scholarly journals Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases

2021 ◽  
Vol 22 (20) ◽  
pp. 11290
Author(s):  
Mahmoud Youssef ◽  
Hanaa Y. Ahmed ◽  
Abel Zongo ◽  
Ali Korin ◽  
Fuchao Zhan ◽  
...  
Keyword(s):  
Essential Role ◽  
Functional Foods ◽  
Viral Infections ◽  
Human Life ◽  
Allergic Diseases ◽  
Immune Disorders ◽  
Close Attention ◽  
Comprehensive Review ◽  
Life Threatening ◽  
Promising Solution

Chronic diseases and viral infections have threatened human life over the ages and constitute the main reason for increasing death globally. The rising burden of these diseases extends to negatively affecting the economy and trading globally, as well as daily life, which requires inexpensive, novel, and safe therapeutics. Therefore, scientists have paid close attention to probiotics as safe remedies to combat these morbidities owing to their health benefits and biotherapeutic effects. Probiotics have been broadly adopted as functional foods, nutraceuticals, and food supplements to improve human health and prevent some morbidity. Intriguingly, recent research indicates that probiotics are a promising solution for treating and prophylactic against certain dangerous diseases. Probiotics could also be associated with their essential role in animating the immune system to fight COVID-19 infection. This comprehensive review concentrates on the newest literature on probiotics and their metabolism in treating life-threatening diseases, including immune disorders, pathogens, inflammatory and allergic diseases, cancer, cardiovascular disease, gastrointestinal dysfunctions, and COVID-19 infection. The recent information in this report will particularly furnish a platform for emerging novel probiotics-based therapeutics as cheap and safe, encouraging researchers and stakeholders to develop innovative treatments based on probiotics to prevent and treat chronic and viral diseases.

scholarly journals Nanomedicine, Viral Infection and Cytokine Stor

2021 ◽  
Vol 8 (4) ◽  
pp. 01-03
Author(s):  
Rajiv Kumar ◽  
Fatemeh Mohammadipanah
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
Viral Infections ◽  
Human Life ◽  
Therapeutic Targets ◽  
Effective Vaccine ◽  
Efficient Treatment ◽  
Life Threatening

Recently, emerged outbreaks of various viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MERS-CoV, and ZIKA infections, are fatal for human life. These life-threatening infections to public health pointed out as a major cause responsible for initiating severe diseases globally. These viral infections heightened the morbidity rates and thus, it is a deadly fear to human life. Researchers left no stone unturned for searching newer therapeutic targets and remedies to treat these viral infections and outbreaks. Simultaneously, some of the researchers have gained success in the discovery of an efficient treatment and development of an effective vaccine [1]. In view of that, numerous developments have been made for innovating nanotherapies, which can treat viral infection and few of them are written off as nanomedicine, have been become reality.

scholarly journals Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 697
Author(s):  
Siming Lu ◽  
Sha Lin ◽  
Hongrui Zhang ◽  
Liguo Liang ◽  
Shien Shen
Keyword(s):  
Viral Load ◽  
Respiratory Virus ◽  
Viral Infections ◽  
Point Of Care ◽  
Human Life ◽  
Low Cost ◽  
Virus Detection ◽  
Frequent Monitoring ◽  
User Friendly ◽  
New Strategies

Respiratory viral infections threaten human life and inflict an enormous healthcare burden worldwide. Frequent monitoring of viral antibodies and viral load can effectively help to control the spread of the virus and make timely interventions. However, current methods for detecting viral load require dedicated personnel and are time-consuming. Additionally, COVID-19 detection is generally relied on an automated PCR analyzer, which is highly instrument-dependent and expensive. As such, emerging technologies in the development of respiratory viral load assays for point-of-care (POC) testing are urgently needed for viral screening. Recent advances in loop-mediated isothermal amplification (LAMP), biosensors, nanotechnology-based paper strips and microfluidics offer new strategies to develop a rapid, low-cost, and user-friendly respiratory viral monitoring platform. In this review, we summarized the traditional methods in respiratory virus detection and present the state-of-art technologies in the monitoring of respiratory virus at POC.

Relations of Post-traumatic Growth and Resilience in Cancer Experience

2017 ◽  
Vol 41 (S1) ◽  
pp. S672-S672 ◽  
Author(s):  
Y.S. Uzar Ozcetin ◽  
D. Hicdurmaz
Keyword(s):  
Human Life ◽  
Well Being ◽  
Traumatic Experience ◽  
Physical Problems ◽  
Post Traumatic Growth ◽  
Life Threatening ◽  
Post Traumatic ◽  
Competing Interest ◽  
Mutual Relations ◽  
Cancer Experience

IntroductionEach individual experience cancer in a different way. While some perceive cancer as a complex and traumatic experience by developing some psychosocial and additional physical problems, others overcome cancer-related difficulties by gaining benefits such as post-traumatic growth (PTG) owing to their resilience. Resilience and PTG that are very valuable concepts in human life to adapt positively to cancer process have relations which need to be better understood.ObjectivesWe aimed to provide a better understanding of relations between resilience and PTG and relations of these two concepts with cancer experience.MethodsLiterature review.ResultsSuccessful adjustment to life-threatening illnesses such as cancer, require resilience. On the other hand, resilience provides a barrier toward stressors by helping improvement of PTG and so, is an antecedent factor of PTG. PTG ensures a deeper perspective and strength to people after traumatic events. Hence, individuals having higher levels of PTG feel powerful enough to handle the problems in their life and can easily adapt to cancer process by focusing on the positive outcomes of trauma, having improved coping mechanisms and an improved psychological well-being.ConclusionsResilience and PTG have strong mutual relations and this phenomenon should be considered for a qualified cancer care.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Pharmacokinetics and Safety of Intravenous Cidofovir for Life-Threatening Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients

2015 ◽  
Vol 59 (7) ◽  
pp. 3718-3725 ◽  
Author(s):  
Amy E. Caruso Brown ◽  
Mindy N. Cohen ◽  
Suhong Tong ◽  
Rebecca S. Braverman ◽  
James F. Rooney ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Half Life ◽  
Viral Infections ◽  
Multiorgan Failure ◽  
Kidney Injury ◽  
Cell Transplant ◽  
Open Label ◽  
Hematopoietic Stem ◽  
Life Threatening

ABSTRACTChildren undergoing hematopoietic stem cell transplantation (HSCT) are at risk for life-threatening viral infections. Cidofovir is often used as a first-line agent for adenovirus infections, despite the absence of randomized controlled trials with HSCT patients, and as a second-line agent for resistant herpesvirus infections. The frequency and severity of adverse effects, particularly nephrotoxicity, in pediatric HSCT recipients are unclear, and pharmacokinetics (PK) of cidofovir in children have not previously been reported. This study was an open-label, nonrandomized, single-dose pilot study to determine the safety and PK of cidofovir in pediatric HSCT recipients with symptomatic adenovirus, nucleoside-resistant cytomegalovirus (CMV) or herpes simplex virus (HSV), and/or human papovavirus infections. Subsequent dosing and frequency were determined by clinical response and side effects, as assessed by the treating physician. Blood and urine samples were obtained from patients for PK studies and assessment of toxicity and virologic response. Twelve patients were enrolled (median age, 9 years; 33.5 days posttransplantation). Four of seven patients with adenovirus infection were successfully treated and eventually cleared their infections. Four of twelve patients died of disseminated viral disease and multiorgan failure. Two of twelve patients had evidence of acute kidney injury after the first dose, and one of these patients developed chronic kidney disease; two other patients developed late nephrotoxicity. The mean drug half-life was 9.5 h. There was no correlation between nephrotoxicity and plasma maximum concentration, clearance, or half-life. PK were similar to those reported for adults, although the drug half-life was significantly longer than that for adults. Cidofovir was well tolerated in the majority of patients. However, effective therapeutic strategies are urgently needed to support patients until immune reconstitution is achieved.

scholarly journals An Overview of Post-COVID-19 Patient’s Health Monitoring Systems

2021 ◽  
Vol 7 (10) ◽  
pp. 61-67
Author(s):  
Chirag Satapathy, Hrishikesh Gokhale, Ali Zoya Syed, Keerti Srivastava and Ruban Nersisson
Keyword(s):  
Health Monitoring ◽  
Human Life ◽  
Vital Role ◽  
Health Conditions ◽  
Smart Sensors ◽  
Monitoring Systems ◽  
Comprehensive Review ◽  
Global Pandemic ◽  
Health Monitoring Systems ◽  
Time Basis

COVID-19 is a global pandemic infecting human life. There are many patients who have recovered from this deadly virus and need to be monitored constantly even when they are at home. IoT plays a vital role in health systems that help to monitor patient’s health conditions. These healthcare frameworks consist of smart sensors to keep a track of patient’s vitals on a real-time basis. These systems will help bridge gaps between the patients and doctors during the pandemic situation. In order to make our system competitive against the already existing devices, we prepared a comprehensive review where we extensively studied other products and compared them to find what's best for the patients.

scholarly journals Medical Ethics during the COVID-19 Pandemic

Acta Medica ◽  
2021 ◽  
pp. 1-10
Author(s):  
Sevim Coşkun ◽  
Nüket Örnek Büken
Keyword(s):  
Healthcare Professionals ◽  
Human Life ◽  
Action Plan ◽  
Disaster Medicine ◽  
Ethical Principles ◽  
Duty Of Care ◽  
Protective Measures ◽  
Life Threatening ◽  
Correct Application ◽  
Difficult Situations

WHO states five ethical principles for the care of patients with COVID-19: Equal moral respect, duty of care, non-abandonment, protection of the community, and confidentiality. Healthcare professionals might have to make difficult decisions such as selecting patients and withholding or withdrawing mechanical ventilation of critically ill patients. In such difficult situations, a well-prepared action plan which considers ethical principles and prioritizes both public health and the safety of healthcare professionals, can help them. In this case, the development of an effective pandemic action plan, together with a triage plan based on emergency and disaster medicine is necessary. The only parameter of selection in this plan must be the correct application of triage, which respects every human life and depends on the criteria of clinical suitability. In this context, the fundamental ethical principles and human rights must be considered when allocating resources and prioritizing patients. Additionally, all protective measures for healthcare professionals must be taken, including all necessary equipment being adequately provided. If healthcare professionals become infected or face a life-threatening risk, then their obligations will be limited. Therefore, it is necessary to realize these limitations which may arise while providing appropriate health services.

scholarly journals Investigation of markers of allergic sensitization and viral infections in children with allergy and asthma

2017 ◽  
Vol 24 (3) ◽  
pp. 145-152
Author(s):  
Rūta Dubakienė ◽  
Vilija Rubinaitė ◽  
Malvina Petronytė ◽  
Indrė Dalgėdienė ◽  
Odilija Rudzevičienė ◽  
...  
Keyword(s):  
Viral Infections ◽  
Allergic Sensitization ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Specific Ige ◽  
High Rate ◽  
Control Group ◽  
Igg Antibodies ◽  
Airway Infections ◽  
Respiratory Viral Infections

Background. Allergic diseases are the most prevalent chronic diseases in the developed countries. It is believed that early allergic sensitization and respiratory viral infections play an important role in the development of allergic diseases and asthma. Methods. The current study investigated the correlation between asthma, allergy, and various markers – allergen-specific IgE, IgG4 and IgA, ECP, IgM, and IgG antibodies against respiratory viruses hRSV and hPIV1-4 – in blood serum samples from 80 children (mean age 5.2 years) recruited from the Lithuanian birth cohort. Children were divided into three groups according to their diagnosis: asthma (n = 25), allergy without asthma (n = 14), and control group (n = 41). Results. Based on retrospective data, airway infections and bronchitis by the age of two years were associated with asthma in later childhood. The presence of IgM and IgG antibodies against hRSV and hPIV1–4 at the age of five years were not associated with asthma and allergy: a high rate of persistent or past respiratory viral infections was revealed in all three groups. Among allergic children, increased levels of allergen-specific IgE and d1-specific IgG4 were determined. Conclusion. The current study provides new insights into the relationships between allergic sensitization and respiratory virus infections in children.

scholarly journals Risk of sensitization to ecopollutants in teenagers with inherited chemical burden

2021 ◽  
pp. 123-131
Author(s):  
L.B. Masnavieva ◽  
◽  
N.V. Efimova ◽  
I.V. Kudaeva ◽  
◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Hazard Index ◽  
Allergic Diseases ◽  
Ambient Air ◽  
Inhibition Test ◽  
Immune Disorders ◽  
Migration Inhibition ◽  
Air Contamination ◽  
Relative Risks ◽  
Research Goal

At present allergic diseases are detected in 30% people and their frequency is only growing. A significant role in allergic pathology occurrence belongs to ambient air contamination and chemicals being introduced not only into children’s bodies, but their parents’ ones as well since pollutants can act as allergens and sensitizing agents. Our research goal was to examine influence exerted by parents’ pre-gestation exposure to chemicals on sensitization among teenagers living in an area where ambient air was contaminated. We examined overall immunoglobulin E contents and leukocytes migration inhibition test with formaldehyde and sodium nitrite in 115 teenagers whose parents worked under adverse working conditions at chemical and petrochemical enterprises and in 244 schoolchildren whose parents didn’t have any occupational contacts with chemicals. Each group was divided into sub-groups depending on inhalation chemical burden on schoolchildren’s bodies caused by ambient air contamination and contaminated air indoors (with hazard index (HI) for immune disorders being lower than 2 and HI≥2). The research allowed establishing that teenagers whose parents had worked at chemical and petrochemical enterprises during a pre-gestation period had elevated IgE contents more frequently as well as changes in leukocytes migration inhibition test with formaldehyde; it indicated there was sensitization to this chemical. Parents’ occupational contacts with chemicals led to an increase in relative risks of elevated igE contents and 2.5 times higher sensitization among schoolchildren with HI<2. Risk that sensitization to formaldehyde might occur was equal to 2.3 among senior schoolchildren with HI≥2 whose parents worked at chemical enterprises.

The Ethical Challenges of Gene Editing

2017 ◽  
Vol 42 (12) ◽  
pp. 3-4
Author(s):  
Jozef Zalot ◽  
Tadeusz Pacholczyk ◽  
Keyword(s):  
Catholic Church ◽  
Gene Editing ◽  
Human Life ◽  
Genetic Diseases ◽  
Future Generations ◽  
Human Embryos ◽  
Human Beings ◽  
Ethical Challenges ◽  
Oregon Health ◽  
Life Threatening

In August 2017, researchers at the Oregon Health and Science University announced that they had successfully used a gene editing technique known as CRISPR-Cas9 to repair disease-causing genes in human embryos. Some members of the scientific and medical communities have hailed the development as a way to ensure that life- threatening diseases are not passed on to future generations. But is gene editing always a good thing? The Catholic Church encourages scientific research that is ethical and serves the human good. In the future, CRISPR may be used to treat people with serious genetic diseases, such as hemophilia and sickle-cell anemia. However, for research on human beings to be ethical, it must be strictly therapeutic and must respect the dignity and sacredness of human life. Gene-editing techniques raise profound ethical challenges in both respects.

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