scholarly journals Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 472
Author(s):  
Stéphane Roulon ◽  
Ian Soulairol ◽  
Valérie Lavastre ◽  
Nicolas Payre ◽  
Maxime Cazes ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Mass Density ◽  
Three Dimensional ◽  
Storage Condition ◽  
Storage Conditions ◽  
Linear Mass ◽  
Fused Filament Fabrication ◽  
Fused Deposition ◽  
Physical Form ◽  
Amiodarone Hydrochloride

Patients need medications at a dosage suited to their physiological characteristics. Three-dimensional printing (3DP) technology by fused-filament fabrication (FFF) is a solution for manufacturing medication on demand. The aim of this work was to identify important parameters for the production of reproducible filament batches used by 3DP for oral formulations. Amiodarone hydrochloride, an antiarrhythmic and insoluble drug, was chosen as a model drug because of dosage adaptation need in children. Polyethylene oxide (PEO) filaments containing amiodarone hydrochloride were produced by hot-melt extrusion (HME). Different formulation storage conditions were investigated. For all formulations, the physical form of the drug following HME and fused-deposition modeling (FDM) 3D-printing processes were assessed using thermal analysis and X-ray powder diffraction (XRPD). Filament mechanical properties, linear mass density and surface roughness, were investigated by, respectively, 3-point bending, weighing, and scanning electron microscopy (SEM). Analysis results showed that the formulation storage condition before HME-modified filament linear mass density and, therefore, the oral forms masses from a batch to another. To obtain constant filament apparent density, it has been shown that a constant and reproducible drying condition is required to produce oral forms with constant mass.

scholarly journals Fused Filament Fabrication Process: A Review of Numerical Simulation Techniques

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3534
Author(s):  
Ans Al Rashid ◽  
Muammer Koç
Keyword(s):  
Numerical Simulation ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Material Behavior ◽  
Future Research ◽  
Fused Filament Fabrication ◽  
Process Improvements ◽  
Fused Deposition ◽  
Simulation Techniques ◽  
Am Processes

Three-dimensional printing (3DP), also known as additive manufacturing (AM), has rapidly evolved over the past few decades. Researchers around the globe have been putting their efforts into AM processes improvement and materials development. One of the most widely used extrusion-based technology under AM processes is Fused Deposition Modeling (FDM), also known as Fused Filament Fabrication (FFF). Numerical simulation tools are being employed to predict the FFF process complexities and material behavior. These tools allow exploring candidate materials for their potential use in the FFF process and process improvements. The prime objective of this study is to provide a comprehensive review of state-of-the-art scientific achievements in numerical simulations of the FFF process for polymers and their composites. The first section presents an in-depth discussion of the FFF process’s physical phenomena and highlights the multi-level complexity. The subsequent section discusses the research efforts, specifically on numerical simulation techniques reported in the literature for simulation of the FFF process. Finally, conclusions are drawn based on the reviewed literature, and future research directions are identified.

scholarly journals Development of multifunctional nanocomposites with 3-D printing additive manufacturing and low graphene loading

2018 ◽  
Vol 32 (3) ◽  
pp. 383-408 ◽  
Author(s):  
Brennan E Yamamoto ◽  
A Zachary Trimble ◽  
Brenden Minei ◽  
Mehrdad N Ghasemi Nejhad
Keyword(s):  
Additive Manufacturing ◽  
Geometric Modeling ◽  
Fused Deposition Modeling ◽  
Graphene Nanosheets ◽  
Three Dimensional ◽  
Acrylonitrile Butadiene Styrene ◽  
Polybutylene Terephthalate ◽  
Fused Filament Fabrication ◽  
Fused Deposition ◽  
Multifunctional Nanocomposites

Fused filament fabrication (FFF) or fused deposition modeling is an additive manufacturing (AM) process commonly used for geometric modeling and rapid prototyping of parts called three-dimensional (3-D) printing. Commonly used thermoplastic materials in FFF 3-D printing AM are acrylonitrile butadiene styrene (ABS), polylactic acid (PLA), and polybutylene terephthalate (PBT). However, these materials exhibit relatively low strength and toughness. Therefore, it is desirable to improve various properties of thermoplastics in 3-D printing AM by employing nanotechnology. The combination of 3-D printing and nanotechnology opens new venues for the manufacture of 3-D engineered materials with optimized properties and multifunctionality (e.g. mechanical, electrical, and thermal properties). Hence, in this work, the multifunctional property improvement effects of graphene oxide (GO) on thermoplastic materials suitable for 3-D printing AM are investigated. Low loading of GO with carboxyl and hydroxyl surface functional groups is incorporated into thermoplastic materials suitable for 3-D printing AM by a special mixing technique. ABS is chosen in this study due to its availability. Graphene nanosheets are employed to improve the properties of the developed nanocomposites by 3-D printing AM. GO is chosen to improve the dispersion of graphene nanosheets into the thermoplastic system to increase their interfacial adhesion. A multifunctional property improvement is observed in the developed nanocomposite with less than 0.1 wt% GO. Employing ASTM standard tests, it was found that at a very small loading of 0.06% by weight, GO could improve the properties of the thermoplastic in terms of strength, strain-to-failure, and toughness, while maintaining the stiffness, rendering the developed nanocomposites suitable for various applications of static and dynamic loading. GOs are now commercially available at low prices. At such low loadings, these graphene-type materials become economically feasible components of nanocomposites.

Thermal characterization of ABS-Graphene blended three dimensional printed functional prototypes for electro chemical energy storage

2018 ◽  
Vol 1 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Kamaljit Singh Boparai ◽  
Rupinder Singh
Keyword(s):  
Energy Storage ◽  
Structural Changes ◽  
Fused Deposition Modeling ◽  
Morphological Changes ◽  
Three Dimensional ◽  
Thermal Characterization ◽  
Chemical Energy ◽  
Flow Index ◽  
Fused Deposition

This study highlights the thermal characterization of ABS-Graphene blended three dimensional (3D) printed functional prototypes by fused deposition modeling (FDM) process. These functional prototypes have some applications as electro-chemical energy storage devices (EESD). Initially, the suitability of ABS-Graphene composite material for FDM applications has been examined by melt flow index (MFI) test. After establishing MFI, the feedstock filament for FDM has been prepared by an extrusion process. The fabricated filament has been used for printing 3D functional prototypes for printing of in-house EESD. The differential scanning calorimeter (DSC) analysis was conducted to understand the effect on glass transition temperature with the inclusion of Graphene (Gr) particles. It has been observed that the reinforced Gr particles act as a thermal reservoir (sink) and enhances its thermal/electrical conductivity. Also, FT-IR spectra realized the structural changes with the inclusion of Gr in ABS matrix. The results are supported by scanning electron microscopy (SEM) based micrographs for understanding the morphological changes.

Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

2019 ◽  
Vol 24 (42) ◽  
pp. 4991-5008 ◽  
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad
Keyword(s):  
Cosmetic Surgery ◽  
Fused Deposition Modeling ◽  
Personalised Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Release Profile ◽  
Small Scale ◽  
Drug Release Profile ◽  
Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

2021 ◽  
pp. 002199832098856
Author(s):  
Marcela Piassi Bernardo ◽  
Bruna Cristina Rodrigues da Silva ◽  
Luiz Henrique Capparelli Mattoso
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Scanning Calorimetry ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.

scholarly journals On the Post-Processing of 3D-Printed ABS Parts

Polymers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1559
Author(s):  
Mohammad Reza Khosravani ◽  
Jonas Schüürmann ◽  
Filippo Berto ◽  
Tamara Reinicke
Keyword(s):  
Surface Treatment ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Acrylonitrile Butadiene Styrene ◽  
Experimental Tests ◽  
Fracture Load ◽  
Post Processing ◽  
Fused Deposition ◽  
Dog Bone ◽  
3D Printed

Application of Additive Manufacturing (AM) has significantly increased in the past few years. AM also known as three-dimensional (3D) printing has been currently used in fabrication of prototypes and end-use products. Considering the new applications of additively manufactured components, it is necessary to study structural details of these parts. In the current study, influence of a post-processing on the mechanical properties of 3D-printed parts has been investigated. To this aim, Acrylonitrile Butadiene Styrene (ABS) material was used to produce test coupons based on the Fused Deposition Modeling (FDM) process. More in deep, a device was designed and fabricated to fix imperfection and provide smooth surfaces on the 3D-printed ABS specimens. Later, original and treated specimens were subjected to a series of tensile loads, three-point bending tests, and water absorption tests. The experimental tests indicated fracture load in untreated dog-bone shaped specimen was 2026.1 N which was decreased to 1951.7 N after surface treatment. Moreover, the performed surface treatment was lead and decrease in tensile strength from 29.37 MPa to 26.25 MPa. Comparison of the results confirmed effects of the surface modification on the fracture toughness of the examined semi-circular bending components. Moreover, a 3D laser microscope was used for visual investigation of the specimens. The documented results are beneficial for next designs and optimization of finishing processes.

scholarly journals Implementation of Fused Filament Fabrication in Dentistry

2021 ◽  
Vol 11 (14) ◽  
pp. 6444
Author(s):  
Jörg Lüchtenborg ◽  
Felix Burkhardt ◽  
Julian Nold ◽  
Severin Rothlauf ◽  
Christian Wesemann ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Present Report ◽  
Cost Effective ◽  
Great Promise ◽  
Temperature Sensitive ◽  
Fused Filament Fabrication ◽  
Digital Light Processing ◽  
Fused Deposition ◽  
Surgical Guides ◽  
Novel Approach

Additive manufacturing is becoming an increasingly important technique for the production of dental restorations and assistive devices. The most commonly used systems are based on vat polymerization, e.g., stereolithography (SLA) and digital light processing (DLP). In contrast, fused filament fabrication (FFF), also known under the brand name fused deposition modeling (FDM), is rarely applied in the dental field. This might be due to the reduced accuracy and resolution of FFF compared to vat polymerization. However, the use of FFF in the dental sector seems very promising for in-house production since it presents a cost-effective and straight forward method. The manufacturing of nearly ready-to-use parts with only minimal post-processing can be considered highly advantageous. Therefore, the objective was to implement FFF in a digital dental workflow. The present report demonstrates the production of surgical guides for implant insertion by FFF. Furthermore, a novel approach using a temperature-sensitive filament for bite registration plates holds great promise for a simplified workflow. In combination with a medical-grade filament, a multi-material impression tray was printed for optimized impression taking of edentulous patients. Compared to the conventional way, the printed thermoplastic material is pleasant to model and can allow clean and fast work on the patient.

Synthesis and properties of modified PBT for FDM

2017 ◽  
Vol 23 (4) ◽  
pp. 804-810 ◽  
Author(s):  
Shiqing Cao ◽  
Dandan Yu ◽  
Weilan Xue ◽  
Zuoxiang Zeng ◽  
Wanyu Zhu
Keyword(s):  
Mechanical Properties ◽  
Impact Strength ◽  
Fused Deposition Modeling ◽  
Complex Structure ◽  
Three Dimensional ◽  
Sebacic Acid ◽  
Wire Drawing ◽  
Content Type ◽  
Fused Deposition ◽  
Deposition Modeling

Purpose The purpose of this paper is to prepare a new modified polybutylene terephalate (MPBT) for fused deposition modeling (FDM) to increase the variety of materials compatible with printing. And the printing materials can be used to print components with a complex structure and functional mechanical parts. Design/methodology/approach The MPBT, poly(butylene terephalate-co-isophthalate-co-sebacate) (PBTIS), was prepared for FDM by direct esterification and subsequent polycondensation using terephthalic acid (PTA), isophthalic acid (PIA), sebacic acid (SA) and 1,4-butanediol (BDO). The effects of the content of PIA (20-40 mol%) on the mechanical properties of PBTIS were investigated when the mole per cent of SA (αSA) is zero. The effects of αSA (0-7mol%) on the thermal, rheological and mechanical properties of PBTIS were investigated at nPTA/nPIA = 7/3. A desktop wire drawing and extruding machine was used to fabricate the filaments, whose printability and anisotropy were tested by three-dimensional (3D) printing experiments. Findings A candidate content of PIA introducing into PBT was obtained to be about 30 per cent, and the Izod notched impact strength of PBTIS increased with the increase of αSA. The results showed that the PBTIS (nPTA/nPIA = 7/3, αSA = 3-5mol%) is suitable for FDM. Originality/value New printing materials with good Izod notched impact strength were obtained by introducing PIA and SA (nPTA/nPIA = 7/3, αSA = 3-5 mol%) into PBT and their anisotropy are better than that of ABS.

scholarly journals Mesh-Type Three-Dimensional (3D) Printing of Human Organs and Tumors: Fast, Cost-Effective, and Personalized Anatomic Modeling of Patient-Oriented Visual Aids

2021 ◽  
Vol 11 (3) ◽  
pp. 1047
Author(s):  
Jungirl Seok ◽  
Sungmin Yoon ◽  
Chang Hwan Ryu ◽  
Junsun Ryu ◽  
Seok-ki Kim ◽  
...  
Keyword(s):  
3D Printing ◽  
3D Modeling ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Tumor Location ◽  
Visual Aids ◽  
Surgical Specimen ◽  
Personalized Care ◽  
Fused Deposition ◽  
Mesh Work

Although three-dimensional (3D)-printed anatomic models are not new to medicine, the high costs and lengthy production times entailed have limited their application. Our goal was developing a new and less costly 3D modeling method to depict organ-tumor relations at faster printing speeds. We have devised a method of 3D modeling using tomographic images. Coordinates are extracted at a specified interval, connecting them to create mesh-work replicas. Adjacent constructs are depicted by density variations, showing anatomic targets (i.e., tumors) in contrasting colors. An array of organ solid-tumor models was printed via a Fused Deposition Modeling 3D printer at significantly less cost ($0.05/cm3) and time expenditure (1.73 min/cm3; both, p < 0.001). Printed models helped promote visual appreciation of organ-tumor anatomy and adjacent tissues. Our mesh-work 3D thyroidal prototype reproduced glandular size/contour and tumor location, readily approximating the surgical specimen. This newly devised mesh-type 3D printing method may facilitate anatomic modeling for personalized care and improve patient awareness during informed surgical consent.

Development of Scaffold Building Units and Assembly for Tissue Engineering Using Fused Deposition Modelling

2009 ◽  
Vol 83-86 ◽  
pp. 269-274 ◽  
Author(s):  
Syed H. Masood ◽  
Kadhim Alamara
Keyword(s):  
Tissue Engineering ◽  
Pore Size ◽  
Fused Deposition Modeling ◽  
Porous Scaffold ◽  
Cell Structure ◽  
Three Dimensional ◽  
Three Dimensions ◽  
Fused Deposition Modelling ◽  
Fused Deposition ◽  
Unit Cells

In tissue engineering (TE), a porous scaffold structure of biodegradable material is required as a template to guide the proliferation, growth and development of cells appropriately in three dimensions. The scaffold must meet design requirements of appropriate porosity, pore size and interconnected structure to allow cell proliferation and adhesion. This paper presents a methodology for design and manufacture of TE scaffolds with varying porosity by employing open structure building units and Fused Deposition Modeling (FDM) rapid prototyping technique. A computer modeling approach for constructing and assembly of three-dimensional unit cell structure is presented to provide a solution of scaffolds design that can potentially meet the diverse requirements of TE applications. A parametric set of open polyhedral unit cells is used to assist the user in designing the required micro-architecture of the scaffold with required porosity and pore size and then the Boolean operation is used to create the scaffold of a given CAD model from the designed microstructure. The procedure is verified by fabrication of physical scaffolds using the commercial FDM system.

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