scholarly journals Isotopic Characterization of 100% Agave Tequila (Silver, Aged and Extra-Aged Class) for Its Use as an Additional Parameter in the Determination of the Authenticity of the Beverage Maturation Time

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1719
Author(s):  
Rocío Fonseca-Aguiñaga ◽  
Walter M. Warren-Vega ◽  
Floriberto Miguel-Cruz ◽  
Luis A. Romero-Cano
Keyword(s):  
Aging Time ◽  
Linear Trend ◽  
Additional Parameter ◽  
Oxidation Reactions ◽  
Clear Trend ◽  
Production Region ◽  
Proportional Allocation ◽  
Significant Difference ◽  
Analytical Parameter ◽  
Isotopic Characterization

Isotopic ratios of δ13CVPDB and δ18OVSMOW have been used as an additional parameter to ensure the authenticity of the aging time of 100% agave tequila. For this purpose, 120 samples were isotopically analyzed (40 silver class, 40 aged class, and 40 extra-aged classes). The samples were obtained through a stratified sampling by proportional allocation, considering tequila producers from the main different regions of Jalisco, Mexico (Valles 41%, Altos Sur 31%, Cienega 16%, and Centro 12%). The results showed that the δ13CVPDB was found in an average of −12.85 ‰ for all the analyzed beverages, with no significant difference between them. Since for all the tested samples the Agave tequilana Weber blue variety was used as source of sugar to obtain alcohol, those results were foreseeable, and confirm the origin of the sugar source. Instead, the results for δ18OVSMOW showed a positive slope linear trend for the aging time (silver class 19.52‰, aged class 20.54‰, extra-aged class 21.45‰), which is associated with the maturation process, there are oxidation reactions that add congeneric compounds to the beverage, these can be used as tracers for the authenticity of the aging time. Additionally, the experimental data showed homogeneity in the beverages regardless of the production region, evidencing the tequila industry’s high-quality standards. However, a particular case occurs with the δ18OVSMOW data for the silver class samples, in which a clear trend is noted with the altitude of the region of origin; therefore, this information suggests that this analytical parameter could be useful to authenticate the regional origin of beverage.

scholarly journals Prevalence of thinness, overweight and obesity among Tibetan adolescents aged 12-17 years

2021 ◽  
pp. 1-17
Author(s):  
Yunfei Zhang ◽  
Jiahong Sun ◽  
Min Zhao ◽  
Costan G. Magnussen ◽  
Xi Bo
Keyword(s):  
Sampling Method ◽  
Total Sample ◽  
Overweight And Obesity ◽  
Cluster Sampling ◽  
Cross Sectional Survey ◽  
Clear Trend ◽  
Cross Sectional ◽  
Significant Difference ◽  
Prevalence Of Obesity ◽  
Study Participants

Abstract Objective: To estimate the prevalence of thinness, overweight and obesity among Tibetan adolescents aged 12-17 years. Design: Cross-sectional survey. Setting: Shigatse city of Tibet municipality, with an average altitude of more than 4000 m. Subjects: Study participants included 2,642 adolescents aged 12-17 years selected from 6 schools using a convenient cluster sampling method. Results: The prevalence of thinness/overweight/obesity among Tibetan adolescents was 9.4%/5.4%/1.4% (China definition), 14.7%/4.4%/0.7% (IOTF definition), and 2.8%/5.7%/0.9% (WHO definition). The prevalence of thinness and overweight was significantly different between both sexes based on each of three BMI classification criteria (P <0.001). There was no significant difference in the prevalence of obesity between both sexes according to each of three BMI criteria. There was no clear trend in the prevalence of thinness across ages according to the China or IOTF definition (both P >0.05), whereas an upward trend was observed for thinness in boys according to the IOTF definition (P for trend <0.05). In contrast, the prevalence of thinness tended to decrease with increasing age in girls according to the IOTF definition, and in total sample according to the WHO definition (P for trend <0.05). Conclusions: Among Tibetan adolescents, the prevalence of overweight and obesity is relatively low, while the prevalence of thinness is high, especially in boys. These data suggest urgent attention is needed to control adolescent thinness in Tibet.

scholarly journals Microtensile Bond Strength of Methacrylate and Silorane Resins to Enamel and Dentin

2014 ◽  
Vol 25 (4) ◽  
pp. 327-331 ◽  
Author(s):  
Gisele Rodrigues da Silva ◽  
Isabela Sousa Araújo ◽  
Rodrigo Dantas Pereira ◽  
Bruno de Castro Ferreira Barreto ◽  
Célio Jesus do Prado ◽  
...  
Keyword(s):  
Bond Strength ◽  
Aging Time ◽  
Storage Time ◽  
Composite Resin ◽  
Glass Plate ◽  
Composite Resins ◽  
Microtensile Bond Strength ◽  
Bonding Interaction ◽  
Significant Difference ◽  
And Storage

The aim of this study was to evaluate the microtensile bond strength (µTBS) of two substrates (enamel and dentin) considering two study factors: type of composite resin [methacrylate-based (Filtek Supreme) or silorane-based (Filtek LS)] and aging time (24 h or 3 months). Twenty human molars were selected and divided into 2 groups (n=10) considering two dental substrates, enamel or dentin. The enamel and dentin of each tooth was divided into two halves separated by a glass plate. Each tooth was restored using both tested composite resins following the manufacturer's instructions. The samples were sectioned, producing 4 sticks for each composite resin. Half of them were tested after 24 h and half after 3 months. µTBS testing was carried out at 0.05 mm/s. Data were analyzed by three-way ANOVA and Tukey's HSD tests at α=0.05. Significant differences between composite resins and substrates were found (p<0.05), but no statistically significant difference was found for aging time and interactions among study factors. The methacrylate-based resin showed higher µTBS than the silorane-based resin. The µTBS for enamel was significantly higher than for dentin, irrespective of the composite resin and storage time. Three months of storage was not sufficient time to cause degradation of the bonding interaction of either of the composite resins to enamel and dentin.

Abstract 469: Residential Lifestyle Interventions Reduce Blood Pressure in 18 Days

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Francisco E Ramirez ◽  
Jill Siebold ◽  
Linda Ivy ◽  
Kathelyn Antuna ◽  
Albert Sanchez ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Linear Trend ◽  
Lifestyle Interventions ◽  
Blood Pressure Medication ◽  
Significant Linear Trend ◽  
Time Points ◽  
Positive Effects ◽  
Significant Difference ◽  
Post Hoc

Background: Tight control of blood pressure can have long term positive effects, non-pharmacological interventions to achieve it are documented in this study. Hypothesis: Vegan diets together with other lifestyle changes can safely decrease blood pressure. Methods: Twelve years of data was used, 1196 patients participated in a lifestyle program in Weimar California. The intervention consisted in whole food plant based diet (WFPD), exercise, sleep hygiene, medical, psychological and spiritual therapies. Treatments of massage and hydrotherapy were also given. A physician monitored the progress of each patient during the 18 days. Blood pressure was measured at baseline, at the end of the first week (time 1) and at the end of the second week (time 2) and at the end of 18 days. Some patients need it to decrease their blood pressure medication during the 18 days. Data was process with SPSS statistics package. Results: From 1196 patients, 764 of them were females. Mean age at baseline was 60.7 SD 15. Both systolic and diastolic blood pressure were reduced throughout treatment. For systolic on average (in mm HG) at baseline: 132.21, at time 1: 125.3, at rime 2: 121.96, at the end : 121.4. For diastolic on average (in mm HG) at baseline: 76.1, time 1: 72.2, time 2: 70.86, at the end : 69.9. A repeated measures ANOVA determined that mean systolic blood pressure differed significantly between time points (F(3,3585) = 69.008, P < .001). Post hoc polynomial contrasts revealed a significant linear trend in the data from start to end (F(1,1195 = 206.474. p<.001, partial η 2 = .14)). A similar pattern was found for diastolic blood pressure. The overall ANOVA found a significant difference in time points (F(3,3585) = 34.738, P < .001). Post hoc polynomial contrasts also showed a significant linear trend (F(1,1195 = 109.031. p<.001, partial η 2 = .08). Participants lost 4.8 pounds on average by the end of the program. Conclusion: WFPD together with lifestyle interventions are associated with a significant reduction of systolic and diastolic blood pressures. Many patients reduced their blood pressure medication. Lifestyle interventions options should be offered to patients with hypertension.

The toxicity of ammonia/ammonium to the vermifiltration wastewater treatment process

2008 ◽  
Vol 58 (6) ◽  
pp. 1215-1220 ◽  
Author(s):  
R. J. Hughes ◽  
J. Nair ◽  
G. Ho
Keyword(s):  
Solid Phase ◽  
Linear Trend ◽  
Ammonia Concentration ◽  
Full Scale ◽  
Nitrifying Bacteria ◽  
Wastewater Treatment Process ◽  
Key Species ◽  
Significant Difference ◽  
System Functioning ◽  
Low Toxicity

This study was undertaken to assess the toxicity of ammonia/ammonium to key species within the vermifiltration process. The key species, the earthworm Eisenia fetida, was subjected to a series of tests in solid phase mesocosms and full-scale units. The solid phase tests showed a relatively low toxicity to ammonium with ammonium chloride having an LC50 for ammonium of 1.49 g/kg. Ammonium sulfate did not show an effect on mortality at 2 g/kg ammonium. The full-scale units showed that ammonia hydroxide can change the pH and concentration of ammonia in wastewater and while it caused some mortality to the worms its overall affect on system functioning was minimal with no significant difference in terms of worm survival found between treatments. The affect on nitrifying bacteria was also minimal with no linear trend shown with ammonia concentration.

Angiopoietin-1 and Osteopontin Expression by CD138+ Myeloma Cells Rather Than VEGF and CD45 Correlates with Bone Marrow Angiogenesis in Multiple Myeloma Patients at the Diagnosis.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2501-2501
Author(s):  
Nicola Giuliani ◽  
Simona Colla ◽  
Francesca Morandi ◽  
Sabrina Bonomini ◽  
Mirca Lazzaretti ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Linear Trend ◽  
The Other ◽  
Vegf Mrna ◽  
Myeloma Cells ◽  
Other Hand ◽  
Significant Difference ◽  
Angiopoietin 1

Abstract Bone marrow (BM) angiogenesis is increased in Multiple Myeloma (MM) patients and correlates with disease progression and patient survival. Myeloma cells secrete the main endothelial growth factor VEGF. In mouse models VEGF secretion as well as the angiogenic properties of MM cells correlate with the lack of CD45 expression by MM cells. However, recent data indicate that VEGF plasma cell expression is similar between MGUS and MM patients suggesting that other molecules could be involved. In line with this hypothesis we have recently demonstrated that myeloma cells may also produce factors with angiogenic properties as angiopoietin-1 (ANG-1) and osteopontin (OPN) that are involved in myeloma induced angiogenesis in vitro. In order to identify which factors correlate with BM angiogenesis in MM patients, we have investigated in a cohort of 121 newly diagnosed MM patients (stage I–III) the expression of the angiogenic molecules VEGF, ANG-1 and OPN and their correlation with bone marrow (BM) angiogenesis and CD45 expression by MM cells. We found that 90% of CD138+ MM cells tested were positive for VEGF mRNA. On the other hand we found that 50% and 40 % of MM patients were positive for ANG-1 and OPN mRNA respectively. Using the previously published cut off for CD45 expression we found that 61 out of 121 MM patients were positive for CD45 and 60 out of 121 were negative for CD45 expression. Any correlation was not observed between VEGF expression and BM angiogenesis in MM patients (p=0.5), whereas the number of microvessels X field was higher in Ang-1 positive patients in comparison with Ang-1 negative ones (mean±SE: 6.23±0.2 vs. 2.94±0.1, median: 6.21 vs. 2.79; p=0.001,) and the microvascular density (MVD) was significantly increased (32.98±1.7 vs. 14.55±1.3, median: 34.69 vs. 13.04; p&lt;0.01; capillaries: 26.73±1.3 vs. 10.42±0.8, median: 24.06 vs. 9.04; p&lt;0.01, small venules: 9.56 ±0.5 vs. 4.14±0.5, median: 10.60 vs. 3.65; p&lt;0.01). Furthermore a significantly positive correlation between Ang-1 expression and MVD was found (Pearson Chi-square: p=0.036, Cochran’s Linear Trend: p=0.01). A significantly higher MVD was also observed in the group of patients positive for OPN, (mean±SE: 29.1±0.7 vs. 17.55±0.37; p&lt;0.01) and similarly, the number of microvessels per field was higher in OPN positive patients in comparison with OPN negative ones (mean±SE: 6.7±0.15 vs. 4.28±0.04; p=0.05). On the other hand, any significant difference was not observed between CD45 positive and CD45 negative patients for the expression of VEGF (p=0.4), ANG-1 (p=0.3) and OPN (p=0.09). Consistently we did not find any significant difference in both MVD and number of vessels X field between CD45 positive patients as compared with CD45 negative ones (p=0.5 and p=0.4, respectively). Finally, a multivariate analysis confirmed that VEGF and CD45 did not correlate with the BM angiogenesis showing that ANG-1 expression by MM cells was more tightly correlated with MVD and the number of vessels X field as compared to OPN. Our data indicate that ANG-1 and in part OPN rather than VEGF and CD45 expression by MM cells are the critical determinants correlated with the increase of BM angiogenesis that occurs in MM patients at the diagnosis.

scholarly journals Chem-Rox Games As A Learning Media For The Concept of Reduction and Oxidation Reactions Material to Increase Students Learning Motivation

2021 ◽  
Vol 4 (1) ◽  
pp. 59
Author(s):  
Ismawati Kusuma Dewi ◽  
Achmad Lutfi
Keyword(s):  
Learning Outcomes ◽  
Student Motivation ◽  
Design Method ◽  
T Test ◽  
Learning Motivation ◽  
Oxidation Reactions ◽  
Significant Difference ◽  
Before And After ◽  
Reduction And Oxidation

The development of technology can be used to improve the quality of learning, for example the use of computers as learning media. This study aims to measure the effectiveness of Chem-Rox games as learning media for the concept of redox  in terms of learning outcomes and student motivation. This study used one group pretest posttest design method. The subjects in the study were conducted on class X students of MA Al-Arifin Probolinggo. Before learning was carried out pretest and after learning was given posttest. The results of the data obtained were analyzed quantitatively. The results of this study indicate that the n-gain obtained is 0.71-1 in the high category and the t test is obtained by the tvalue of 11.266 > ttable 2.093 and the increase in students learning motivation as seen from the tvalue 21.838 > ttable 2.093. From these data it can be stated that there is a significant difference between the average learning motivation of students before and after learning using the Chem-Rox game. Thus can be concluded that the Chem-Rox game is effectively used as a learning media based on increasing learning outcomes and increasing learning motivation of students on the concept of redox material.

scholarly journals Outcomes after Intermediate-Risk Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL) and the Role of Allogeneic Stem Cell Transplantation (SCT): A Report from Children's Oncology Group (COG) AALL0433

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 684-684 ◽  
Author(s):  
Glen Lew ◽  
Xiaomin Lu ◽  
Rochelle Yanofsky ◽  
Susan R. Rheingold ◽  
James Whitlock ◽  
...  
Keyword(s):  
Research Funding ◽  
Residual Disease ◽  
Lymphoblastic Leukemia ◽  
Intermediate Risk ◽  
Clinical Predictors ◽  
Clear Trend ◽  
Significant Difference ◽  
Alternative Donor ◽  
Family Donor

Abstract BACKGROUND Relapsed childhood B-ALL has a poor prognosis, with time to and site of relapse being the best clinical predictors of outcome. The role of allogeneic SCT is unclear for patients with late bone marrow (BM) or isolated extramedullary (IEM) relapse. We recently reported initial results from the AALL0433 trial for intermediate-risk relapse of childhood B-ALL, which established a 0.1% end-induction minimal residual disease (MRD) threshold as the best predictor of outcome (Lew, ASCO 2014). We now report an updated analysis, including outcomes for patients receiving SCT vs. continued chemotherapy. METHODS AALL0433 included patients with early CNS/testicular (IEM) relapse (<18 mo. from diagnosis), or late BM/combined relapse (≥36 mo. from diagnosis) of B-ALL, enrolling 271 eligible patients between 3/2007 and 10/2013. Therapy was based upon the earlier COG AALL01P2 / P9412 platforms. BM MRD was measured by flow cytometry at the end of Induction block 1, and for this analysis was considered positive (MRD+) if ≥0.1%, or negative (MRD-) if <0.1%. MRD testing was performed centrally by a COG reference lab, with results blinded to local investigators. 48 patients underwent matched family donor SCT per protocol after 3 induction blocks. An additional 31 patients were removed from protocol therapy to pursue off-study alternative donor SCT. Donor sources for these patients were 21 unrelated BM, 9 unrelated cord blood, and 1 haploidentical BM. The remaining 192 patients received chemotherapy (plus irradiation for those with EM involvement at relapse). Event free and overall survival (EFS/OS) comparisons for patients receiving chemotherapy vs. SCT were adjusted to start from median time to SCT (138 days) or the actual time of SCT if <138d. Patients who had events or dropped out before the adjusted starting time were excluded from the survival analyses. RESULTS The 3-yr. EFS/OS for the entire cohort of 271 patients were 61.4 ± 4.3% and 72.9 ± 3.9% respectively. Focusing on patients with BM/combined relapse, the 3-yr EFS/OS for the 175 patients with available MRD data showed EFS/OS of 80.4 ± 4.7% and 88.3 ± 3.8% respectively for MRD- patients, compared to 45.1 ± 8.4% and 60.1% ± 8.3% for those who were MRD+ (p<0.01) (FIGURE 1). Because outcomes for patients who received matched family donor or alternative donor SCT were highly similar, these were pooled in all analyses of chemotherapy vs. SCT. There was no significant difference in survival for MRD- patients; 3-yr EFS and OS for the chemotherapy group were 75.4 ± 6.7% / 91.8 ± 4.3%, vs. 80.1 ± 8.9% / 84.0 ± 8.1% in the SCT group (p>0.5). In MRD+ patients the 3-yr EFS was 42.2 ± 13.1% vs 62.8 ± 13.5% (p=0.30) for the chemotherapy and SCT groups respectively, corresponding to a 3-yr OS of and 57.6 ± 12.5% vs 78.1 ± 12.9% (p=0.14), with a trend toward improved survival after 3 years with SCT (FIGURE 2). Although numbers were small, there was a clear trend toward improved outcomes in IEM patients receiving SCT over chemotherapy (FIGURE 3). 3-yr EFS for the chemotherapy vs. SCT groups were 31.3% ± 25.9% vs. 71.4% ± 22% (p=0.16), with OS of 31.3% ± 25.9% vs. 77.8% ± 21.2% (p=0.08). No IEM relapse patients were MRD+ at end induction. CONCLUSIONS Patients with late BM relapse of B-ALL who are MRD- after induction have a relatively good outcome (3-yr EFS of 80.4 ± 4.7%) on COG AALL0433. While additional follow-up is needed, there was no obvious benefit of SCT over chemotherapy for these patients. Outcomes were worse for BM relapse patients who remained MRD+ after induction (3-yr EFS 45.1 ± 8.4%). There was a trend toward benefit for SCT over chemotherapy for MRD+ patients. In the small number with early IEM, there was also a clear trend toward superiority of SCT over chemotherapy + radiotherapy. These data support the approach of reserving SCT for patients with late BM relapse of childhood B-ALL who remain MRD+, and also for patients with early IEM relapse. Figure 1 Figure 1. Figure 2 Figure 2. Figure 3 Figure 3. Disclosures Rheingold: Novartis: Consultancy. Whitlock:Glaxo-Smith-Kline: Research Funding. Borowitz:Becton Dickinson Biosciences: Research Funding. Hunger:Sigma Tau Pharmaceuticals: Honoraria; Jazz Pharmaceuticals: Honoraria.

scholarly journals Challenging the 10-year rule: The accuracy of patient life expectancy predictions by physicians in relation to prostate cancer management

2012 ◽  
Vol 6 (5) ◽  
Author(s):  
Kevin M.Y.B. Leung ◽  
Wilma M. Hopman ◽  
Jun Kawakami
Keyword(s):  
Prostate Cancer ◽  
Life Expectancy ◽  
Linear Trend ◽  
Cancer Management ◽  
Clinical Scenarios ◽  
Significant Difference ◽  
Level Of Training ◽  
Prostate Cancer Management ◽  
Actual Life ◽  
Actual Survival

Introduction: We assess physicians’ ability to accurately predictlife expectancies. In prostate cancer this prediction is especiallyimportant as it affects screening decisions. No previous studieshave examined accuracy in the context of real cases and concreteend points.Methods: Seven clinical scenarios were summarized from chartsof deceased patients. We recruited 100 medical professionals toreview these scenarios and estimate each patient’s life expectancy.Responses were analyzed with respect to the patients’ actual survivalend points, then stratified based on the demographic informationprovided.Results: Respondent factors, such as sex, level of training, locationof work or specialty, made no significant difference on predictionaccuracy. Furthermore, respondents were typically pessimistic intheir estimations with a negative linear trend between estimated lifeexpectancy and actual survival. Overall, respondents were within 1year of actual life expectancy only 15.9% of the time; on average,respondents were 67.4% inaccurate in relation to actual survival. Ifframed in terms of correctly identifying which patients would livemore than or less than 10 years (dichotomous accuracy), physicianswere correct 68.3% of the time.Conclusions: Physicians do poorly at predicting life expectancyand tend to underestimate how long patients have left to live.This overall inaccuracy raises the question of whether physiciansshould refine screening and treatment criteria, find a better proxyor dispose of the criteria altogether.

scholarly journals 1230 The atrial stiffness index in hypertensive women with indeterminate diastolic function

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Y Kolesnyk ◽  
M V Sokolova
Keyword(s):  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Normal Function ◽  
Stiffness Index ◽  
Additional Parameter ◽  
Deformation Curves ◽  
Additional Information ◽  
Significant Difference

Abstract Background Despite new 2016 ASE/EACVI guidelines on diastolic function (DF), there is still significant amount of patients with indeterminate results. The left atrial (LA) longitudinal strain could provide additional information in case of inconclusive results. Recenty, a new LA stiffness index was proposed as ratio between E/e" and LA global longitudinal strain (GLS). The purpose of this study was to test the diagnostic utility of LA stiffness index in hypertensive women with inderterminate DF. Methods The study enrolled 100 postmenopausal women (mean age 57 ± 4 years) with uncomplicated arterial hypertension, divided into 3 groups (normal DF, indeterminate DF, diastolic dysfunction). The DF was assessed with both 2009 and 2016 ASE/EACVI algorithms. LA longitudinal strain was measured as peak of deformation curves with R-wave variant of ECG triggering. The LA GLS was measured by averaging 12 segmental values. The atrial stiffness index was calculated as E/e" ratio to LA GLS. Results The prevalence of indeterminate DF was higher with assessment by 2016 algorithm (53 % vs 38 %). The E/e" ratio was significantly increased in patients with indeterminate DF compared to normal function (Table). LA GLS was decreased only in patients with inconclusive resuts by 2009 algorithm. LA stiffness index was increased gradually according to diastolic abnormalities severity. The significant difference between three groups was only found with categorization of patients by 2016 algorithm. Conclusions The novel LA stiffness index could be additional parameter of DF assessment in case of indeterminate results. However, it needs further validation in simultaneous echo-invasive studies. LA mechanics in diastolic dysfucntion Parameter Normal diastolic function Indeterminate function Diastolic dysfunction p 2009 guidelines Prevalence, % 31 38 31 E/e" ratio 8,07 (7,36-9,6) 9,91 (8,44-11,6)* 11 (10,52-13)*^ p &lt; 0,0001 LA GLS, % 34,8 (30,2-39,9) 30,8 (26,5-34,9)* 28,9 (24,2-36)* p = 0,028 LA stiffness index 0,24 (0,18-0,31) 0,32 (0,27-0,39)* 0,37 (0,31-0,46)* p &lt; 0,0001 2016 guidelines Prevalence, % 40 53 7 E/e" ratio 8,8 (7,74-10,1) 10 (8,6-11,7)* 14 (12-14,9)*^ p &lt; 0,0001 LA GLS, % 34,2 (28,4-39,1) 30,8 (26,5-34,8) 29,6 (25,1-37,8) p = 0,18 LA stiffness index 0,27 (0,2-0,34) 0,33 (0,27-0,4)* 0,47 (0,38-0,59)*^ p = 0,001 The values are given as median and interquartile range. * - compared to normal function ^ - compared to indeterminate result

Diffuse Large B-Cell Lymphoma: Relevance of bcl-2 Expression at a National Hospital from Lima Peru 2000–2002.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4610-4610
Author(s):  
Cecilia M. Egoavil R. ◽  
Victor M. Delgado G. ◽  
Jesus La Serna
Keyword(s):  
B Cell ◽  
Clinical Characteristics ◽  
De Novo ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Response To Treatment ◽  
Clear Trend ◽  
Large B Cell Lymphoma ◽  
Significant Difference ◽  
Large B Cell

Abstract Diffuse large B-cell lymphoma (DLCL) exhibits heterogeneous clinical features and varies in response to treatment and prognosis. Establishment of parameters that can predict outcome could help to identify patients who may benefit from risk-adjusted therapies. Because apoptosis-related proteins may play an important role in predicting the prognosis of DLCL, the current study investigated the significance of bcl-2 expression in relation to clinical characteristics in this patients. We studied 125 patients (74/51 men/women; median age 64.17 years) consecutively diagnosed with de novo DLBCL in a single institution from Peru (HNGAI) during 3-year period (2000–2002).Morphology, and clinical characteristics were analyzed according to the primary site of the lymphoma and edge. Paraffin-embedded specimens from 88 were analyzed immunohistochemically for bcl-2 protein expression. Cases with a positive immunohistological stain in more than 20% of the tumor cells were considered positive expression. Results: Sites of the disease were: lymph node, 78 cases (62.4%); Waldeyer’s ring, 18 (14.4%); and extranodal sites, 45 (36%), including GI tract in 33 cases. 5-year overall survival (OS) was 19.7%. Log-rank analyses of survival showed significant differences between ≥60 years old and younger patients (P=0.003).bcl-2 expression was identified in 34 patients (38.6%), There was no significant difference in the OS (P=0.453) between the bcl-2+ (n=34) and bcl-2− (n=54) groups. In conclusion, bcl-2 expression appeared to be non predictive of a good OS in patients with DLCL, however, there was still a clear trend that the bcl-2+ patients died sooner than the patients with tumors that contained bcl-2− lymphoma cells. The current study show all patients as were staged or confined in a group with high or high intermediate IPI scores and could be candidates for alternative therapeutic approaches.

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