scholarly journals Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1601
Author(s):  
Patrícia Weimer ◽  
Rochele Cassanta Rossi ◽  
Letícia Scherer Koester
Keyword(s):  
Scoping Review ◽  
Transdermal Delivery ◽  
Protein Delivery ◽  
Quality Parameters ◽  
The Body ◽  
Dissolving Microneedles ◽  
Main Challenge ◽  
Nanostructured Systems ◽  
Regulatory Guidelines ◽  
Main Barrier

The largest organ of the body provides the main challenge for the transdermal delivery of lipophilic or high molecular weight drugs. To cross the main barrier of the skin, the stratum corneum, many techniques have been developed and improved. In the last 20 years, the association of microneedles with nanostructured systems has gained prominence for its versatility and for enabling targeted drug delivery. Currently, the combination of these mechanisms is pointed to as an emerging technology; however, some gaps need to be answered to transcend the development of these devices from the laboratory scale to the pharmaceutical market. It is known that the lack of regulatory guidelines for quality control is a hindrance to market conquest. In this context, this study undertakes a scoping review of original papers concerning methods applied to evaluate both the quality and drug/protein delivery of dissolving and hydrogel-forming microneedles developed in association with nanostructured systems.

scholarly journals Penambahan Lisin pada Pakan Komersial terhadap Retensi Protein dan Retensi Energi Ikan Bawal Air Tawar (Colossoma macropomum) [Lysine Addition on Commercial Feed to the Protein Retention and Energy Retention Colossoma macropomum]

2017 ◽  
Vol 9 (2) ◽  
pp. 98 ◽  
Author(s):  
Afifa Khalida ◽  
Agustono Agustono ◽  
Widya Paramita
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Quality Parameters ◽  
The Body ◽  
Colossoma Macropomum ◽  
Protein Retention ◽  
Body Tissues ◽  
Commercial Feed ◽  
Energy Retention ◽  
Range Test

                                                                   AbstrakAsam amino adalah komponen terkecil yang menyusun protein. Sejumlah asam amino akan dihubungkan satu sama lain melalui perantara ikatan peptida untuk membentuk protein. Asam amino telah dibagi menjadi dua; yaitu asam amino esensial dan asam amino non-esensial. Asam amino esensial adalah asam amino yang tidak dapat disintesis oleh tubuh ikan; karena itu asam amino esensial harus ada dalam pakan. Lisin adalah salah satu dari sepuluh asam amino esensial, fungsi lisin adalah untuk pertumbuhan dan perbaikan jaringan tubuh. Penelitian ini bertujuan untuk mengetahui pengaruh lisin dalam pakan komersial terhadap retensi protein dan retensi energi ikan bawal air tawar. Metode yang digunakan adalah desain eksperimen rancangan acak lengkap. Perlakuan yang digunakan adalah kadar lisin yang berbeda, yaitu P0 (0%), P1 (0,6%), P2 (1,2%), P3 (2,4%), P4 (4,8%) dan perlakuan  diulang 4 kali. Parameter utama yang diamati adalah retensi protein dan retensi energi pada air tawar bawal. Parameter yang diukur didukung oleh parameter kualitas air. Analisis data menggunakan Analisis Varian (ANOVA) dan untuk menentukan perlakuan terbaik digunakan Duncan's multiple range test. Hasil penelitian menunjukkan perbedaan yang signifikan (p <0,05) dalam retensi protein dan energi adalah daging ikan bawal air tawar. Retensi protein dan retensi energi dalam pengobatan P1 (0,6% lisin), P2 (1,2% lisin), P3 (2,4% lisin) dan P4 (4,8% lisin) berbeda secara signifikan dengan perlakuan P0 (kontrol). Kualitas air selama 40 hari perlakuan ditetapkan pada suhu 27-300 C, pH 7,5-8,5, amonia 4 mg / l dan oksigen terlarut 4 mg / l.                                                                 AbstractAmino acids are the smallest components that compose proteins. A number of amino acids will be conducted to one another through the intermediary of peptide bonds to form proteins. Amino acids have divided into two; those are essential amino acids and non-essential amino acids. The essential amino acids are amino acids that can not be synthesized by the body of fish; therefore the essential amino acids must be in feed. Lysine is one of the ten essentials amino acids , the function of lysine are for the growth and repair body tissues. This research was aimed to determine the effect of lysine in commercial feed on protein retention and energy retention of freshwater Bawal.The method used is experiment with a completely randomized design as an experimental design. The treatment used is different lysine levels , namely P0 ( 0 % ) , P1 ( 0.6 % ) , P2 ( 1.2 % ) , P3 ( 2.4 % ) , P4 (4.8 % ) and treatment was repeated 4 times. The main parameters were observed protein retention and energy retention on Bawal fresh water. Parameters measured were supported by water quality parameters. Analysis of the data using Analysis of Varian ( ANOVA ) and to determine the best treatment used Duncan 's multiple range test. The results showed the significant differences ( p < 0.05 ) in protein retention and energy were freshwater pomfret fish meat. Retention of protein and energy retention in treatment P1 ( 0.6 % lysine ) , P2 ( 1.2 % lysine ) , P3 ( 2.4 % lysine ) and P4 ( 4.8 % lysine ) was significantly different with treatment P0 ( control ). The quality of water for 40 days treatment was set to temperature 27-300 C, pH 7.5-8.5, ammonia 4 mg/l and dissolved oxygen 4 mg/l.

scholarly journals 'Strategy-as-practice' by hospital personnel in hospitals: a scoping review protocol

2021 ◽  
Vol 4 ◽  
pp. 26
Author(s):  
Carolyn Donohoe ◽  
Kate Frazer ◽  
Diarmuid Stokes ◽  
Thilo Kroll
Keyword(s):  
Scoping Review ◽  
Scientific Evidence ◽  
The Body ◽  
Future Research ◽  
Hospital Personnel ◽  
Use Of Resources ◽  
Strategic Process ◽  
Review Protocol ◽  
Strategy As Practice ◽  
Effective Use

Background: Strategy in hospitals is based on distinct principles and rules which lead organisations to act on chosen priorities. Hospitals are struggling to cope with increasing service demands and activity and need to become more responsive to changing environments while demonstrating effective use of resources. Strategizing involves the active process of sensing, planning, implementing and evaluating strategy. Strategy-as-practice is concerned with what people do about strategy in an organisation, as opposed to the traditional focus on what the organisation has as a strategy. It is recognised that there is a disconnection between strategic planning and implementation, however little is known about how organisational context influences the strategic process or how hospital personnel engage in strategic activities. The aim of this scoping review is to explore the literature on strategizing by hospital personnel in hospitals, and will include literature for hospital both professional and managerial backgrounds, to establish the extent and breadth of strategizing or as it is often termed ‘strategy-as-practice’ in hospitals. Methods: The systematic scoping review will search the literature within the databases of PubMed, Embase, CINAHL, PsycINFO, ABI/INFORM (Proquest) and OpenGrey.net to explore the scientific evidence on strategizing in hospitals. The review will be based on the Arksey & O’Malley (2005) framework of five mandatory steps which was updated (Levac et al 2010, Colquhoun et al 2014 & Peters 2015) and is published online by the Joanna Briggs Institute. It will follow the PRISMA-ScP reporting guidelines. Conclusion: A scoping review methodology will provide a framework to explore strategizing in hospitals comprehensively and map the body of literature for this subject, which has not been conducted previously. This review will summarise the evidence on the use of strategy as practice in hospitals.  Based on the findings we will identify knowledge gaps and areas for future research.

scholarly journals Scoping Review: Pengaruh Paparan Asap Rokok Terhadap Kadar Kotinin Dalam Tubuh Perokok Pasif

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Madina Tul Munawaroh ◽  
Annisa Rahmah Furqaani ◽  
Lelly Resna Nugrahawati
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Clinical Trial ◽  
Coronary Heart Disease ◽  
Scoping Review ◽  
The Body ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Cytochrome P450 Family

Perokok pasif adalah orang tidak merokok, namun ikut menghirup asap rokok dari orang-orang merokok di sekitarnya. Produk yang dihirup dihasilkan dari asap utama yang dihembuskan dan asap dari ujung rokok yang masih membara. Perokok pasif memiliki kandungan nikotin yang akan dimetabolisme menjadi kotinin menggunakan enzim CYP2A6 Cytochrome P450, Family 2, Subfamily A, Polypeptide dan didistribusikan dalam tubuh perokok pasif seperti darah, saliva, dan urine. Hasil metabolisme mengakibatkan peningkatan kadar kotinin dalam tubuh perokok pasif. Dampak peningkatan kadar kotinin menyebabkan gangguan kesehatan seperti lung cancer, oral cancer, asthma, chronic obstructive pulmonary disease (COPD), dan coronary heart disease. Tujuan penelitian menganalisis pengaruh paparan asap rokok terhadap kadar kotinin dalam tubuh perokok pasif. Penelitian dilakukan dengan metode scoping review dengan subjek artikel ilmiah nasional dan internasional yang memenuhi kriteria kelayakan (eligible). Hasil pada penelitian ini diambil dari artikel yang akan dinilai secara PICOS, yaitu Population: anak-anak perokok pasif yang terdapat pada jurnal artikel, Intervention/Exposure: asap rokok sekunder, Comparison: anak-anak yang tidak tinggal dengan perokok, Outcome: kadar kotinin dalam tubuh perokok pasif, Studi: RCT, clinical trial, dan cross sectional. Artikel yang memenuhi kelayakan (eligible) ada 6 artikel. Simpulan penelitian ini menunjukkan bahwa pada perokok pasif menunjukan kadar kotinin yang meningkat.  Scope Review: The Effect of Cigarette Exposure to Cotinine Levels in The Body of Passive SmokersSecondhand smoke is a product produced from the main smoke that is exhaled and the smoke from the tip of the cigarette that is still burning. Passive smokers who contain nicotine which will be metabolized into cotinine use the enzymes CYP2A6 Cytochrome P450, Family 2, Subfamily A, Polypeptides and distros in the body of passive smokers such as blood, saliva and urine. From the measurement results the increase in cotinine levels in the body of passive smokers. The impact of increasing levels of cotinins causes health problems such as lung cancer, oral cancer, asthma, chronic obstructive pulmonary disease (COPD), and coronary heart disease. The research objective was to analyze the effect of cigarette smoke on cotinine levels in the body of passive smokers. The research was taken using the scoping review method with the subject of national and international scientific articles that meet the eligibility criteria (elegible). The results in this study were taken from articles to be taken using PICOS, namely Population: children of passive smoking found in journal articles, Intervention/Exposure:secondary cigarette smoke, Comparison: children who do not live with smokers, Results: body cotinine levels in passive smokers, Studies (RCT, clinical trial, and cross sectional). There are 6 articles that fulfill the eligibility (elegible). The conclusion of this study shows that exposure to passive smoking using cotinine concentrations taken in the body of passive smokers shows an increase in cotinine levels.

scholarly journals Equilibrium disorders in elderly: diagnostic classification and differential diagnosis

2013 ◽  
pp. 16-22
Author(s):  
Alessandro Castiglione ◽  
Claudia Aimoni ◽  
Giovanni Scanelli
Keyword(s):  
Differential Diagnosis ◽  
Elderly Patients ◽  
Neurological Disorders ◽  
Sensory Input ◽  
Neurological Diseases ◽  
Specific Treatment ◽  
The Body ◽  
Diagnostic Classification ◽  
Main Challenge ◽  
Clinical Conditions

Background: Balance is primarily related to the proper functioning of three sensory input: vestibular, visual and proprioceptive. The integration of these different afferences contributes to the proper attitude of the body in static and dynamic conditions. Equilibrium disorders are common among elderly patients and are responsible for falls and fractures, leading sometimes to catastrophic outcomes, representing a serious health and social problem. Approximately one third of elderly patients at home and about 50% of institutionalized, over 75 year-old, suffer from this particular condition, with at least one fall a year and almost 50% of these with recurrent episodes. Females are more affected than males. Attempts to ascertain the underlying cause of unbalance should be done, leading then to specific treatment. Nevertheless, many elderly patients do not have a single disease but rather a multitude of medical conditions which may cause dizziness, imbalance and vertigo: effects of ageing, drugs, cardiovascular and neurological disorders, ocular and orthopaedic diseases. Aim of the study: A literature review was carried out with the intention to offer practical and useful notions for the management and treatment of equilibrium disorders. Discussion: In clinical practice, the main challenge is to distinguish between peripheral and central imbalance disorders. The data collected from history and clinical exams should be integrated with the intent to include the patient in one of the following clinical conditions: vertiginous syndrome, pre-syncope and/or syncope, neurological diseases, other conditions.Conclusions: Following the differential diagnosis, treatment mainly consists in drug administration (antiemetic and vestibular suppressor drugs) and vestibular rehabilitation (physiotherapy and vestibular exercises).

scholarly journals Tissue Interlocking Dissolving Microneedles for Accurate and Efficient Transdermal Delivery of Biomolecules

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shayan Fakhraei Lahiji ◽  
Youseong Kim ◽  
Geonwoo Kang ◽  
Suyong Kim ◽  
Seunghee Lee ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Dissolving Microneedles

scholarly journals Prospective Life Cycle Assessment of a Structural Battery

2019 ◽  
Vol 11 (20) ◽  
pp. 5679 ◽  
Author(s):  
Zackrisson ◽  
Jönsson ◽  
Johannisson ◽  
Fransson ◽  
Posner ◽  
...  
Keyword(s):  
Life Cycle Assessment ◽  
Life Cycle ◽  
Electric Vehicle ◽  
Mechanical Load ◽  
Climate Impacts ◽  
The Body ◽  
Environmental Benefits ◽  
Environmental Implications ◽  
Main Challenge ◽  
Structural Battery

With increasing interest in reducing fossil fuel emissions, more and more development is focused on electric mobility. For electric vehicles, the main challenge is the mass of the batteries, which significantly increase the mass of the vehicles and limits their range. One possible concept to solve this is incorporating structural batteries; a structural material that both stores electrical energy and carries mechanical load. The concept envisions constructing the body of an electric vehicle with this material and thus reducing the need for further energy storage. This research is investigating a future structural battery that is incorporated in the roof of an electric vehicle. The structural battery is replacing the original steel roof of the vehicle, and part of the original traction battery. The environmental implications of this structural battery roof are investigated with a life cycle assessment, which shows that a structural battery roof can avoid climate impacts in substantive quantities. The main emissions for the structural battery stem from its production and efforts should be focused there to further improve the environmental benefits of the structural battery. Toxicity is investigated with a novel chemical risk assessment from a life cycle perspective, which shows that two chemicals should be targeted for substitution.

scholarly journals Digital Phenotyping and Patient-Generated Health Data for Outcome Measurement in Surgical Care: A Scoping Review

2020 ◽  
Vol 10 (4) ◽  
pp. 282
Author(s):  
Prakash Jayakumar ◽  
Eugenia Lin ◽  
Vincent Galea ◽  
Abraham J. Mathew ◽  
Nikhil Panda ◽  
...  
Keyword(s):  
Scoping Review ◽  
Outcome Measurement ◽  
Clinical Care ◽  
Surgical Care ◽  
Health Data ◽  
The Body ◽  
Bibliographic Databases ◽  
Digital Phenotyping ◽  
Scoping Reviews ◽  
Patient Reported

Digital phenotyping—the moment-by-moment quantification of human phenotypes in situ using data related to activity, behavior, and communications, from personal digital devices, such as smart phones and wearables—has been gaining interest. Personalized health information captured within free-living settings using such technologies may better enable the application of patient-generated health data (PGHD) to provide patient-centered care. The primary objective of this scoping review is to characterize the application of digital phenotyping and digitally captured active and passive PGHD for outcome measurement in surgical care. Secondarily, we synthesize the body of evidence to define specific areas for further work. We performed a systematic search of four bibliographic databases using terms related to “digital phenotyping and PGHD,” “outcome measurement,” and “surgical care” with no date limits. We registered the study (Open Science Framework), followed strict inclusion/exclusion criteria, performed screening, extraction, and synthesis of results in line with the PRISMA Extension for Scoping Reviews. A total of 224 studies were included. Published studies have accelerated in the last 5 years, originating in 29 countries (mostly from the USA, n = 74, 33%), featuring original prospective work (n = 149, 66%). Studies spanned 14 specialties, most commonly orthopedic surgery (n = 129, 58%), and had a postoperative focus (n = 210, 94%). Most of the work involved research-grade wearables (n = 130, 58%), prioritizing the capture of activity (n = 165, 74%) and biometric data (n = 100, 45%), with a view to providing a tracking/monitoring function (n = 115, 51%) for the management of surgical patients. Opportunities exist for further work across surgical specialties involving smartphones, communications data, comparison with patient-reported outcome measures (PROMs), applications focusing on prediction of outcomes, monitoring, risk profiling, shared decision making, and surgical optimization. The rapidly evolving state of the art in digital phenotyping and capture of PGHD offers exciting prospects for outcome measurement in surgical care pending further work and consideration related to clinical care, technology, and implementation.

scholarly journals Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding

2018 ◽  
Vol 541 (1-2) ◽  
pp. 56-63 ◽  
Author(s):  
Aaron R.J. Hutton ◽  
Helen L. Quinn ◽  
Paul J. McCague ◽  
Courtney Jarrahian ◽  
Annie Rein-Weston ◽  
...  
Keyword(s):  
Vitamin K ◽  
Transdermal Delivery ◽  
Vitamin K Deficiency ◽  
Vitamin K Deficiency Bleeding ◽  
Dissolving Microneedles ◽  
K Deficiency

scholarly journals Potential Developmental and Reproductive Impacts of Triclocarban: A Scoping Review

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Johanna R. Rochester ◽  
Ashley L. Bolden ◽  
Katherine E. Pelch ◽  
Carol F. Kwiatkowski
Keyword(s):  
Systematic Review ◽  
Scoping Review ◽  
Estrogenic Activity ◽  
The Body ◽  
Future Research ◽  
Human Populations ◽  
Developmental Effects ◽  
Androgenic Activity ◽  
The Us

Triclocarban (TCC) is an antimicrobial agent used in personal care products. Although frequently studied with another antimicrobial, triclosan, it is not as well researched, and there are very few reviews of the biological activity of TCC. TCC has been shown to be a possible endocrine disruptor, acting by enhancing the activity of endogenous hormones. TCC has been banned in the US for certain applications; however, many human populations, in and outside the US, exhibit exposure to TCC. Because of the concern of the health effects of TCC, we conducted a scoping review in order to map the current body of literature on the endocrine, reproductive, and developmental effects of TCC. The aim of this scoping review was to identify possible endpoints for future systematic review and to make recommendations for future research. A search of the literature until August 2017 yielded 32 relevant studies in humans, rodents, fish, invertebrates, and in vitro. Based on the robustness of the literature in all three evidence streams (human, animal, and in vitro), we identified three endpoints for possible systematic review: estrogenic activity, androgenic activity, and offspring growth. In this review, we describe the body of evidence and make recommendations for future research.

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