scholarly journals Development and Improvement of an Effective Method for Air and Surfaces Disinfection with Ozone Gas as a Decontaminating Agent

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 578
Author(s):  
Giuseppina Moccia ◽  
Francesco De Caro ◽  
Concetta Pironti ◽  
Giovanni Boccia ◽  
Mario Capunzo ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Threshold Value ◽  
Low Risk ◽  
Clinical Settings ◽  
Microbial Count ◽  
Hospital Infections ◽  
Air Treatment ◽  
Hospital Environments ◽  
Before And After ◽  
Selection Of

Background and objectives: Ozone has been one of the most investigated and discussed sanitization methods. This paper reports a procedure to sanitize air hospital environments, in particular chirurgical surgery rooms that require high levels of disinfection. The purpose of this work was the development and implementation of a cleansing and sanitizing procedure for critical clinical settings with ozone, to prevent hospital infections by the elimination of all toxic and harmful microorganisms in the air, and ensure safe use for operators and patients. Materials and Methods: The protocol for the study involved a structured selection of a representative environment of healthcare structures such as high, medium, and low-risk settings in air and examples of hospital furniture. Results: The concentration of ozone was measured during sanitization treatment and the estimation of the total microbial count in the air and on different surfaces before and after the sanitization operations was performed. The results demonstrated a significant reduction in the microbial count that always fell below the threshold value. Conclusions: Currently, there are no air treatment strategies available for inactivating airborne organisms during hospital outbreaks, which is most probably due to the lack of approved protocols.

scholarly journals The influence of microclimate conditions on ozone disinfection efficacy in working places

2021 ◽  
Author(s):  
Concetta Pironti ◽  
Giuseppina Moccia ◽  
Oriana Motta ◽  
Giovanni Boccia ◽  
Gianluigi Franci ◽  
...  
Keyword(s):  
Threshold Value ◽  
Environmental Safety ◽  
Microbial Count ◽  
International Studies ◽  
Indoor Environments ◽  
Prevention Measures ◽  
Hospital Environments ◽  
Individual Protection ◽  
Microclimate Conditions ◽  
Ozone Disinfection

AbstractIn recent years, the sanitization of environments, devices, and objects has become mandatory to improve human and environmental safety, in addition to individual protection and prevention measures. International studies considered ozone one of the most useful and easy sanitization methods for indoor environments, especially hospital environments that require adequate levels of disinfection. The purpose of this work was to evaluate the microclimate influence on sanitizing procedure for indoor settings with ozone, to prevent infections and ensure the safe use of the environments. The concentration of ozone was measured during sanitization treatment and estimation of microorganisms’ survival on the air and different contaminated plates after the sanitization operations were performed. The results demonstrated a significant reduction in the microbial count that always fell below the threshold value in different conditions of distance, temperature, and relative humidity.

scholarly journals A microfluidic device enabling drug resistance analysis of leukemia cells via coupled dielectrophoretic detection and impedimetric counting

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yağmur Demircan Yalçın ◽  
Taylan Berkin Töral ◽  
Sertan Sukas ◽  
Ender Yıldırım ◽  
Özge Zorlu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
K562 Cells ◽  
Leukemia Cells ◽  
Drug Resistant ◽  
Wild Type ◽  
Gene Expressions ◽  
Before And After ◽  
The Difference ◽  
Selection Of ◽  
Resistant Cells

AbstractWe report the development of a lab-on-a-chip system, that facilitates coupled dielectrophoretic detection (DEP-D) and impedimetric counting (IM-C), for investigating drug resistance in K562 and CCRF-CEM leukemia cells without (immuno) labeling. Two IM-C units were placed upstream and downstream of the DEP-D unit for enumeration, respectively, before and after the cells were treated in DEP-D unit, where the difference in cell count gave the total number of trapped cells based on their DEP characteristics. Conductivity of the running buffer was matched the conductivity of cytoplasm of wild type K562 and CCRF-CEM cells. Results showed that DEP responses of drug resistant and wild type K562 cells were statistically discriminative (at p = 0.05 level) at 200 mS/m buffer conductivity and at 8.6 MHz working frequency of DEP-D unit. For CCRF-CEM cells, conductivity and frequency values were 160 mS/m and 6.2 MHz, respectively. Our approach enabled discrimination of resistant cells in a group by setting up a threshold provided by the conductivity of running buffer. Subsequent selection of drug resistant cells can be applied to investigate variations in gene expressions and occurrence of mutations related to drug resistance.

scholarly journals Monotonic Functions Method and Its Application to Staging of Patients with Prostate Cancer According to Pretreatment Data

2021 ◽  
Vol 11 (9) ◽  
pp. 3836
Author(s):  
Valeri Gitis ◽  
Alexander Derendyaev ◽  
Konstantin Petrov ◽  
Eugene Yurkov ◽  
Sergey Pirogov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Learning Algorithm ◽  
Binary Classification ◽  
Preoperative Staging ◽  
Threshold Value ◽  
Logical Function ◽  
Adequate Treatment ◽  
Monotonic Functions ◽  
Selection Of

Prostate cancer is the second most frequent malignancy (after lung cancer). Preoperative staging of PCa is the basis for the selection of adequate treatment tactics. In particular, an urgent problem is the classification of indolent and aggressive forms of PCa in patients with the initial stages of the tumor process. To solve this problem, we propose to use a new binary classification machine-learning method. The proposed method of monotonic functions uses a model in which the disease’s form is determined by the severity of the patient’s condition. It is assumed that the patient’s condition is the easier, the less the deviation of the indicators from the normal values inherent in healthy people. This assumption means that the severity (form) of the disease can be represented by monotonic functions from the values of the deviation of the patient’s indicators beyond the normal range. The method is used to solve the problem of classifying patients with indolent and aggressive forms of prostate cancer according to pretreatment data. The learning algorithm is nonparametric. At the same time, it allows an explanation of the classification results in the form of a logical function. To do this, you should indicate to the algorithm either the threshold value of the probability of successful classification of patients with an indolent form of PCa, or the threshold value of the probability of misclassification of patients with an aggressive form of PCa disease. The examples of logical rules given in the article show that they are quite simple and can be easily interpreted in terms of preoperative indicators of the form of the disease.

scholarly journals Validation of the Zwolle score for selection of very low-risk STEMI patients treated with primary angioplasty

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Cordero ◽  
B Cid ◽  
P Monteiro ◽  
J.M Garcia-Acuna ◽  
M Rodriguez-Manero ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Risk Score ◽  
Mortality Risk ◽  
Area Under The Curve ◽  
Coronary Intervention ◽  
Low Risk ◽  
Individual Risk ◽  
Care Organization ◽  
Grace Score ◽  
Selection Of

Abstract Background The Zwolle risk score was designed to stratify the actual in-hospital mortality risk of ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (p-PCI) but, also, for decision-making related to patients location in an intensive care unit or not. Since the GRACE score continues being the gold-standard for individual risk assessment in STEMI in most institutions we assessed the specificity of both scores for in-hospital mortality. Methods We assessed the accuracy of Zwolle risk score for in-hospital mortality estimation as compared to the GRACE score in all patients admitted for STEMI in 3 tertitary hospitals. Patients with Zwolle risk score <3 would qualify as “low risk”, 3–5 as “intermediate risk” and ≥6 as “high risk”. Patients with GRACE score <140 were classified as low-risk. Specificity, sensitivity and classification were assessed by ROC curves and the area under the curve (AUC). Results We included 4,446 patients, mean age 64.7 (13.6) years, 24% women and 39% with diabetes. Mean GRACE score was 157.3 (4.9) and Zwolle was 2.8 (3.3). In-hospital mortality was 10.6% (471 patients). Patients who died had higher GRACE score (218.4±4.9 vs. 149.6±37.5; p<0.001) and Zwolle score (7.6±4.3 vs. 2.3±2.18; p<0.001); a statistically significant increase of in-hospital mortality risk, adjusted adjusted by age, gender and revascularization, was observed with both scores (figure). A total of 1,629 patients (40.0%) were classified as low risk by the GRACE score and 2,962 (66.6%) by the Zwolle score; in-hospital mortality was 1.6% and 2.7%, respectively. Moreover, the was a significant increase of in-hospital mortality rate according to Zwolle categories (2.7%; 13.0%; 41.6%)The AUC of both score was the same (p=0.49) but the specificity of GRACE score <140 was 43.1% as compared to 72.6% obtained by Zwolle score <3; patients accurately classified was also lower with the GRACE score threshold (48.8% vs. 73.7%). Conclusions Selection of low-risk STEMI patients treated with p-PCI based on the Zwolle risk score has higher specificity than the GRACE score and might be useful for the care organization in clinical practice. Funding Acknowledgement Type of funding source: None

Manufacturing of LSAW Pipes Using Hot Rolled Sheets for Sour-Service Application

2021 ◽  
Author(s):  
Rajesh Kumar Goyal ◽  
Mahesh Gajjar ◽  
Ashok Joshi ◽  
Anupkumar Tamhane
Keyword(s):  
Steel Mill ◽  
Corrosion Resistant ◽  
Behavioural Changes ◽  
H2s Corrosion ◽  
Before And After ◽  
Service Application ◽  
Hot Rolled ◽  
Sour Service ◽  
Geographical Locations ◽  
Selection Of

Abstract The exploration and transportation of fluids from corrosive fields or reserves demand corrosion-resistant pipelines. The pipelines for sour-service application demand higher resistance to H2S corrosion because of higher sulphur content observed in the geographical locations. The pipelines laid in the corrosive and marshy lands demand high wall thickness to allow for wall thinning due to corrosion. The linepipes manufactured using TMCP plates are widely accepted for sour-service applications. The use of cut-to-length sheets from hot rolled coils for the manufacturing of LSAW pipes is economical but having limited acceptance by the pipeline operators. Welspun took an initiative to develop the linepipes for an onshore sour-service application using API 5L X60MS grade cut-to-length sheets from TMCP hot rolled coils procured from an approved steel mill. The LSAW pipes of 24” OD × 14.27 mm WT were manufactured by the JCO-E press at Welspun Pipes Mill in Anjar-Gujarat-India. The experience of 24”OD × 14.30 mm WT, API 5L X60MO grade pipes manufacturing using TMCP plates procured from another approved steel mill, was used to decide factors such as alloy design, cleanliness, strength, DWTT, hardness, HIC, SSCC, CVN for the selection of cut-to-length sheets. This paper deals with sheet-to-pipe behavioural changes in properties before and after cold mechanical expansion. Wherever possible, the comparison was also made with plate-pipe behavioural changes in properties.

Strategies for Risk-Adapted Therapy in Myeloma

Hematology ◽  
2007 ◽  
Vol 2007 (1) ◽  
pp. 304-310 ◽  
Author(s):  
Rafael Fonseca
Keyword(s):  
Treatment Strategies ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Disease Biology ◽  
Patient Will ◽  
Baseline Knowledge ◽  
The Individual ◽  
Limited Duration ◽  
Cell Support ◽  
Selection Of

AbstractIt is clear that the clinical heterogeneity of multiple myeloma (MM) is dictated, in large part, by disease biology, predominantly genetics.1 As novel therapeutics have emerged, and augmented our treatment armamentarium against the disease, it is increasingly important to introduce a risk-adapted approach for the optimal management of patients.2 The selection of ideal candidates for high-dose chemotherapy with stem cell support (HDT) and maintenance will undoubtedly have to include baseline knowledge of the genetic nature of the individual. The limited duration of responses after HDT for patients with t(4;14)(p16;q32), t(14;16)(q32;q23) and 17p13 deletions highlight the need to develop a risk-adapted treatment strategy.3–5 Novel ways of determining outcome such as the use of gene expression profiling have demonstrated differentiating capabilities not previously observed.6 Likewise, the order of introduction of novel therapeutic agents (during induction and in the relapsing patient) will be potentially directed by similar information. As we have previously stated, MM is not only multiple but also “many.”7 Accordingly, treatment strategies will be tailored based on risk determination, genetic composition and host features.

Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis

2008 ◽  
Vol 100 (10) ◽  
pp. 693-698 ◽  
Author(s):  
Michael Buerke ◽  
Sebastian Schubert ◽  
Iris Reindl ◽  
Thomas Michel ◽  
Baerbel Hauroeder ◽  
...  
Keyword(s):  
Unfractionated Heparin ◽  
Continuous Infusion ◽  
Treatment Strategies ◽  
In Vitro Study ◽  
Coronary Intervention ◽  
Thrombin Inhibitor ◽  
P Value ◽  
Cardiac Catheter ◽  
Before And After

SummaryBivalirudin, a direct thrombin inhibitor binds specifically and reversibly to both fibrin-bound and unbound thrombin. Bivalirudin is approved for use as an anticoagulant in patients undergoing percutaneous coronary intervention. The OASIS-5 trial presented a significant increase in cardiac catheter thrombosis for the pentasaccharid fondaparinux compared to enoxaparin. Catheter thrombosis has never been reported in any trial using bivalirudin. Our study compared the development of catheter thrombosis for bivalirudin, enoxaparin, and unfractionated heparin in a controlled in-vitro environment. Ten healthy male volunteers were pretreated with aspirin 500 mg 2 hours before venesection of 50 ml of blood. The seven groups of anticoagulant combinations tested were:UFH, UFH + eptifibatide, enoxaparin, enoxaparin + eptifibatide, bivalirudin bolus, bivalirudin + eptifibatide, bivalirudin bolus + continuous infusion. The blood/anticoagulant mix continuously circulated through a cardiac guiding catheter for 60 minutes or until the catheter became blocked with thrombus. Thrombus development was assessed by weighing each catheter before and after the procedure. Electron microscopy was used to quantify the degree of erythrocyte, platelet and fibrin deposition. Following anticoagulation with bolus dose bivalirudin, the catheter was invariably occluded with thrombus after 33 minutes of circulation. However, a continuous infusion of Bivalirudin prevented the development of occlusive catheter thrombosis. In the bolus bivalirudin group the mean thrombus weight was significantly greater than in all other groups (p-value < 0.01 in all analyses). Bivalirudin given as a bolus was not sufficient to prevent cardiac catheter thrombosis in our in-vitro study. However, a continuous infusion of bivalirudin had similar anti-thrombotic efficacy compared to other treatment strategies.

scholarly journals PENERAPAN METODE BERMAIN PERAN MAKRO TERHADAP KEMAMPUAN BERBICARA

Instruksional ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 9
Author(s):  
Nirwana Nirwana
Keyword(s):  
Statistical Analysis ◽  
Role Playing ◽  
Wilcoxon Test ◽  
Control Group ◽  
Observation Data ◽  
Group Data ◽  
Before And After ◽  
Group B ◽  
Nonparametric Statistical ◽  
Selection Of

Effect of  role playing macro methods on children's speaking ability in group B in Nurul Rohmah Bekasi. This research is motivated by the lack of ability to speak children. This is because the method used in the learning process is more likely to use conventional methods. The selection of methods to role playing macro so that children can be motivated and interested in learning and can stimulate the ability to speak children. The population in this study were all children of group B in kindergarten Nurul Rohmah while the study sample was B3 group 11 children for the experimental group and B1 group 11 children for the control group. Data collection techniques through test techniques, and observation. Data analysis techniques used were descriptive statistical analysis and nonparametric statistical analysis. Based on the results of the Wilcoxon test calculation, the calculated T value is 66 and T table 11 then the results obtained T count (66)> T table (11) H1 is accepted and Ho is rejected means that there is an effect of role playing macro  methods on children's speaking ability. Whereas the calculated Z value obtained is 2.93 and 1.645 table Z then the result of Z arithmetic (2.93)> Z table (1.645) H1 is accepted and Ho is rejected which means that there is an effect of role playing macro method on children's speaking ability. These results indicate that there is a change in the value of the child's speaking ability before and after getting learning based on the role playing macro method.

scholarly journals Sistem Pendukung Keputusan Pemilihan Mobil Bekas Menggunakan Metode Analythical Hierarchy Process

2021 ◽  
Vol 3 (2) ◽  
pp. 380-386
Author(s):  
Gushelmi Gushelmi ◽  
Dodi Guswandi
Keyword(s):  
Selection Process ◽  
Threshold Value ◽  
Internet Technology ◽  
A Value ◽  
Used Cars ◽  
Hierarchy Process ◽  
Selection Of ◽  
Comparison Data

Showroom Ragasa Motor Padang is a showroom that sells various types of used cars. The old system of selecting used cars in The Ragasa Motor Padang Showroom is that customers come directly to the address of this Showroom and the selection process is still done by manual means. With the development of internet technology today is increasing rapidly and in order to be accessible to everyone, the AHP can do a comparison of the criteria in pairs on the selection of used cars and can determine the consistency of the comparison data paired with a threshold value of < 0.1. The purpose of this research is to make it easier for customers to choose used cars quickly and accurately, as well as the application of programs used to make it easier for customers to use them. The result of this study is the SPK System that was built to be able to take the decision of the selection of used cars in the Showroom Ragasa Motor Padang with the selection of the 2nd alternative with a value of 2.55 as the best choice.

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