scholarly journals Complex Factors and Challenges that Affect the Pharmacology, Safety and Efficacy of Nanocarrier Drug Delivery Systems

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 114
Author(s):  
Joseph A. Piscatelli ◽  
Jisun Ban ◽  
Andrew T. Lucas ◽  
William C. Zamboni
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Drug Delivery Systems ◽  
Systemic Exposure ◽  
Clinical Development ◽  
Pharmacological Effects ◽  
Safety And Efficacy ◽  
The Past ◽  
Tumor Delivery ◽  
Systemic Disposition

Major developments in nanomedicines, such as nanoparticles (NPs), nanosomes, and conjugates, have revolutionized drug delivery capabilities over the past four decades. Although nanocarrier agents provide numerous advantages (e.g., greater solubility and duration of systemic exposure) compared to their small-molecule counterparts, there is considerable inter-patient variability seen in the systemic disposition, tumor delivery and overall pharmacological effects (i.e., anti-tumor efficacy and unwanted toxicity) of NP agents. This review aims to provide a summary of fundamental factors that affect the disposition of NPs in the treatment of cancer and why they should be evaluated during preclinical and clinical development. Furthermore, this chapter will highlight some of the translational challenges associated with elements of NPs and how these issues can only be addressed by detailed and novel pharmacology studies.

scholarly journals Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2380
Author(s):  
Diedie Li ◽  
Chengzhi Gao ◽  
Meiyan Kuang ◽  
Minhao Xu ◽  
Ben Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Strategy ◽  
Target Gene ◽  
Treatment Approach ◽  
Systemic Delivery ◽  
Efficient Delivery ◽  
Rnai Therapeutics ◽  
Cellular Machinery ◽  
Tumor Delivery

RNA interference (RNAi) can mediate gene-silencing by knocking down the expression of a target gene via cellular machinery with much higher efficiency in contrast to other antisense-based approaches which represents an emerging therapeutic strategy for combating cancer. Distinct characters of nanoparticles, such as distinctive size, are fundamental for the efficient delivery of RNAi therapeutics, allowing for higher targeting and safety. In this review, we present the mechanism of RNAi and briefly describe the hurdles and concerns of RNAi as a cancer treatment approach in systemic delivery. Furthermore, the current nanovectors for effective tumor delivery of RNAi therapeutics are classified, and the characteristics of different nanocarriers are summarized.

Hydrogels for modified-release drug delivery systems

2021 ◽  
Vol 28 ◽  
Author(s):  
Aleksandra Zielińska ◽  
Piotr Eder ◽  
Lucas Rannier ◽  
Juliana C. Cardoso ◽  
Patrícia Severino ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Search Strategy ◽  
Delivery Systems ◽  
Global Market ◽  
Modified Release ◽  
Safety And Efficacy ◽  
Area Of Interest ◽  
Release Drug

Abstract: Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy did in January 2021, and it conducted an extensive database to identify studies published from January 2010 to December 2020.We described the main characteristic of the polymers to obtain an ideal hydrogel for a specific route of administration and the formulations that was a highlight in the literature. It concluded that the hydrogels are a set useful to decrease the number of doses, side effects, promote adhesion of patient and enhances the bioavailability of the drugs improving the safety and efficacy of the treatment.

The application progress of peptides in drug delivery systems in the past decade

2021 ◽  
Vol 66 ◽  
pp. 102880
Author(s):  
Bing Yang ◽  
Tian-tian Wang ◽  
Yu-shun Yang ◽  
Hai-liang Zhu ◽  
Jian-hua Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past

scholarly journals Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo
Keyword(s):  
Drug Delivery ◽  
Sialic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

Functional Nanomaterials and Their Potential Applications in Antibacterial Therapy

2019 ◽  
Vol 7 (2) ◽  
pp. 129-146 ◽  
Author(s):  
Le Hong ◽  
Shu-Han Luo ◽  
Chen-Hao Yu ◽  
Yu Xie ◽  
Meng-Ying Xia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Lower Side ◽  
Functional Nanomaterials ◽  
Graphene Oxides ◽  
The Past ◽  
Potential Applications ◽  
Carbon Based Nanomaterials ◽  
Direct Use

In the past decades, nanomaterials have shown great potential in biomedical fields, especially in drug delivery, imaging and targeted therapy. Recently, the development of novel functional nanomaterials for antibacterial application has attracted much attention. Compared to the traditional direct use of antibiotics, antibacterial nanomaterials either as drug delivery systems or active agents have a higher efficacy and lower side effects. Herein, we will focus on the antibacterial applications of four commonly used nanomaterials, including metal-based nanomaterials, polymeric nanoparticles, graphene oxides or carbon-based nanomaterials and nanogels.

Functional peptide-based drug delivery systems

2020 ◽  
Vol 8 (31) ◽  
pp. 6517-6529 ◽  
Author(s):  
Zheng Lian ◽  
Tianjiao Ji
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past ◽  
Functional Peptides ◽  
Functional Peptide ◽  
Smart Drug ◽  
Smart Drug Delivery

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.

scholarly journals UNDERSTANDING NOVEL POLYMER AND LIPID BASED CARRIER SYSTEMS IN CLINICIAN PERSPECTIVE

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Kallem Sharat Venkat Reddy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Dosage ◽  
Delivery Systems ◽  
Review Article ◽  
Point Of View ◽  
Smart Polymers ◽  
The Past ◽  
Novel Drug ◽  
Carrier Systems

From the past two decades, technological advancements in science and chemistry made possible many new drug delivery systems that have the potential to completely change the course of routine therapeutic ways.  Lipid and polymer-based drug delivery systems are considered to be the pillars of many drug dosage forms, irrespective of their route of administration. With increasing knowledge on their chemistry, lipids and polymers are being modified and used as potential novel drug delivery systems with smart polymers and lipid nanotechnology paving the way for efficient drug delivery into the patient. This review article covers the swing of these drug delivery systems in the current market and interpreting all this from a health care professional’s point of view. Keywords: Gene delivery, Lipid based drug delivery, Polymer based drug delivery, Target specific drugs, Solid lipid nanoparticles

scholarly journals A mini-review of Nanocarriers in drug delivery systems Nanocarriers in drug delivery systems

2021 ◽  
Author(s):  
Mahsa Mazdaei ◽  
Kofi Asare-Addo
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Cancer Chemotherapy ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Therapeutic Gene ◽  
Solid Lipid ◽  
The Past

The application of nanotechnology indrug delivery systems (DDS) has been researched widely and seen an advancementover the past three decades. Since the 1970s, nanoparticles were primarilyutilised in vaccine deliveries and cancer chemotherapy. In more recent years,they have been found to hold promises for broader applications such as inproteins and therapeutic gene delivery systems. To date, there have been only ahandful of nanocarrier-loaded drugs commercialised into the pharmaceuticalmarket. More research is thus needed to facilitate a breakthrough of theseproducts into the current market. This mini-review mainly focuses on four typesof commonly utilised organic nanocarriers including micelles, compactpolymerics, solid-lipid nanoparticles and liposomal vesicles and discusses theprogress and some challenges associated with these nanoparticles (NP). 

scholarly journals THE THE MICROEMULSION AS A KEY PLAYER IN CONQUERING THE SKIN BARRIER FOR THE AIM OF TRANSDERMAL DELIVERY OF DRUGS: REVIEWING A SUCCESSFUL DECADE

2019 ◽  
pp. 34-48
Author(s):  
RANIA YEHIA ◽  
DALIA A ATTIA
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Barrier ◽  
The Other ◽  
Penetration Enhancers ◽  
The Past ◽  
Transdermal Drug Delivery Systems ◽  
The One

Microemulsion (ME) systems are now considered of the most successful transdermal drug delivery systems. This is due to their nanodroplets size in the one hand and to their composition that enables the use of several mechanistically penetration enhancers in the same formulation on the other hand. This work summarizes the types, properties, and the merits of the use of MEs for transdermal delivery and reviews the successful studies that were performed to deliver several drugs through this important route during the past 10–12 years.

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