Dietary Patterns and Interventions to Alleviate Chronic Pain

Pain is one of the main problems for modern society and medicine, being the most common symptom described by almost all patients. When pain becomes chronic, the life of the patients is dramatically affected, being associated with significant emotional distress and/or functional disability. A complex biopsychosocial evaluation is necessary to better understand chronic pain, where good results can be obtained through interconnected biological, psychological, and social factors. The aim of this study was to find the most relevant articles existent in the PubMed database, one of the most comprehensive databases for medical literature, comprising dietary patterns to alleviate chronic pain. Through a combined search using the keywords “chronic pain” and “diet” limited to the last 10 years we obtained 272 results containing the types of diets used for chronic pain published in the PubMed database. Besides classical and alternative methods of treatment described in literature, it was observed that different diets are also a valid solution, due to many components with antioxidant and anti-inflammatory qualities capable to influence chronic pain and to improve the quality of life. Thirty-eight clinical studies and randomized controlled trials are analyzed, in an attempt to characterize present-day dietary patterns and interventions to alleviate chronic pain.

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Duloxetine for chronic pain

Russian Medical Inquiry ◽

10.32364/2587-6821-2021-5-10-687-693 ◽

2021 ◽

Vol 5 (10) ◽

pp. 687-693

Author(s):

E.V. Ekusheva ◽

◽

Keyword(s):

Chronic Pain ◽

Neuropathic Pain ◽

Pain Syndrome ◽

Modern Society ◽

Developed Countries ◽

Antidepressant Effect ◽

Keywords Chronic Pain ◽

Serotoninergic And Noradrenergic Systems ◽

Anxiety Depression

Chronic pain is still a critical medical issue in modern society that results in severe deadaptation and reduces the quality of life in 15–40% of people in developed countries. Neuropathic pain is an essential issue characterized by recurrent course and the presence of comorbidities, e.g., depression. Duloxetine is particularly important among drugs with established efficacy prescribed for neuropathic pain. This agent significantly affects serotoninergic and noradrenergic systems and significant pathogenic mechanisms of the development of chronic pain, i.e., processes of disinhibition, thereby increasing the functional activity of the descending system of pain inhibition. The analgesic effect of duloxetine occurs much earlier and is independent of its antidepressant effect. Duloxetine is prescribed for many conditions that are often challenging for practitioners and associated with chronic pain. In addition, duloxetine has a significant effect on comorbid anxiety, depression, and sleep disorders. KEYWORDS: chronic pain, neuropathic pain, chronic pain syndrome, duloxetine. FOR CITATION: Ekusheva E.V. Duloxetine for chronic pain. Russian Medical Inquiry. 2021;5(10):687–693 (in Russ.). DOI: 10.32364/2587- 6821-2021-5-10-687-693.

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The Pain Situation of Older Home-Care Recipients and Influencing Factors

Innovation in Aging ◽

10.1093/geroni/igaa057.662 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 204-205

Author(s):

Dagmar Dräger ◽

Reinhold Kreutz ◽

Adelheid Kuhlmey ◽

Andrea Budnick ◽

Dagmar Draeger

Keyword(s):

Chronic Pain ◽

Home Care ◽

Older People ◽

Pain Intensity ◽

Prevalence Rate ◽

Severe Pain ◽

Self Report ◽

Primary Data ◽

Common Symptom ◽

Care Recipients

Abstract Chronic pain is a common symptom among older people. The international prevalence rate reaches 50% for older home-care recipients (aged ≥60). The most common causes of pain among older people are degenerative arthropathy and musculoskeletal diseases. Care recipients (81% aged ≥65) constitute a specific sub-group among pain patients, due to the restrictions they experience. In Germany, the prevalence rate in this group is 70%. Currently, no comprehensive information on the pain situation of older home-care recipients exists in Germany. The findings presented are based on a cross-sectional study of older (aged ≥65) home-care recipients (SGB XI) in Berlin, with chronic pain (n=225), capable of self-report (MMST≥18). Structured interviews comprised the primary data source. The pain situation was determined using the German Brief Pain Inventory (BPI-NH). Multiple regression analysis was applied to test how the most severe pain (dependent variable) was influenced by socio-demographic and medical parameters, mental and physical restrictions and pain medication. Analyses of the pain situation show a value of M=4.81 (SD±1.88) on the BPI intensity index, and a BPI pain interference index of M=5.47 (SD±2.15). The most intense pain averaged 6.96 (SD±2.15). On average, respondents reported 16.20 (SD±13.25) pain locations (range: 0-65). The number of pain locations, alongside other factors, had a significant influence, R²=0.038 (corrected R²=0.034), F (1.219) = 8.760, p<0.01), on pain intensity. The findings show severe pain intensity among older home-care recipients not reported in previous findings (e.g. in long-term in-patient care). Action in medical care, nursing care and educational aspects is urgently needed.

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Pain Management in Context of Emotionally Unstable Personality Disorder

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.1843 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S500-S500

Author(s):

E. Dobrzynska ◽

N. Clementi

Keyword(s):

Chronic Pain ◽

Pain Management ◽

Personality Disorder ◽

English Language ◽

Opioid Analgesics ◽

Management Options ◽

Cognitive Behavioural ◽

Keywords Chronic Pain ◽

Competing Interest ◽

Emotionally Unstable Personality Disorder

IntroductionEmotionally unstable personality disorder (EUPD) is characterised by Pain Paradox. The response for acute, self-induced pain seems to be attenuated while chronic, endogenous pain is usually intolerable. Pain management of this group of patients poses many difficulties, including discrepancies between subjective and objective pain assessment, patients’ demands for strong analgesics and impact on relationship with other professionals.Objectives and aimsThe purpose of the study was to review pain management options for persons diagnosed with EUPD and complaining of chronic pain.MethodsMEDLINE and PsycINFO databases were searched for all English-language articles containing the keywords “chronic pain”, “pain management”, “borderline personality disorder”, and “emotionally unstable personality disorder”.ResultsSeventeen relevant papers were identified. Suggested first step in pain management was ongoing clarification with EUPD patients that analgesics are unlikely to fully treat their pain and support of non-pharmacological approaches to pain, including cognitive-behavioural strategies. Regarding pharmacology, liberal use of non-addicting analgesics was recommended with highly conservative use of opioid analgesics. Importance of evaluation and treatment of any underlying mood and/or anxiety syndromes was stressed as well as liaison with other professionals (e.g. psychologists, neurologists, orthopaedics, and physiotherapists).ConclusionsPatients with EUPD often report chronic pain, which can only be managed by close collaboration of professionals from different disciplines.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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GLOBAL PROBLEMS OF MODERNITY AND THE SOCIETY OF INFORMATION TECHNOLOGIES

INTERNATIONAL JOURNAL OF CONSENSUS ◽

10.26739/2181-0788-2021-1-1 ◽

2021 ◽

Vol 2 (1) ◽

pp. 4-16

Author(s):

Narzulla Juraev ◽

Keyword(s):

Information And Communication Technologies ◽

Information Society ◽

Information Technologies ◽

Intellectual Development ◽

Modern Society ◽

Scientific Article ◽

Consumer Attitude ◽

Political Analysis ◽

Information And Communication ◽

Almost All

The rapid breakthrough observed today in the field of information and communication technologies testifies to the movement of mankind towards a new post-industrial phase of development -the information society. At the present stage, information is the main source of development of society. The penetration of information technology into almost all socio-economic spheres entails the formation of new needs and a new way of life for mankind.While noting the positive aspects of the information society, one should not forget about its negative aspects. With the development of modern society, the consumer attitude of people to the world is increasing. There is a danger of information dependence. For some people, virtual reality is often more significant than reality itself. To fully disclose the research, the scientific article used methods such as a systematic approach, historicity, comparative historical, structural, political analysis, functional and cultural analysis.At the end, scientifically grounded conclusions, recommendations and proposals on the need for spiritual and intellectual development of society weredeveloped.

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Daily Physical Activity and Functional Disability Incidence in Community-Dwelling Older Adults with Chronic Pain: A Prospective Cohort Study

Pain Medicine ◽

10.1093/pm/pny263 ◽

2018 ◽

Vol 20 (9) ◽

pp. 1702-1710 ◽

Cited By ~ 4

Author(s):

Keitaro Makino ◽

Sangyoon Lee ◽

Sungchul Lee ◽

Seongryu Bae ◽

Songee Jung ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Chronic Pain ◽

Functional Disability ◽

Community Dwelling ◽

Daily Physical Activity ◽

Activity Duration ◽

Intensity Physical Activity ◽

Physical Activity Duration ◽

Community Dwelling Older Adults

Abstract Objective This study examined the association between daily physical activity and functional disability incidence in community-dwelling older adults with chronic pain. Design Prospective cohort study. Setting Japanese community. Subjects Of the 5,257 participants enrolled for baseline assessment, data on the 693 participants who had chronic lower back or knee pain and underwent daily physical activity assessment using an accelerometer were analyzed. Methods Participants were assessed for regular physical activity (step counts, moderate- to vigorous-intensity physical activity duration, and light-intensity physical activity duration) using an accelerometer at baseline and were followed up for monthly functional disability incidence, based on the national long-term care insurance system, for approximately two years. We determined the effect of physical activity cutoff points on functional disability incidence using receiver operating characteristic curves and Youden index. Cox proportional hazards regression models were used to analyze associations between the cutoff points and disability incidence. Results Among the 693 participants with chronic pain, 69 (10.0%) developed functional disability during the follow-up period. Participants with lower physical activity levels showed significantly higher risk of disability. After adjusting for all covariates, functional disability was associated with step counts (hazard ratio [HR] = 1.79, 95% confidence interval [CI] = 1.02–3.14) and moderate- to vigorous-intensity physical activity duration (HR = 2.02, 95% CI = 1.16–3.51) but had no relationship with light-intensity physical activity duration (HR = 1.72, 95% CI = 0.97–3.05). Conclusions Maintenance of physical activity with at least moderate intensity may be effective in preventing disability even among older adults with chronic pain.

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Molecular Docking Senyawa Gingerol dan Zingiberol pada Tanaman Jahe sebagai Penanganan COVID-19

Jurnal e-Biomedik ◽

10.35790/ebm.v9i1.32361 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Belinda D. P. M. Ratu ◽

Widdhi Bodhi ◽

Fona Budiarso ◽

Billy J. Kepel ◽

. Fatimawali ◽

...

Keyword(s):

Molecular Docking ◽

Binding Affinity ◽

Amino Acid Residues ◽

Autodock Vina ◽

Discovery Studio ◽

Main Protease ◽

Docking Method ◽

Pubmed Database ◽

Almost All ◽

The Impact

Abstract: COVID-19 is a new disease. Many people feel the impact of this disease. There is no definite cure for COVID-19, so many people use traditional medicine to ward off COVID-19, including ginger. This study aims to determine whether there is an interaction between compounds in ginger (gingerol and zingiberol) and the COVID-19’s main protease (6LU7). This study uses a molecular docking method using 4 main applications, namely Autodock Tools, Autodock Vina, Biovia Discovery Studio 2020, and Open Babel GUI. The samples used were gingerol and zingiberol compounds in ginger plants downloaded from Pubchem. The data used in this study used Mendeley, Clinical Key, and PubMed database. The study showed that almost all of the amino acid residues in the gingerol compound acted on the 6LU7 active site, whereas the zingiberol did not. The results of the binding affinity of ginger compounds, both gingerol and zingiberol, do not exceed the binding affinity of remdesivir, a drug that is widely researched as a COVID-19 handling drug. In conclusion, gingerol and zingiberol compounds in ginger can’t be considered as COVID-19’s treatment.Keywords: molecular docking, gingerol, zingiberol Abstrak: COVID-19 merupakan sebuah penyakit yang baru. Banyak masyarakat yang merasakan dampak dari penyakit ini. Belum ada pengobatan pasti untuk menyembuhkan COVID-19, sehingga banyak masyarakat yang menggunakan pengobatan tradisional untuk menangkal COVID-19, termasuk jahe. Penelitian ini bertujuan untuk mengetahui apakah ada interaksi antara senyawa pada jahe (gingerol dan zingiberol) dengan main protease COVID-19 (6LU7). Penelitian ini menggunakan metode molecular docking dengan menggunakan 4 aplikasi utama, yaitu Autodock Tools, Autodock Vina, Biovia Discovery Studio 2020, dan Open Babel GUI. Sampel yang digunakan yaitu senyawa gingerol dan zingiberol pada tanaman jahe yang diunduh di Pubchem. Data yang digunakan dalam penelitian ini menggunakan database Mendeley, Clinical Key, dan PubMed. Penelitian menunjukkan bahwa hampir semua residu asam amino pada senyawa gingerol bekerja pada sisi aktif 6LU7, sedangkan tidak demikian pada zingiberol. Hasil binding affinity senyawa jahe, baik gingerol maupun zingiberol tidak melebihi binding affinity remdesivir, obat yang banyak diteliti sebagai obat penanganan COVID-19. Sebagai simpulan, senyawa gingerol dan zingiberol pada tanaman jahe tidak dapat dipertimbangkan sebagai penanganan COVID-19Kata Kunci: molecular docking, gingerol, zingiberol

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Biomarkers of Allostatic Load as Correlates of Impairment in Youth with Chronic Pain: An Initial Investigation

Children ◽

10.3390/children8080709 ◽

2021 ◽

Vol 8 (8) ◽

pp. 709

Author(s):

Sarah Nelson ◽

Samantha Bento ◽

Michelle Bosquet Enlow

Keyword(s):

Risk Factors ◽

Chronic Pain ◽

Allostatic Load ◽

Functional Disability ◽

Pain Treatment ◽

Pediatric Pain ◽

Childhood Experiences ◽

High Exposure ◽

Pediatric Chronic Pain ◽

Study Results

Pediatric chronic pain is common and responsible for significant healthcare burden. However, the mechanisms underlying the development and/or maintenance of pediatric chronic pain remain poorly understood. Allostatic load (AL), or wear and tear on the nervous system following significant or prolonged stress, has been proposed to play a role in the maintenance of chronic pain, but minimal research has examined this possibility. This gap in research is particularly notable given the high exposure to adverse childhood experiences (ACEs; abuse/neglect, etc.) and psychological stress in this population. Accordingly, the current study aimed to preliminarily examine the measurement of AL in a treatment-seeking pediatric pain population. Biomarkers were collected during an already scheduled new patient pain evaluation and included salivary cortisol, dehydroepiandrosterone (DHEA), and C-reactive protein, in addition to waist–hip ratio, body-mass index, and blood pressure. A total of 61 children and adolescents with chronic pain (Mage = 14.47 years; 88.5% female and white/Caucasian) completed study procedures and were included in analyses. Preliminary results indicated that a multifactorial AL composite is feasible to assess for in a tertiary pain treatment setting and that over 50% of youth with chronic pain were classified as high risk for AL (two or more risk factors). Further, it was found that individual AL risk factors were significantly associated with functional disability and that AL may moderate the association between psychosocial and functional outcomes. Given the pilot nature of this study, results should be used to inform future investigations with larger and more diverse pediatric pain samples.

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Akad Murakkab dalam Produk Keuangan Syariah

Jurnal BAABU AL-ILMI: Ekonomi dan Perbankan Syariah ◽

10.29300/ba.v5i1.3122 ◽

2020 ◽

Vol 5 (1) ◽

pp. 104

Author(s):

Siti Kholijah

Keyword(s):

Product Development ◽

Modern Society ◽

Islamic Banking ◽

Important Thing ◽

Financial Products ◽

Development Agreement ◽

Almost All ◽

Financial Transactions

The most important thing for creating sharia banking and financial products in addressing the demands of modern society is the development of multiple agreement.The form of a single agreement is not able to respond to contemporary financial transactions. Multiple agreement method should be superior in product development. Agreement in sharia transaction are modified from the exciting agreements in which such agreements are found in almost all sharia product. Multiple Agreement(al-Uqud al- Murakkabah) is one of contempory in Islamic banking whose implementation develops in line with business developments.

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Neurological manifestations associated with SARS-CoV-2 infection: a narrative review

10.5327/1516-3180.442 ◽

2021 ◽

Author(s):

Poliana Rafaela dos Santos Araújo ◽

Kauan Alves Sousa Madruga ◽

Bruna Alves Rocha ◽

Lucas Oliveira Braga

Keyword(s):

Nervous System ◽

Meta Analysis ◽

Neurological Complications ◽

Neurological Symptoms ◽

Narrative Review ◽

Common Symptom ◽

Neurological Manifestations ◽

Cns Involvement ◽

Pubmed Database ◽

Critical Patients

Background: Coronavirus disease (COVID-19), once identified, soon spread globally, becoming a pandemic. Although patients present mainly with respiratory complaints, several neurological symptoms have been reported. Symptoms range from headache and nonspecific dizziness to seizures and cerebrovascular disease (CVD). It has also been shown that the severity of the infection is directly proportional to the development of neurological symptoms, especially CVD and changes in mental status. Objective: The present study aims to briefly review the neurological manifestations of COVID-19 and discuss the pathogenic mechanisms of Central Nervous System (CNS) involvement. Methods: This is an exploratory narrative review with a descriptive approach, consisting of an active search for scientific articles in the PubMed database. The descriptors “coronavirus infections”, “COVID-19” and “Nervous system” were used, with the Boolean operators “OR” and “AND”. Eighteen articles of systematic review and meta-analysis were included. Results: CNS manifestations included, among others: encephalitis, encephalopathy, consciousness decrease, headache, dizziness, acute myelitis, and stroke. As for the peripheral nervous system, skeletal muscle damage, chemosensory dysfunction, and Guillain-Barré syndrome were observed, with hyposmia being the most common symptom. CNS involvement may be related to a worse prognosis. Conclusion: The clinical involvement of the nervous system in COVID-19 is not uncommon, and can result in several neurological complications, especially in the most critical patients. The pathophysiological mechanisms of these events still need further investigation. In the meantime, physicians should value extra-respiratory symptoms ranging from hyposmia, to potentially fatal manifestations, such as stroke and encephalopathy.

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Đánh giá ảnh hưởng của đau mạn tính lên sức khỏe tổng quát ở bệnh nhân điều trị tại khoa YHCT Bệnh viện TW Huế cơ sở 2

Journal of Clinical Medicine- Hue Central Hospital ◽

10.38103/jcmhch.2020.60.2 ◽

2020 ◽

Author(s):

Kim Lan Lại Thị

Keyword(s):

Chronic Pain ◽

Traditional Medicine ◽

General Health ◽

Common Symptom ◽

Low Back ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Medicine Department ◽

Common Location ◽

The Common

EVALUATING THE EFFECT OF CHRONIC PAIN TO PATIENT’S GENERAL HEALTH AT TRADITIONAL MEDICINE DEPARTMENT OF HUE CENTRAL HOSPITAL BRANCH 2 Background: Pain is a very common symptom in the community and it is a leading cause of patients have to meet doctors and come to hospitals. Chronic pain results in poor quality of life, many days lost from work and high direct and indirect costs for the health care system. Objective: To investigate on chronic pain and general health with their ralated factors on patients at Traditional medicine department. To evaluate the effects of chronic pain to general health. Participants and method: A cross-sectional survey was performed for patients at Traditional medicine department with the pain and general health questionaire from 6/2018 to 6/2019. Results: Duration of chronic pain is very long. The common location of pain is low back. Majority of patients reported their pain condition is from moderate to severe level. Majority of patients have general health is lower moderate level. Conclusion: Chronic pain is one of the major health problems of the population. The common location of pain is low-back. The first is not to determine the effect of pain to general health of patient. Keywords: chronin pain, general health

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