scholarly journals Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2

Pathogens ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 240 ◽  
Author(s):  
Saif ur Rehman ◽  
Laiba Shafique ◽  
Awais Ihsan ◽  
Qingyou Liu
Keyword(s):  
Infectious Agent ◽  
Evolutionary Strategies ◽  
Human Society ◽  
Whole Genome Analysis ◽  
Evolutionary Trajectory ◽  
Emerging Virus ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
Genomic Regions ◽  
First Time

Over the last two decades, the world experienced three outbreaks of coronaviruses with elevated morbidity rates. Currently, the global community is facing emerging virus SARS-CoV-2 belonging to Betacoronavirus, which appears to be more transmissible but less deadly than SARS-CoV. The current study aimed to track the evolutionary ancestors and different evolutionary strategies that were genetically adapted by SARS-CoV-2. Our whole-genome analysis revealed that SARS-CoV-2 was the descendant of Bat SARS/SARS-like CoVs and bats served as a natural reservoir. SARS-CoV-2 used mutations and recombination as crucial strategies in different genomic regions including the envelop, membrane, nucleocapsid, and spike glycoproteins to become a novel infectious agent. We confirmed that mutations in different genomic regions of SARS-CoV-2 have specific influence on virus reproductive adaptability, allowing for genotype adjustment and adaptations in rapidly changing environments. Moreover, for the first time we identified nine putative recombination patterns in SARS-CoV-2, which encompass spike glycoprotein, RdRp, helicase and ORF3a. Six recombination regions were spotted in the S gene and are undoubtedly important for evolutionary survival, meanwhile this permitted the virus to modify superficial antigenicity to find a way from immune reconnaissance in animals and adapt to a human host. With these combined natural selected strategies, SARS-CoV-2 emerged as a novel virus in human society.

scholarly journals A miRNA-Peptide Fusion as a Vaccine Candidate Against the Novel Coronavirus (COVID-19). Exosomes as Potential Biomarkers of SARS-Cov-2 in Lung: After and Before Vaccination LCR_2020_b008-13

2020 ◽  
Keyword(s):  
In Silico ◽  
Vaccine Candidate ◽  
Unknown Etiology ◽  
The Novel ◽  
Preventive Vaccine ◽  
The Family ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
First Time ◽  
Cancer Diseases

A new coronavirus named Covid-19 was reported in Wuhan, China in December 2019. The first time these cases were published they were classified as “pneumonia of unknown etiology”. The etiology of this illness is now attributed to a novel virus belonging to the coronavirus (CoV) family, COVID-19. Different from both MERS-CoV and SARS-CoV, 2019-nCoV it is the seventh member of the family of coronaviruses to infect humans. We have designed a preventive vaccine in Silico aimed to protect against Covid-19 infection and transmission. Our analysis identified 16 microRNA (miRNA) with theorical Exosome Affinity (EA) with peptide among 85.44-92.84 range. According to antiviral monitoring after and before vaccination using the candidate miRNA-peptide number 13 (LCR_2020_B008-13) with value EA=92.84 Ro. We proposed the exosomes as biomarkers of SARS-Covid-2 in lung: after and before vaccination. Due to, the miRNA-peptides, in Silico, manifesting highly affinity with exosomes, where our chimera LCR_2020_B008-13 could reach a representative activity against the Covid-19 virogenes due to “exosome sequestering”; and also, the treatment of cancer diseases due to “podosome depletion” in metastasis stage.

An effectiveness of training program on COVID-19 among healthcare students: A cross section study

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1250-1254
Author(s):  
Kurvatteppa Halemani ◽  
Merlin Cheema ◽  
Shabana Khatun ◽  
Yadidya ◽  
Bhumika Singh ◽  
...  
Keyword(s):  
Nursing Students ◽  
Training Program ◽  
Cross Section ◽  
Sampling Technique ◽  
Teaching Session ◽  
Post Intervention ◽  
Post Test ◽  
College Of Nursing ◽  
Novel Coronavirus ◽  
First Time

The pandemic COVID-19 is a highly infected disease caused by a novel coronavirus or SARS-Cov-2. The virus was reported for the first time  December 2019 in, China's Wuhan province. Later the virus has broken down into the world and claimed millions of lives. In India, the disease was reported for the first time in Kerala on 30th January 2020. a cross-section one group pre-test & post-test research design was used among the 40 final year BSc nursing students, College of Nursing SGPGIMS, Lucknow India. Samples were selected based on purposive sampling technique and sample criteria. An instrument, the first tool included demographic characteristics Similarly, second instrument used for knowledge assessment. After pre-test assessment, a teaching session was held at the seminar room, college of nursing SGPGIMS Lucknow, India. Subsequently post assessment was held after intervention.  A total of 40 participants responded to the study. Demographic variables like 30(75%) participants had less than 22 years of age, 22(55%) were girls, 14(35%) families income found INR 10000-15000, and the majority of participants obtained COVID-19 related knowledge from news paper16(40%). A gender was found significant with pretest knowledge, and other variables weren't found significant (P=0.05). Knowledge mean & standard deviation in pre & post-intervention, 11.90±2.16 vs15.82±1.39. The mean difference was found in a pre-test & post-test-1 &post-test-2, 3.9, 5.02, & 1.1, respectively. The effectiveness of the training program was checked by paired t-test -10.20 & -13.93, P=0.00.  The study revealed that the teaching session was efficient in the COVID-19 program among BSc nursing students.

NEW INSPIRATION FROM CHINA'S PHILOSOPHY OF "UNITY OF MAN AND HEAVEN": CONTEMPORARY INTERNATIONAL RELATIONS UNDER THE COVID-19 PANDEMIC

2021 ◽  
pp. 21-34
Author(s):  
PU JINGXIN
Keyword(s):  
International Relations ◽  
Human Society ◽  
The Novel ◽  
The World ◽  
The Face ◽  
New Type ◽  
Novel Coronavirus ◽  
The Ancient Chinese ◽  
Self Protection ◽  
Harmonious Community

Abstract: The danger of the novel coronavirus has not yet come to an end, and new variants have begun to attack the world. What philosophy should humankind’s strategy be based on when human society as a group is fighting against Covid-19, as the pandemic ravages the world? Unfortunately, political leaders of various countries have failed to achieve the overall awareness of attacking the pandemic for a shared future for mankind so far. In the face of the pandemic, mankind as a whole urgently needs to break through the narrow nation-oriented ideology of seeking only self-protection. The International Community should establish a new type of international cooperation featuring the concept of harmony of "all things under heaven as a unity". The international relations system dominated by the power ofwestern discourse is now in a bottleneck. The main aim of this article is to study the ancient Chinese wisdom of "the Unity of Man and Heaven" philosophy and build a global harmonious community. The author argues that the “export” of the aforementioned wisdom must be a priority for Chinese scholars. Keywords: Tao; Unity of Man and Heaven; Novel Coronavirus; Anthropocentrism; Harmony.

scholarly journals EFFECT OF EXTRACHROMOSOMAL ELEMENTS OF HEREDITY ON TOXIC PROPERTIES OF YERSINIA PESTIS

2017 ◽  
pp. 28-33 ◽  
Author(s):  
G. V. Demidova ◽  
E. P. Sokolova ◽  
V. P. Zyuzina ◽  
V. A. Rykova ◽  
I. V. Morozova ◽  
...  
Keyword(s):  
Yersinia Pestis ◽  
Active Form ◽  
Infectious Agent ◽  
Toxic Shock ◽  
Toxic Activity ◽  
Virulent Strains ◽  
Extrachromosomal Elements ◽  
Live Bacteria ◽  
First Time

Aim. Elucidation of the role of extrachromosomal elements of heredity in manifestations of toxic properties of Yersinia pestis. Materials and methods. The study was carried out in vaccine strain Y. pestis EV76 (pMTl, pCDl, pPCPl) and non-plasmid variants of vaccine EV76 (pMTl\ pCDl', pPCPl') and virulent 231 (рМТГ, pCDl’, pPCPl') strains of Y. pestis. Presence of functionally active form of lipopolysaccharide (LPS) in the incubation medium of the bacteria was evaluated via toxicity of supernatant of Y. pestis for intact animals (infection-toxic shock) and mice sensitized by D-GalN. Results. 37°C cultures of Y. pestis EV76 containing a full amount of plasmids were established to release LPS into the environment. Non-plasmid variants of both vaccine and virulent strains of Y. pestis pMTl', pCD Г, рРСР 1 do not have this ability. Separation of LPS from cell wall was detected in live bacteria of plague infectious agent. This process is assumed to be coupled with translocation of proteins coded by pMTl, pCDl, pPCPl plasmids from the cell into the environment. Conclusion. Functional interconnection between extrachromosomal elements of heredity and toxic activity of Y. pestis LPS is established for the first time.

scholarly journals Safety and Effectiveness of Favipiravir for Novel Coronavirus (COVID-19): A Rapid Review of Available Evidence

2021 ◽  
Author(s):  
Mohammadreza Mobinizadeh ◽  
Morteza Arab-Zozani
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Therapeutic Potential ◽  
Data Extraction ◽  
Rapid Review ◽  
Eligibility Criteria ◽  
Clinical Trial Registration ◽  
Registration System ◽  
Novel Coronavirus ◽  
First Time

Context: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared for the first time in December 2019 in Wuhan, China. Due to the lack of unified and integrated evidence for Favipiravir, this study was conducted to rapidly review the existing evidence to help evidence-based decision-making on the therapeutic potential of this drug in the treatment of COVID-19 patients. Evidence Acquisition: This study is a rapid Health Technology Assessment (HTA). By searching pertinent databases, the research team collected relevant articles and tried to create a policy guide through a thematic approach. This rapid review was done in four steps: (1) Searching for evidence through databases; (2) screening the evidence considering eligibility criteria; (3) data extraction; and (4) analyzing the data through thematic analysis. Results: After applying the inclusion criteria, four studies were finally found, including three review studies and a clinical trial that was temporarily removed by its publisher from the journal’s website. After searching the sources mentioned in the articles, two ongoing clinical trials were found in China. Also, by searching the clinical trial website, www.clinicaltrials.gov, five clinical trials were found in the search. The result of the search in the clinical trial registration system in Iran showed a study that is in the process of patient recruitment. A limited number of other articles were found, mostly in the form of reflections from physicians or researchers and letters to editors who have predicted the drug’s performance on SARS-CoV-2, which needs further clinical study to be approved. Conclusions: With the available evidence, it is not possible to make a definite conclusion about the safety and efficacy of Favipiravir in the treatment of patients with COVID-19.

Pure Land for the People

2017 ◽  
Author(s):  
Melissa Anne-Marie Curley
Keyword(s):  
East Asia ◽  
Human Society ◽  
Pure Land ◽  
Kyoto School ◽  
Positive Role ◽  
Untimely Death ◽  
The Earth ◽  
The People ◽  
Proletarian Revolution ◽  
First Time

Following the untimely death in prison of Kyoto School philosopher Miki Kiyoshi, his unfinished essay on Shinran was assembled for publication, serving as a kind of final testament. Early in his career, Miki had come into conflict with other Japanese Marxists over his contention that religion could play a positive role in the proletarian revolution. The Shinran essay picks up on this possibility, framing the Pure Land Buddhist view of the Dharma ages in terms of the historical dialectic. According to Miki, Shinran (like Marx) discerned that the trajectory of history points toward the establishment of a truly human society, or a buddha land built upon the earth, in which the full exercise of individual human capacity will be possible for the first time. Miki’s utopianism is complicated by his role in articulating a vision of the Greater East Asia Co-Prosperity Sphere, relying on some of the same logic we see in the Shinran essay.

Introduction

2019 ◽  
pp. 1-3
Author(s):  
Alan Shuback
Keyword(s):  
Human Development ◽  
Turning Point ◽  
Human Society ◽  
History Of ◽  
Object Lesson ◽  
First Time

The invention of the wheel is frequently cited as a seminal turning point in the history of human development, but that grand event was surely predated by an equally important occurrence: the first time a man managed to climb onto a horse’s back and ride the animal an appreciable distance without falling off. Since that long-ago day in the misty past, horses have become an integral part of human society, providing us with recreation, sport, companionship, a means of transportation, an ally in war, and an aid to labor, as well as supplying an object lesson in the appreciation of beauty. Simply looking at horses makes a person feel better....

The Study of Traditional Medicine for the Treatment of COVID-19

2022 ◽  
pp. 221-241
Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Pallab Datta ◽  
Amit Roy Chowdhury
Keyword(s):  
Traditional Medicine ◽  
Communicable Disease ◽  
Respiratory Condition ◽  
Immune Modulators ◽  
First Case ◽  
The Family ◽  
Preclinical Trials ◽  
Novel Virus ◽  
Novel Coronavirus

SARS-CoV-2 is a novel virus communicable disease affected by serious acute respiratory condition coronavirus 2 (SARS-CoV-2) which goes to the family of coronavirus. December 2019, in Wuhan, China, the first case of novel coronavirus was reported, and this widespread virus globally became a pandemic. Various studies show that drug applicants are used as antivirals or immune modulators. Yet, the outcome of this examination reported the drug applicants were not ominously operative in contrast to the infection. In the interim, it's believed that taking herbal immune-modulators can avoid and/or resist COVID-19. Unluckily, definite clinical and preclinical trials to assess the special herbal immune regulators' effects have not been directed. Specific natural elements might be actual for treating COVID-19 built on universal thoughts from former tests. Though there are no exact anti-COVID-19 medicines as well as a drugs until now, the use of traditional medicine and epidemiology of novel coronavirus disease will be discussed for COVID-19 treatment.

scholarly journals Operational considerations for peritoneal dialysis management during the COVID-19 pandemic

2020 ◽  
Vol 13 (3) ◽  
pp. 322-327 ◽  
Author(s):  
Zhikai Yang ◽  
Jie Dong
Keyword(s):  
Public Health ◽  
Peritoneal Dialysis ◽  
Healthcare Providers ◽  
Healthcare Personnel ◽  
Human Society ◽  
Public Health Response ◽  
Clinic Management ◽  
Precautionary Measures ◽  
Novel Coronavirus ◽  
Remote Patient

Abstract Background Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by a novel coronavirus—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is spread from human to human and has resulted in a global pandemic, posing a disastrous public health risk worldwide. Patients with chronic kidney disease, especially those on dialysis, are considered to be at higher risk of developing severe COVID-19 due to their immunocompromised status and frail condition. The home treatment setting of peritoneal dialysis (PD) has advantages in terms of implementing self-care when routine hospital visits and social activities are restricted, thus greatly reducing exposure of PD patients to the virus. Methods and Results We outline general operational considerations in PD management during the COVID-19 pandemic, including precautionary measures for PD patients and healthcare staff. Precautionary measures for PD patients include education on prevention of, and screening for, COVID-19, preclinic screening, in-clinic management, meticulous remote patient management and special hospitalization arrangements. The diagnosis and treatment of PD patients with COVID-19 are discussed. Precautionary measures for PD staff include continuous education on, and training in, COVID-19, exposure history surveillance and self-monitoring for COVID-19 among healthcare personnel, appropriate personal protective equipment and hand hygiene, organization of medical activities and staffing, and adequate environment cleaning. Conclusions This is a battle of the entire human society against the novel coronavirus. Integrated teamwork among healthcare providers, supported by society as a whole, is needed as part of the ongoing public health response to try to slow the spread of COVID-19.

scholarly journals Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Prasun Dutta ◽  
Andrea Talenti ◽  
Rachel Young ◽  
Siddharth Jayaraman ◽  
Rebecca Callaby ◽  
...  
Keyword(s):  
Water Buffalo ◽  
Whole Genome ◽  
Selective Sweeps ◽  
Whole Genome Analysis ◽  
Genetic Studies ◽  
Cattle Breeds ◽  
Functional Variants ◽  
Species Comparisons ◽  
Disproportionate Number ◽  
Genomic Regions

Abstract More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can provide important insights into the shared evolutionary basis of domestication. Here, we sequence the genomes of 79 water buffalo across seven breeds and compare patterns of between breed selective sweeps with those seen for 294 cattle genomes representing 13 global breeds. The genomic regions under selection between cattle breeds significantly overlap regions linked to stature in human genetic studies, with a disproportionate number of these loci also shown to be under selection between water buffalo breeds. Investigation of potential functional variants in the water buffalo genome identifies a rare example of convergent domestication down to the same mutation having independently occurred and been selected for across domesticated species. Cross-species comparisons of recent selective sweeps can consequently help identify and refine important loci linked to domestication.

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