Narrow-Margin Excision for Invasive Acral Melanoma: Is It Acceptable?

In this retrospective review of 100 patients with primary invasive acral melanoma, we examined whether narrow-margin excision is warranted for acral melanoma. Patients treated with surgical margins recommended by the National Comprehensive Cancer Network (R-group) were compared to those treated with narrow margins (N-group). A total of 65 patients underwent narrow-margin excision. Positive margin status or local recurrence rarely occurred regardless of the excision margins, whereas fatal events frequently occurred, particularly among the patients with T4 melanoma. The mortality rates of N- and R-group with T1–3 melanomas were similar (1.36 and 1.28 per 100 person-years, respectively). However, patients with T4 melanoma treated with narrow-margin excision had a higher mortality rate (11.44 vs. 5.03 per 100 person-years). Kaplan–Meier analyses showed a worse prognosis in the N-group (p = 0.045) but this group had thicker Breslow thickness (4.21 mm vs. 2.03 mm, p = 0.0013). A multivariate analysis showed that Breslow thickness was an independent risk factor, but surgical margin was not a risk factor for melanoma-specific survival or disease-free survival. In conclusion, although we could not find a difference between the narrow-margin excision and recommended-margin excision in this study, we suggest following current recommendations of guidelines. Our study warrants the prospective collection of data on acral melanoma to better define the prognosis of this infrequent type of melanoma.

Download Full-text

Survival Outcomes and Predictors for Patients who Failed Chemoradiotherapy/Radiotherapy and Underwent Salvage Total Laryngectomy

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020371 ◽

2021 ◽

Vol 18 (2) ◽

pp. 371

Author(s):

Ming-Hsien Tsai ◽

Hui-Ching Chuang ◽

Yu-Tsai Lin ◽

Tai-Lin Huang ◽

Fu-Min Fang ◽

...

Keyword(s):

Total Laryngectomy ◽

Univariate Analysis ◽

Disease Free Survival ◽

Stage Iv ◽

Oncologic Outcome ◽

Positive Margin ◽

Definitive Treatment ◽

Kaplan Meier ◽

Stage Iv Disease ◽

Risk Patients

Background: To assess the presence of adverse pathological features at the time of salvage total laryngectomy (TL) associated with oncologic outcome. Methods: Ninety patients with persistent/locally recurrent disease and who subsequently underwent salvage TL after definitive treatment by radiation alone (RTO) or concurrent chemo-radiation (CCRT) from 2009 to 2018 were retrospectively enrolled. Kaplan–Meier methods were used to estimate overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Results: Lymphovascular invasion (LVI), perineural invasion, positive margin, and stage IV disease were associated with worse survival in the univariate analysis. In the multivariate analysis, the presence of LVI and positive margin were both independent negative predictors in OS (LVI: adjusted hazard ratio (aHR) = 2.537, 95% CI: 1.163–5.532, p = 0.019; positive margin: aHR = 5.68, 95% CI: 1.996–16.166, p = 0.001), DSS (LVI: aHR = 2.975, 95% CI: 1.228–7.206, p = 0.016); positive margin: aHR = 11.338, 95% CI: 2.438–52.733, p = 0.002), and DFS (LVI: aHR 2.705, 95% CI: 1.257–5.821, p = 0.011; positive margin (aHR = 6.632, 95% CI: 2.047–21.487, p = 0.002). Conclusions: The presence of LVI and positive margin were both associated with poor OS, DSS, and DFS among patients who underwent salvage TL after failure of RTO/CCRT. The role of adjuvant therapy for high-risk patients after salvage TL to improve the chance of survival requires more investigation in the future.

Download Full-text

Oncologic significance of pathologic T2 positive surgical margin in robotic-assisted laparoscopic prostatectomy

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.15607 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 15607-15607

Author(s):

A. Levinson ◽

D. S. Berkman ◽

E. T. Goluboff ◽

D. B. Samadi

Keyword(s):

Linear Regression Analysis ◽

Surgical Margin ◽

Disease Free Survival ◽

Positive Margin ◽

Multiple Linear Regression Analysis ◽

Positive Surgical Margin ◽

Robotic Assisted ◽

Laparoscopic Prostatectomy ◽

Pathologic Stage

15607 Background: A positive margin (PM) after radical prostatectomy (RP) in organ confined (pT2) prostate cancer (CaP) is considered a surgical error. In addition, capsular incision may occur at a higher frequency with robotic and laparoscopic techniques than with traditional open RP. However, the mechanism and significance of capsular violation may be different between open RP and Robotic Assisted Laparoscopic Prostatectomy (RALP). We sought to determine biochemical disease free survival (BDFS) for patients (pts) who underwent RALP at our institution who had a pT2 PM and compared them to those who did not. Methods: We reviewed our prospective IRB approved database for RALPs performed by a single surgeon. To permit adequate follow-up only cases prior to March 2006 were included. Biochemical failure (BF) strictly defined as any PSA >0.1ng/ml. No pt received adjuvant therapy without a BF. Results: Since Jan 2003, 435 consecutive pts underwent RALP for clinically localized CaP. 211 of these cases were before March 2006, of which 194/211 (92%) had sufficient data for analysis. Mean follow-up was 9.8 mos (range 0.7–41.6). Mean age, preoperative PSA, and path Gleason Score were 60 yrs, 6.6 ng/ml, and 6.9, respectively. Pathologic stages: pT2 77%; pT3a 13%; pT3b 7%, pT4 3%. Overall, 7.2% (14/194) experienced BF at a median of 2.5mos (0.7–15.3). BDFS rates by pathologic stage were pT2 95.3% (142/149), pT3a 91.7% (22/24), pT3b 76.9% (10/13), and pT4 71% (5/7). pT2 pts with a PM had the same rate of BF, (4.4% 1/23), as pT2 pts with negative margins (NM) (4.8% 6/126, p=0.932) and pT3 NM (0% 0/19, p=0.36), but was statistically less than pT3 PM (27.8% 5/18, p=0.035). In multiple linear regression analysis, preoperative PSA >10ng/ml was the most predictive variable of BF even after adjusting for Gleason sum, pathologic stage, and surgical margin status. Conclusions: There may be a different mechanism between a PM in organ confined open RP pts and RALP pts. In our series of RALPs, only one of 23 pT2 PM pts suffered a biochemical recurrence. BDFS for these pts was 95.7%, and did not vary significantly from pT2 NM nor pT3 NM pts. A larger series with longer follow-up will determine whether the oncologic significance of a PM in pT2 RALP pts is different than that of open RP pts. No significant financial relationships to disclose.

Download Full-text

Outcomes for a multi-institutional cohort of patients treated with intra-operative radiation therapy for advanced or recurrent renal cell carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.6_suppl.442 ◽

2013 ◽

Vol 31 (6_suppl) ◽

pp. 442-442

Author(s):

Jonathan J. Paly ◽

Christopher Leigh Hallemeier ◽

Peter J. Biggs ◽

Andrzej Niemierko ◽

Falk Roeder ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Radiation Therapy ◽

Cell Carcinoma ◽

Renal Cell ◽

Disease Free Survival ◽

Positive Margin ◽

Entire Cohort ◽

Initial Node ◽

Kaplan Meier ◽

Recurrent Renal Cell Carcinoma

442 Background: For patients with advanced or locally recurrent (LR) renal cell carcinoma (RCC), the role of intra-operative radiation therapy (IORT) remains controversial. We analyzed outcomes in a multi-institutional cohort of patients with RCC who received IORT. Methods: Between 1985 and 2010, 98 patients were treated with IORT for advanced or LR RCC at 9 institutions. We collected demographic, clinical, treatment, and outcomes data for all patients. Overall (OS), disease specific (DSS), and disease-free survival (DFS) was estimated using the Kaplan-Meier method. A multivariate Cox hazards regression was used to test significance. Results: IORT was delivered at nephrectomy for advanced disease (28%) or during resection of LR RCC in the renal fossa (72%). 69% of patients were male and mean age at RCC diagnosis was 57. At initial nephrectomy, primary T-stage was 17% T1, 12% T2, 55% T3, and 16% T4. Prior to IORT, 87% had visibly complete surgical resection of tumor. Mean IORT dose delivered was 14.7Gy (range 9-20Gy). Average post-op hospitalization was 10.7 days. Median follow-up after IORT was 1.6 years. OS at 1 and 5 years after IORT was 69% and 37% for advanced patients and 94% and 55% for LR patients, respectively. DFS at 1 and 5 years was 72% and 39% for advanced patients and 96% and 52% for LR patients, respectively. DSS at 1 and 5 years was 72% and 41% for advanced patients and 96% and 60% for LR patients, respectively. For the entire cohort, higher IORT dose (HR 1.3, p < 0.001), positive initial node status (HR 2.9-3.6, p < 0.01), and presence of sarcomatoid features (HR 3.7-6.9, p < 0.05) had a significant association with decreased OS, DFS and DSS. Patients who received adjuvant systemic therapy after IORT showed decreased DSS (HR 2.4, p = 0.03). When analyzing LR tumors alone, positive margin (HR 2.6, p = 0.01) was associated with decreased OS. Conclusions: We report on the largest known cohort of patients with RCC managed with IORT and we have identified factors associated with survival. Outcomes in our cohort with LR RCC treated with local resection and IORT compare favorably to similar groups treated with resection alone suggesting improved DSS may be possible with IORT.

Download Full-text

Randomized trial comparing an anterograde versus a retrograde approach to open radical prostatectomy: results in terms of positive margin rate

Canadian Urological Association Journal ◽

10.5489/cuaj.851 ◽

2013 ◽

Vol 4 (3) ◽

pp. 192

Author(s):

Alessandro Sciarra ◽

Cristiano Cristini ◽

Magnus Von Heland ◽

Stefano Salciccia ◽

Vincenzo Gentile

Keyword(s):

Specific Antigen ◽

Surgical Margin ◽

Positive Margin ◽

Patient Characteristics ◽

Radical Retropubic Prostatectomy ◽

Open Radical Prostatectomy ◽

Positive Margin Rate ◽

Pathological Review ◽

Group A ◽

Group B

Objectives: Surgical technique, patient characteristics and methodof pathological review may influence surgical margin (SM) status.Positive surgical margin (SM+) rates of 14% to 46% have beenreported in different radical retropubic prostatectomy (RRP) series.We evaluated the effect of an anterograde versus retrograde approachto RRP and specifically focused on the incidence of SM+.Methods: From January 2003 to November 2007, we randomlyassigned 200 patients with clinically localized prostate adenocarcinomasto undergo a retrograde (Group A) versus an anterograde(Group B) open RRP. All RRPs were performed at our institutionby 2 surgeons. For all 200 patients, we evaluated a panelof clinical and pathological variables relating to their associationwith SM status.Results: In Group A, 22% of cases after RRP showed a pT3 tumourand 39% of cases with a Gleason score ≥7 (4+3); in Group B,20% of cases showed a pT3 tumour and 37% of cases with aGleason score ≥7 (4+3) (p > 0.10). The incidence of SM+ was18% in Group A and 14% in Group B (p = 0.0320). In Group A,22.2% of cases with SM+ had multiple positive margins, whereasno cases in Group B showed multiple SM+. Regarding the localizationof SM+, no difference was found between the 2 groups.In the multivariate analysis, only prostate-specific antigen(p = 0.0090 and p = 0.0020, respectively in the 2 groups) andpathological stage (p < 0.0001 in both groups) were significantand independently associated with SM+ occurrence.Conclusion: In our experience, the anterograde approach to openRRP is associated with lower SM+ rates and no risk of multipleSM+ when compared with the retrograde approach.Objectifs : La technique chirurgicale, les caractéristiques du patientet la méthode d’examen pathologique peuvent tous avoir un impactsur le statut des marges chirurgicales. Des taux de marges chirurgicalespositives de 14 à 46 % ont été notés lors de différentesséries de prostatectomies radicales rétropubiennes (PRR). Nousavons évalué l’effet d’un abord antérograde ou rétrograde, plusprécisément sur l’incidence des marges chirurgicales positives.Méthodologie: Entre janvier 2003 et novembre 2007, nous avonschoisi au hasard 200 patients porteurs d’un adénocarcinome prostatiquecliniquement localisé pour qu’ils subissent une PRR ouverterétrograde (groupe A) ou antérograde (groupe B). Toutes les PRRont été réalisées à notre établissement par deux chirurgiens. Pourchacun des 200 patients, nous avons évalué un ensemble de variablescliniques et pathologiques quant à leur lien avec le statutdes marges chirurgicales.Résultats : Dans le groupe A, 22 % des patients présentaient unetumeur pT3 et 39 %, un score de Gleason ≥ 7 (4+3) après la PRR;dans le groupe B, 20 % des patients présentaient une tumeur pT3et 37 %, un score de Gleason ≥ 7 (4+3) (p > 0,10). L’incidencedes marges chirurgicales positives était de 18 % dans le groupeA et de 14 % dans le groupe B (p = 0,0320). Dans le groupe A,22,2 % des cas de marges chirurgicales positives étaient des casmultiples, tandis qu’aucun des patients du groupe B n’avaient demarges chirurgicales positives multiples. Aucune différence n’aété notée entre les deux groupes concernant l’emplacement desmarges positives. Dans l’analyse multivariée, seuls l’antigène prostatiquespécifique (p = 0,0090 et p = 0,0020, respectivement,dans les deux groupes) et le stade pathologique (p < 0,0001 dansles deux groupes) étaient significatifs et liés de façon indépendanteà la présence de marges chirurgicales positives.Conclusion: Selon nos observations, l’abord antérograde est lié àdes taux inférieurs de marges chirurgicales positives et à un risquenul de charges chirurgicales positives multiples, en comparaisonavec l’abord rétrograde.

Download Full-text

RESULTS OF TREATMENT OF LOCALLY RECURRING SOFT TISSUES SARCOMAS OF EXTREMITIES

Problems in oncology ◽

10.37469/0507-3758-2018-64-3-408-413 ◽

2018 ◽

Vol 64 (3) ◽

pp. 408-413

Author(s):

Grigoriy Zinovev ◽

Georgiy Gafton ◽

Sergey Novikov ◽

Ivan Gafton ◽

Yekaterina Busko ◽

...

Keyword(s):

Radiation Therapy ◽

Soft Tissues ◽

Cox Regression ◽

Disease Free Survival ◽

Tumor Location ◽

Long Term Results ◽

Clinical Feature ◽

National Medical ◽

Results Of Treatment ◽

Kaplan Meier

Background: The most striking clinical feature of soft tissues sarcomas (STS) is their ability to recur. At present disputes about the clinical and morphological factors of STS recurrence such as the degree of malignancy, size, location, depth of tumor location, patient’s age and the presence of previous relapses in the anamnesis do not subside. It also requires clarification of the effect of the volume of tissues removed on the long-term results of treatment of STS as well as indications for the application of various regimes of remote radiation therapy. Materials and methods: Of 1802 registered cases of STS of extremities at the N.N. Petrov National Medical Research Center of Oncology from 2004 to 2016 there were selected data on 213 patients who suffered from at least one relapse of the disease. There was performed an assessment of overall, non-metastatic and disease-free survival using a single-factor (the Kaplan-Meier method) and multivariate analysis (the Cox regression model). Conclusion: The detection of various prognostic factors of locally recurrent STS allows determining the necessary treatment tactics (the vastness and traumatism of surgery and the advisability of radiation therapy).

Download Full-text

Bioinformatics Analysis Identifies CPZ as a Tumor Immunology Biomarker For Gastric Cancer

Current Bioinformatics ◽

10.2174/1574893615999200707145643 ◽

2020 ◽

Vol 15 ◽

Author(s):

Yuan Gu ◽

Ying Gao ◽

Xiaodan Tang ◽

Huizhong Xia ◽

Kunhe Shi

Keyword(s):

Gastric Cancer ◽

T Cells ◽

Signaling Pathway ◽

Tumor Immunology ◽

Bioinformatics Analysis ◽

Human Cancer ◽

Disease Free Survival ◽

Kaplan Meier ◽

Potential Biomarker ◽

Pathway Regulation

Background: Gastric cancer (GC) is one of the most common malignancies worldwide. However, the biomarkers for the prognosis and diagnosis of Gastric cancer were still need. Objective: The present study aimed to evaluate whether CPZ could be a potential biomarker for GC. Method: Kaplan-Meier plotter (http://kmplot.com/analysis/) was used to determine the correlation between CPZ expression and overall survival (OS) and disease-free survival (DFS) time in GC [9]. We analyzed CPZ expression in different types of cancer and the correlation of CPZ expression with the abundance of immune infiltrates, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells, via gene modules using TIMER Database. Results: The present study identified that CPZ was overexpressed in multiple types of human cancer, including Gastric cancer. We found that overexpression of CPZ correlates to the poor prognosis of patients with STAD. Furthermore, our analyses show that immune infiltration levels and diverse immune marker sets are correlated with levels of CPZ expression in STAD. Bioinformatics analysis revealed that CPZ was involved in regulating multiple pathways, including PI3K-Akt signaling pathway, cGMP-PKG signaling pathway, Rap1 signaling pathway, TGF-beta signaling pathway, regulation of cell adhesion, extracellular matrix organization, collagen fibril organization, collagen catabolic process. Conclusion: This study for the first time provides useful information to understand the potential roles of CPZ in tumor immunology and validate it to be a potential biomarker for GC.

Download Full-text

Prognostic role of aberrant mTOR activation in patients with stage II and III colorectal cancer

Biomarkers in Medicine ◽

10.2217/bmm-2020-0141 ◽

2020 ◽

Vol 14 (12) ◽

pp. 1127-1137

Author(s):

Tong-Tong Zhang ◽

Yi-Qing Zhu ◽

Hong-Qing Cai ◽

Jun-Wen Zheng ◽

Jia-Jie Hao ◽

...

Keyword(s):

Colorectal Cancer ◽

Cox Regression ◽

Disease Free Survival ◽

Stage Ii ◽

Poor Prognostic Factor ◽

Cox Regression Analysis ◽

Kaplan Meier ◽

Potential Biomarker ◽

Risk Predictor

Aim: This study aimed to develop an effective risk predictor for patients with stage II and III colorectal cancer (CRC). Materials & methods: The prognostic value of p-mTOR (Ser2448) levels was analyzed using Kaplan–Meier survival analysis and Cox regression analysis. Results: The levels of p-mTOR were increased in CRC specimens and significantly correlated with poor prognosis in patients with stage II and III CRC. Notably, the p-mTOR level was an independent poor prognostic factor for disease-free survival and overall survival in stage II CRC. Conclusion: Aberrant mTOR activation was significantly associated with the risk of recurrence or death in patients with stage II and III CRC, thus this activated proteins that may serve as a potential biomarker for high-risk CRC.

Download Full-text

Lamin B1 promotes tumor progression and metastasis in primary prostate cancer patients

Future Oncology ◽

10.2217/fon-2020-0825 ◽

2020 ◽

Author(s):

Fei Luo ◽

Jiaxi Han ◽

Yatong Chen ◽

Kuo Yang ◽

Zhihua Zhang ◽

...

Keyword(s):

Prostate Cancer ◽

Tumor Progression ◽

Cancer Metastasis ◽

Disease Free Survival ◽

Free Survival ◽

Lamin B1 ◽

Kaplan Meier ◽

Primary Prostate Cancer ◽

Clinical Relationship

Aims: To determine the role of lamin B1 (LMNB1) in the progression and metastasis of primary prostate cancer (PC). Patients & methods: Two PC cohorts were used to investigate the clinical relationship between LMNB1 expression and tumor progression and metastasis. Results: The qRT-PCR results revealed that LMNB1 expression was markedly increased in patients with aggressive features and was associated with worse prognosis. Logistic regression analyses indicated that LMNB1 expression is an independent risk factor for distant metastasis. Kaplan–Meier analysis showed that increased LMNB1 levels were related to poor disease-free survival in the primary PC cohort. Conclusion: This study reveals that upregulation of LMNB1 is associated with cancer metastasis and poor survival outcomes in primary PC patients.

Download Full-text

Anaemia: A risk factor for death and adverse outcomes following surgery for acute lower limb ischaemia

Vascular ◽

10.1177/17085381211026167 ◽

2021 ◽

pp. 170853812110261

Author(s):

Daniel Perren ◽

Lauren Shelmerdine ◽

Luke Boylan ◽

Craig Nesbitt ◽

James Prentis ◽

...

Keyword(s):

Risk Factor ◽

Cox Model ◽

Univariate Analysis ◽

Adverse Outcomes ◽

Limb Ischaemia ◽

Risk Of Death ◽

Kaplan Meier ◽

Acute Limb Ischaemia ◽

Impact On Survival ◽

Poor Outcomes

Introduction Acute limb ischaemia (ALI) forms a significant part of the vascular surgery workload and carries with it high rates of morbidity and mortality. Anaemia is also common amongst vascular surgical patients and has been linked with poor outcomes in some subgroups. We aimed to assess the frequency of anaemia in patients with ALI and its impact on survival and complications following revascularisation to help direct future efforts to optimise outcomes in this patient group. Methods A retrospective analysis of prospectively collected departmental data on patients undergoing surgical intervention for ALI between 2014 and 2018 was performed. Anaemia was defined as a pre-operative haemoglobin (Hb) of <120 g/L for women and <130 g/L for men. The primary outcome was overall survival, assessed with the Kaplan–Meier estimator, with application of Cox proportional hazard modelling to adjust for confounding covariates. Results There were 158 patients who underwent treatment for ALI: 89 (56.3%) of these were non-anaemic with a mean Hb of 146 (SD = 18.4), and 69 (43.7%) were anaemic with a mean Hb of 106 (SD = 13.4). Anaemic patients had a significantly higher risk of death than their non-anaemic counterparts on univariate analysis (HR = 2.11, 95% CIs, 1.28–3.5, p = 0.0036). There was ongoing divergence in survival up to around 6 months between anaemic and non-anaemic groups. Under the Cox model, anaemia was similarly significant as a predictor of death (HR = 2.15, 95% CIs, 1.17–3.95, p = 0.013), accounting for recorded comorbidities, medication use and blood transfusion. Conclusions Anaemia is a significant and independent risk factor for death following revascularisation for ALI and can be potentially be modified. Vascular surgical centres should ensure they have robust pathways in place to identify and consider treating anaemia. There is scope for further work to assess how to best optimise a patient’s levels of circulating haemoglobin.

Download Full-text

Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients

Blood Purification ◽

10.1159/000513418 ◽

2021 ◽

pp. 1-8

Author(s):

Yuanhao Wu ◽

Fan Wang ◽

Tingting Wang ◽

Yin Zheng ◽

Li You ◽

...

Keyword(s):

Risk Factor ◽

Arteriovenous Fistula ◽

Independent Risk Factor ◽

Binding Protein ◽

Retinol Binding Protein ◽

Youden Index ◽

Serum Concentrations ◽

Retinol Binding Protein 4 ◽

Kaplan Meier ◽

Increased Risk

Background: Arteriovenous fistula (AVF) is the most common vascular access for patients undergoing hemodialysis (HD). Neointimal hyperplasia (NIH) might be a potential mechanism of AVF dysfunction. Retinol-binding protein 4 (RBP4) may play an important role in the pathogenesis of NIH. The aim of this study was to investigate whether AVF dysfunction is associated with serum concentrations of RBP4 in HD subjects. Methods: A cohort of 65 Chinese patients undergoing maintenance HD was recruited between November 2017 and June 2019. The serum concentrations of RBP4 of each patient were measured with the ELISA method. Multivariate logistic regression was used to analyze data on demographics, biochemical parameters, and serum RBP4 level to predict AVF dysfunction events. The cutoff for serum RBP4 level was derived from the highest score obtained on the Youden index. Survival data were analyzed with the Cox proportional hazards regression analysis and Kaplan-Meier method. Results: Higher serum RBP4 level was observed in patients with AVF dysfunction compared to those without AVF dysfunction events (174.3 vs. 168.4 mg/L, p = 0.001). The prevalence of AVF dysfunction events was greatly higher among the high RBP4 group (37.5 vs. 4.88%, p = 0.001). In univariate analysis, serum RBP4 level was statistically significantly associated with the risk of AVF dysfunction (OR = 1.015, 95% CI 1.002–1.030, p = 0.030). In multivariate analysis, each 1.0 mg/L increase in RBP4 level was associated with a 1.023-fold-increased risk of AVF dysfunction (95% CI for OR: 1.002–1.045; p = 0.032). The Kaplan-Meier survival analysis indicated that the incidence of AVF dysfunction events in the high RBP4 group was significantly higher than that in the low-RBP4 group (p = 0.0007). Multivariate Cox regressions demonstrated that RBP4 was an independent risk factor for AVF dysfunction events in HD patients (HR = 1.015, 95% CI 1.001–1.028, p = 0.033). Conclusions: HD patients with higher serum RBP4 concentrations had a relevant higher incidence of arteriovenous dysfunction events. Serum RBP4 level was an independent risk factor for AVF dysfunction events in HD patients.

Download Full-text