scholarly journals Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6371
Author(s):  
Anton A. Larenkov ◽  
Artur G. Makichyan ◽  
Vladimir N. Iatsenko
Keyword(s):  
Reaction Time ◽  
Molecular Imaging ◽  
Teva Resin ◽  
Post Processing ◽  
Generator System ◽  
Average Value ◽  
Processing Procedure ◽  
Precursor Structure ◽  
Stable Yield ◽  
One Year

Today, 44Sc is an attractive radionuclide for molecular imaging with PET. In this work, we evaluated a 44Ti/44Sc radionuclide generator based on TEVA resin as a source of 44Sc. The generator prototype (5 MBq) exhibits high 44Ti retention and stable yield of 44Sc (91 ± 6 %) in 1 mL of eluate (20 bed volumes, eluent—0.1 M oxalic acid/0.2 M HCl) during one year of monitoring (more than 120 elutions). The breakthrough of 44Ti did not exceed 1.5 × 10−5% (average value was 6.5 × 10−6%). Post-processing of the eluate for further use in radiopharmaceutical synthesis was proposed. The post-processing procedure using a combination of Presep® PolyChelate and TK221 resins made it possible to obtain 44Sc-radioconjugates with high labeling yield (≥95%) while using small precursor amounts (5 nmol). The proposed method takes no more than 15 min and provides ≥90% yield relative to the 44Sc activity eluted from the generator. The labeling efficiency was demonstrated on the example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis. Some superiority of PSMA-I&T over PSMA-617 in terms of 44Sc labeling efficiency was demonstrated (likely due to presence of DOTAGA chelator in the precursor structure). It was also shown that microwave heating of the reaction mixture considerably shortened the reaction time and improved radiolabeling yield and reproducibility of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis.

scholarly journals Automatic instance segmentation of mitochondria in electron microscopy data

2021 ◽  
Author(s):  
Luke Nightingale ◽  
Joost de Folter ◽  
Helen Spiers ◽  
Amy Strange ◽  
Lucy M Collinson ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Large Scale ◽  
Machine Learning Algorithms ◽  
Public Repository ◽  
Post Processing ◽  
Human Cortex ◽  
Electron Microscopy Data ◽  
Processing Procedure ◽  
Microscopy Data ◽  
Instance Segmentation

We present a new method for rapid, automated, large-scale 3D mitochondria instance segmentation, developed in response to the ISBI 2021 MitoEM Challenge. In brief, we trained separate machine learning algorithms to predict (1) mitochondria areas and (2) mitochondria boundaries in image volumes acquired from both rat and human cortex with multi-beam scanning electron microscopy. The predictions from these algorithms were combined in a multi-step post-processing procedure, that resulted in high semantic and instance segmentation performance. All code is provided via a public repository.

The effect of size on the fast-start performance of rainbow trout Salmo gairdneri, and a consideration of piscivorous predator-prey interactions

1976 ◽  
Vol 65 (1) ◽  
pp. 157-177 ◽  
Author(s):  
P. W. Webb
Keyword(s):  
Rainbow Trout ◽  
Reaction Time ◽  
Reaction Times ◽  
The Body ◽  
Salmo Gairdneri ◽  
Escape Behaviour ◽  
Predator Prey ◽  
Average Value ◽  
Fast Start ◽  
Prey Escape

The fast-start (acceleration) performance of seven groups of rainbow trout from 9-6 to 38-7 cm total length was measured in response to d.c. electric shock stimuli. Two fast-start kinematic patterns, L- and S-start were observed. In L-starts the body was bent into an L or U shape and a recoil turn normally accompanied acceleration. Free manoeuvre was not possible in L-starts without loss of speed. In S-starts the body was bent into an S-shape and fish accelerated without a recoil turn. The frequency of S-starts increased with size from 0 for the smallest fish to 60–65% for the largest fish. Acceleration turns were common. The radius of smallest turn for both fast-start patterns was proportional to length (L) with an overall radius of 0–17 L. The duration of the primary acceleration stages increased with size from 0–07 s for the group of smallest fish to 0–10 s for the group of largest fish. Acceleration rates were independent of size. The overall mean maximum rate was 3438 cm/s2 and the average value to the end of the primary acceleration movements was 1562 cm/s2. The distance covered and velocity attained after a given time for fish accelerating from rest were independent of size. The results are discussed in the context of interactions between a predator and prey fish following initial approach by the predator. It is concluded that the outcome of an interaction is likely to depend on reaction times of interacting fish responding to manoeuvres initiated by the predator or prey. The prey reaction time results in the performance of the predator exceeding that of the prey at any instant. The predator reaction time and predator error in responses to unpredictable prey manoeuvre are required for prey escape. It is predicted that a predator should strike the prey within 0-1 s if the fish are initially 5–15 cm apart as reported in the literature for predator-prey interactions. These distances would be increased for non-optimal prey escape behaviour and when the prey body was more compressed or depressed than the predator.

P1075CONTROL AND MONITORING OF DIAGNOSTIC AND TREATMENT PROCESS IN HEMODIALYSIS CLINIC USING TELEMEDICINE TOOLS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Dmitriy Zinovev ◽  
Vladimir Novitskiy ◽  
Andrey Malkoch
Keyword(s):  
Quality Of Life ◽  
Reaction Time ◽  
Medical Staff ◽  
Positive Impact ◽  
Hemodialysis Patients ◽  
Patient’S Satisfaction ◽  
Average Value ◽  
Patients Satisfaction ◽  
Number Of Patients

Abstract Background and Aims Quality of life of hemodialysis patients and adequacy of hemodialysis therapy in general, is defined by the number and duration of incidents during hemodialysis procedures. In this study we examined the effect of telemedical system for control and monitoring of hemodialysis procedures on patients’ condition and their quality of life. Method The system described in this work included: doctor/patient video call functionality initiated from both ends; functionality of hemodialysis procedure parameters and patient’s condition parameters monitoring and registration; functionality of alerting medical staff about registered incidents, functionality of visual control of hemodialysis procedure. The effect of control and monitoring system usage was studied on population of 2300 hemodialysis patients (at the start of the study) with median follow-up of 2 years. The primary end-point was doctor’s reaction time on patient’s complaint, medical staff reaction time on intradialysis hypertension incidents. Secondary end-points were: number of patients who left the clinic due to reasons besides lethality, patients’ satisfaction by hemodialysis therapy (according to survey), number of incidents of intradialysis and interdialysis hypertension. Results During the study we observed that as a result of system deployment average doctor’s reaction time on patient’s complaint (defined as the time from emergence of the complaint to start of patient/doctor communication) reduced from 8 to 1.5 minutes, average staff reaction time on intradialysis hypertension incidents (defined as time from registration of hypertension incident to start of blood pressure normalization actions) reduced from 5 to 2 minutes. Number of patients who left the clinic due to reasons besides lethality reduced from 2.5 per 100 patients before system deployment to 1.7 per 100 patients at the end of the study. Average value of patient’s satisfaction by dialysis therapy increased from 7.2 to 9.1 points on 10-point scale (according to survey conducted at the beginning and at the end of the study). By the end of the study, average number (across population) of hypertension incidents per month reduced from 8.3 to 6.2 and from 20.7 to 16.5 episodes for intradialysis and interdialysis hypertension correspondingly. Conclusion The use of telemedical tools of hemodialysis procedures control and monitoring has positive impact on patients’ satisfaction level by the dialysis procedure and on duration/frequency of incidents registered by these tools, which, in return may improve the quality of patient’s life.

Numerical Weather Forecast Post-processing with Ensemble Learning and Transfer Learning

2020 ◽  
Author(s):  
Yuwen Chen ◽  
Xiaomeng Huang
Keyword(s):  
Machine Learning ◽  
Transfer Learning ◽  
Ensemble Learning ◽  
Weather Forecasting ◽  
Weather Forecast ◽  
Processing Temperature ◽  
Forecast Errors ◽  
Post Processing ◽  
Numerical Weather ◽  
One Year

<p>Statistical approaches have been used for decades to augment and interpret numerical weather forecasts. The emergence of artificial intelligence algorithms has provided new perspectives in this field, but the extension of algorithms developed for station networks with rich historical records to include newly-built stations remains a challenge. To address this, we design a framework that combines two machine learning methods: temperature prediction based on ensemble of multiple machine learning models and transfer learning for newly-built stations. We then evaluate this framework by post-processing temperature forecasts provided by a leading weather forecast center and observations from 301 weather stations in China. Station clustering reduces forecast errors by 24.4% averagely, while transfer learning improves predictions by 13.4% for recently-built sites with only one year of data available. This work demonstrates how ensemble learning and transfer learning can be used to supplement weather forecasting.</p><p></p>

scholarly journals Observation on dominance of swells over wind-seas in the coastal waters of Gulf of Mannar, India

2017 ◽  
Author(s):  
M. M. Amrutha ◽  
V. Sanil Kumar
Keyword(s):  
Wave Height ◽  
Coastal Waters ◽  
Indian Subcontinent ◽  
Sea Breeze ◽  
Early Morning ◽  
Gulf Of Mannar ◽  
Study Region ◽  
Average Value ◽  
Late Evening ◽  
One Year

Abstract. In coastal gulfs generally, predominance of wind-seas are expected. Waves measured at a location having a water depth of 15 m in the nearshore waters of Gulf of Mannar during one year period (1 May 2015 to 30 April 2016) is used to examine the predominance of wind-seas and swells through spectral characterization. The study shows that even though the location is in a gulf, the annual average value (~ 0.84 m) of the significant wave height at this area is comparable to that along the coastal waters of the Indian subcontinent, but the annual maximum value (~ 1.7 m) recorded is much less than that (3 to 5 m) observed in those regions. Also, large seasonal variations are not observed in the wave height. The waves of the study region are under the control of sea-breeze with the maximum in the late evening hours and the minimum in the early morning hours. 53 % of the surface height variance in the study area is a result of southeast and south swells and the remaining are the east and southeast wind-seas.

scholarly journals Bomb 14C Recorded in Laminated Speleothems: Calculation of Dead Carbon Proportion

Radiocarbon ◽  
1997 ◽  
Vol 39 (1) ◽  
pp. 33-48 ◽  
Author(s):  
Dominique Genty ◽  
Marc Massault
Keyword(s):  
Forest Cover ◽  
Open Systems ◽  
Sampling Site ◽  
Uncertainty Range ◽  
Average Value ◽  
Soil Zone ◽  
Calcite Deposition ◽  
The Dead ◽  
Local Geology ◽  
One Year

We performed radiocarbon measurements using accelerator mass spectrometry (AMS) on 6 stalagmites 3 stalactites and 7 seepage waters from four different caves in Southwest France and Belgium in order to calculate the dead carbon proportion (dcp). All the speleothems studied are modern and annually laminated, which offers the advantage of an accurate chronology, with better than one-year resolution. Coupled with the fact that very little calcite is necessary for an AMS measurement (between 1.5 and 7 yr of calcite deposit), we obtained dead carbon values within an uncertainty limit of ± 1.5%. Results show that the dead carbon proportion varies from 9.2% to 21.9% for calcite deposits and from 3.6% to 21.9% for water. In each sampling site, the dcp is homogeneous. Although the inter-site dcp varies by >11%, its average value of 15.5% ± 4.4 still lies within the uncertainty range of the accepted value of 15% ± 5 (dilution factor of 0.85 ± 0.5). We compare the average dcp of each site with the local geology, vegetation and climate. Given similar geology and temperature the highest dcp values are found under forest cover; dcp difference is up to 9%. However, the Belgian site, which is also under a forest shows a dcp very close to the dcp found under grassland sites of Southwest France, which proves that other unknown factors may play an important role in dissolution processes. Secondary calcite deposition and redissolution in the soil zone or more likely in the fracture system before reaching the cave itself could also explain the inter-site differences. The IAEA isotopic model (Pearson model adapted for open systems) is in good agreement with the measured activities.

Research about Post Processing for Fagor CNC System Based on Visual C++

2011 ◽  
Vol 80-81 ◽  
pp. 1273-1277
Author(s):  
Chao Wang ◽  
Yuan Yao ◽  
Qian Sheng Zhao ◽  
Qing Xi Hu
Keyword(s):  
File Format ◽  
Post Processing ◽  
Cnc Machine ◽  
Cnc System ◽  
Matching Problem ◽  
Processing Procedure ◽  
Cnc Programming ◽  
New Type ◽  
Machine Systems ◽  
Cam Systems

Post processing is one of the key technologies of CNC programming. Nowadays, the wide application of new type CNC machines is limited by the matching problem between the CAM systems and the developing CNC machine systems. This paper based on XDK9070 CNC engraving machine, researched the file format of cutter location files generated from Pro/Toolmaker and the CNC program format of FAGOR system, expounded the method and process for post processing, designed a special post processing procedure for FAGOR CNC system based on Visual C++, verified the correctness and practicality of the post processing procedure by a example of product processing.

scholarly journals Effect of Work Attitude and Total Productive Maintenance on the Overall Equipment Effectiveness and Production Continuity

2017 ◽  
Vol 7 (3) ◽  
pp. 423
Author(s):  
Puadi Haming ◽  
Mahfud Nurnajamuddin ◽  
Hamzah Hafied ◽  
Serlin Serang
Keyword(s):  
Work Experience ◽  
Partial Least Square ◽  
Least Square ◽  
Total Productive Maintenance ◽  
Work Attitude ◽  
Average Value ◽  
Mediating Role ◽  
Endogenous Variables ◽  
One Year ◽  
The Impact

<div><p><em>This study aims to examine and analyze the impact of work attitude, Total Productive Maintenance (TPM) on the Overall Equipment Effectiveness (OEE) and production continuity and the other effect of Work Attitude and Total Productive Maintenance (TPM) on production continuity: The mediating role of Overall Equipment Effectiveness (OEE). The research was conducted at PT. Semen Tonasa i.e. units II to V unit which is the largest cement producer in eastern Indonesia. Withdrawal of respondents did with the criteria that only respondents yang having their respective sectors and who have work experience of at least one year were used as samples. Results of analysis Partial Least Square (PLS) Version 2.0.M3 used in analyzing the contribution of exogenous variables on endogenous variables directly, Sobel Test was used for pushing analyze the contribution of the indirect effect (mediation) whereas importance- performance analysis (IPA) to analogous interpret the relationship loading factor value and the average value. The results of this study provide evidence of work attitude has a positive and significant effect on the overall equipment effectiveness (OEE), total productive maintenance (TPM) has a positive and  significant effect on overall equipment effectiveness (OEE), work attitude, total productive maintenance (TPM) and overall equipment effectiveness (OEE) positive and significant impact on production continuity.</em></p></div>

scholarly journals Surface ablation variability of mountain glaciers of West Spitsbergen

2019 ◽  
Vol 65 (4) ◽  
pp. 438-448
Author(s):  
O. R. Sidorova ◽  
G. V. Tarasov ◽  
S. R. Verkulich ◽  
R. A. Chernov
Keyword(s):  
Significant Contribution ◽  
Climatic Conditions ◽  
Altitude Range ◽  
Model Calculations ◽  
Average Value ◽  
Mountain Glaciers ◽  
Surface Ablation ◽  
One Year ◽  
West Spitsbergen ◽  
Interannual Scale

Measurements of surface ablation in 2016–2018 on the neighboring glaciers Aldegondabreen, Austre and Vestre Grønfjordbreen (West Spitsbergen) revealed significant differences in its magnitude both within the same altitude zones for one year, and on an interannual scale. Comparison of the region’s common variations in climatic conditions (air temperature, rainfall) and ablation data showed a significant contribution of the following additional factors of melting: aspect, size, altitude range, surface slope, the rocky bordering of glaciers. The maximum ablation were measured on the Aldegondabreen (with the smallest area and altitude range), which has a northeastern aspect; the average value over three years of observations was 1947 mm w.e. Austre Grønfjordbreen and Vestre Grønfjordbreen had in 2016–2018 average ablation values 1512 and 1385 mm w.e., respectively. The largest Vestre Grønfjordbreen has the lowest values of average ablation also because it lies higher then neighboring glaciers. Interannual variations of mean ablation in the same altitudinal zones show: the minimum scatter of values for the Aldegondabreen (130–370 mm w.e.); higher scatter of values for the Austre Grønfjordbreen (200–450 mm w.e.); the maximum scatter of values for the Vestre Grønfjordbreen (from 400–600 mm w.e. in most altitude zones to 1000 mm w.e. at altitudes of 250–350 m). Due to the influence of additional factors, the maximum average ablation was observed on the Aldegondabreen in 2016, on the Vestre Grønfjordbreen in 2017, and on the Austre Grønfjordbreen in 2017 and 2018. The results of the study indicate the need to take into account the contribution of these factors to the ablation parameters of the region’s glaciers in model calculations, as well as the relevance of a detailed study of the distribution of solar radiation on glaciers.

scholarly journals Cytoreductive surgery and hyperthermal intraperitoneal chemoperfusion in colorectal cancer and cancer of ovaries: our experience and perspectives of a new method

2020 ◽  
Vol 87 (9-10) ◽  
pp. 54-58
Author(s):  
A. V. Malynovskyi ◽  
V. V. Grubnik ◽  
I. Z. Gladchuk
Keyword(s):  
Colorectal Cancer ◽  
Ovarian Cancer ◽  
Intraoperative Complications ◽  
Optimal Cytoreduction ◽  
Women Patients ◽  
Average Value ◽  
Visceral Peritoneum ◽  
One Year ◽  
Intraperitoneal Chemoperfusion

Objective. Studying of results of the cytoreductive operations and hyperthermal intraperitoneal chemoperfusion application for treatment of canceromatosis in colorectal cancer and ovarian cancer. Materials and methods. In 10 patients, suffering colorectal cancer (6 men and 4 women) were performed peritonectomy, diathermo-ablation of implants, made from visceral peritoneum. Average value of the peritoneal canceromatosis index have constituted 18 (14 - 21). In 11 patients, suffering ovarian cancer, panhisterectomy, peritonectomy, omentectomy, and ablation of the visceral peritoneum implants was conducted. Median value of the peritoneal canceromatosis index was 16 (12 - 20). For hyperthermal intraperitoneal chemoperfusion oxaliplatin was used. Results. Complete and optimal cytoreduction (degree CC0-CC1 in accordance to classification of P. H. Sugarbaker) was achieved in 5 patients, while suboptimal one (degree CC2) - in 10, and nonoptimal (degree CC3) cytoreduction - in 6 patients. Intraoperative complications were absent. Postoperative complications have occurred in 5 (23.8%) patients: the wound infection, persisting ileus, episode of partial ileus. Of 10 patients, suffering colorectal cancer, 5 died in 9-12 mo. One-year barrier have had survived 45.5% patients. Of 11 women-patients, suffering ovarian cancer, 7 died in 6-24 mo. One-year barrier have had survived 36.4% women-patients. Conclusion. In patients, suffering colorectal cancer, the survival median was 12 mo, while in the women-patients, suffering ovarian cancer - 18 mo. Cytoreductive operations and hyperthermal intraperitoneal chemoperfusion constitute perspective method for the survival enhancement in patients, suffering canceromatosis, but only if their selection was organized.

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