scholarly journals Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1609
Author(s):  
Lutfun Nahar ◽  
Shaymaa Al-Majmaie ◽  
Afaf Al-Groshi ◽  
Azhar Rasul ◽  
Satyajit D. Sarker
Keyword(s):  
Medicinal Plant ◽  
Critical Appraisal ◽  
Therapeutic Potential ◽  
Therapeutic Agents ◽  
Review Article ◽  
Natural Distribution ◽  
Antiplatelet Aggregation ◽  
Ruta Chalepensis ◽  
The Family ◽  
Novel Therapeutic

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.

scholarly journals Coumarin sulfonamide derivatives: An emerging class of therapeutic agents

2020 ◽  
Vol 26 (1) ◽  
pp. 46-59 ◽  
Author(s):  
Ali Irfan ◽  
Laila Rubab ◽  
Mishbah Ur Rehman ◽  
Rukhsana Anjum ◽  
Sami Ullah ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Structural Features ◽  
Therapeutic Agents ◽  
Review Article ◽  
Structural Motif ◽  
Structure Activity ◽  
Anti Cancer ◽  
Novel Therapeutic

AbstractCoumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.

scholarly journals A review on phytochemical and ethnopharmacological studies of Ajuga Bracteosa Wall. Ex Benth.

2019 ◽  
Vol 9 (2) ◽  
pp. 489-492
Author(s):  
Tabasum Ali ◽  
Zahida Shah ◽  
Rabiah Bashir
Keyword(s):  
Therapeutic Potential ◽  
Iridoid Glycosides ◽  
Herbal Medicines ◽  
Review Article ◽  
Pharmacological Activities ◽  
Cardiotonic Activity ◽  
Traditional System ◽  
The Family ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds

Herbal medicines as the major remedy in traditional system of medicine have been used in medical practices since antiquity. The plants of genus Ajuga are evergreen, clump-forming rhizomatous perennial or annual herbaceous flowering species, with Ajuga being one of the 266 genera of the family Lamiaceae. There are at least 301 species of the genus Ajuga with many variations. Ajugabracteosa Wall. ex Benth (A. bracteosa) is an important medicinal plant of Himalaya regions. Medicinal potential is due to presence of of various pharmacologically active compounds such as neo-clerodane diterpenoids, flavonol glycosides, iridoid glycosides, ergosterol-5,8- endoperoxide and phytoecdysones. The aim of this review article was to gather information about A. bracteosa which is currently scattered in form of various publications. This review article tried to attract the attention from people for therapeutic potential of A. bracteosa. The present review comprises upto date information of,traditional uses, botanical aspects, active ingredients and pharmacological activities such as antitumor, antimicrobial, antimalarial, anti-inflammatory, cardiotonic activity, antiarthritic activity, antioxidant activity . A large variety of compounds have so far been isolated from Ajuga bracteosa. Keywords:  Ajuga bracteosa, Herbal medicines, pharmacological activities.

scholarly journals Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review

2019 ◽  
Vol 20 (6) ◽  
pp. 1461 ◽  
Author(s):  
Tomonari Kinoshita ◽  
Taichiro Goto
Keyword(s):  
Lung Cancer ◽  
Pulmonary Fibrosis ◽  
Molecular Mechanisms ◽  
Survival Rates ◽  
Therapeutic Agents ◽  
Review Article ◽  
Specific Form ◽  
Optimal Management ◽  
Current State ◽  
Novel Therapeutic

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and limited to the lungs. Despite the increasing research interest in the pathogenesis of IPF, unfavorable survival rates remain associated with this condition. Recently, novel therapeutic agents have been shown to control the progression of IPF. However, these drugs do not improve lung function and have not been tested prospectively in patients with IPF and coexisting lung cancer, which is a common comorbidity of IPF. Optimal management of patients with IPF and lung cancer requires understanding of pathogenic mechanisms and molecular pathways that are common to both diseases. This review article reflects the current state of knowledge regarding the pathogenesis of pulmonary fibrosis and summarizes the pathways that are common to IPF and lung cancer by focusing on the molecular mechanisms.

scholarly journals Phytochemical and Therapeutic Potential of Alstonia scholaris R. Br.- A Magical Traditional Plant

2021 ◽  
pp. 41-51
Author(s):  
Neeraj Bainsal ◽  
Pratibha Aggarwal ◽  
Kundan Singh Bora
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Health Condition ◽  
Pharmacological Properties ◽  
Alstonia Scholaris ◽  
The Family ◽  
Ancient Times ◽  
Phytochemical Constituents ◽  
Important Medicinal Plant

Alstonia scholaris R.Br. commonly known as devil tree is a potential medicinal plant belongs to the family Apocynaceae. Endemic to the geographical areas like India, China and Bangladesh. From the ancient times it is an important medicinal plant containing medicinal potential viabilities to treat number of health condition such as stomach ache, diarrhea, abdominal disorders etc. using various preparations like decoctions, powders etc. Its parts can be administered for the treatment of various diseases. The morphological, organoleptic and microscopic characteristics are also established. It is reported to be rich source of alkaloids. Also, it contains chemical constituents like irioids, coumarins, sugars, oils, phenolics etc. The phytochemical constituents contained in each part are described in the present review. The plant was investigated by the scientists, researchers while performing the experiments on animals they concluded that the plant have pharmacological properties such as antimicrobial, antidiarreal, antitussive, antiasthmatic, immunostimulatory, antidiabetic etc. which are discussed in the article.

Family-Planning Knowledge and Attitude Surveys in Pakistan (Review Article)

1964 ◽  
Vol 4 (2) ◽  
pp. 332-355 ◽  
Author(s):  
Khurshid Haroon ◽  
Yasmin Azra Jan
Keyword(s):  
Family Planning ◽  
Preliminary Data ◽  
Review Article ◽  
Research Projects ◽  
Family Planning Programme ◽  
The Family ◽  
National Family ◽  
National Family Planning ◽  
Knowledge And Attitude ◽  
The Government

Very little of the intense interest and activity in the field of family planning in Pakistan has come up in the form of publications. Since the formation of the Family Planning Association of Pakistan in 1953 and the initiative of the government in promoting a national family-planning programme in its Second Five-Year Plan, relatively few reports have been printed. Most of what has been written in Pakistan about family planning has either been reported at conferences abroad or published in foreign journals, or submitted as graduate dissertations at universities within the country and abroad1. While numerous papers presented at conferences in Pakistan have been given limited circulation in mimeographed form2, much of the preliminary data, emanating from most of the action-research projects in progress, are held up till substantive demographic changes are measured and approaches evaluated accordingly.

Current Advances in the Biological Activity of Polysaccharides in Dendrobium with Intriguing Therapeutic Potential

2018 ◽  
Vol 25 (14) ◽  
pp. 1663-1681 ◽  
Author(s):  
Chun-Ting Lee ◽  
Heng-Chun Kuo ◽  
Yung-Hsiang Chen ◽  
Ming-Yen Tsai
Keyword(s):  
Biological Activity ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Research Field ◽  
Protective Effects ◽  
Pharmacological Effects ◽  
The Family ◽  
Anti Tumor Activity

The polysaccharides in many plants are attracting worldwide attention because of their biological activities and medical properties, such as anti-viral, anti-oxidative, antichronic inflammation, anti-hypertensive, immunomodulation, and neuron-protective effects, as well as anti-tumor activity. Denodrobium species, a genus of the family orchidaceae, have been used as herbal medicines for hundreds of years in China due to their pharmacological effects. These effects include nourishing the Yin, supplementing the stomach, increasing body fluids, and clearing heat. Recently, numerous researchers have investigated possible active compounds in Denodrobium species, such as lectins, phenanthrenes, alkaloids, trigonopol A, and polysaccharides. Unlike those of other plants, the biological effects of polysaccharides in Dendrobium are a novel research field. In this review, we focus on these novel findings to give readers an overall picture of the intriguing therapeutic potential of polysaccharides in Dendrobium, especially those of the four commonly-used Denodrobium species: D. huoshanense, D. offininale, D. nobile, and D. chrysotoxum.

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