation, recruitment and cytokine secretion. This review will also show that platelets, thanks to their wide range of innate immune receptors, and in particular toll-like receptors, and can be considered sentinels actively participating in the immuno-surveillance of the body. We will discuss the diversity of platelet responses following the engagement of these receptors as well as the signaling pathways involved. Finally, we will show that while platelets contribute significantly, via their TLRs, to immune response and inflammation, these receptors also participate in the pathophysiological processes associated with various pathogens and diseases, including cancer and atherosclerosis.

scholarly journals Interleukin-22 Influences the Th1/Th17 Axis

2021 ◽  
Vol 12 ◽  
Author(s):  
Hannes Lindahl ◽  
Tomas Olsson
Keyword(s):  
T Cells ◽  
Immune Cells ◽  
Inflammatory Diseases ◽  
Adaptive Immune System ◽  
Cell Polarization ◽  
The Body ◽  
Innate Immune ◽  
Interleukin 22 ◽  
Downstream Effects ◽  
Wide Range

Interleukin-22 (IL-22) is secreted by a wide range of immune cells and its downstream effects are mediated by the IL-22 receptor, which is present on non-immune cells in many organs throughout the body. IL-22 is an inflammatory mediator that conditions the tissue compartment by upregulating innate immune responses and is also a homeostatic factor that promotes tissue integrity and regeneration. Interestingly, the IL-22 system has also been linked to many T cell driven inflammatory diseases. Despite this, the downstream effects of IL-22 on the adaptive immune system has received little attention. We have reviewed the literature for experimental data that suggest IL-22 mediated effects on T cells, either transduced directly or via mediators expressed by innate immune cells or non-immune cells in response to IL-22. Collectively, the reviewed data indicate that IL-22 has a hitherto unappreciated influence on T helper cell polarization, or the secretion of signature cytokines, that is context dependent but in many cases results in a reduction of the Th1 type response and to some extent promotion of regulatory T cells. Further studies are needed that specifically address these aspects of IL-22 signaling, which can benefit the understanding and treatment of a wide range of diseases.

scholarly journals Non-hormonal options for the relief of menopausal disorders

2022 ◽  
pp. 190-196
Author(s):  
O. V. Yakushevskaya
Keyword(s):  
Large Scale ◽  
Estrogen Deficiency ◽  
Alternative Methods ◽  
Main Function ◽  
Hormonal Changes ◽  
Social Self ◽  
Number Of Patients ◽  
Wide Range ◽  
Long Time

Woman’s nature is unique. Taking into account some historical milestones, it can be noted that the role of women in society has undergone large-scale changes. The woman took a confident position in society. Its main function remains unchanged and it consists in procreation and procreation. A woman’s activity is consistent with the work of her reproductive system (RS). The gradual decrease, and then the cessation of the work of the ovaries, contributes to the life order and health of the fair sex. Menopause is a natural stage in a woman’s life, which corresponds to the peak of social self-realization. However, in some cases, hormonal changes characteristic of this period can serve as a favorable background for the formation of a number of pathological changes. The growing estrogen deficiency is becoming a pathogenetic impetus for the development of a wide range of climacteric disorders. Vasomotor symptoms and hyperhidrosis are the most frequent companions of women during the perimenopausal transition and early postmenopause. Maintaining optimal activity and the full quality of life of patients should be the goal of correcting the negative manifestations of estrogen deficiency and the complications associated with it. Compensating for estrogen deficiency with menopausal hormone therapy (HRT) is the benchmark for menopausal problems. However, there are a number of patients who have contraindications to prescribing HRT or who refuse to receive it for some reason. For this category of patients, alternative methods of diet correction. Combinations of plant extracts with vitamins and minerals have been successfully used in clinical practice for a long time. The article will provide information on the most studied phytoestrogens contained in soy.

Impairment Tutorial: Dermatological Impairment Assessment

1998 ◽  
Vol 3 (5) ◽  
pp. 6-7
Author(s):  
Laura Welch
Keyword(s):  
Contact Dermatitis ◽  
Contact Allergy ◽  
Skin Lesions ◽  
Limited Range ◽  
The Body ◽  
Main Function ◽  
Multiple Systems ◽  
Occupational Contact Dermatitis ◽  
Wide Range ◽  
The Face

Abstract The main function of the skin is to protect the body that it encloses. Anatomically and physiologically, the skin's regions differ to the extent that skin is not one organ but a combination of multiple systems. The skin has a limited range of reaction patterns, but these may express a wide range of clinical syndromes. The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) states that the morphology of the lesion and the pattern of distribution suggest the differential diagnosis. Skin lesions can be characterized as macule, papule, change in pigmentation, plaque, erythema, or eczema. The evaluating physician should consider relevant characteristics, including: Is the condition localized or generalized? Does in involve the face or spare it? Does the condition involve or spare the palms and soles? Approximately 95% of occupational skin disease involves contact dermatitis from irritation, contact allergy, or both. The remaining instances usually arise from biological, physical, mechanical, or other miscellaneous causes. The AMA Guides directs the evaluating physician to complete a detailed work description and conduct a physical examination with biopsy or patch testing as needed. Because most cases of occupational contact dermatitis involve irritants, a systematic approach to examination of the skin and use of good dermatology tests can pinpoint the diagnosis in the majority of cases.

Compensatory-adaptive mechanism of cardiorespiratory system in athletes’ fatigue state

2019 ◽  
pp. 98-104
Author(s):  
Artem Savelyev
Keyword(s):  
The Body ◽  
Training Process ◽  
Cardiorespiratory System ◽  
Functional Capabilities ◽  
Preparatory Period ◽  
Long Time ◽  
Competition Period ◽  
Sufficient Degree ◽  
Preparatory Stage ◽  
High Level

At the present level of sports development, the search for opportunities to improve the performance and endurance of athletes is one of the most important terms for achieving high sports results. Performing physical activity at the limit level makes increased demands on the ac-tivity of the body, requires more significant adaptive changes in the functioning of all organs and systems, but it allows to raise the overall level of efficiency. Factors that determine the effective-ness of combinations of training loads are the volume of loads, their direction and sequence of ex-ecution. Consideration of these factors should be reflected in the organization of the training process. The combination of training loads aimed at the education of general, special and strength endurance should be most often used in the general preparatory stage of the preparatory period, and the combination of loads aimed at the education of special, speed and strength endurance – in the special preparatory stage of the preparatory period and in the competitive period. Planning the volume and intensity of the training load and its implementation should correspond to the functional capabilities of the athlete’s body. To prevent the probability of any deviation from normal functioning of energy sustaining systems of the body, one needs a speedy and effective recovery of these systems. Only in this case the training process can proceed quite systematically, and the results of the trainee will become more stable at all stages of the competition period. All this makes it relevant to study the processes of rational interaction of cardiorespiratory and motor systems of the body during training and competition. This knowledge allows with a sufficient degree of accuracy to determine the development of the performance of athletes, optimize the training process, improve its quality and efficiency, maintain a high level of performance for a long time.

Motoneurone Discharges to the Eyecup Muscles of the Crab carcinus

1968 ◽  
Vol 49 (2) ◽  
pp. 251-267
Author(s):  
M. BURROWS ◽  
G. A. HORRIDGE
Keyword(s):  
The Body ◽  
Muscle Fibres ◽  
Tonic Activity ◽  
Large Scatter ◽  
Absolute Position ◽  
Wide Range ◽  
Long Time ◽  
Slow Muscle Fibres ◽  
The Mean ◽  
The Right

1. During imposed tilt the eyecup or the crab tends to preserve an absolute position which depends upon the tonic activity of eight of the nine eyecup muscles. The detailed activity of all these muscles during imposed tilt in different planes has been recorded intracellularly. 2. The slow- and fast-motoneurone discharges to the eyecup muscles differ in that the former have intervals which are more variable at lower frequencies but the latter are more variable at higher frequencies. 3. The standard deviation of the interval between impulses is 20-30% of the mean interval for a wide range of frequencies of the tonic motoneurones. This large scatter is tolerable because the slow muscle fibres are sluggish and because the eyecup is also visually stabilized by a system of long time-constant. 4. In roll the two eyecups move in opposite directions relative to the midline of the animal. In pitch the two eyecups move in the same direction relative to the body of the animal, but in neither case is there a correlation between individual impulses to the muscles of the right and left eyecups which are active at the same time. 5. Possible mechanisms of linkage between the two eyecups are discussed.

The Problem of Identifying and Modeling the Relationship between Monetary Factor and Inflation in the Russian Economy

2008 ◽  
pp. 61-76
Author(s):  
A. Porshakov ◽  
A. Ponomarenko
Keyword(s):  
Money Supply ◽  
Money Demand ◽  
Russian Economy ◽  
Long Run ◽  
Complex Approach ◽  
Wide Range ◽  
Long Time ◽  
The Relationship ◽  
Supply Side Factors

The role of monetary factor in generating inflationary processes in Russia has stimulated various debates in social and scientific circles for a relatively long time. The authors show that identification of the specificity of relationship between money and inflation requires a complex approach based on statistical modeling and involving a wide range of indicators relevant for the price changes in the economy. As a result a model of inflation for Russia implying the decomposition of inflation dynamics into demand-side and supply-side factors is suggested. The main conclusion drawn is that during the recent years the volume of inflationary pressures in the Russian economy has been determined by the deviation of money supply from money demand, rather than by money supply alone. At the same time, monetary factor has a long-run spread over time impact on inflation.

Questions on the role of biofilms for the adaptation of microorganisms to unfavorable environmental factors by the example of P. aeruginosa

2020 ◽  
Vol 99 (4) ◽  
pp. 379-383
Author(s):  
Vasily N. Afonyushkin ◽  
N. A. Donchenko ◽  
Ju. N. Kozlova ◽  
N. A. Davidova ◽  
V. Yu. Koptev ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Environmental Factors ◽  
Barrier Function ◽  
Infectious Agent ◽  
Antagonistic Activity ◽  
The Body ◽  
Main Function ◽  
Pathogenic Potential ◽  
The Face

Pseudomonas aeruginosa is a widely represented species of bacteria possessing of a pathogenic potential. This infectious agent is causing wound infections, fibrotic cystitis, fibrosing pneumonia, bacterial sepsis, etc. The microorganism is highly resistant to antiseptics, disinfectants, immune system responses of the body. The responses of a quorum sense of this kind of bacteria ensure the inclusion of many pathogenicity factors. The analysis of the scientific literature made it possible to formulate four questions concerning the role of biofilms for the adaptation of P. aeruginosa to adverse environmental factors: Is another person appears to be predominantly of a source an etiological agent or the source of P. aeruginosa infection in the environment? Does the formation of biofilms influence on the antibiotic resistance? How the antagonistic activity of microorganisms is realized in biofilm form? What is the main function of biofilms in the functioning of bacteria? A hypothesis has been put forward the effect of biofilms on the increase of antibiotic resistance of bacteria and, in particular, P. aeruginosa to be secondary in charcter. It is more likely a biofilmboth to fulfill the function of storing nutrients and provide topical competition in the face of food scarcity. In connection with the incompatibility of the molecular radii of most antibiotics and pores in biofilm, biofilm is doubtful to be capable of performing a barrier function for protecting against antibiotics. However, with respect to antibodies and immunocompetent cells, the barrier function is beyond doubt. The biofilm is more likely to fulfill the function of storing nutrients and providing topical competition in conditions of scarcity of food resources.

Creating the Wind

2020 ◽  
Vol 2 (4) ◽  
pp. 14-31
Author(s):  
Élodie Dupey García
Keyword(s):  
Indigenous Communities ◽  
The Body ◽  
Historical Sources ◽  
Natural Behavior ◽  
Sensory Experiences ◽  
Identity And Agency ◽  
Wide Range ◽  
Late Postclassic ◽  
Comparative Examination ◽  
Meteorological Phenomenon

This article explores how the Nahua of late Postclassic Mesoamerica (1200–1521 CE) created living and material embodiments of their wind god constructed on the basis of sensory experiences that shaped their conception of this divinized meteorological phenomenon. In this process, they employed chromatic and design devices, based on a wide range of natural elements, to add several layers of meaning to the human, painted, and sculpted supports dressed in the god’s insignia. Through a comparative examination of pre-Columbian visual production—especially codices and sculptures—historical sources mainly written in Nahuatl during the viceregal period, and ethnographic data on indigenous communities in modern Mexico, my analysis targets the body paint and shell jewelry of the anthropomorphic “images” of the wind god, along with the Feathered Serpent and the monkey-inspired embodiments of the deity. This study identifies the centrality of other human senses beyond sight in the conception of the wind god and the making of its earthly manifestations. Constructing these deity “images” was tantamount to creating the wind because they were intended to be visual replicas of the wind’s natural behavior. At the same time, they referred to the identity and agency of the wind god in myths and rituals.

Comperehencive review of Tankana

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Jyotsna Sankpal ◽  
Dr. Jyotsna Takalikar
Keyword(s):  
Heart Disease ◽  
Medical Science ◽  
Menstrual Disorders ◽  
Therapeutic Applications ◽  
Indian Medical ◽  
Wide Range ◽  
Long Time

Rasa Shastra and Bhaishajya Kalpana is branch of the ancient Indian medical science based on herbs and herbo-mineral preparation. Tankana has been described under Uparasa Tankana, which is one among the Kshara Trayas has been used since very long time in Ayurveda. It has a wide range of therapeutic applications, including diseases like Varna (ulcers), Shvasa (asthma), Kasa (cough), Hrudya (beneficial to heart disease), Streepushpajanana (menstrual disorders) etc. It is used in the form of compound formulations like Parpati, Kupipakwa, Khalvee Rasayana, Churna, Vati, Lepa etc. In this paper Tankana Shodhana procedure, different synonyms, dose, Anupana, indications and different formulations containing Tankana Bhasma has been discussed.

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