scholarly journals Spray Drying of Chitosan Acid Salts: Process Development, Scaling Up and Physicochemical Material Characterization

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 329
Author(s):  
Nilia de la Paz ◽  
Mirna Fernández ◽  
Orestes López ◽  
Caridad Garcia ◽  
Antonio Nogueira ◽  
...  
Keyword(s):  
Spray Drying ◽  
Air Temperature ◽  
Water Soluble ◽  
Industrial Scale ◽  
Process Conditions ◽  
Outlet Temperature ◽  
Drying Process ◽  
Polymer Backbone ◽  
Spray Dried ◽  
Acid Salts

We investigated a spray drying process for preparing water-soluble salts of high molecular weight chitosan (CH) intended for pharmaceutical excipient applications. CH was derived from chitin of marine lobster origin (Panulirus argus). The effects of organic acid (acetic or lactic acid) and the ratio (difference) of inlet/outlet air temperature (140/90 °C or 160/100 °C) on spray drying were studied. The yield of spray-dried CH salt powders ranged from 50% to 99% in laboratory and industrial-scale processes. The spray-dried dry powder of CH salts consisted of spherical agglomerated particles with an average diameter of 36.2 ± 7.0 µm (CH acetate) and 108.6 ± 11.5 µm (CH lactate). After dispersing the spray-dried CH salt powder samples in purified water, the mean particle sizes obtained for the CH acetate salts were 31.4 nm (batch A001), 33.0 nm (A002) and 44.2 nm (A003), and for the CH lactate salts 100.8 nm (batch L001), 103.2 nm (L002) and 121.8 nm (L003). The optimum process conditions for spray drying were found: an inlet air temperature of 160 ± 5 °C, an outlet temperature of 100 ± 5 °C and an atomizer disk rotational speed of 18,200 min−1. The X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) results confirmed the amorphous state of the CH salts. The 1H nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectra of CH acetate and lactate salts verified that the spray drying process does not affect the polymer backbone. In conclusion, both laboratory and industrial-scale spray drying methods for preparing water-soluble acid salts of CH are reproducible, and the physicochemical properties of the corresponding CH acid salts are uniform.

Synthesis of Cu-Coated Ni-Based Amorphous Composite Powders by Gas Atomization and Spray Drying Process

2007 ◽  
Vol 534-536 ◽  
pp. 133-136 ◽  
Author(s):  
Byoung Kee Kim ◽  
Yong Jin Kim ◽  
Jin Chun Kim
Keyword(s):  
Metallic Glass ◽  
Spray Drying ◽  
Water Soluble ◽  
Process Conditions ◽  
Gas Atomization ◽  
Initial Powder ◽  
Drying Process ◽  
Composite Powders ◽  
Atomization Process ◽  
Micron Size

Ni59Zr20Ti16Si2Sn3 bulk metallic glass (BMG) powders were produced by a gas atomization process, and ductile Cu powders were coated on the Ni-based BMG powders using a spray drying process in order to increase the ductility. Characteristics of the as-prepared powders with the atomization and spray drying process conditions were investigated. The atomization was conducted at 1450oC under the vacuum of 10-2 torr and the powders were mixed with water-soluble Cu nitrate. The mixture was sprayed at the temperature of 130oC to prepared initial powder. After reduction treatment, sub-micron size Cu powders were successfully coated on the surface of the atomized Ni BMG powders.

Effect of Formulations and Spray Drying Process Conditions on Physical Properties of Resveratrol Spray-Dried Emulsions

2019 ◽  
Vol 819 ◽  
pp. 246-251
Author(s):  
Pontip Benjasirimongkol ◽  
Suchada Piriyaprasarth ◽  
Pornsak Sriamornsak
Keyword(s):  
Particle Size ◽  
Moisture Content ◽  
Physical Properties ◽  
Spray Drying ◽  
Feed Rate ◽  
Water Soluble ◽  
Process Conditions ◽  
Box Behnken Design ◽  
Drying Conditions ◽  
Spray Dried

Spray-dried emulsion is one of the useful strategies to enhance dissolution properties of poorly water-soluble drug for example resveratrol. Physical properties i.e. particle size and moisture content of spray-dried emulsions could affect their quality attributes. In this study, Box-Behnken design was performed in order to determine effect of formulation and spray drying condition parameters i.e. feed rate on responses including particle size and moisture content of resveratrol spray-dried emulsions. The spray-dried emulsions were prepared by varying content of low-methoxyl pectin (LMP) and caprylic/capric glycerides (CCG) and sprayed at different feed rate. Box-Behnken design results reveled that the particle size of spray-dried emulsions was significantly influenced by the content of LMP, interactions between LMP and CCG, interactions between LMP and feed rate. LMP content showed positive relationships with the particle size. The content of CCG had negative significantly effect on moisture content of the spray-dried emulsion. Mathematical models describing the relationships between studied parameters and responses provided good predictability. Based on model, the optimal formulation was prepared using 2.6% w/w of LMP, 9% w/w of CCG, and feed rate of 6.8 mL/min and the small particle size (~5.9 μm) and low moisture content (~5.6%) were obtained. The spray-dried emulsions were successfully prepared with satisfy quality. The Box-Behnken design would be an effective tool to elucidate influence of formulation and spray drying conditions on particle size and moisture content of the spray-dried emulsions. Further, the design aided in developing and optimizing the spray-dried emulsions with specified quality.

scholarly journals Influence of Maltodextrin and Spray Drying Process Conditions on Sugarcane Juice Powder Quality

2015 ◽  
Vol 68 (1) ◽  
pp. 7509-7520 ◽  
Author(s):  
Esteban Largo Ávila ◽  
Misael Cortés Rodríguez ◽  
Héctor José Ciro Velásquez
Keyword(s):  
Spray Drying ◽  
Air Temperature ◽  
Fruits And Vegetables ◽  
Industrial Sector ◽  
Sugarcane Juice ◽  
Operating Conditions ◽  
Process Conditions ◽  
Drying Process ◽  
Food Powder ◽  
Central Composite

Food powder liquid extracts obtained from fruits and vegetables can be manufactured using spray drying technologies while maintaining the quality attributes that are required by the industrial sector. The aim of this study was to evaluate the effect of maltodextrin and spray drying process conditions on sugarcane juice powder. A central composite design was used with a response surface analysis of four factors: (A) maltodextrin (10-20%), (B) inlet air temperature (130-150 °C), (C) outlet air temperature (75-85 °C) and (D) atomization speed (22,000-26,000 rpm). Moisture, hygroscopicity, solubility, effective recovery and formation of deposits on the walls presented significant differences (P<0.05) with respect to all factors, while, for water activity, no statistical differences were observed. The optimization of the factors found for the drying operating conditions were: (A) 20%, (B) 130 °C, (C) 75 °C and (D) 22,000 rpm, respectively.

scholarly journals Effect of Spray Dryer Scale Size on the Properties of Dried Beetroot Juice

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6700
Author(s):  
Jolanta Gawałek
Keyword(s):  
Spray Drying ◽  
Industrial Process ◽  
Laboratory Scale ◽  
Industrial Scale ◽  
Process Conditions ◽  
Spray Dryer ◽  
Beetroot Juice ◽  
Centrifugal Atomization ◽  
Drying Conditions ◽  
Drying Efficiency

Experiments detailing the spray drying of fruit and vegetable juices are necessary at the experimental scale in order to determine the optimum drying conditions and to select the most appropriate carriers and solution formulations for drying on the industrial scale. In this study, the spray-drying process of beetroot juice concentrate on a maltodextrin carrier was analyzed at different dryer scales: mini-laboratory (ML), semi-technical (ST), small industrial (SI), and large industrial (LI). Selected physicochemical properties of the beetroot powders that were obtained (size and microstructure of the powder particles, loose and tapped bulk density, powder flowability, moisture, water activity, violet betalain, and polyphenol content) and their drying efficiencies were determined. Spray drying with the same process parameters but at a larger scale makes it possible to obtain beetroot powders with a larger particle size, better flowability, a color that is more shifted towards red and blue, and a higher retention of violet betalain pigments and polyphenols. As the size of the spray dryer increases, the efficiency of the process expressed in powder yield also increases. To obtain a drying efficiency >90% on an industrial scale, process conditions should be selected to obtain an efficiency of a min. of 50% at the laboratory scale or 80% at the semi-technical scale. Designing the industrial process for spray dryers with a centrifugal atomization system is definitely more effective at the semi-technical scale with the same atomization system than it is at laboratory scale with a two-fluid nozzle.

scholarly journals Enhancing antioxidant property of instant coffee by microencapsulation via spray drying

2018 ◽  
Author(s):  
Chaleeda Borompichaichartkul ◽  
Desi Sakawulan ◽  
Richard Archer
Keyword(s):  
Spray Drying ◽  
Air Temperature ◽  
Antioxidant Property ◽  
Konjac Glucomannan ◽  
Scavenging Activity ◽  
Instant Coffee ◽  
Dpph Scavenging Activity ◽  
Dpph Scavenging ◽  
Spray Dried ◽  
Better Than

This study is aimed to improve the antioxidant property of instant coffee by using microencapsulation technique and spray drying. Concentrated coffee extract was mixed with Konjac glucomannan hydrolysate (KGMH) and Maltodextrin (MD). The mixture of coating material and coffee extract was then spray dried at 160 - 180 °C inlet air temperature and at 85-90 °C outlet air temperature. KGMH can preserve retention of phenolic compounds, DPPH scavenging activity and antioxidant activity of FRAP (p&lt;0.05 of instrant coffee better than other treatment. Keywords: Hydrolysed Konjac Glucomannan; Spray Drying; Microencapsulation; Instant Coffee, Antioxidant 

scholarly journals Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material

2021 ◽  
Author(s):  
Aleksandra A. Jovanović ◽  
Steva M. Lević ◽  
Vladimir B. Pavlovic ◽  
Smilja B. Markovic ◽  
Rada V. Pjanovic ◽  
...  
Keyword(s):  
Spray Drying ◽  
Dry Weight ◽  
Drying Process ◽  
Scanning Calorimetry ◽  
Coating Agent ◽  
Microwave Assisted ◽  
Freeze Dried ◽  
Wild Thyme ◽  
The Impact ◽  
Spray Dried

Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 &micro;m) compared to small microspheres (~8 &micro;m) in spray-dried powder.

Microencapsulation of GuaLou Seed Oil by Spray Drying

2012 ◽  
Vol 554-556 ◽  
pp. 934-937
Author(s):  
Jian Yu ◽  
Xiang Hong Li ◽  
Yong Le Liu ◽  
Chi Ling Li
Keyword(s):  
Spray Drying ◽  
Air Temperature ◽  
Seed Oil ◽  
Core Material ◽  
Wall Material ◽  
Process Conditions ◽  
Arabic Gum ◽  
Solids Content ◽  
Drying Conditions ◽  
Best Parameters

The objective of this work was to study the influence of some process conditions on the microencapsulation of Gualou seed oil by spray drying. The results showed that the best parameters of microencapsulation were as follows: the ratio of arabic gum to maltodextrin was 1:1, and that of core material to wall material was 2:3; and the total solids content was 25%. The optimum spray drying conditions were that the air temperature of inlet was 180 °C, and that of outlet was 80 °C; the homogenizing pressure was 35MPa. The maximum microencapsulation efficiency was 86±0.95%.

scholarly journals Comparison of a Novel Miniaturized Screening Device with Büchi B290 Mini Spray-Dryer for the Development of Spray-Dried Solid Dispersions (SDSDs)

Processes ◽  
2018 ◽  
Vol 6 (8) ◽  
pp. 129 ◽  
Author(s):  
Aymeric Ousset ◽  
Joke Meeus ◽  
Florent Robin ◽  
Martin Schubert ◽  
Pascal Somville ◽  
...  
Keyword(s):  
Drug Loading ◽  
Solid Dispersions ◽  
Morphological Properties ◽  
Similar Process ◽  
Process Conditions ◽  
Outlet Temperature ◽  
Spray Dryer ◽  
Residual Solvent ◽  
Screening Device ◽  
Spray Dried

Spray-drying is an increasingly popular technology for the production of amorphous solid dispersions (ASDs) in the pharmaceutical industry that is used in the early evaluation and industrial production of formulations. Efficient screening of ASD in the earliest phase of drug development is therefore critical. A novel miniaturized atomization equipment for screening spray-dried solid dispersions (SDSDs) in early formulation and process development was developed. An in-depth comparison between the equipment/process parameters and performance of our novel screening device and a laboratory Büchi B290 mini spray-dryer was performed. Equipment qualification was conducted by comparing the particle/powder attributes, i.e., miscibility/solid state, residual solvent, and morphological properties of binary SDSDs of itraconazole prepared at both screening and laboratory scales. The operating mode of the miniaturized device was able to reproduce similar process conditions/parameters (e.g., outlet temperature (Tout)) and to provide particles with similar drug–polymer miscibility and morphology as laboratory-scale SDSDs. These findings confirm that the design and operation of this novel screening equipment mimic the microscale evaporation mechanism of a larger spray-dryer. The miniaturized spray-dryer was therefore able to provide a rational prediction of adequate polymer and drug loading (DL) for SDSD development while reducing active pharmaceutical ingredient (API) consumption by a factor of 120 and cycle time by a factor of 4.

scholarly journals DRYING OF THE NEW WATER-SOLUBLE POLYMER COMPLEX OF ALBENDAZOL WITH PECTIN

2021 ◽  
pp. 319-325
Author(s):  
Askar Sheralievich Abdurazakov
Keyword(s):  
Biological Activity ◽  
Spray Drying ◽  
Lethal Dose ◽  
Water Soluble ◽  
Hazardous Substances ◽  
High Yield ◽  
Solution Flow Rate ◽  
Polymer Complex ◽  
Drying Process ◽  
Water Soluble Polymer

The drying process of the aqueous solution of the complex of Albendazole with pectin (Alpec) in a vacuum oven and by spray drying was studied. It was found that the drying in a nozzle-type spray dryer is preferable in yield and subsequent solubility of the final product. As a result of the studying of the parameters affecting to the drying process, the optimal mode of the dryer was established, which provides the high yield of the dry product: the temperature of the coolant at the inlet is 130–140 °С, the output is 60–70 °С, the solution flow rate is 2.5 l/h·min. The yield of the dry product is 85%. The comparative IR spectra of Alpec powder after spray drying, after drying in air, the starting Albendazole and pectin unambiguously indicate that the structure of the complex of Albendazole with pectin (Alpec) is identical after different types of drying. The biological activity of Alpec dry substance after spray drying compared with Albendazole was studied. The increased biological activity of Alpec compared with Albendazole was established, which can, probably, be explained by the good water solubility of Alpec in contrast to Albendazole and, as a consequence, the increase of bioavailability of the drug. It was found that the average lethal dose of Alpec (LD50) is 680 (601.8–768.4) mg·kg-1 (LD50 Albendazole - 400.2–450.4 mg·kg-1), i.e. the drug "Alpec" in terms of acute toxicity during intragastric use is classified as moderately hazardous substances. On the base of the results obtained, the technology of the obtaining of the anthelmintic drug alpec substance in the form of a water-soluble dry powder has been developed.

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