scholarly journals Long-GRIN-Lens Microendoscopy Enabled by Wavefront Shaping for a Biomedical Microdevice: An Analytical Investigation

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3392
Author(s):  
Guigen Liu ◽  
Jeon Woong Kang ◽  
Oliver Jonas
Keyword(s):  
Clinical Stage ◽  
Three Dimensional ◽  
Numerical Aperture ◽  
Diffraction Theory ◽  
Analytical Investigation ◽  
The Body ◽  
Phase Compensation ◽  
Graded Index ◽  
Grin Lens ◽  
Wavefront Shaping

We analytically investigate the feasibility of long graded-index (GRIN)-lens-based microendoscopes through wavefront shaping. Following the very well-defined ray trajectories in a GRIN lens, mode-dependent phase delay is first determined. Then, the phase compensation needed for obtaining diffraction limited resolution is derived. Finally, the diffraction pattern of the lens output is computed using the Rayleigh–Sommerfeld diffraction theory. We show that diffraction-limited resolution is obtained for a 0.5 mm diameter lens with a length over 1 m. It is also demonstrated that different imaging working distances (WDs) can be realized by modifying the phase compensation. When a short design WD is used, a large imaging numerical aperture (NA) higher than 0.4 is achievable even when a low NA lens (NA = 0.1) is used. The long- and thin-GRIN-lens-based microendoscope investigated here, which is attractive for biomedical applications, is being prioritized for use in a clinical stage microdevice that measures three-dimensional drug responses inside the body. The advance described in this work may enable superior imaging capabilities in clinical applications in which long and flexible imaging probes are favored.

Scanning electron microscopy of freeze-fractured prescapular lymph node of caprine

1984 ◽  
Vol 42 ◽  
pp. 244-245
Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Lymphatic System ◽  
Three Dimensional ◽  
Meat Products ◽  
The Body ◽  
Morphological Data ◽  
The World ◽  
Cellular Constituent ◽  
Scanning Electron

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.

Clinical Utility of an Exoskeleton Robot Using 3-Dimensional Scanner Modeling in Burn Patient: A Case Report

2021 ◽  
Author(s):  
So Young Joo ◽  
Seung Yeol Lee ◽  
Yoon Soo Cho ◽  
Sangho Yi ◽  
Cheong Hoon Seo
Keyword(s):  
Burn Injury ◽  
Hand Function ◽  
Three Dimensional ◽  
The Body ◽  
3D Technology ◽  
Early Management ◽  
3 Dimensional ◽  
Exoskeleton Robot ◽  
Physical Abilities ◽  
Upper Limb Dysfunction

Abstract Hands are the part of the body that are most commonly involved in burns, and the main complications are finger joint contractures and nerve injuries. Hypertrophic scarring cannot be avoided despite early management of acute hand burn injuries, and some patients may need application of an exoskeleton robot to restore hand function. To do this, it is essential to individualize the customization of the robot for each patient. Three-dimensional (3D) technology, which is widely used in the field of implants, anatomical models, and tissue fabrication, makes this goal achievable. Therefore, this report is a study on the usefulness of an exoskeleton robot using 3D technology for patients who lost bilateral hand function due to burn injury. Our subject was a 45-year-old man with upper limb dysfunction of 560 days after a flame and chemical burn injury, with resultant impairment of manual physical abilities. After wearing an exoskeleton robot made using 3D printing technology, he could handle objects effectively and satisfactorily. This innovative approach provided considerable advantages in terms of customization of size and reduction in manufacturing time and costs, thereby showing great potential for use in patients with hand dysfunction after burn injury.

scholarly journals H-plane horn antenna with enhanced directivity using conformal transformation optics

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hossein Eskandari ◽  
Juan Luis Albadalejo-Lijarcio ◽  
Oskar Zetterstrom ◽  
Tomáš Tyc ◽  
Oscar Quevedo-Teruel
Keyword(s):  
Conformal Transformation ◽  
Phase Error ◽  
Three Dimensional ◽  
Physical Space ◽  
Horn Antenna ◽  
High Gain ◽  
Transformation Optics ◽  
Graded Index ◽  
Low Profile ◽  
Dielectric Lens

AbstractConformal transformation optics is employed to enhance an H-plane horn’s directivity by designing a graded-index all-dielectric lens. The transformation is applied so that the phase error at the aperture is gradually eliminated inside the lens, leading to a low-profile high-gain lens antenna. The physical space shape is modified such that singular index values are avoided, and the optical path inside the lens is rescaled to eliminate superluminal regions. A prototype of the lens is fabricated using three-dimensional printing. The measurement results show that the realized gain of an H-plane horn antenna can be improved by 1.5–2.4 dB compared to a reference H-plane horn.

scholarly journals Metalens Eyepiece for 3D Holographic Near-Eye Display

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1920
Author(s):  
Chang Wang ◽  
Zeqing Yu ◽  
Qiangbo Zhang ◽  
Yan Sun ◽  
Chenning Tao ◽  
...  
Keyword(s):  
Light Field ◽  
Three Dimensional ◽  
Fresnel Diffraction ◽  
Virtual Image ◽  
Display Devices ◽  
Computer Generated Holography ◽  
Wavefront Shaping ◽  
3D Scene ◽  
Optimum Solution ◽  
532 Nm

Near-eye display (NED) systems for virtual reality (VR) and augmented reality (AR) have been rapidly developing; however, the widespread use of VR/AR devices is hindered by the bulky refractive and diffractive elements in the complicated optical system as well as the visual discomfort caused by excessive binocular parallax and accommodation-convergence conflict. To address these problems, an NED system combining a 5 mm diameter metalens eyepiece and a three-dimensional (3D), computer-generated holography (CGH) based on Fresnel diffraction is proposed in this paper. Metalenses have been extensively studied for their extraordinary capabilities at wavefront shaping at a subwavelength scale, their ultrathin compactness, and their significant advantages over conventional lenses. Thus, the introduction of the metalens eyepiece is likely to reduce the issue of bulkiness in NED systems. Furthermore, CGH has typically been regarded as the optimum solution for 3D displays to overcome limitations of binocular systems, since it can restore the whole light field of the target 3D scene. Experiments are carried out for this design, where a 5 mm diameter metalens eyepiece composed of silicon nitride anisotropic nanofins is fabricated with diffraction efficiency and field of view for a 532 nm incidence of 15.7% and 31°, respectively. Furthermore, a novel partitioned Fresnel diffraction and resample method is applied to simulate the wave propagations needed to produce the hologram, with the metalens capable of transforming the reconstructed 3D image into a virtual image for the NED. Our work combining metalens and CGH may pave the way for portable optical display devices in the future.

scholarly journals Virtual Archaeology of Death and Burial: A Procedure for Integrating 3D Visualization and Analysis in Archaeothanatology

2021 ◽  
Vol 7 (1) ◽  
pp. 540-555
Author(s):  
Hayley L. Mickleburgh ◽  
Liv Nilsson Stutz ◽  
Harry Fokkens
Keyword(s):  
Spatial Information ◽  
3D Visualization ◽  
Rapid Development ◽  
Three Dimensional ◽  
3D Models ◽  
The Body ◽  
Test Case ◽  
Archaeology Of Death ◽  
Human Burials ◽  
3D Information

Abstract The reconstruction of past mortuary rituals and practices increasingly incorporates analysis of the taphonomic history of the grave and buried body, using the framework provided by archaeothanatology. Archaeothanatological analysis relies on interpretation of the three-dimensional (3D) relationship of bones within the grave and traditionally depends on elaborate written descriptions and two-dimensional (2D) images of the remains during excavation to capture this spatial information. With the rapid development of inexpensive 3D tools, digital replicas (3D models) are now commonly available to preserve 3D information on human burials during excavation. A procedure developed using a test case to enhance archaeothanatological analysis and improve post-excavation analysis of human burials is described. Beyond preservation of static spatial information, 3D visualization techniques can be used in archaeothanatology to reconstruct the spatial displacement of bones over time, from deposition of the body to excavation of the skeletonized remains. The purpose of the procedure is to produce 3D simulations to visualize and test archaeothanatological hypotheses, thereby augmenting traditional archaeothanatological analysis. We illustrate our approach with the reconstruction of mortuary practices and burial taphonomy of a Bell Beaker burial from the site of Oostwoud-Tuithoorn, West-Frisia, the Netherlands. This case study was selected as the test case because of its relatively complete context information. The test case shows the potential for application of the procedure to older 2D field documentation, even when the amount and detail of documentation is less than ideal.

scholarly journals Petiole-Lamina Transition Zone: A Functionally Crucial but Often Overlooked Leaf Trait

Plants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 774
Author(s):  
Max Langer ◽  
Thomas Speck ◽  
Olga Speck
Keyword(s):  
Transition Zone ◽  
Three Dimensional ◽  
Spatial Arrangement ◽  
Body Plan ◽  
The Body ◽  
Vascular Bundles ◽  
Cross Sectional ◽  
Thin Sections ◽  
Transition Zones ◽  
The Cross

Although both the petiole and lamina of foliage leaves have been thoroughly studied, the transition zone between them has often been overlooked. We aimed to identify objectively measurable morphological and anatomical criteria for a generally valid definition of the petiole–lamina transition zone by comparing foliage leaves with various body plans (monocotyledons vs. dicotyledons) and spatial arrangements of petiole and lamina (two-dimensional vs. three-dimensional configurations). Cross-sectional geometry and tissue arrangement of petioles and transition zones were investigated via serial thin-sections and µCT. The changes in the cross-sectional geometries from the petiole to the transition zone and the course of the vascular bundles in the transition zone apparently depend on the spatial arrangement, while the arrangement of the vascular bundles in the petioles depends on the body plan. We found an exponential acropetal increase in the cross-sectional area and axial and polar second moments of area to be the defining characteristic of all transition zones studied, regardless of body plan or spatial arrangement. In conclusion, a variety of terms is used in the literature for describing the region between petiole and lamina. We prefer the term “petiole–lamina transition zone” to underline its three-dimensional nature and the integration of multiple gradients of geometry, shape, and size.

Design and fabrication of anisotropic textile brace for exerting corrective forces on spinal curvature

2021 ◽  
pp. 152808372110326
Author(s):  
Queenie Fok ◽  
Joanne Yip ◽  
Kit-lun Yick ◽  
Sun-pui Ng
Keyword(s):  
Medical Condition ◽  
Three Dimensional ◽  
Case Series ◽  
The Body ◽  
Spinal Curvature ◽  
Radiographic Examination ◽  
Interface Pressure ◽  
Pressure System ◽  
Case Series Study ◽  
Point Pressure

This study focuses on the fabrication of an anisotropic textile brace that exerts corrective forces based on the three-point pressure system to treat scoliosis, which is a medical condition that involves deformity of the spine. The design and material properties of the proposed anisotropic textile brace are discussed in detail here. A case series study with 5 scoliosis patients has been conducted to investigate the immediate in-brace effect and biomechanics of the proposed brace. Radiographic examination, three-dimensional scanning of the body and interface pressure measurements have been used to evaluate the immediate effect of the proposed brace on reducing the spinal curvature and asymmetry of the body contours and its biomechanics. The results show that the proposed brace on average reduces the spinal curvature by 11.7° and also increases the symmetry of the posterior trunk by 14.1% to 43.2%. The interface pressure at the corrective pad ranges from 6.0 to 24.4 kPa. The measured interface pressure shows that a sufficient amount of pressure has been exerted and a three-point pressure distribution is realized to reduce the spinal curvature. The obtained results indicate the effectiveness of this new approach which uses elastic textile material and a hinged artificial backbone to correct spinal deformity.

scholarly journals Digital-Based Healthy Bra Top Design That Promotes the Physical Activity of New Senior Women by Applying an Optimal Pressure

2021 ◽  
Vol 18 (9) ◽  
pp. 4651
Author(s):  
Kuengmi Choi ◽  
Jungil Jun ◽  
Youngshil Ryoo ◽  
Sunmi Park
Keyword(s):  
Physical Activity ◽  
Three Dimensional ◽  
Reduction Rate ◽  
The Body ◽  
Adult Women ◽  
Design Development ◽  
Design Elements ◽  
Body Form ◽  
Senior Women ◽  
Clothing Pressure

A bra use can reduce physiological and physical functions because of clothing pressure, which can be a problem for new senior women starting to lose physical function. The present study presents a bra top design development method for promoting new senior women’s physical activity by identifying problems related to bras’ effects on women’s health and minimizing clothing pressure. The analysis utilized the 3D scan data of 42 adult women (age range: 50s) from the 5th Size Korea Project. Bra top design elements were extracted based on new senior consumers’ needs. We developed an average wireframe reflecting the new senior’s physical characteristics, and a standard body form was developed through surface modeling. To produce a consumer-oriented bra with a body shaping effect and reduced clothing pressure that would not affect physical activities, a three-dimensional pattern was developed applying an optimal reduction rate of 80%. To verify the bra’s adequacy for the body form of new senior women, two market-available bras were selected and fit-compared to the developed product. The developed bra received higher expert appearance evaluation and 3D virtual clothing evaluation scores. This study is significant because by using virtual fitting technology, it provides foundational data to quantify the quality of fashion products.

scholarly journals Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shotaro Harada ◽  
Takao Imai ◽  
Yasumitsu Takimoto ◽  
Yumi Ohta ◽  
Takashi Sato ◽  
...  
Keyword(s):  
Eye Movement ◽  
Three Dimensional ◽  
Vertical Component ◽  
Inertial Force ◽  
Linear Acceleration ◽  
The Body ◽  
Body Axis ◽  
Gravitational Acceleration ◽  
Ocular Reflex ◽  
Translational Movement

AbstractIn the interaural direction, translational linear acceleration is loaded during lateral translational movement and gravitational acceleration is loaded during lateral tilting movement. These two types of acceleration induce eye movements via two kinds of otolith-ocular reflexes to compensate for movement and maintain clear vision: horizontal eye movement during translational movement, and torsional eye movement (torsion) during tilting movement. Although the two types of acceleration cannot be discriminated, the two otolith-ocular reflexes can distinguish them effectively. In the current study, we tested whether lateral-eyed mice exhibit both of these otolith-ocular reflexes. In addition, we propose a new index for assessing the otolith-ocular reflex in mice. During lateral translational movement, mice did not show appropriate horizontal eye movement, but exhibited unnecessary vertical torsion-like eye movement that compensated for the angle between the body axis and gravito-inertial acceleration (GIA; i.e., the sum of gravity and inertial force due to movement) by interpreting GIA as gravity. Using the new index (amplitude of vertical component of eye movement)/(angle between body axis and GIA), the mouse otolith-ocular reflex can be assessed without determining whether the otolith-ocular reflex is induced during translational movement or during tilting movement.

Generation of steady longitudinal vortices in hypersonic boundary layer

2013 ◽  
Vol 729 ◽  
pp. 702-731 ◽  
Author(s):  
A. I. Ruban ◽  
M. A. Kravtsova
Keyword(s):  
Boundary Layer ◽  
Flow Analysis ◽  
Three Dimensional ◽  
Viscosity Coefficient ◽  
Momentum Equation ◽  
The Body ◽  
Nonlinear Behaviour ◽  
Hypersonic Boundary Layer ◽  
Stagnation Temperature ◽  
Characteristic Distance

AbstractIn this paper we study the three-dimensional perturbations produced in a hypersonic boundary layer by a small wall roughness. The flow analysis is performed under the assumption that the Reynolds number, $R{e}_{0} = {\rho }_{\infty } {V}_{\infty } L/ {\mu }_{0} $, and Mach number, ${M}_{\infty } = {V}_{\infty } / {a}_{\infty } $, are large, but the hypersonic interaction parameter, $\chi = { M}_{\infty }^{2} R{ e}_{0}^{- 1/ 2} $, is small. Here ${V}_{\infty } $, ${\rho }_{\infty } $ and ${a}_{\infty } $ are the flow velocity, gas density and speed of sound in the free stream, ${\mu }_{0} $ is the dynamic viscosity coefficient at the ‘stagnation temperature’, and $L$ is the characteristic distance the boundary layer develops along the body surface before encountering a roughness. We choose the longitudinal and spanwise dimensions of the roughness to be $O({\chi }^{3/ 4} )$ quantities. In this case the flow field around the roughness may be described in the framework of the hypersonic viscous–inviscid interaction theory, also known as the triple-deck model. Our main interest in this paper is the nonlinear behaviour of the perturbations. We study these by means of numerical solution of the triple-deck equations, for which purpose a modification of the ‘skewed shear’ technique suggested by Smith (United Technologies Research Center Tech. Rep. 83-46, 1983) has been used. The technique requires global iterations to adjust the viscous and inviscid parts of the flow. Convergence of such iterations is known to be a major problem in viscous–inviscid calculations. In order to achieve improved stability of the method, both the momentum equation for the viscous part of the flow, and the equations describing the interaction with the flow outside the boundary layer, are treated implicitly in this study. The calculations confirm the fact that in this sort of flow the perturbations are capable of propagating upstream in the boundary layer, resulting in a perturbation field which surrounds the roughness on all sides. We found that the perturbations decay rather fast with the distance from the roughness everywhere except in the wake behind the roughness. We found that if the height of the roughness is small, then the perturbations also decay in the wake, though much more slowly than outside the wake. However, if the roughness height exceeds some critical value, then two symmetric counter-rotating vortices form in the wake. They appear to support themselves and grow as the distance from the roughness increases.

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