scholarly journals Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3169
Author(s):  
Porfirio Alonso Ruiz-Hurtado ◽  
Leticia Garduño-Siciliano ◽  
Pilar Domínguez-Verano ◽  
Daniela Balderas-Cordero ◽  
Gustavo Gorgua-Jiménez ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Public Health Problem ◽  
Good Alternative ◽  
Gastric Ulcers ◽  
Major Public Health Problem ◽  
Gastroprotective Activity ◽  
Future Studies ◽  
Ulcer Disease ◽  
Potential Use ◽  
Different Doses

Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people.

scholarly journals WARAM-I MEDA (GASTRITIS) AND ITS MANAGEMENT FROM UNANI PERSPECTIVE

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Azma Waseem ◽  
Waseem Ahmad ◽  
Anwar Jamal ◽  
Mohammad Fazil ◽  
Asim Ali Khan
Keyword(s):  
Developing Countries ◽  
Bile Reflux ◽  
Public Health Problem ◽  
Developed Countries ◽  
The Body ◽  
Gastric Ulcers ◽  
Major Public Health Problem ◽  
Two Factors ◽  
Inflammatory Drugs ◽  
Continuous Use

In the present scenario, gastritis still remains a major public health problem that affects the population of both the developed as well as developing countries. More than 50% of the population in developing countries suffers from gastritis, whereas 34.7 % of the population in developed countries had health problems due to gastritis. Main causes of gastritis are infections, stress, continuous use of non steroidal anti-inflammatory drugs, alcohol and bile reflux. Gastritis if remains untreated or undiagnosed causes Quruh-i Meda (gastric ulcers). Prolonged and progressive inflammation results in destruction of gastric mucosa (Atrophic gastritis) and reduction in gastric acid secretions. These two factors are considered as the main risk factors in the pathogenesis of gastric cancer. Unani physicians have given much importance to this disease. In Unani system of medicine, there is elaborated description of gastritis under the heading of Waram-i Meda with causes, symptoms and its effective management. The fundamental principles of Unani treatment of gastritis is to restore the normalcy of the patient, correction of temperament (Mizaj ), humoral balance in the organ and the body, and toning up of the stomach. All these principles are achieved mostly by three modes of treatment i.e. Iaj bil Tadbeer (Regimenal therapy), Ilaj bil Ghiza (Dietotherapy) and Ilaj bil Dawa (Pharmacotherapy). In this review article, Waram-i Meda (gastritis) is elaborated with its type, causes and treatment in Unani perspective with the objective to reduce the burden of gastritis and prevention of complications associated with gastritis.

scholarly journals EPISODES OF HEARTBURN AND BLOATING IN MEDICAL PRACTICE

2021 ◽  
Author(s):  
VAZHA GVANTSELADZE ◽  
NANA GNANTSELADZE
Keyword(s):  
Quality Of Life ◽  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Gastric Ulcers ◽  
Ability To Work ◽  
Ulcer Disease ◽  
Impaired Ability ◽  
Georgian Population

The aim of the study was to study the frequency and nature of episodes of heartburn and bloating in patients with duodenal and gastric ulcers in the Georgian population, considering the histomorphological and morphometric changes of the gastric mucosa and the parameters of gastric secretion. At the same time, we were interested in analyzing patients' anamnesis before being hospitalized for the last 2 months. The analysis of the material showed that incidence of heartburn episodes in the Georgian population is clearly higher in patients with peptic ulcer disease 12 - (79.9%) than in patients with gastric ulcer (9 - 31.9%). Episodes of heartburn in these patients are characterized not only by increasing of rate (more than 50 episodes), both day and night, but the intensity and duration (which is due to abnormal gastroesophageal reflux). This is a high risk for the occurrence of heartburn episodes. As for bloating, it was detected in patients with duodenal ulcer (11–26.2%), in gastric ulcer 11– (32.9%). The main pathogenetic aspects of heartburn episodes were found to be diffuse fundal glands hyperplasia and high acidity (duodenal ulcer and pyloric anterior ulcer). It was also found that a large percentage of patients were not treated properly, leading to impaired ability to work and changes in quality of life and disease progression.

scholarly journals (-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models

2021 ◽  
Vol 12 ◽  
Author(s):  
Catarina Alves de Lima Serafim ◽  
Maria Elaine Cristina Araruna ◽  
Edvaldo Balbino Alves Júnior ◽  
Leiliane Macena Oliveira Silva ◽  
Alessa Oliveira Silva ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Animal Models ◽  
Gastric Secretion ◽  
Gastric Wall ◽  
Lethal Dose ◽  
Mechanisms Of Action ◽  
Gastric Ulcers ◽  
Ethanol Stress ◽  
Gastroprotective Activity ◽  
Pylorus Ligation

Background: (-)-Carveol (p-Mentha-6,8-dien-2-ol) is a monocyclic monoterpenic alcohol, present in essential oils of plant species such as Cymbopogon giganteus, Illicium pachyphyllum and in spices such as Carum carvi (cumin). Pharmacological studies report its antitumor, antimicrobial, neuroprotective, vasorelaxant, antioxidant and anti-inflammatory activity.Hypothesis/Purpose: The objective of this study was to evaluate the acute non-clinical oral toxicity, gastroprotective activity of monoterpene (-)-Carveol in animal models and the related mechanisms of action.Methods: Acute toxicity was assessed according to OECD guide 423 in mice. Ethanol, stress, NSAIDs and pylorus ligation-induced gastric ulcer models were used to investigate antiulcer properties. The related mechanisms of action were using the ethanol-gastric lesions protocol.Results: (-)-Carveol has low toxicity, with a lethal dose 50% (LD50) equal to or greater than 2,500 mg/kg according to OECD guide nº 423. In all gastric ulcer induction methods evaluated, (-)-Carveol (25, 50, 100 and 200 mg/kg, p.o.) significantly reduced the ulcerative lesion in comparison with the respective control groups. To investigate the mechanisms involved in the gastroprotective activity, the antisecretory or neutralizing of gastric secretion, cytoprotective, antioxidant and immunoregulatory effects were evaluated. In the experimental protocol of pylorus ligation-induced gastric ulcer, (-)-Carveol (100 mg/kg) reduced (p < 0.001) the volume of gastric secretion in both routes (oral and intraduodenal). The previous administration of blockers NEM (sulfhydryl groups blocker), L-NAME (nitric oxide synthesis inhibitor), glibenclamide (KATP channel blocker) and indomethacin (cyclo-oxygenase inhibitor), significantly reduced the gastroprotection exercised by (-)-Carveol, suggesting the participation of these pathways in its gastroprotective activity. In addition, treatment with (-)-Carveol (100 mg/kg) increased (p < 0.001) mucus adhered to the gastric wall. Treatment also increased (p < 0.001) levels of reduced glutathione (GSH), superoxide dismutase (SOD) and interleukin-10 (IL-10). It also reduced (p < 0.001) malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels.Conclusion: Thus, it is possible to infer that (-)-Carveol presents gastroprotective activity related to antisecretory, cytoprotective, antioxidant and immunomodulatory mechanisms.

scholarly journals ANTIOXIDANT EFFECT OF POLYHERBAL FORMULATION IN ISOPRENALINE HYDROCHLORIDE INDUCED MYOCARDIAL INFARCTION IN RATS

2017 ◽  
Vol 9 (10) ◽  
pp. 273
Author(s):  
Kavitha P. ◽  
Sowmia C.
Keyword(s):  
Myocardial Infarction ◽  
Reduced Glutathione ◽  
Public Health Problem ◽  
Antioxidant Effect ◽  
Major Public Health Problem ◽  
Enzymatic Antioxidants ◽  
Degree Of Protection ◽  
Polyherbal Formulation ◽  
Cardioprotective Effects ◽  
Different Doses

Objective: Myocardial infarction (MI) continues to be a major public health problem in the world. The prepared polyherbal formulation (PHF) exhibit cardioprotective effects by several mechanisms. The objective of the research was to evaluate the antioxidant effect of a polyherbal formulation in isoprenaline hydrochloride (ISO) induced myocardial infarction in rats.Methods: Oxidative stress and myocardial infarction was induced by administration of isoprenaline hydrochloride (25 mg/kg) for 2 d. The degree of protection was determined by measuring the levels of lipid peroxidation (LPO), enzymatic antioxidants (superoxide dismutase-SOD, Catalase, Glutathione peroxidase) and non-enzymatic antioxidants (Vitamin C, E and reduced glutathione-GSH).Results: Two different doses (250 mg and 500 mg/kg body wt) of the formulation was used to prove the cardioprotective effect. Pretreatment with polyherbal formulation significantly (P<0.05) lowered LPO and elevated the enzymatic and non-enzymatic antioxidants in heart homogenate.Conclusion: The polyherbal formulation exhibited cardioprotective activity, which could be attributed to its antioxidant activity. 

scholarly journals Osteoporosis and the Potential of Cell-Based Therapeutic Strategies

2020 ◽  
Vol 21 (5) ◽  
pp. 1653 ◽  
Author(s):  
Iratxe Macías ◽  
Natividad Alcorta-Sevillano ◽  
Clara I. Rodríguez ◽  
Arantza Infante
Keyword(s):  
Metabolic Bone Disease ◽  
Public Health Problem ◽  
Bone Fragility ◽  
Molecular Evidence ◽  
Major Public Health Problem ◽  
Low Bone Mass ◽  
Metabolic Bone ◽  
Decrease Bone Resorption ◽  
Potential Use

Osteoporosis, the most common chronic metabolic bone disease, is characterized by low bone mass and increased bone fragility. Nowadays more than 200 million individuals are suffering from osteoporosis and still the number of affected people is dramatically increasing due to an aging population and longer life, representing a major public health problem. Current osteoporosis treatments are mainly designed to decrease bone resorption, presenting serious adverse effects that limit their safety for long-term use. Numerous studies with mesenchymal stem cells (MSCs) have helped to increase the knowledge regarding the mechanisms that underlie the progression of osteoporosis. Emerging clinical and molecular evidence suggests that inflammation exerts a significant influence on bone turnover, thereby on osteoporosis. In this regard, MSCs have proven to possess broad immunoregulatory capabilities, modulating both adaptive and innate immunity. Here, we will discuss the role that MSCs play in the etiopathology of osteoporosis and their potential use for the treatment of this disease.

scholarly journals Plasma microRNA profiling for malaria disease: association with severity and P. falciparum biomass

2020 ◽  
Author(s):  
Himanshu Gupta ◽  
Mercedes Rubio ◽  
Antonio Sitoe ◽  
Rosauro Varo ◽  
Pau Cistero ◽  
...  
Keyword(s):  
Differential Expression ◽  
Prognostic Value ◽  
Public Health Problem ◽  
Disease Association ◽  
Major Public Health Problem ◽  
Future Studies ◽  
Microrna Profiling ◽  
Plasma Microrna ◽  
Generation Sequencing

Severe malaria (SM) is a major public health problem in malaria-endemic countries. Sequestration of Plasmodium falciparum (Pf) infected erythrocytes in vital organs and the associated inflammation leads to organ dysfunction. MicroRNAs (miRNAs), which are rapidly released from damaged tissues into the host fluids, constitute a promising biomarker for the prognosis of SM. This study applied next-generation sequencing to evaluate the differential expression of miRNAs in SM compared to uncomplicated malaria (UM). Six miRNAs were associated with in vitro Pf cytoadhesion, severity in Mozambican children and Pf biomass. Relative expression of hsa-miR-4497 quantified by TaqMan-RT-qPCR, was higher in SM children plasmas compared to that of UM (p<0.048), and again correlated with Pf biomass (p=0.033). These findings suggest that different physiopathological processes in SM and UM lead to differential expression of miRNAs and pave the way to future studies aiming to assess the prognostic value of these miRNAs in malaria.

scholarly journals Effect of quercetin on histamine induced gastric ulcers in male guinea pigs

2019 ◽  
Vol 8 (9) ◽  
pp. 2018 ◽  
Author(s):  
Uma Narayanamurthy ◽  
Ranjani Jayachandran ◽  
Sudar Codi Ramarajan ◽  
Manimekalai Kumarappan
Keyword(s):  
Gastric Ulcer ◽  
Guinea Pigs ◽  
Gastrointestinal Diseases ◽  
Gastric Ulcers ◽  
Control Group ◽  
Ulcer Disease ◽  
Group I ◽  
Permanent Cure ◽  
Group 3 ◽  
Group 2

Background: Peptic ulcer disease is the most prevalent gastrointestinal diseases caused by an imbalance between gastric stimulant or aggressive factors and the mucosal defensive factors. The defence of flavonoids against the tissue oxidative stress is being proved in various animal models for wide pharmacological effects. The aim of the present study is to evaluate the anti-oxidant effect of quercetin in histamine induced gastric ulcers.Methods: Male guinea pigs were divided into 4 groups (n=6). Group I includes normal control. Group 2, 3 and 4 were induced gastric ulcers with histamine as intraperitoneal (IP) injection. Group 2 serves as the gastric ulcer control. Group 3 and Group 4 are pre-treated with quercetin 200 mg/kg per orally (PO) and ranitidine 100 mg/kg PO respectively 45mins before histamine injection. After 4 hours of histamine injection, the animals were sacrificed to collect blood samples and stomach tissue for estimation of plasma and tissue antioxidant levels.Results: On estimation of antioxidant levels both in plasma and stomach tissues the SOD and CAT levels increased in the Group 3 and 4 significantly and also a significant reduction in MDA levels were noted in the Group 3 and 4 compared to the gastric ulcer control group.Conclusions: Hence, with flavonoids quercetin utilization in histamine induced gastric ulcers, the antioxidants showed comparative levels with ranitidine treatment groups. So a permanent cure for the chronic gastric ulcers could be proved in further studies as this is the milestone, tough to achieve in general clinical practice.

scholarly journals Enhancing Fluoride: Clinical Human Studies of Alternatives or Boosters for Caries Management

2016 ◽  
Vol 50 (Suppl. 1) ◽  
pp. 22-37 ◽  
Author(s):  
Margherita Fontana
Keyword(s):  
Longitudinal Design ◽  
Human Subjects ◽  
Public Health Problem ◽  
Caries Prevention ◽  
High Risk Population ◽  
Major Public Health Problem ◽  
Test Product ◽  
Caries Management ◽  
Prospective Longitudinal ◽  
Potential Use

Dental caries remains a major public health problem, especially for certain high-risk population groups. The goal of this study was to assess the evidence regarding strategies meant to be used as alternatives or booster/supplements to fluoride for caries prevention and management. Articles were selected for inclusion if they had a prospective longitudinal design, with a fluoride control arm, and were conducted in human subjects. Of the included studies, 7/18 studies on calcium-based strategies favored the test product (the majority of studies included exposure of fluoride in all groups). All the arginine studies (8/8) included a combination of arginine and a calcium base, and concluded that this has the potential to significantly boost the performance of fluoride. The remaining included studies focused on the addition of microbial-related strategies to a fluoride-containing vehicle (2 xylitol studies and 1 study using a probiotic milk), and all favored the combination as a booster to fluoride. Thus, the current study did not identify evidence for any strategy to effectively be used as a substitute or alternative to fluoride, but identified some consistent evidence derived from the use of prebiotic strategies (primarily from use of arginine combined with calcium) to support their potential use to boost the mechanism of action of fluoride. Thus, fluoride-based strategies remain the standard for caries prevention and management, with some evidence that boosting the effects of fluoride by the use of prebiotic strategies is a promising possibility.

Peptic Ulcer Diseases

2018 ◽  
Author(s):  
Edward A Lew
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Clinical Manifestations ◽  
Muscularis Propria ◽  
Gastric Ulcers ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
H Pylori

Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. This chapter discusses the pathogenesis of peptic ulcer disease and the etiologic contribution of Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, and gastrinoma or other hypersecretory states. Also addressed are rare and unusual causes for ulcers and GI bleeding. A section on the diagnosis of peptic ulcers discusses clinical manifestations, physical examination findings, laboratory and imaging studies, and surgical diagnosis. Differential diagnosis is also reviewed. Tests to establish the etiology of peptic ulcer disease include endoscopy, quantitative serologic tests, the urea breath test, and the fecal antigen test. Discussed separately are treatments for uncomplicated duodenal ulcers, uncomplicated gastric ulcers, intractable duodenal or gastric ulcers, complicated peptic ulcers (bleeding ulcers, acute stress ulcers, perforated ulcers, obstructing ulcers, fistulizing ulcers, and Cameron ulcers), H. pylori ulcers, and gastric cancer. Figures illustrate the etiopathogenesis of peptic ulcers, prevalence of H. pylori infection in duodenal and gastric ulcer patients compared with normal controls, the approach to a patient with new and undiagnosed ulcerlike symptoms refractory to antisecretory therapy, an upper GI series showing an uncomplicated duodenal ulcer, a chest x-ray showing pneumoperitoneum from a perforated duodenal ulcer, gastric biopsy samples showing H. pylori organisms, and the approach to treatment and follow-up in patients with either complicated or uncomplicated duodenal or gastric ulcer. Tables list differential diagnoses of peptic ulcer disease, commonly used regimens to eradicate H. pylori, additional antimicrobial agents with activity against H. pylori, and FDA-approved antisecretory drugs for active peptic ulcer disease. This chapter contains 76 references.

Peptic Ulcer Diseases

2020 ◽  
Author(s):  
Edward A Lew
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Clinical Manifestations ◽  
Muscularis Propria ◽  
Gastric Ulcers ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
H Pylori

Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. This chapter discusses the pathogenesis of peptic ulcer disease and the etiologic contribution of Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, and gastrinoma or other hypersecretory states. Also addressed are rare and unusual causes for ulcers and GI bleeding. A section on the diagnosis of peptic ulcers discusses clinical manifestations, physical examination findings, laboratory and imaging studies, and surgical diagnosis. Differential diagnosis is also reviewed. Tests to establish the etiology of peptic ulcer disease include endoscopy, quantitative serologic tests, the urea breath test, and the fecal antigen test. Discussed separately are treatments for uncomplicated duodenal ulcers, uncomplicated gastric ulcers, intractable duodenal or gastric ulcers, complicated peptic ulcers (bleeding ulcers, acute stress ulcers, perforated ulcers, obstructing ulcers, fistulizing ulcers, and Cameron ulcers), H. pylori ulcers, and gastric cancer. Figures illustrate the etiopathogenesis of peptic ulcers, prevalence of H. pylori infection in duodenal and gastric ulcer patients compared with normal controls, the approach to a patient with new and undiagnosed ulcerlike symptoms refractory to antisecretory therapy, an upper GI series showing an uncomplicated duodenal ulcer, a chest x-ray showing pneumoperitoneum from a perforated duodenal ulcer, gastric biopsy samples showing H. pylori organisms, and the approach to treatment and follow-up in patients with either complicated or uncomplicated duodenal or gastric ulcer. Tables list differential diagnoses of peptic ulcer disease, commonly used regimens to eradicate H. pylori, additional antimicrobial agents with activity against H. pylori, and FDA-approved antisecretory drugs for active peptic ulcer disease. This chapter contains 5 figures, 6 tables and 78 references.

Sign in / Sign up

Export Citation Format

Share Document