scholarly journals Protective Roles of Honey in Reproductive Health: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3322
Author(s):  
Siti Sarah Mohamad Zaid ◽  
Siti Suraya Ruslee ◽  
Mohd Helmy Mokhtar
Keyword(s):  
Reproductive Health ◽  
Hormone Replacement ◽  
Large Body ◽  
Protective Role ◽  
Modern Medicine ◽  
Convincing Evidence ◽  
Main Role ◽  
Clinical Investigations ◽  
Women's Lives

Nowadays, most people who lead healthy lifestyles tend to use natural products as supplements, complementary medicine or alternative treatments. Honey is God’s precious gift to mankind. Honey has been highly appreciated and extensively used since ancient history due to its high nutritional and therapeutic values. It is also known to enhance fertility. In the last few decades, the important role of honey in modern medicine has been acknowledged due to the large body of convincing evidence derived from extensive laboratory studies and clinical investigations. Honey has a highly complex chemical and biological composition that consists of various essential bioactive compounds, enzymes, amino and organic acids, acid phosphorylase, phytochemicals, carotenoid-like substances, vitamins and minerals. Reproductive health and fertility rates have declined in the last 30 years. Therefore, this review aimed to highlight the protective role of honey as a potential therapeutic in maintaining reproductive health. The main role of honey is to enhance fertility and treat infertility problems by acting as an alternative to hormone replacement therapy for protecting the vagina and uterus from atrophy, protecting against the toxic effects of xeno-oestrogenic agents on female reproductive functions and helping in the treatment of gynaecological disorders, such as vulvovaginal candidiasis infection, that affect women’s lives.

scholarly journals Effect of estrogens and their metabolites genotoxicity on the pathogenesis and progression of estrogen-dependent breast cancer

2019 ◽  
Vol 73 ◽  
pp. 909-919
Author(s):  
Ewa Sawicka ◽  
Arkadiusz Woźniak ◽  
Małgorzata Drąg-Zalesińska ◽  
Agnieszka Piwowar
Keyword(s):  
Mammary Gland ◽  
Hormone Replacement ◽  
Modern Medicine ◽  
The Body ◽  
Mammary Gland Tissue ◽  
Oncological Diseases ◽  
17Β Estradiol ◽  
Estradiol Metabolites ◽  
Genotoxic Action

Oncological diseases, due to the still increasing morbidity and mortality, are one of the main problems of modern medicine. Cancer of the mammary gland is the most common cancer among women around the world, and is the second cause of cancer deaths in this group, immediately after lung cancer. This kind of cancer belongs to an estrogen-dependent cancer, with proven associations with hormonal disorders in the body, occurring especially in the perimenopausal period and among women using hormone replacement therapy, as well as a result of the action of various xenobiotics that may interact with the estrogen receptor. Hormone steroids are widely used in medicine and their side effects are constantly discussed. The role of these compounds and their metabolites in maintaining hormonal balance is well understood, while many studies indicate the possible contribution of these steroids in the progression of the cancer process, especially in mammary gland tissue. Therefore, the genotoxic action of this group of compounds is still studied. Due to the limited number of scientific reports, the aim of this paper was to review and critically analyze data from the literature regarding the participation of estrogens (17β-estradiol) and their metabolites (2-methoxy estradiol, 4-hydroxy estradiol, 16α-hydroxyestrone) in the induction of carcinogenesis in mammary gland, in particular concerning the genotoxic activity of 17β-estradiol metabolites.

scholarly journals On the role of Susanna in Susanna: A Greimassian contribution

2014 ◽  
Vol 70 (3) ◽  
Author(s):  
Dickh M. Kanonge ◽  
Pierre J. Jordaan
Keyword(s):  
Jewish People ◽  
Convincing Evidence ◽  
Suitable Method ◽  
Levels Of Analysis ◽  
Main Role ◽  
Central Action ◽  
The Subject ◽  
Level Of Analysis

This article addresses the highly disputed distribution of roles in the story of Susanna. Susanna consists of a number of actors of whom only a few such as Susanna, the two elders, the Jewish people and Daniel are directly related to the central action of the story. With regard to roles of these actors in the story however, a question arises: ‘who is the subject of the story of Susanna?’ Most scholars question the attribution of the role of subject to Susanna.Their contention however, has not yet been sustained by convincing evidence stemming from the use of a suitable method.  This study attempts to fill this gap by using the Greimassian approach to narratives, as refined by Everaert-Desmedt. The approach comprises three levels of analysis: the figurative, the narrative and the thematic. The contribution focuses only on the narrative level of analysis, particularly on the actantial model because the main role of this structure is to reveal different functions of actors called here actants. It is the contention here that following the actantial model of the Greimassian approach of analysis Susanna emerges as the subject of the aim concern of the story.

scholarly journals COVID-19 and the Fourth Burden of Women in Developing Countries: A Mini Review

2020 ◽  
Vol 8 (T1) ◽  
pp. 476-479
Author(s):  
Putri C. Eyanoer ◽  
Fotarisman Zaluchu
Keyword(s):  
Developing Countries ◽  
Protective Role ◽  
Traditional Role ◽  
Psychological Burden ◽  
Additional Burden ◽  
Women's Lives ◽  
Prevention Protocol ◽  
Potential Impact ◽  
Role Of Women

It is known that women experience heavier physical and psychological burdens more than men. This is closely related to the traditional role of women because of the absence of women’s authority in themselves. In the coronavirus disease (COVID)-19 pandemic situation, the role of women has increased, namely taking on a protective role. With this additional burden, the physical and psychological burden on women becomes heavier and has the potential to create health problems in the future. In this mini review, the authors discuss the potential impact of implementing the COVID-19’s prevention protocol on women’s lives. It was concluded that there were serious and very large potential consequences for women, in terms of physically, psychologically, or emotionally; thus, early anticipations are really needed.

The Protective Role of Nutraceuticals and Functional Food in Hyperlipidemia

2019 ◽  
pp. 233-254
Author(s):  
Raushan Kumar ◽  
Syed Ibrahim Rizvi
Keyword(s):  
Functional Food ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Protective Role ◽  
Main Role ◽  
Low Density ◽  
Food Ingredients ◽  
Beneficial Effects ◽  
Major Factors

Diets rich in fats and cholesterol are mainly responsible for the production of free radicals which contribute to the incidence of hyperlipidemia and hypercholesterolemia. Both of these are the major factors responsible for CVDs. Hyperlipidemia is characterized by elevated level of total cholesterol (TC), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), and reduced level of high-density lipoprotein (HDL) in serum. The main role of diet is to provide ample amount of nutrients to meet the nutritional requirements of an individual. However, there are increasing scientific approaches helping the hypothesis that some food ingredients have beneficial effects over and above the provision of the basic nutrients. So in this chapter, the main focus is food categorized under nutraceutical and functional food and their various protective roles in the case of hyperlipidemia.

Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats

2011 ◽  
Vol 32 (2) ◽  
pp. 146-154 ◽  
Author(s):  
S.B. Sainath ◽  
R. Meena ◽  
Ch. Supriya ◽  
K. Pratap Reddy ◽  
P. Sreenivasula Reddy
Keyword(s):  
Oxidative Stress ◽  
Reproductive Health ◽  
Centella Asiatica ◽  
Protective Role ◽  
Male Rats

scholarly journals The History of the Discovery of Parathyroid Glands, and Their Role in the Body

2019 ◽  
Vol 74 (1) ◽  
pp. 35-43
Author(s):  
Natalia G. Mokrysheva ◽  
Julia A. Krupinova
Keyword(s):  
Modern Medicine ◽  
The Body ◽  
Parathyroid Glands ◽  
Main Role ◽  
Phosphorus Metabolism ◽  
Pathological Conditions ◽  
Long Time ◽  
Calcium Phosphorus ◽  
History Of

Currently, the parathyroid glands (PG) are admited as vital organs in humans. At the same time, the way to this acknowledgment was long and difficult, and the establishment of a link between the pathological conditions of the PG and their complications passed through many mistakes and errors. Understanding the regulation of calcium-phosphorus metabolism in the body and recognition of the main role of parathyroid hormone (PTH) in it was slow, throughout the XIX − early XX centuries. Despite the increasing number of observations confirming the development of complications because of hyperfunction of the PG or development of tetany due to their removal, the main link of this relationship remained unidentified for a long time. In view of the unique anatomical features of the PG, they were the last of the endocrine glands found, which the main obstacle was in the rapid study of their functional characteristics. Today, the structure and functions of the PG are described in detail, the manifestations of their various pathological conditions are well studied, and the capabilities of modern medicine allow timely diagnosis and treatment of diseases. The review describes the history of the discovery of the PG, highlights the main stages in the study of their role in calcium-phosphorus metabolism in particular and in the body as a whole, and discusses the prospects for further development in this direction. We analyzed the work devoted to the evolution in the notions of anatomical, physiological, pathological features of the PG.

Glabridin alleviates ischemia/reperfusion-induced functional failure of smooth muscle of rat ileum by upregulating the cAMP

2020 ◽  
Vol 19 (6) ◽  
pp. 555-568
Author(s):  
Ali Parlar ◽  
◽  
Saliha Ayşenur Çam ◽  
Seyfullah Oktay Arslan ◽  
◽  
...  
Keyword(s):  
Sham Group ◽  
Ischemia Reperfusion ◽  
Smooth Muscles ◽  
Protective Role ◽  
Modern Medicine ◽  
Contractile Responses ◽  
Rat Ileum ◽  
Functional Failure

Despite the development of modern medicine, alternative medicine, which has not lost its timeliness, remains attractive for the treatment of various diseases. Glabridin, a major flavonoid of Glycyrrhiza glabra, is known for its antioxidant and anti-inflammatory activity. The aim of this study was: 1) to determine the possible protective role of glabridin against ischemia/reperfusion (I/R) injury of the intestine; 2) to evaluate the in vitro contractile responses of ileum smooth muscles to acetylcholine after an intestinal I/R; and 3) to explain the underlying molecular mechanism of its effect. Rats were assigned to groups of six rats each; 1) I/R, 2) gla10, 3) gla20, 4) gla40, 5) N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester monohydrochloride (L-NAME)+gla40, and 6) Sham group. The healing effect of glabridin was abolished by L-NAME. Glabridin did not cause contractility of the smooth muscles to acetylcholine-induced contractile responses in intestinal I/R. Yet, it increased to spontaneous basal activity.

scholarly journals Ayurveda and Modern Perspective on Rajonivrittiw.s.r. to Menopause: Review Based on Literary Study

2021 ◽  
Vol 04 (11) ◽  
pp. 109-113
Author(s):  
Monika Kumari ◽  
Mahesh Dixit ◽  
Narendra Kumar Meena
Keyword(s):  
Hormone Replacement ◽  
Cost Effective ◽  
Modern Medicine ◽  
The Body ◽  
Term Therapy ◽  
Cost Effective Treatment ◽  
Long Term Therapy ◽  
Modern Perspective

Menopause, a phenomenon unique to women, is the ending of a woman’s monthly menstrual period and ovulation. It, alongside, several other changes in the bodyand mind, brought in due to a decline in the amount of the hormones estrogen and progesterone being produced by the body. Menopause is, occasionally, viewed as an end to youth and sexuality, making it a socially unacceptable occurrence. Menopause, though,one of the important physical and mental milestones in a woman’s life, many women lack information about what is taking place and what are their options. There comes the role of Ayurveda , in Ayurveda literature there is no detailed description of Rajonivrittior menopause except the age of Rajonivrittiis given as 50 years. Ayurveda involves a holistic physiological system based on balance, with its cardinal doctrine of human physiology being constituted by “vata”, “pitta” and “kapha”. In modern medicine the only treatment for these symptoms is Hormone replacement therapy (HRT), which is not a long-term therapy to be given as it has side effects on the overall health of the women. In Ayurveda Dhatu kshaya can be treated with Rasayanatherapy and other symptoms of hypo-estrogenic conditions can be treated with Phytoestrogens. So, Ayurveda gives a non-hormonal and cost-effective treatment for Rajonivrittior Menopause.

Role of spectrin in membrane fusion and in shape change of human erythrocyte ghost

1978 ◽  
Vol 36 (2) ◽  
pp. 328-329
Author(s):  
Hideo Hayashi ◽  
Yoshikazu Hirai ◽  
John T. Penniston
Keyword(s):  
Conformational Changes ◽  
Human Erythrocyte ◽  
Shape Change ◽  
Membrane Surface ◽  
Slight Modification ◽  
Active Role ◽  
Main Role ◽  
Bank Blood ◽  
Human Erythrocyte Ghost

Spectrin is a membrane associated protein most of which properties have been tentatively elucidated. A main role of the protein has been assumed to give a supporting structure to inside of the membrane. As reported previously, however, the isolated spectrin molecule underwent self assemble to form such as fibrous, meshwork, dispersed or aggregated arrangements depending upon the buffer suspended and was suggested to play an active role in the membrane conformational changes. In this study, the role of spectrin and actin was examined in terms of the molecular arrangements on the erythrocyte membrane surface with correlation to the functional states of the ghosts.Human erythrocyte ghosts were prepared from either freshly drawn or stocked bank blood by the method of Dodge et al with a slight modification as described before. Anti-spectrin antibody was raised against rabbit by injection of purified spectrin and partially purified.

Mesophyll conductance: the leaf corridors for photosynthesis

2020 ◽  
Vol 48 (2) ◽  
pp. 429-439 ◽  
Author(s):  
Jorge Gago ◽  
Danilo M. Daloso ◽  
Marc Carriquí ◽  
Miquel Nadal ◽  
Melanie Morales ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Main Role ◽  
Mesophyll Conductance ◽  
Future Studies ◽  
Cell Structures ◽  
Leaf Tissues ◽  
Change Framework ◽  
Chloroplast Stroma

Besides stomata, the photosynthetic CO2 pathway also involves the transport of CO2 from the sub-stomatal air spaces inside to the carboxylation sites in the chloroplast stroma, where Rubisco is located. This pathway is far to be a simple and direct way, formed by series of consecutive barriers that the CO2 should cross to be finally assimilated in photosynthesis, known as the mesophyll conductance (gm). Therefore, the gm reflects the pathway through different air, water and biophysical barriers within the leaf tissues and cell structures. Currently, it is known that gm can impose the same level of limitation (or even higher depending of the conditions) to photosynthesis than the wider known stomata or biochemistry. In this mini-review, we are focused on each of the gm determinants to summarize the current knowledge on the mechanisms driving gm from anatomical to metabolic and biochemical perspectives. Special attention deserve the latest studies demonstrating the importance of the molecular mechanisms driving anatomical traits as cell wall and the chloroplast surface exposed to the mesophyll airspaces (Sc/S) that significantly constrain gm. However, even considering these recent discoveries, still is poorly understood the mechanisms about signaling pathways linking the environment a/biotic stressors with gm responses. Thus, considering the main role of gm as a major driver of the CO2 availability at the carboxylation sites, future studies into these aspects will help us to understand photosynthesis responses in a global change framework.

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