scholarly journals Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3042
Author(s):  
Aswir Abd Rashed ◽  
Devi-Nair Gunasegavan Rathi
Keyword(s):  
English Language ◽  
Health Benefit ◽  
Biologically Active ◽  
Antidiabetic Agent ◽  
Bioactive Components ◽  
Active Components ◽  
Antidiabetic Agents ◽  
Bioactive Component ◽  
Phenolic Components ◽  
Salvianolic Acids

The utilization of therapeutic plants is expanding around the globe, coupled with the tremendous expansion of alternative medicine and growing demand in health treatment. Plants are applied in pharmaceuticals to preserve and expand health—physically, mentally and as well as to treat particular health conditions and afflictions. There are more than 600 families of plants identified so far. Among the plants that are often studied for their health benefit include the genus of Salvia in the mint family, Lamiaceae. This review aims to determine the bioactive components of Salvia and their potential as antidiabetic agents. The search was conducted using three databases (PubMed, EMBASE and Scopus), and all relevant articles that are freely available in the English language were extracted within 10 years (2011–2021). Salvia spp. comprises many biologically active components that can be divided into monoterpenes, diterpenes, triterpenes, and phenolic components, but only a few of these have been studied in-depth for their health benefit claims. The most commonly studied bioactive component was salvianolic acids. Interestingly, S. miltiorrhiza is undoubtedly the most widely studied Salvia species in terms of its effectiveness as an antidiabetic agent. In conclusion, we hope that this review stimulates more studies on bioactive components from medicinal plants, not only on their potential as antidiabetic agents but also for other possible health benefits.

scholarly journals Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-Coronaviruses

2021 ◽  
Vol 11 ◽  
Author(s):  
Sourodip Sengupta ◽  
Debina Bhattacharyya ◽  
Grishma Kasle ◽  
Souvik Karmakar ◽  
Omkar Sahu ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Biologically Active ◽  
World Health ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Bioactive Components ◽  
Active Components ◽  
Health Crisis ◽  
Essential Components ◽  
Anti Inflammatory

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced COVID-19 has emerged as a defining global health crisis in current times. Data from the World Health Organization shows demographic variations in COVID-19 severity and lethality. Diet may play a significant role in providing beneficial host cell factors contributing to immunity against deadly SARS-CoV-2 pathogenesis. Spices are essential components of the diet that possess anti-inflammatory, antioxidant, and antiviral properties. Hyperinflammation, an aberrant systemic inflammation associated with pneumonia, acute respiratory failure, and multiorgan dysfunction, is a major clinical outcome in COVID-19. Knowing the beneficial properties of spices, we hypothesize that spice-derived bioactive components can modulate host immune responses to provide protective immunity in COVID-19. This study emphasizes that biologically active components of spices might alleviate the sustained pro-inflammatory condition by inhibiting the activity of tumor necrosis factor-alpha (TNF-α), interleukins (IL6, IL8), and chemokine (CCL2) known to be elevated in COVID-19. Spices may potentially prevent the tissue damage induced by oxidative stress and pro-inflammatory mediators during SARS-CoV-2 infection. The current study also highlights the effects of spices on the antioxidant pathways mediated by Nrf2 (nuclear factor erythroid 2-related factor 2) and Hmox1 (heme oxygenase 1) to restore oxidative homeostasis and protect from aberrant tissue damage. Taken together, the anti-inflammatory and antioxidant activities of bioactive components of spices may hold a promise to target the cellular pathways for developing antivirals against SARS-CoV-2 and pan β-coronaviruses.

scholarly journals Screening of the polyphenolic content of Amur grapes Rupr. and its identification by the method of tandem mass spectrometry

2021 ◽  
pp. 393-404
Author(s):  
М.П. Разгонова ◽  
А.Ш. Сабитов ◽  
Е.В. Перминова ◽  
Н.М. Михайлова ◽  
К.С. Голохваст
Keyword(s):  
High Performance ◽  
Ion Trap ◽  
Biologically Active ◽  
Vitis Amurensis ◽  
Active Components ◽  
Ionization Source ◽  
Grape Berries ◽  
Salvianolic Acids ◽  
Ethanol Extracts ◽  
First Time

Виноград амурский Vitis amurensis Ruprecht содержит большое количество полифенольных комплексов, являющихся биологически активными соединениями. В данной работе впервые проведено сравнительное метаболомное исследование биологически активных веществ дикого винограда, собранного из пяти различных мест Приморского и Хабаровского краёв. Для идентификации целевых аналитов в этанольных экстрактах ягод винограда использована высокоэффективная жидкостная хроматография (ВЭЖХ) в комплексе с ионной ловушкой amaZon SL, оснащенной источником ионизации электрораспылением ESI в режимах отрицательных и положительных ионов. Масс-спектрометр использовался в диапазоне сканирования m/z 100 - 1.700 для MС и МС/МС. Использовано фрагментирование 4-го порядка. Первичные масс-спектрометрические результаты показали присутствие 94 биологически активных соединений, соответствующих виду V. Amurensis ; причем сальвианоловые кислоты F, D и G, олеаноловая, урсоловая, миристолеиновая кислоты, берберицинин, меарнсетин, эскулин, невадензин, стигмастерол, фукостерол, флоризин, триптофан идентифицированы впервые в V. amurensis . Vitis amurensis Ruprecht contains a large number of polyphenolic compounds which are the biologically active components. In this work, for the first time, a comparative metabolomic study of biologically active substances of wild grapes collected from five different places of the Primorsky and Khabarovsk territories is carried out. To identify target analytes in ethanol extracts of grape berries, high performance liquid chromatography (HPLC) was used in combination with an amaZon SL ion trap (manufactured by BRUKER DALTONIKS, Germany) equipped with an ESI electrospray ionization source in negative and positive ion modes. The mass spectrometer was used in the scan range m / z 100 - 1.700 for MS and MS/MS. The fragmentation of the 4 order was used. Primary mass spectrometric results showed presence of 94 biologically active compounds corresponding to the species V. amurensis ; moreover, salvianolic acids F, D and G, oleanoic, ursolic, myristoleic acids, berbericinin, mearnsetin, esculin, nevadensin, stigmasterol, fucosterol, phlorizin, L-tryptophan were identified for the first time in V. amurensis .

Ganodermataceae: Natural Products and Their Related Pharmacological Functions

2007 ◽  
Vol 35 (04) ◽  
pp. 559-574 ◽  
Author(s):  
Xuanwei Zhou ◽  
Juan Lin ◽  
Yizhou Yin ◽  
Jingya Zhao ◽  
Xiaofen Sun ◽  
...  
Keyword(s):  
Natural Products ◽  
Ganoderma Lucidum ◽  
Folk Medicine ◽  
Biologically Active ◽  
Bioactive Components ◽  
Active Components ◽  
Molecular Weights ◽  
The Past ◽  
Representative Species ◽  
Health Products

The objective of this paper is to review the natural products and the pharmacological functions of Ganodermataceae family. Presently, studies on the bioactive components of Lingzhi are focused on polysaccharides and triterpenes/triterpenoids compounds. New Ganoderma polysaccharides, including their molecular weights, glycosyl residue compositions, glycosyl linkage and branches, are summarized in this paper. Also presented are new types of triterpenes and their characteristics from Lingzhi. Taking Ganoderma lucidum as an example, we reviewed its pharmacological functions in anti-tumor and immune-modulating activities for treating hypoglycemosis, hepatoprotection, and the effect on blood vessel system. Based on the advances in Lingzhi research in the past few decades, both G. lucidum and G. sinense are considered as the representative species of medicinal mushroom Lingzhi in China. Until 2001, G. tsugae was only advised to be used as the materials of the health products. The biologically-active components related to pharmacological functions of these three species were studied more than other Ganodermataceae family species; however, which have been used in less modern folk medicine.

scholarly journals FRESHWATER SAPROPEL: BIOLOGICALLY ACTIVE COMPONENTS AND METHODS OF EXTRACTION

2020 ◽  
Vol 1 ◽  
pp. 37-46
Author(s):  
Aneka Klavina ◽  
Agris Auce ◽  
Ilona Pavlovska ◽  
Ivars Vanadzins
Keyword(s):  
Quality Criteria ◽  
Analytical Techniques ◽  
Fulvic Acids ◽  
Extraction Process ◽  
Extraction Methods ◽  
Storage Conditions ◽  
Biologically Active ◽  
Bioactive Components ◽  
Active Components ◽  
Solid Liquid

Previously, sapropel has been commonly used in agriculture, cosmetology and medicine in its raw form and there has been no generally accepted method or standard for realizing sapropel extract. However, for sapropel usage in medicine, balneology and pharmacy, it is essential to develop quality criteria for raw sapropel and its extracts. This review aims at discussing and summing up different techniques for extracting bioactive compounds from sapropel as well as the possibilities of creating quality criteria. This paper covers existing analytical techniques and methodologies; currently, there are few extraction methods using several extractants for obtaining bioactive components from raw sapropel. Different freshwater sapropel types have been described and characterized. Bioactive components in sapropel have been identified and explained. Humic acids and fulvic acids have been identified as the main substances and their extraction methods have been listed. Solid-liquid, ultrasound assisted and supercritical fluid extraction methods have been pointed out as the most suitable. Additionally, analysis and storage conditions of the extracts have been discussed. There have been found to be no commonly accepted standard methods for sapropel extraction, or for the analysis and characterization of the sapropel extracts. For pharmacological applications, a common approach for the extraction process of active substances from sapropel and the analysis procedures of the extracts need to be established. This review will help equip other researchers with the latest information on this topic.

scholarly journals Simultaneous determination of polyphenol content Vitis amurensis Rupr. by tandem mass spectrometry

2021 ◽  
Vol 39 ◽  
pp. 02004
Author(s):  
Mayya P. Razgonova ◽  
Evgeniy I. Kislin ◽  
Andrey Sh. Sabitov ◽  
Elena V. Perminova ◽  
Natalia M. Mikhailova ◽  
...  
Keyword(s):  
High Performance ◽  
Ion Trap ◽  
Biologically Active ◽  
Vitis Amurensis ◽  
Active Components ◽  
Ionization Source ◽  
Grape Berries ◽  
Salvianolic Acids ◽  
Ethanol Extracts ◽  
First Time

Vitis amurensis Ruprecht contains a large number of polyphenolic compounds which are biologically active components. For the most efficient and safe extraction supercritical carbon dioxide was used. In this work, for the first time, a comparative metabolomic study of biologically active substances of wild grapes collected from five different places of the Primorsky and Khabarovsk territories is carried out. To identify target analytes in ethanol extracts of grape berries, high performance liquid chromatography (HPLC) was used in combination with an amaZon SL ion trap (manufactured by BRUKER DALTONIKS, Germany) equipped with an ESI electrospray ionization source in negative and positive ion modes. The mass spectrometer was used in the scan range m / z 100 - 1.700 for MS and MS / MS. Used fragmentation of the 4th order. Primary mass spectrometric results showed the presence of 94 biologically active compounds corresponding to the species V. amurensis, moreover, salvianolic acids F, D and G, oleanoic, ursolic, myristoleic acids, berbericinin, mearnsetin, esculin, nevadensin, stigmasterol, fucosterol, phlorizin, L-tryptophan identified for the first time in V. amurensis.

scholarly journals Antioxidant Capacity and Total Phenolic and Flavonoid Contents of Methanolic Extracts of Urtica dioica L. by Different Extraction Techniques

2020 ◽  
pp. 207-214
Author(s):  
Sabina Begić ◽  
Emir Horozić ◽  
Hurija Alibašić ◽  
Edita Bjelić ◽  
Salih Seferović ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Capacity ◽  
Soxhlet Extraction ◽  
Biologically Active ◽  
Total Phenolic ◽  
Bioactive Components ◽  
Extraction Techniques ◽  
Active Components ◽  
Methanolic Extracts ◽  
High Antioxidant Activity

In this study, the efficacy of different extraction techniques (maceration, ultrasound-assisted and Soxhlet extraction) on the content of biologically active components in extracts from fresh and dried nettle leaves, and their antioxidant activity were analyzed. Methanol was used as the solvent. Total phenolic content and antioxidant capacity were determined by Folin-Ciocalteu, DPPH and FRAP methods, respectively. High content of total phenolic compounds and high antioxidant activity were recorded in extracts of dried nettle. Extracts obtained from fresh nettle samples showed significantly lower content of analyzed bioactive components and lower antioxidant activity. In the case of all extracts, Soxhlet extraction proved to be the most efficient, and maceration the least efficient extraction technique for isolation of bioactive components from nettle leaves.

scholarly journals Antidiabetic Potential of Medicinal Plants and Their Active Components

Biomolecules ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 551 ◽  
Author(s):  
Salehi ◽  
Ata ◽  
V. Anil Kumar ◽  
Sharopov ◽  
Ramírez-Alarcón ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biologically Active ◽  
The Other ◽  
Concerted Action ◽  
Active Components ◽  
Alternative Source ◽  
Antidiabetic Agents ◽  
Major Health ◽  
The World ◽  
Preclinical And Clinical Studies

Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.

PRODUCTION OF BLENDED JUICE FROM PUMPKIN, QUINCE, PERSIMMON

2018 ◽  
pp. 59-62
Author(s):  
I. A. Kyazimova ◽  
А. А. Kasumova ◽  
А. А. Nabiev
Keyword(s):  
Phenolic Compounds ◽  
Organic Acids ◽  
New Technology ◽  
Mineral Elements ◽  
Biologically Active ◽  
Active Components ◽  
Aliphatic Acids ◽  
Free Glucose ◽  
Dietary Value ◽  
Quantitative Indicators

Production of plant products, including juices around the world increases continuously. In the fruit and vegetable juices contain a significant amount of monosaccharides (glucose and fructose), organic acids, vitamins, phenolic compounds, mineral substances and other biologically active components that determine the nutritional and dietary value. For the prevention of various diseases associated with impaired metabolic processes, we developed a new technology of preparation of food by blending juice of pumpkin, quince and persimmon. Thus prepared organic blended juice contains a substantial amount of free glucose and fructose, different phenolic compounds, a sufficient amount of organic acids, mineral elements, including iodine and other components that determine its nutritional and biological value. In prepared juices were evaluated the quantitative indicators of β-carotene, vitamin C, glucose and fructose, sucrose, starch, pectin substances. Also in the atomic absorbtion spectrometer Analyst 400 (PerkinElmer, USA) was analyzed content of the organic acids and phenolic compounds. Prepared juices were tested in accordance with 10 point scoring scale. It is established that all juices contain a sufficient amount of the minerals. In pumpkin and quince juices not contain iodine while it presents in sufficient amount in persimmon juice that’s why in the blended juice mineral in addition to mineral elements iodine are contained. In pumpkin and persimmon aliphatic acids are contained in small amount. For this reason during the blending process was used quince juice which is rich in aliphatic acids. The blended juice is light straw color, with delicious flavor, a slight astringent property and a balanced taste.

A Comprehensive Review on Pharmacology and Toxicology of Bioactive Compounds of Lagerstroemia Speciosa (L.) Pers.

2020 ◽  
Vol 06 ◽  
Author(s):  
Surya Kant Tripathi ◽  
Sunayna Behera ◽  
Munmun Panda ◽  
Gokhan Zengin ◽  
Bijesh K. Biswal
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Health Benefit ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Lagerstroemia Speciosa ◽  
Novel Drugs ◽  
Corosolic Acid ◽  
Current Article ◽  
Preclinical And Clinical Studies

Background: Lagerstroemia speciosa (L.) Pers is one of the most valuable plants due to its ornamental and pharmacological relevance. It is known for its anti-diabetic activity with proved potent blood sugar-lowering activity. The anti-diabetic activity is due to presence of its biologically active component corosolic acid. Moreover, L. speciosa and its novel purified compounds are also well-known for its several biological activities with beneficial health benefit on the human being. Objectives: This review provides a summary of pharmacokinetics, toxicity, and pharmacological properties of L. speciosa and its purified phytochemicals which may help researchers for building up new researches in near future. Methods: The current article is prepared by collecting through various online and offline databases. Preliminary source of study and data collection for outlining the review was research articles and reviews that have been already published by many reputed publishers, including Springer, Elsevier, Taylor & Francis imprints, BMC, Willy, The Norwegian Academy of Science and Letters, Environmental health prospective (EHP), and PLOS One. Result: The available studies results suggested that the L. speciosa and its phytochemicals showed antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiviral, anti-obesity, and cardio-protective activities. Pharmacokinetic stud-ies suggested the low bioavailability of its purified compounds. However, nano-encapsulation can improve the bioavaila-bility related issue and effectively potentiate the medicinal properties of its constituents. Conclusion: Considering the worthy pharmacological properties, L. speciosa is considered as a potent source of several novel drugs. Though, still preclinical and clinical studies are needed to reveal the targets, molecular mechanisms, bioavail-ability, and toxicity of its constituents.

Placental Therapy as Panacea: An Insight to Its Therapeutic Potential

2020 ◽  
Vol 06 ◽  
Author(s):  
Sayed Md Mumtaz ◽  
Madhu Gupta ◽  
Ramesh K. Goyal
Keyword(s):  
Tissue Regeneration ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Bioactive Components ◽  
Biochemical Mechanisms ◽  
Clinically Significant ◽  
Available Information ◽  
Clinical Potential ◽  
Placental Extract

Abstract:: The placenta that maintains and regulates the growth of fetus, consists of various biological treasures nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors and other biologically active constituents. Their therapeutic usefulness can well define in the terms of biochemical mechanisms of various components present in it. Biomedical waste derived extract is also a panacea for treatment of various diseases. Placental therapy has been reported specifically to have potent action on recovery of diseases and tissue regeneration. Placental bioactive components and their multi targeting identity prompted us to compile the précised information on placental extract products. However, some findings are needed to be explored by scientific community to prove their clinical potential with clinically significant statistical conclusions. In the light of available information and the usefulness of the placental extract, it is necessary for the development of various formulations for various unmet meet for the treatment as well as access their adverse effects as well as contradictions and precisely evaluated in the short and in the long-term periods.

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