scholarly journals Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice

2021 ◽  
Vol 14 (7) ◽  
pp. 651
Author(s):  
Godfried Dougnon ◽  
Michiho Ito
Keyword(s):  
Locomotor Activity ◽  
Essential Oil ◽  
Caryophyllene Oxide ◽  
Chromolaena Odorata ◽  
Cns Depressant ◽  
Action Mechanisms ◽  
Naturally Occurring ◽  
Gabaa Receptor Antagonist ◽  
Sedative Activity ◽  
The Central Nervous System

Chromolaena odorata (L.) R.M.King & H.Rob. essential oil (COEO) was investigated for its sedative activity in mice. The results showed that COEO significantly reduced mice locomotor activity and the most efficient concentrations were 0.04 and 0.00004 mg/cage (volume of the cage 61.2L). Analysis of chemical composition of the oil indicated that caryophyllene oxide (43.75%) was the major compound and bioactivity-guided fractionation of the oil was performed to isolate the compound responsible for activity. The data clearly identified sesquiterpene caryophyllene oxide as the compound inducing COEO sedative activity and it was effective in decreasing mice locomotor activity by 56% and 57% at 0.0004 and 0.04 mg/cage, respectively. In order to understand the action mechanisms, caryophyllene oxide was tested for its effects on the central nervous system (CNS) by using a caffeine pre-excited mice test and a pentobarbital sleeping-induced test in mice. The results showed that caryophyllene oxide is a potent CNS depressant. Nevertheless, it fails to potentiate the effects of pentobarbital on the GABAergic system, nor did flumazenil, a GABAA receptor antagonist, reversed its effects. It was especially interesting to note that β-caryophyllene, the precursor of caryophyllene oxide, demonstrated a similar pattern of sedative activity, and the present work further extends actual knowledge on these naturally occurring sesquiterpenes. The findings in this study reveal the new activity of caryophyllene oxide as an innovative way to manage sleep and CNS-related disorders, and demonstrates a satisfactory effect of two interesting sesquiterpene compounds on the CNS.

scholarly journals GC Analyses of Salvia Seeds as Valuable Essential Oil Source

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mouna Ben Taârit ◽  
Kamel Msaada ◽  
Karim Hosni ◽  
Brahim Marzouk
Keyword(s):  
Essential Oil ◽  
Large Range ◽  
Essential Oil Composition ◽  
Caryophyllene Oxide ◽  
Oil Composition ◽  
Linalyl Acetate ◽  
Salvia Sclarea ◽  
Naturally Occurring ◽  
Germacrene D ◽  
Oil Source

The essential oils of seeds of Salvia verbenaca, Salvia officinalis, and Salvia sclarea were obtained by hydrodistillation and analyzed by gas chromatography (GC) and GC-mass spectrometry. The oil yields (w/w) were 0.050, 0.047, and 0.045% in S. verbenaca, S. sclarea, and S. officinalis, respectively. Seventy-five compounds were identified. The essential oil composition of S. verbenaca seeds showed that over 57% of the detected compounds were oxygenated monoterpenes followed by sesquiterpenes (24.04%) and labdane type diterpenes (5.61%). The main essential oil constituents were camphor (38.94%), caryophyllene oxide (7.28%), and 13-epi-manool (5.61%), while those of essential oil of S. officinalis were α-thujone (14.77%), camphor (13.08%), and 1,8-cineole (6.66%). In samples of S. sclarea, essential oil consists mainly of linalool (24.25%), α-thujene (7.48%), linalyl acetate (6.90%), germacrene-D (5.88%), bicyclogermacrene (4.29%), and α-copaene (4.08%). This variability leads to a large range of naturally occurring volatile compounds with valuable industrial and pharmaceutical outlets.

Physical exercise protects dynamic balance and motor coordination of rats treated with vincristine

2020 ◽  
Vol 19 (5) ◽  
pp. 336
Author(s):  
Luiza Minato Sagrillo ◽  
Viviane Nogueira De Zorzi ◽  
Luiz Fernando Freire Royes ◽  
Michele Rechia Fighera ◽  
Beatriz Da Silva Rosa Bonadiman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Locomotor Activity ◽  
Physical Exercise ◽  
Motor Coordination ◽  
Dynamic Balance ◽  
Exercise Group ◽  
Adult Rats ◽  
The Central Nervous System ◽  
Stress Damage ◽  
Training Protocol

Physical exercise has been shown to be an important modulator of the antioxidant system and neuroprotective in several diseases and treatments that affect the central nervous system. In this sense, the present study aimed to evaluate the effect of physical exercise in dynamic balance, motor coordination, exploratory locomotor activity and in the oxidative and immunological balance of rats treated with vincristine (VCR). For that, 40 adult rats were divided into two groups: exercise group (6 weeks of swimming, 1h/day, 5 days/week, with overload of 5% of body weight) and sedentary group. After training, rats were treated with 0.5 mg/kg of vincristine sulfate for two weeks or with the same dose of 0.9% NaCl. The behavioral tests were conducted 1 and 7 days after each dose of VCR. On day 15 we carried out the biochemical analyzes of the cerebellum. The physical exercise was able to protect against the loss of dynamic balance and motor coordination and, had effect per se in the exploratory locomotor activity, and neutralize oxidative stress, damage DNA and immune damage caused by VCR up to 15 days after the end of the training protocol. In conclusion, we observed that previous physical training protects of the damage motor induced by vincristine.Key-words: exercise, oxidative stress, neuroprotection, cerebellum.

Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments

2019 ◽  
Vol 15 (1) ◽  
pp. 102-118 ◽  
Author(s):  
Carolina Campos-Rodríguez ◽  
José G. Trujillo-Ferrara ◽  
Ameyali Alvarez-Guerra ◽  
Irán M. Cumbres Vargas ◽  
Roberto I. Cuevas-Hernández ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
In Silico ◽  
Biological Properties ◽  
Chiral Molecules ◽  
Chiral Compounds ◽  
Plus Maze ◽  
In Silico Studies ◽  
The Central Nervous System

Background: Thalidomide, the first synthesized phthalimide, has demonstrated sedative- hypnotic and antiepileptic effects on the central nervous system. N-substituted phthalimides have an interesting chemical structure that confers important biological properties. Objective: Non-chiral (ortho and para bis-isoindoline-1,3-dione, phthaloylglycine) and chiral phthalimides (N-substituted with aspartate or glutamate) were synthesized and the sedative, anxiolytic and anticonvulsant effects were tested. Method: Homology modeling and molecular docking were employed to predict recognition of the analogues by hNMDA and mGlu receptors. The neuropharmacological activity was tested with the open field test and elevated plus maze (EPM). The compounds were tested in mouse models of acute convulsions induced either by pentylenetetrazol (PTZ; 90 mg/kg) or 4-aminopyridine (4-AP; 10 mg/kg). Results: The ortho and para non-chiral compounds at 562.3 and 316 mg/kg, respectively, decreased locomotor activity. Contrarily, the chiral compounds produced excitatory effects. Increased locomotor activity was found with S-TGLU and R-TGLU at 100, 316 and 562.3 mg/kg, and S-TASP at 316 and 562.3 mg/kg. These molecules showed no activity in the EPM test or PTZ model. In the 4-AP model, however, S-TGLU (237.1, 316 and 421.7 mg/kg) as well as S-TASP and R-TASP (316 mg/kg) lowered the convulsive and death rate. Conclusion: The chiral compounds exhibited a non-competitive NMDAR antagonist profile and the non-chiral molecules possessed selective sedative properties. The NMDAR exhibited stereoselectivity for S-TGLU while it is not a preference for the aspartic derivatives. The results appear to be supported by the in silico studies, which evidenced a high affinity of phthalimides for the hNMDAR and mGluR type 1.

scholarly journals Multifaceted Approach to Resveratrol Bioactivity: Focus on Antioxidant Action, Cell Signaling and Safety

2010 ◽  
Vol 3 (2) ◽  
pp. 86-100 ◽  
Author(s):  
Peter Kovacic ◽  
Ratnasamy Somanathan
Keyword(s):  
Cell Signaling ◽  
Red Wine ◽  
Wide Spectrum ◽  
Physiological Activity ◽  
Protective Agent ◽  
Multifaceted Approach ◽  
Beneficial Effects ◽  
Naturally Occurring ◽  
The Central Nervous System ◽  
Future Work

Resveratrol (RVT) is a naturally occurring trihydroxy stilbene that displays a wide spectrum of physiological activity. Its ability to behave therapeutically as a component of red wine has attracted wide attention. The phenol acts as a protective agent involving various body constituents. Most attention has been given to beneficial effects in insults involving cancer, aging, cardiovascular system, inflammation and the central nervous system. One of the principal modes of action appears to be as antioxidant. Other mechanistic pathways entail cell signaling, apoptosis and gene expression. There is an intriguing dichotomy in relation to pro-oxidant property. Also discussed are metabolism, receptor binding, rationale for safety and suggestions for future work. This is the first comprehensive review of RVT based on a broad, unifying mechanism.

scholarly journals Essential Oil Constituents of The Rhizomes of Two Types of Curcuma longa of Bangladesh

1970 ◽  
Vol 43 (2) ◽  
pp. 259-266 ◽  
Author(s):  
Jasim Uddin Chowdhury ◽  
Nemai Chandra Nandi ◽  
M Nazrul Islam Bhuiyan ◽  
M Hosnay Mobarok
Keyword(s):  
Essential Oil ◽  
Key Words ◽  
Curcuma Longa ◽  
Caryophyllene Oxide ◽  
Yellow Type

Essential oil from the rhizomes of two types of Curcuma longa, yellow and red originated in Bangladesh was analyzed by GC-MS. 54 compounds have been identified from the yellow type of which the major compounds are ar-tumerone (27.78%), tumerone (17.16%), culone (13.82%), 2-carene (4.78%), zingiberene (4.37%) and β-sesquiphellandrene (5.57%). The red type contained 39 compounds with carvacrol (21.14%), citral (13.91%), methyleugenol (7.31%), geraniol (6.99%), menthol (5.11%) and caryophyllene oxide (4.14%) as major constituents. Key words: Curcuma longa, GC-MS, Ar-tumerone, Carvacrol, Tumerone, Citral. DOI: 10.3329/bjsir.v43i2.970  Bangladesh J. Sci. Ind. Res. 43(2), 259-266, 2008 

scholarly journals Influence of Drying in Hyptis pectinata Essential Oil

2018 ◽  
Vol 10 (4) ◽  
pp. 96
Author(s):  
Núbia Angélica de Ávila Branquinho ◽  
Fabiano Guimarães Silva ◽  
Osvaldo Resende ◽  
Luiz Cláudio Almeida Barbosa ◽  
Daniel Emanuel Cabral de Oliveira ◽  
...  
Keyword(s):  
Essential Oil ◽  
Anhydrous Sodium Sulfate ◽  
Fixed Bed ◽  
Chemical Characterization ◽  
Automated System ◽  
Caryophyllene Oxide ◽  
System A ◽  
Different Temperatures ◽  
Drying Conditions

The present study assessed the effects of drying at different temperatures (35, 45 and 55 °C) and air velocities (1 and 2 m s-1) on the content and chemical characteristics of Hyptis pectinata essential oil. Drying was conducted in a fixed-bed dryer, and the temperatures and air velocities were controlled and recorded by an automated system. A 350±0.12 g quantity of fresh leaves was used for each of the four repetitions in each dryer. From the material obtained after drying, 60 g of each repetition was used to extract essential oil by the hydrodistillation method. Dichloromethane was used as the solvent, and anhydrous sodium sulfate was used as the desiccating agent. Gas chromatography in the forms of GC-MS and GC-FID were used for the chemical characterization of the essential oil compounds. Decreasing drying times and decreasing concentrations of essential oils were observed with increasing temperatures. A GC-MS analysis of the essential oil from H. pectinata leaves led to the identification of 19 compounds. A sesquiterpene called caryophyllene oxide was the most abundant compound under all drying conditions, with the highest concentration at a temperature of 55 °C, ranging from approximately 42 to 53%.

scholarly journals Composition of essential oil and allelopathic activity of aromatic water of Aster lanceolatus Willd: (Asteraceae)

2009 ◽  
Vol 45 (3) ◽  
pp. 469-474 ◽  
Author(s):  
Josiane de Fátima Gaspari Dias ◽  
Obdúlio Gomes Miguel ◽  
Marilis Dallarmi Miguel
Keyword(s):  
Essential Oil ◽  
Lactuca Sativa ◽  
Extraction Process ◽  
Caryophyllene Oxide ◽  
Allelopathic Activity ◽  
Germination And Growth

The essential oil obtained from flowers of Aster lanceolatus was submitted the CG-MS and presented as result thirteen substances with largest concentration; among them, the caryophyllene oxide with the larger one. The aromatic water obtained during the extraction process of this essential oil was forwarded to allelopathic test, and demonstrated to be capable to inhibit the germination and growth of Lactuca sativa.

scholarly journals Investigation of Aronia Melanocarpa Fruit Juice for Sedative-Hypnotic Effects in Rats

2018 ◽  
Vol 11 (1) ◽  
pp. 77-82
Author(s):  
Miroslav Ts. Eftimov ◽  
StefkaV. Valcheva-Kuzmanova
Keyword(s):  
Locomotor Activity ◽  
Acute Treatment ◽  
Fruit Juice ◽  
Open Field Test ◽  
Treatment Control ◽  
Aronia Melanocarpa ◽  
Subchronic Treatment ◽  
Male Wistar Rats ◽  
The Central Nervous System ◽  
Time Test

Summary Aronia melanocarpa fruit juice (AMFJ) has been intensively studied for effects on the central nervous system. The study aimed to investigate AMFJ for possible sedative-hypnotic effects in rats after acute and subchronic administration. Male Wistar rats were treated orally with three doses of AMFJ (2.5, 5.0 and 10.0 ml/kg) either once (acute treatment) or in 30 days (subchronic treatment). Control rats were similarly treated with distilled water. The tests were performed 1 hour after the last AMFJ administration. The possible sedative-hypnotic effects of the juice were investigated in the open field test (OFT) and thiopental-induced sleeping time test. Substances with sedative-hypnotic effects decrease locomotor activity in the OFT and prolong the time of thiopental-induced sleep. The results from the OFT showed that neither the acute, nor the subchronic treatment of rats with all AMFJ doses affected the horizontal and vertical locomotor activity significantly. The two patterns of administration of AMFJ (acute and subchronic) had no significant effect on the duration of thiopental-induced sleep. The lack of effect of AMFJ on locomotor activity and the lack of prolongation of thiopental-induced sleep showed that AMFJ did not display sedative-hypnotic effects in rats.

scholarly journals Sedative activity of ethanolic and aqueous extracts of Euphorbia hirta

2018 ◽  
Vol 7 (1) ◽  
pp. 29-32
Author(s):  
Dhanapal Venkatachalam ◽  
◽  
Samuel Thavamani B ◽  
Sampath Kumar ◽  
◽  
...  
Keyword(s):  
Folk Medicine ◽  
Physical Disorder ◽  
Plant Family ◽  
Euphorbia Hirta ◽  
Falling Asleep ◽  
Wide Range ◽  
Ethanolic Extracts ◽  
Sedative Activity ◽  
The Central Nervous System ◽  
Behavioural Therapies

Insomnia is persistent difficulty in falling asleep that affects regular day time activities. It can induce significant psychological and physical disorder. Insomnia is treated pharmacologically and nonpharmacologically or by a combination of both. Relaxation, sleep restriction, stimulus control and sleep hygiene are known behavioural therapies for insomnia. Modern studies have shown that herbal drugs exert good sedative and hypnotic effect on the central nervous system. One such medicinal plants is Euphorbia hirta.. E. hirta belongs to the plant family Euphorbiaceae and genus Euphorbia. The leaf of Euphorbia hirta have several therapeutic applications in folk medicine in curing or managing wide range of diseases including insomnia. In the present study ethanol and aqueous extract of leaf Euphorbia ssssshirta was evaluated for sedative activity using phenobarbiton–induced sleep model in rat. Aqueous and ethanolic extracts (100mg/kg and 200 mg/kg) produced significant onset of sleep and duration of sleep (p<0.01). These results suggest that the fractions of aqueous and ethanolic extracts obtained from the leaf of Euphorbia hirta possess sedative activity

scholarly journals Antifeedant and larvicidal activities of leaf essential oils from Hyptis suaveolens (L.) Poit., Chromolaena odorata (L.) R.M. King and Lantana camara L. against Spodoptera litura Fab. (Lepidoptera: Noctuidae)

2020 ◽  
Vol 3 (4) ◽  
pp. 244-251
Author(s):  
Hung Thanh Tran ◽  
My-Ngan Thi Luong ◽  
Le Van Bui ◽  
Hieu Trung Tran
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Spodoptera Litura ◽  
Ipomoea Batatas ◽  
Pupal Stage ◽  
Lantana Camara ◽  
Volatile Components ◽  
Chromolaena Odorata ◽  
Hyptis Suaveolens ◽  
Larvicidal Activities

The current study was carried out to evaluate antifeedant and insecticidal activities of three essential oils from leaves of Hyptis suaveolens, Chromolaena odorata and Lantana camara against fourth instar larvae of Spodoptera litura under the laboratory conditions. Results indicated that the essential oil from leaves of Hyptis suaveolens had a strong antifeedant impact on the larvae with antifeedant index (AI) of 75.4, 88.5 and 92.9 when leaf disks of Ipomoea batatas were treated with the essential oil at concentration of 1.5, 2.0 and 2.5 %, respectively. Also dose dependent mortalities were observed in the larvae topical treated with the essential oil at different concentrations. At the treated concentration of 0.4 mg per each larva, 68.3 % of the larvae were killed after 24 hours, and 25.0 % were died at the pupal stage after 30 days of observation. At the concentration of 1.2 mg/larva, 93.3 % of the larvae were killed after 24 hours, and no emergence of adults was recorded after 30 days of observation. Larvicidal activity of the H. suaveolens essential oil (with the lethal doses LD50=0.16 and LD95=1.52 mg/larva) was stronger than those of the C. odorata and L. camara essential oils (with LD50=0.57–0.63 and LD95=4.64–4.97 mg/larva) after 24 hour of treatment. GC–MS analysis indicates that the major volatile components of the essential oil from leaves of H. suaveolens are composed of b-caryophyllene (30.0 %), eucalyptol (12.0 %), copaene (5.9 %), and a-bergamotene (5.7 %). This essential oil needs to be further investigated and used as a bio-insecticide for control of S. litura.  

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