scholarly journals DRYING OF THE NEW WATER-SOLUBLE POLYMER COMPLEX OF ALBENDAZOL WITH PECTIN

2021 ◽  
pp. 319-325
Author(s):  
Askar Sheralievich Abdurazakov
Keyword(s):  
Biological Activity ◽  
Spray Drying ◽  
Lethal Dose ◽  
Water Soluble ◽  
Hazardous Substances ◽  
High Yield ◽  
Solution Flow Rate ◽  
Polymer Complex ◽  
Drying Process ◽  
Water Soluble Polymer

The drying process of the aqueous solution of the complex of Albendazole with pectin (Alpec) in a vacuum oven and by spray drying was studied. It was found that the drying in a nozzle-type spray dryer is preferable in yield and subsequent solubility of the final product. As a result of the studying of the parameters affecting to the drying process, the optimal mode of the dryer was established, which provides the high yield of the dry product: the temperature of the coolant at the inlet is 130–140 °С, the output is 60–70 °С, the solution flow rate is 2.5 l/h·min. The yield of the dry product is 85%. The comparative IR spectra of Alpec powder after spray drying, after drying in air, the starting Albendazole and pectin unambiguously indicate that the structure of the complex of Albendazole with pectin (Alpec) is identical after different types of drying. The biological activity of Alpec dry substance after spray drying compared with Albendazole was studied. The increased biological activity of Alpec compared with Albendazole was established, which can, probably, be explained by the good water solubility of Alpec in contrast to Albendazole and, as a consequence, the increase of bioavailability of the drug. It was found that the average lethal dose of Alpec (LD50) is 680 (601.8–768.4) mg·kg-1 (LD50 Albendazole - 400.2–450.4 mg·kg-1), i.e. the drug "Alpec" in terms of acute toxicity during intragastric use is classified as moderately hazardous substances. On the base of the results obtained, the technology of the obtaining of the anthelmintic drug alpec substance in the form of a water-soluble dry powder has been developed.

scholarly journals Creation of New Analogues of Natural Phytogormons for Increasing the Yield of Agricultural Crops

2018 ◽  
Vol 7 (3.32) ◽  
pp. 59
Author(s):  
Zhylkybaev Oral ◽  
Alimzhanova Mereke ◽  
Ashimuly Kazhybek ◽  
Shoinbekova Sabina ◽  
Tukenova Zulfia
Keyword(s):  
Biological Activity ◽  
Growth Regulator ◽  
High Efficiency ◽  
Field Tests ◽  
Dry Mass ◽  
Water Soluble ◽  
High Yield ◽  
Small Scale ◽  
Wide Range ◽  
Reference Preparation

Synthesis of new potential plant growth regulators (analogues of natural phytohormones) is accomplished by mixing an equimolar mixture of aryloxypropin and 1-methylpiperidin-4-one under the conditions of Favorsky's reactions. New derivatives of acetylene aminoalcohols - the ZhOT series - have been obtained. The structure of the synthesized compounds was established by IR and NMR 1H spectroscopy. Screening of their water-soluble forms, on wheat and barley seeds, two preparations (ZhOT-4 and ZhOT-7) were selected, which exceed both the control and standards of known phytohormones, such as heteroauxin (indolyl-3-acetic acid), 6-BAP (6-benzylaminopurine) for further testing. Conducted in-depth laboratory and demonstration field tests on cereals (wheat and barley) showed high efficiency of ZhOT-4 and ZhOT-7, the indicators of which exceeded the well-known reference preparation - Agrostimulin (Ukraine). The growth regulating activity of synthesized compounds was determined. Processing of wheat seeds ZhOT-4 and ZhOT-7 increased the field germination of seeds, plant height, leaf area, the mass of the aerial part and the total area. The conducted studies showed that the biological activity of the tested compounds largely depends on the concentration and the best growth regulator is ZhOT-4. The activity of the synthesized growth regulatory compounds has been determined. Treatment of seeds of with ZhOT-4 and ZhOT-7 increased seed germination, height of plants, leave areas, weight of an elevated part and the total area, weight of an elevated part and the total area. Studies have shown that the biological activity of tested compounds is largely dependent on the concentration and the best growth regulator is ZhОТ-4. Thus, the advanced laboratory and demonstration (small-scale) comparative tests of ZhOT-4 and ZhOT-7 and the well-known reference preparation "Agrostimulin" (Ukraine) for cereals (wheat and barley) showed high efficiency of new synthesized preparations. The use of ZhOT preparations increases the germination and germination energy, the number of spikelets, the mass of grains, the bushiness and the yield of wheat and barley, leads to the accumulation of dry mass in both the ground and underground parts of plants. The advantages of ZhOT-4 and ZhOT-7 are: high efficiency, a wide range of cultures, good solubility in water, low application dose of 0.0001% by active ingredient (1g per 1t of water) or 13-50 mg per hectare, comparable to natural phytohormones, long shelf life, safety, high yield of target products, sequential 3-stage reaction in one reactor. 

Synthesis of Cu-Coated Ni-Based Amorphous Composite Powders by Gas Atomization and Spray Drying Process

2007 ◽  
Vol 534-536 ◽  
pp. 133-136 ◽  
Author(s):  
Byoung Kee Kim ◽  
Yong Jin Kim ◽  
Jin Chun Kim
Keyword(s):  
Metallic Glass ◽  
Spray Drying ◽  
Water Soluble ◽  
Process Conditions ◽  
Gas Atomization ◽  
Initial Powder ◽  
Drying Process ◽  
Composite Powders ◽  
Atomization Process ◽  
Micron Size

Ni59Zr20Ti16Si2Sn3 bulk metallic glass (BMG) powders were produced by a gas atomization process, and ductile Cu powders were coated on the Ni-based BMG powders using a spray drying process in order to increase the ductility. Characteristics of the as-prepared powders with the atomization and spray drying process conditions were investigated. The atomization was conducted at 1450oC under the vacuum of 10-2 torr and the powders were mixed with water-soluble Cu nitrate. The mixture was sprayed at the temperature of 130oC to prepared initial powder. After reduction treatment, sub-micron size Cu powders were successfully coated on the surface of the atomized Ni BMG powders.

The Effect of Processing Parameters Onpoly (Lactic Acid)/Poly(Ethylene Oxide)Bicomponentultrafine Fibersby Co-Electrospinning

2013 ◽  
Vol 701 ◽  
pp. 254-258 ◽  
Author(s):  
Suttipan Pavasupree ◽  
Kawee Srikulkit ◽  
Ratthapol Rangkupan
Keyword(s):  
Lactic Acid ◽  
Flow Rate ◽  
Applied Voltage ◽  
Water Soluble ◽  
Flow Rate Ratio ◽  
Poly Lactic Acid ◽  
Solution Flow Rate ◽  
Electrospinning Technique ◽  
Solution Flow ◽  
Water Soluble Polymer

Poly (lactic acid) (PLA)/polyethylene oxide (PEO) bicomponent fibers werefabricated by co-electrospinning technique in a side by side configuration. Effect of PEO concentration, PLA and PEO solution flow rate and an applied voltage on formation, size and morphology of the fibers were investigated. The results showed that the fibers size increased with increasing PEO concentration, PEO flow rate ratio and applied voltage. The composition of the fibers was confirmed by IR spectrum. Additionally, by pairing PEO, which is a water soluble polymer, with PLA, follow by PEO phase removal in water, a C-shaped ultrafine fiber was prepared.

scholarly journals Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1522 ◽  
Author(s):  
Marta Szekalska ◽  
Katarzyna Sosnowska ◽  
Anna Czajkowska-Kośnik ◽  
Katarzyna Winnicka
Keyword(s):  
Spray Drying ◽  
Drug Loading ◽  
Water Soluble ◽  
Cross Linking ◽  
Metformin Hydrochloride ◽  
Drying Process ◽  
Process Modification ◽  
Water Soluble Drug ◽  
Water Soluble Drugs ◽  
One Step

Alginate (ALG) cross-linking by CaCl2 is a promising strategy to obtain modified-release drug delivery systems with mucoadhesive properties. However, current technologies to produce CaCl2 cross-linked alginate microparticles possess major disadvantages, such as a poor encapsulation efficiency of water-soluble drugs and a difficulty in controlling the process. Hence, this study presents a novel method that streamlines microparticle production by spray drying; a rapid, continuous, reproducible, and scalable technique enabling obtainment of a product with low moisture content, high drug loading, and a high production yield. To model a freely water-soluble drug, metformin hydrochloride (MF) was selected. It was observed that MF was successfully encapsulated in alginate microparticles cross-linked by CaCl2 using a one-step drying process. Modification of ALG provided drug release prolongation—particles obtained from 2% ALG cross-linked by 0.1% CaCl2 with a prolonged MF rate of dissolution of up to 12 h. Cross-linking of the ALG microparticles structure by CaCl2 decreased the swelling ratio and improved the mucoadhesive properties which were evaluated using porcine stomach mucosa.

scholarly journals Synthesis and biological activity of water-soluble polymer complexes of arbidol

2009 ◽  
Vol 43 (10) ◽  
pp. 563-567 ◽  
Author(s):  
M. Yu. Eropkin ◽  
M. V. Solovskii ◽  
M. Yu. Smirnova ◽  
T. S. Bryazzhikova ◽  
T. M. Gudkova ◽  
...  
Keyword(s):  
Biological Activity ◽  
Water Soluble ◽  
Soluble Polymer ◽  
Polymer Complexes ◽  
Water Soluble Polymer

scholarly journals Spray Drying of Chitosan Acid Salts: Process Development, Scaling Up and Physicochemical Material Characterization

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 329
Author(s):  
Nilia de la Paz ◽  
Mirna Fernández ◽  
Orestes López ◽  
Caridad Garcia ◽  
Antonio Nogueira ◽  
...  
Keyword(s):  
Spray Drying ◽  
Air Temperature ◽  
Water Soluble ◽  
Industrial Scale ◽  
Process Conditions ◽  
Outlet Temperature ◽  
Drying Process ◽  
Polymer Backbone ◽  
Spray Dried ◽  
Acid Salts

We investigated a spray drying process for preparing water-soluble salts of high molecular weight chitosan (CH) intended for pharmaceutical excipient applications. CH was derived from chitin of marine lobster origin (Panulirus argus). The effects of organic acid (acetic or lactic acid) and the ratio (difference) of inlet/outlet air temperature (140/90 °C or 160/100 °C) on spray drying were studied. The yield of spray-dried CH salt powders ranged from 50% to 99% in laboratory and industrial-scale processes. The spray-dried dry powder of CH salts consisted of spherical agglomerated particles with an average diameter of 36.2 ± 7.0 µm (CH acetate) and 108.6 ± 11.5 µm (CH lactate). After dispersing the spray-dried CH salt powder samples in purified water, the mean particle sizes obtained for the CH acetate salts were 31.4 nm (batch A001), 33.0 nm (A002) and 44.2 nm (A003), and for the CH lactate salts 100.8 nm (batch L001), 103.2 nm (L002) and 121.8 nm (L003). The optimum process conditions for spray drying were found: an inlet air temperature of 160 ± 5 °C, an outlet temperature of 100 ± 5 °C and an atomizer disk rotational speed of 18,200 min−1. The X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) results confirmed the amorphous state of the CH salts. The 1H nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectra of CH acetate and lactate salts verified that the spray drying process does not affect the polymer backbone. In conclusion, both laboratory and industrial-scale spray drying methods for preparing water-soluble acid salts of CH are reproducible, and the physicochemical properties of the corresponding CH acid salts are uniform.

scholarly journals Optimization of Spray-Drying Process with Response Surface Methodology (RSM) for Preparing High Quality Graphene Oxide Slurry

Processes ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 1116
Author(s):  
Xingxing Ye ◽  
Yexun Shi ◽  
Liming Shen ◽  
Peng Su ◽  
Ningzhong Bao
Keyword(s):  
Response Surface Methodology ◽  
Graphene Oxide ◽  
Response Surface ◽  
Spray Drying ◽  
Average Particle Size ◽  
High Yield ◽  
Average Particle ◽  
Airflow Rate ◽  
Drying Process ◽  
High Quality

The “Drying-redissolution” method is promising for the industrial production of high-concentration well-dispersed graphene oxide slurry (GOS). As the potential key step in this method, the spray drying process requires a statistical investigation which guides the large-scale preparation of graphene oxide powder (GOP). This work systematically studies the effects of operating parameters, including nozzle airflow rate (439–895 L·h−1), atomization pressure (0.5–0.7 MPa), and liquid feed rate (3.0–9.0 mL·min−1), by using the response surface methodology integrated Box–Behnken design (RSM–BBD), aiming to produce GOP with high yield and easy re-dispersion. The optimized spray drying condition is predicted to be 439 L·h−1, 0.59 MPa, and 9.0 mL·min−1, at which a powder yield of 70.45% can be achieved. The experimentally obtained GOP has an average particle size of 11.65 μm and the low crumpling degree of the particle morphology results in the good re-dispersibility (97.95%) and excellent adsorption performance (244.1 mg·g−1) of GOP. The GOS prepared by the spray-dried GOP possess low viscosity and high exfoliation efficiency with a single-layer fraction up to 90.8%, exhibiting good prospects for application. This work first applied the RSM–BBD model on the spray drying process of GO, and evidenced the possibility of producing high-quality GO slurry with the “drying-redissolution” method.

Neurotoxicity and Neuroprotective Effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2)

2011 ◽  
Vol 8 (2) ◽  
pp. 33
Author(s):  
Norfaezah Mazalan ◽  
Mazatulikhma Mat Zain ◽  
Nor Saliyana Jumali ◽  
Norhanim Mohalid ◽  
Zurina Shaameri ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Drug Delivery Systems ◽  
Neuronal Cells ◽  
Water Soluble ◽  
Brain Delivery ◽  
Specific Therapy ◽  
Neuroprotective Effects ◽  
Water Soluble Polymer ◽  
Site Specific ◽  
Novel Drugs

Recently, research and development in the field of drug delivery systems (DDS) facilitating site-specific therapy has reached significant progression. DDS based on polymer micelles, coated micro- and nanoparticles, and various prodrug systems including water-soluble polymer have been prepared and extensively studied as novel drugs designed for cancer chemotherapy and brain delivery. Since polymers are going to be used in human, this study has the interest of testing two types of polymer, polyimides (PI) and polyphenylenevinylene (PPV) on neuronal cells. The objective of this study was to determine the possible neurotoxicity and potential neuroprotective effects of PI and PPV towards SH-SY5Y neuronal cells challenged by hydrogen peroxide (H2O2) as an oxidant. Cells were pretreated with either PI or PPV for 1 hour followed by incubation for 24 hour with 100 µM of H2O2. MTS assay was used to assess cell viability. Results show that PI and PPV are not harmful within the concentration up to 10 µM and 100 µM, respectively. However, PI and PPV do not protect neuronal cells against toxicity induced by H2O2 or further up the cell death.

scholarly journals Self-Healing Polymer-Clay Hybrids by Facile Complexation of a Waterborne Polymer with a Clay

2021 ◽  
Author(s):  
Aranee Pleng Teepakakorn ◽  
Makoto Ogawa
Keyword(s):  
Vinyl Alcohol ◽  
Aqueous Media ◽  
Water Soluble ◽  
Poly Vinyl Alcohol ◽  
Self Healing ◽  
Soluble Polymer ◽  
Water Soluble Polymer ◽  
Smectite Clay

Water-induced self-healing materials were prepared by the hybridization of a water-soluble polymer, poly(vinyl alcohol), with a smectite clay by mixing in an aqueous media and subsequent casting. Without using chemical...

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