scholarly journals Application of Electrospun Nanofiber Membrane in the Treatment of Diabetic Wounds

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 6
Author(s):  
Zhaoju Gao ◽  
Qiuxiang Wang ◽  
Qingqiang Yao ◽  
Pingping Zhang
Keyword(s):  
Fiber Surface ◽  
Electrospun Nanofibers ◽  
Electrospun Fibers ◽  
Pathological State ◽  
Electrospun Nanofiber ◽  
Delayed Wound Healing ◽  
New Ideas ◽  
Application Potential ◽  
And Migration ◽  
Diabetic Wounds

Diabetic wounds are complications of diabetes which are caused by skin dystrophy because of local ischemia and hypoxia. Diabetes causes wounds in a pathological state of inflammation, resulting in delayed wound healing. The structure of electrospun nanofibers is similar to that of the extracellular matrix (ECM), which is conducive to the attachment, growth, and migration of fibroblasts, thus favoring the formation of new skin tissue at the wound. The composition and size of electrospun nanofiber membranes can be easily adjusted, and the controlled release of loaded drugs can be realized by regulating the fiber structure. The porous structure of the fiber membrane is beneficial to gas exchange and exudate absorption at the wound, and the fiber surface can be easily modified to give it function. Electrospun fibers can be used as wound dressing and have great application potential in the treatment of diabetic wounds. In this study, the applications of polymer electrospun fibers, nanoparticle-loaded electrospun fibers, drug-loaded electrospun fibers, and cell-loaded electrospun fibers, in the treatment of diabetic wounds were reviewed, and provide new ideas for the effective treatment of diabetic wounds.

scholarly journals Focused Patterning of Electrospun Nanofibers Using a Dielectric Guide Structure

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1505
Author(s):  
Byeongjun Lee ◽  
Younghyeon Song ◽  
Chan Park ◽  
Jungmin Kim ◽  
Jeongbeom Kang ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Finite Elements ◽  
Electric Field ◽  
Electrospun Nanofibers ◽  
Electrospun Fibers ◽  
Continuous Line ◽  
Key Factors ◽  
Key Technology ◽  
Vertical Electric Field ◽  
Dielectric Guide

The patterning of electrospun fibers is a key technology applicable to various fields. This study reports a novel focused patterning method for electrospun nanofibers that uses a cylindrical dielectric guide. The finite elements method (FEM) was used to analyze the electric field focusing phenomenon and ground its explanation in established theory. The horizontal and vertical electric field strengths in the simulation are shown to be key factors in determining the spatial distribution of nanofibers. The experimental results demonstrate a relationship between the size of the cylindrical dielectric guide and that of the electrospun area accumulated in the collector. By concentrating the electric field, we were able to fabricate a pattern of less than 6 mm. The demonstration of continuous line and square patterning shows that the electrospun area can be well controlled. This novel patterning method can be used in a variety of applications, such as sensors, biomedical devices, batteries, and composites.

scholarly journals Conformal Fabrication of an Electrospun Nanofiber Mat on a 3D Ear Cartilage-Shaped Hydrogel Collector Based on Hydrogel-Assisted Electrospinning

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jin Yeong Song ◽  
Hyun Il Ryu ◽  
Jeong Myeong Lee ◽  
Seong Hwan Bae ◽  
Jae Woo Lee ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Electrospun Nanofibers ◽  
Cell Delivery ◽  
Complex Geometries ◽  
Two Dimensional ◽  
Uniform Thickness ◽  
Electrospun Nanofiber ◽  
Electrospinning Technique ◽  
Ear Cartilage ◽  
Focused Electric Field

AbstractElectrospinning is a common and versatile process to produce nanofibers and deposit them on a collector as a two-dimensional nanofiber mat or a three-dimensional (3D) macroscopic arrangement. However, 3D electroconductive collectors with complex geometries, including protruded, curved, and recessed regions, generally caused hampering of a conformal deposition and incomplete covering of electrospun nanofibers. In this study, we suggested a conformal fabrication of an electrospun nanofiber mat on a 3D ear cartilage-shaped hydrogel collector based on hydrogel-assisted electrospinning. To relieve the influence of the complex geometries, we flattened the protruded parts of the 3D ear cartilage-shaped hydrogel collector by exploiting the flexibility of the hydrogel. We found that the suggested fabrication technique could significantly decrease an unevenly focused electric field, caused by the complex geometries of the 3D collector, by alleviating the standard deviation by more than 70% through numerical simulation. Furthermore, it was experimentally confirmed that an electrospun nanofiber mat conformally covered the flattened hydrogel collector with a uniform thickness, which was not achieved with the original hydrogel collector. Given that this study established the conformal electrospinning technique on 3D electroconductive collectors, it will contribute to various studies related to electrospinning, including tissue engineering, drug/cell delivery, environmental filter, and clothing.

scholarly journals Electrospun Nanofibers for Sensing and Biosensing Applications—A Review

2021 ◽  
Vol 22 (12) ◽  
pp. 6357
Author(s):  
Kinga Halicka ◽  
Joanna Cabaj
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Toxic Metal ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Clinical Diagnostics ◽  
Loading Capacity ◽  
Electrospun Nanofiber ◽  
Sensing Platforms ◽  
Different Types

Sensors and biosensors have found applications in many areas, e.g., in medicine and clinical diagnostics, or in environmental monitoring. To expand this field, nanotechnology has been employed in the construction of sensing platforms. Because of their properties, such as high surface area to volume ratio, nanofibers (NFs) have been studied and used to develop sensors with higher loading capacity, better sensitivity, and faster response time. They also allow to miniaturize designed platforms. One of the most commonly used techniques of the fabrication of NFs is electrospinning. Electrospun NFs can be used in different types of sensors and biosensors. This review presents recent studies concerning electrospun nanofiber-based electrochemical and optical sensing platforms for the detection of various medically and environmentally relevant compounds, including glucose, drugs, microorganisms, and toxic metal ions.

Electrospun nanofiber/cotton composite yarn with enhanced moisture management ability

2021 ◽  
pp. 004051752098497
Author(s):  
Ning Mao ◽  
Xiaohong Qin ◽  
Liming Wang ◽  
Jianyong Yu
Keyword(s):  
Water Transport ◽  
Moisture Absorption ◽  
Water Evaporation ◽  
Electrospun Fibers ◽  
Electrospun Nanofiber ◽  
Knitted Fabrics ◽  
Moisture Management ◽  
Composite Yarn ◽  
Management Ability ◽  
Cotton Yarns

Wet comfort is a critical performance for fabrics, especially when human bodies release sweat in daily life. Despite excellent moisture absorption performance, cotton yarns are still limited in the moisture release/transfer ability. Here, based on a novel electrospinning technology, polyacrylonitrile and polystyrene (PS) electrospun nanofiber/cotton composite yarns were produced, respectively. Under fluorescence microscopic observation, electrospun fibers within the composite yarns showed a uniform distribution. As a result, these composite yarn-based knitted fabrics obtained a good water transport ability and a fast water evaporation rate. According to the moisture management test, PS electrospun nanofiber composite yarn-based fabrics exhibited a relatively high one-way transport index R (400%), claiming an enhanced moisture management performance. Finally, specific surface area tests and finite element analyses were used to analyze the water transport mechanism inside the yarns. The results proved that a small number of electrospun fibers played a predominant role in enhancing the moisture management ability of the composite yarns.

scholarly journals Antimicrobial Properties and Release Profile of Ampicillin from Electrospun Poly(εepsilon;-caprolactone) Nanofiber Yarns

2010 ◽  
Vol 5 (4) ◽  
pp. 155892501000500 ◽  
Author(s):  
Hang Liu ◽  
Karen K. Leonas ◽  
Yiping Zhao
Keyword(s):  
In Vitro Release ◽  
Antimicrobial Properties ◽  
Fiber Surface ◽  
Electrospun Nanofibers ◽  
Release Profile ◽  
Burst Release ◽  
Spun Yarns ◽  
Surgical Sutures ◽  
Release Model

Poly(εepsilon;-caprolactone) (PCL) electrospun fibers containing ampicillin sodium salt have been produced and twisted into nanofiber yarns. The fiber diameters and crystallinity, the in vitro antimicrobial properties of the yarns, and the in vitro release of ampicillin from yarns containing various ampicillin concentrations are studied. Decreased fiber diameters and reduced diameter variation are observed with the addition of ampicillin salt into the polymer solution. The results from the zone of inhibition test of the yarns against both gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumoniae indicate that the released ampicillin retains its effectiveness after the production processes, therefore the as-spun yarns are antimicrobial active. A burst release of ampicillin from the yarns has been observed in the first hour, and the release is almost completed in 96 hours. The burst release is believed to be due to the low compatibility of ampicillin with PCL, the accumulation of ampicillin on fiber surface and the small fiber diameters. An empirical release model is developed to describe the release profile. The results indicate that the electrospun nanofibers yarns will have a great potential to be used for biomaterials, such as surgical sutures, to decrease the surgical site infection rate.

scholarly journals Study on the Morphologies and Formational Mechanism of Poly(hydroxybutyrate-co-hydroxyvalerate) Ultrafine Fibers by Dry-Jet-Wet-Electrospinning

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Shuqi Zhu ◽  
Hao Yu ◽  
Yanmo Chen ◽  
Meifang Zhu
Keyword(s):  
Fiber Surface ◽  
Double Diffusion ◽  
Electrospun Fibers ◽  
Surface Porosity ◽  
Morphological Comparison ◽  
Ultrafine Fibers ◽  
Stability And Instability ◽  
Boundary Of Stability

Dry-jet-wet-electrospinning (DJWE) was carried out to study the formational mechanism of poly(hydroxybutyrate-co-hydroxyvalerate) electrospun fibers. Morphological comparison between normal electrospinning (NE) and DJWE was investigated. The results showed that jet could solidify quickly in DJWE to avoid bead collapse or fiber coherence. Jet structures could be maintained at very low collection distance. Beanpod-like beads, which were named as primary beads, could be seen at the boundary of stability and instability section and divided into spindle-like beads with longer collection distance. Bead-free electrospun fibers from DJWE had few bonding points among each other, and fast solidification and double-diffusion led to rough and shriveled fiber surface. DJWE mats were higher hydrophobic than that from NE due to more loose structure and higher surface porosity. Higher bead ratio on the surface and rounder bead structure resulted in higher hydrophobicity.

AB2 Y-shaped miktoarm star conductive polyaniline-modified poly(ethylene glycol) and its electrospun nanofiber blend with poly(ε-caprolactone)

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36715-36726 ◽  
Author(s):  
Bakhshali Massoumi ◽  
Somayeh Davtalab ◽  
Mehdi Jaymand ◽  
Ali Akbar Entezami
Keyword(s):  
Ethylene Glycol ◽  
Electrospun Nanofibers ◽  
Synthesis And Characterization ◽  
Electrospun Nanofiber ◽  
Poly Ethylene Glycol ◽  
Conductive Polyaniline ◽  
Miktoarm Star ◽  
Poly Ethylene ◽  
Type Ab

The aim of this study is the synthesis, and characterization of novel type AB2 Y-shaped miktoarm star conductive polyaniline-modified poly(ethylene glycol), and preparation of its electrospun nanofibers blend with poly(ε-caprolactone).

scholarly journals Mechanical and Dielectric Properties of Aligned Electrospun Fibers

Fibers ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Blesson Isaac ◽  
Robert M. Taylor ◽  
Kenneth Reifsnider
Keyword(s):  
Dielectric Properties ◽  
Dielectric Property ◽  
Electrospun Nanofibers ◽  
Cold Drawing ◽  
General Interest ◽  
Electrospun Fibers ◽  
Energy Storage Devices ◽  
Electrospinning Technique ◽  
Specific Strength ◽  
Aligned Nanofibers

This review paper examines the current state-of-the-art in fabrication of aligned fibers via electrospinning techniques and the effects of these techniques on the mechanical and dielectric properties of electrospun fibers. Molecular orientation, system configuration to align fibers, and post-drawing treatment, like hot/cold drawing process, contribute to better specific strength and specific stiffness properties of nanofibers. The authors suggest that these improved, aligned nanofibers, when applied in composites, have better mechanical and dielectric properties for many structural and multifunctional applications, including advanced aerospace applications and energy storage devices. For these applications, most fiber alignment electrospinning research has focused on either mechanical property improvement or dielectric property improvement alone, but not both simultaneously. Relative to many other nanofiber formation techniques, the electrospinning technique exhibits superior nanofiber formation when considering cost and manufacturing complexity for many situations. Even though the dielectric property of pure nanofiber mat may not be of general interest, the analysis of the combined effect of mechanical and dielectric properties is relevant to the present analysis of improved and aligned nanofibers. A plethora of nanofibers, in particular, polyacrylonitrile (PAN) electrospun nanofibers, are discussed for their mechanical and dielectric properties. In addition, other types of electrospun nanofibers are explored for their mechanical and dielectric properties. An exploratory study by the author demonstrates the relationship between mechanical and dielectric properties for specimens obtained from a rotating mandrel horizontal setup.

scholarly journals A general strategy for generating gradients of bioactive proteins on electrospun nanofiber mats by masking with bovine serum albumin

2017 ◽  
Vol 5 (28) ◽  
pp. 5580-5587 ◽  
Author(s):  
Michael L. Tanes ◽  
Jiajia Xue ◽  
Younan Xia
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Electrospun Nanofibers ◽  
General Strategy ◽  
Electrospun Nanofiber ◽  
Bioactive Proteins ◽  
Nanofiber Mats

Gradients of bioactive proteins on mats of electrospun nanofibers were generated by masking with bovine serum albumin.

Polymer nanofibers for biomedical applications: advances by electrospinning

2021 ◽  
Vol 04 ◽  
Author(s):  
Anna L.M.M. Toledo ◽  
Talita N. da Silva ◽  
Arianne C. dos S. Vaucher ◽  
Arthur H. V. Miranda ◽  
Gabriela C. C. Silva de Miranda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
New Technologies ◽  
Low Cost ◽  
Electrospun Nanofibers ◽  
Delivery Systems ◽  
Electrospun Fibers ◽  
Sustained Delivery ◽  
Biomedical Devices ◽  
Ultrathin Fibers

Background: The demand for novel biomaterials has been exponentially rising in the last years as well as the searching for new technologies able to produce more efficient products in both drug delivery systems and regenerative medicine. Objective: The technique that can pretty well encompass the needs for novel and high-end materials with a relatively low-cost and easy operation is the electrospinning of polymer solutions. Methods: Electrospinning usually produces ultrathin fibers that can be applied in a myriad of biomedical devices including sustained delivery systems for drugs, proteins, biomolecules, hormones, etc that can be applied in a broad spectrum of applications, from transdermal patches to cancer-related drugs. Results: Electrospun fibers can be produced to mimic certain tissues of the human body, being an option to create new scaffolds for implants with several advantages. Conclusions: In this review, we aimed to encompass the use of electrospun fibers in the field of biomedical devices, more specifically in the use of electrospun nanofibers applications toward the production of drug delivery systems and scaffolds for tissue regeneration.

Sign in / Sign up

Export Citation Format

Share Document