scholarly journals Natural Products, Traditional Uses and Pharmacological Activities of the Genus Biebersteinia (Biebersteiniaceae)

Plants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 595 ◽  
Author(s):  
Benyin Zhang ◽  
Xiaona Jin ◽  
Hengxia Yin ◽  
Dejun Zhang ◽  
Huakun Zhou ◽  
...  
Keyword(s):  
Natural Products ◽  
Molecular Mechanisms ◽  
Chemical Properties ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Drug Discovery And Development ◽  
Chemical Structures ◽  
Traditional Uses ◽  
Novel Drugs ◽  
Major Chemical

Medicinal plants have been known as a rich source of natural products (NPs). Due to their diverse chemical structures and remarkable pharmacological activities, NPs are regarded as important repertoires for drug discovery and development. Biebersteinia plant species belong to the Biebersteiniaceae family, and have been used in folk medicines in China and Iran for ages. However, the chemical properties, bioactivities and modes of action of the NPs produced by medicinal Biebersteinia species are poorly understood despite the fact that there are only four known Biebersteinia species worldwide. Here, we reviewed the chemical classifications and diversity of the various NPs found in the four known Biebersteinia species. We found that the major chemical categories in these plants include flavonoids, alkaloids, phenylpropanoids, terpenoids, essential oils and fatty acids. We also discussed the anti-inflammatory, analgesic, antibacterial, antioxidant, antihypertensive and hypoglycemic effects of the four Biebersteinia species. We believe that the present review will facilitate the exploration of traditional uses and pharmacological properties of Biebersteinia species, extraction of the NPs and elucidation of their molecular mechanisms, as well as the development of novel drugs based on the reported properties and mode-of-action.

Novel Phytochemical Constituents and their Potential to Manage Diabetes

2020 ◽  
Vol 26 ◽  
Author(s):  
Shaik Ibrahim Khalivulla ◽  
Arifullah Mohammed ◽  
Kokkanti Mallikarjuna
Keyword(s):  
Natural Products ◽  
Large Population ◽  
World Health ◽  
In Vivo Studies ◽  
Antidiabetic Activity ◽  
Therapeutic Drug ◽  
Pharmacological Activities ◽  
Chemical Structures

Background: Diabetes is a chronic disease affecting a large population worldwide and stands as one of the major global health challenges to be tackled. According to World Health Organization, about 400 million are having diabetes worldwide and it is the seventh leading cause of deaths in 2016. Plant based natural products had been in use from ancient time as ethnomedicine for the treatment of several diseases including diabetes. As a result of that, there are several reports on plant based natural products displaying antidiabetic activity. In the current review, such antidiabetic potential compounds reported from all plant sources along with their chemical structures are collected, presented and discussed. This kind of reports are essential to pool the available information to one source followed by statistical analysis and screening to check the efficacy of all known compounds in a comparative sense. This kind of analysis can give rise to few numbers of potential compounds from hundreds, whom can further be screened through in vitro and in vivo studies, and human trails leading to the drug development. Methods: Phytochemicals along with their potential antidiabetic property were classified according to their basic chemical skeleton. The chemical structures of all the compounds with antidiabetic activities were elucidated in the present review. In addition to this, the distribution and their other remarkable pharmacological activities of each species is also included. Results: The scrutiny of literature led to identification of 44 plants with antidiabetic compounds (70) and other pharmacological activities. For the sake of information, the distribution of each species in the world is given. Many plant derivatives may exert antidiabetic properties by improving or mimicking the insulin production or action. Different classes of compounds including sulfur compounds (1-4), alkaloids (5-11), phenolic compounds (12-17), tannins (18-23), phenylpropanoids (24-27), xanthanoids (28-31), amino acid (32), stilbenoid (33), benzofuran (34), coumarin (35), flavonoids (36-49) and terpenoids (50-70) were found to be active potential compounds for antidiabetic activity. Of the 70 listed compounds, majorly 17 compounds are from triterpenoids, 13 flavonoids and 7 are from alkaloids. Among all the 44 plant species, maximum number (7) of compounds are reported from Lagerstroemia speciosa followed by Momordica charantia (6) and S. oblonga with 5 compounds. Conclusion: This is the first paper to summarize the established chemical structures of phytochemicals that have been successfully screened for antidiabetic potential and their mechanisms of inhibition. The reported compounds could be considered as potential lead molecules for the treatment of type-2 diabetes. Further, molecular and clinical trials are required to select and establish the therapeutic drug candidates.

A Comprehensive Review on Pharmacology and Toxicology of Bioactive Compounds of Lagerstroemia Speciosa (L.) Pers.

2020 ◽  
Vol 06 ◽  
Author(s):  
Surya Kant Tripathi ◽  
Sunayna Behera ◽  
Munmun Panda ◽  
Gokhan Zengin ◽  
Bijesh K. Biswal
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Health Benefit ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Lagerstroemia Speciosa ◽  
Novel Drugs ◽  
Corosolic Acid ◽  
Current Article ◽  
Preclinical And Clinical Studies

Background: Lagerstroemia speciosa (L.) Pers is one of the most valuable plants due to its ornamental and pharmacological relevance. It is known for its anti-diabetic activity with proved potent blood sugar-lowering activity. The anti-diabetic activity is due to presence of its biologically active component corosolic acid. Moreover, L. speciosa and its novel purified compounds are also well-known for its several biological activities with beneficial health benefit on the human being. Objectives: This review provides a summary of pharmacokinetics, toxicity, and pharmacological properties of L. speciosa and its purified phytochemicals which may help researchers for building up new researches in near future. Methods: The current article is prepared by collecting through various online and offline databases. Preliminary source of study and data collection for outlining the review was research articles and reviews that have been already published by many reputed publishers, including Springer, Elsevier, Taylor & Francis imprints, BMC, Willy, The Norwegian Academy of Science and Letters, Environmental health prospective (EHP), and PLOS One. Result: The available studies results suggested that the L. speciosa and its phytochemicals showed antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiviral, anti-obesity, and cardio-protective activities. Pharmacokinetic stud-ies suggested the low bioavailability of its purified compounds. However, nano-encapsulation can improve the bioavaila-bility related issue and effectively potentiate the medicinal properties of its constituents. Conclusion: Considering the worthy pharmacological properties, L. speciosa is considered as a potent source of several novel drugs. Though, still preclinical and clinical studies are needed to reveal the targets, molecular mechanisms, bioavail-ability, and toxicity of its constituents.

scholarly journals Ethnobotanical, phytochemical and pharmacological aspects of Bengal Pogostemon (Pogostemon benghalensis)

2020 ◽  
Vol 9 (4) ◽  
pp. 318-327
Author(s):  
Sangeeta Dahiya ◽  
Daizy R. Batish ◽  
Harminader Pal Singh
Keyword(s):  
Molecular Level ◽  
Antioxidant Activities ◽  
Chemical Compounds ◽  
Biologically Active ◽  
Pharmacological Activities ◽  
Plant Parts ◽  
Chemical Structures ◽  
Traditional Uses ◽  
Traditional Remedies ◽  
Pharmacological Studies

Pogostemon benghalensis (Burm.f.) Kuntze (Lamiaceae) is an important aromatic plant. Multiple classes of phytochemicals such as flavonoids, phenols, phytosteroids, carbohydrates, fatty acids, glycosides, sterols, terpenoids, tannins, essential oil, and alkaloids have been isolated from the title species. Different plant parts have been used as traditional remedies for various ailments. The present review aims to update and coherent the fragmented information on botanical aspects, phytochemistry, traditional uses, and pharmacological activities. An extensive review of the literature was carried out by using various search engines like PubMed, Scopus, Science Direct, Google Scholar, Google, Scifinder for information. The articles were searched using the keywords "Pogostemon", "Parviflorus’, "benghalensis". Chemical structures of the chemical compounds were drawn using software Chem Draw ultra 8.0. Most of the plant parts have been used for the treatment of various ailments. Phytochemistry reveals that the plant is a rich source of various biologically active compounds. Pogostemon extracts exhibited numerous pharmacological effects like anticancer, anti-inflammatory, antimicrobial and antioxidant activities. In sum, P. benghalensis is a promising aromatic and medicinal plant as depicted by its various traditional uses and pharmacological studies. Bioactive compounds, responsible for its various pharmacological activities at the molecular level, need further detailed investigations. Future clinical studies are also required to validate the various traditional uses of P. benghalensis.

scholarly journals Phytochemistry, Traditional Uses and Pharmacological Properties of the Genus Opopanax W. D. J. Koch: A Mini-Review

2020 ◽  
Vol 26 (2) ◽  
pp. 99-106
Author(s):  
Alev Önder ◽  
Lutfun Nahar ◽  
Sushmita Nath ◽  
Satyajit D. Sarker
Keyword(s):  
Traditional Medicine ◽  
Mediterranean Region ◽  
Antimicrobial Activities ◽  
Evidence Based ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
Phytochemical Profile ◽  
The Mediterranean ◽  
Antioxidant And Antimicrobial Activities

The genus Opopanax W.D.J. Koch is a member of the Apiaceae family, distributed throughout the Mediterranean region and comprises only three recognized and well-defined species, O. chironium (L.) W.D.J. Koch, O. hispidus (Friv.) Griseb. and O. persicus Boiss. The species of this genus with yellow flowers are well-known in traditional medicine and consumed as food. This review critically appraises published literature on the phytochemistry, traditional usages, and pharmacological activities of the genus Opopanax. In addition, it provides evidence to suggest that the plants from this genus have potential phytotherapeutic applications. Previous phytochemical and bioactivity studies revealed that the genus Opopanax predominantly produces coumarins, diterpenes, phenolics, and phthalides, and possesses various biological and pharmacological properties, including anticancer, antioxidant and antimicrobial activities. The phytochemical profile and pharmacological activities of the genus Opopanax could be useful for further study and might find additional medicinal applications in evidence-based phytotherapy

scholarly journals Marine Natural Products: A Source of Novel Anticancer Drugs

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 491 ◽  
Author(s):  
Shaden A. M. Khalifa ◽  
Nizar Elias ◽  
Mohamed A. Farag ◽  
Lei Chen ◽  
Aamer Saeed ◽  
...  
Keyword(s):  
Natural Products ◽  
Anticancer Drugs ◽  
Marine Natural Products ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Marine Organisms ◽  
New Drugs ◽  
Bioactive Metabolites ◽  
Chemical Structures ◽  
The Impact

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

scholarly journals PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF JUSTICIA PROCUMBENS L.: A REVIEW

2020 ◽  
Vol 11 (5) ◽  
pp. 190-193
Author(s):  
Amritha C K ◽  
Suma C ◽  
Ananya V M ◽  
Thushara P V ◽  
Deepak V S
Keyword(s):  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Active Compounds ◽  
Traditional Uses ◽  
Current Review ◽  
Snake Bites ◽  
Anti Inflammatory ◽  
Water Willow ◽  
Anti Hiv

Justicia procumbens L. is usually known as water willow which belongs to family Acanthaceae growing widely in southern regions of China, Japan, Vietnam, India and Australia. It is one of the important herbal being used in Ayurvedic system of medicine. The plant contains various active compounds like arylnaphthalide and diarylbutane lignans, glycosides, flavonoids. Few pharmacological properties including anti-inflammatory, anti-arthritic, anti-arrhythmic, anti-asthmatic, anti-proliferative, anti-allergic, antibacterial, cytotoxic and anti-HIV activities activity have been reported for this plant. Conventionally, it is used for the treatment of fever, inflammation, cold, cough, asthma, cancer, snake bites etc. The current review is created with an intended to focus on the numerous ethnobotanical and traditional uses as well as the phytochemical and pharmacological report on Justicia procumbens.

scholarly journals Chemistry and Biochemistry of Sulfur Natural Compounds: Key Intermediates of Metabolism and Redox Biology

2020 ◽  
Vol 2020 ◽  
pp. 1-27 ◽  
Author(s):  
Antonio Francioso ◽  
Alessia Baseggio Conrado ◽  
Luciana Mosca ◽  
Mario Fontana
Keyword(s):  
Natural Products ◽  
Sulfur Metabolism ◽  
Chemical Properties ◽  
Natural Compounds ◽  
Chemical Diversity ◽  
Redox Biology ◽  
Inorganic Sulfur ◽  
Chemical Structures ◽  
Sulfurous Compounds ◽  
Sulfur Containing

Sulfur contributes significantly to nature chemical diversity and thanks to its particular features allows fundamental biological reactions that no other element allows. Sulfur natural compounds are utilized by all living beings and depending on the function are distributed in the different kingdoms. It is no coincidence that marine organisms are one of the most important sources of sulfur natural products since most of the inorganic sulfur is metabolized in ocean environments where this element is abundant. Terrestrial organisms such as plants and microorganisms are also able to incorporate sulfur in organic molecules to produce primary metabolites (e.g., methionine, cysteine) and more complex unique chemical structures with diverse biological roles. Animals are not able to fix inorganic sulfur into biomolecules and are completely dependent on preformed organic sulfurous compounds to satisfy their sulfur needs. However, some higher species such as humans are able to build new sulfur-containing chemical entities starting especially from plants’ organosulfur precursors. Sulfur metabolism in humans is very complicated and plays a central role in redox biochemistry. The chemical properties, the large number of oxidation states, and the versatile reactivity of the oxygen family chalcogens make sulfur ideal for redox biological reactions and electron transfer processes. This review will explore sulfur metabolism related to redox biochemistry and will describe the various classes of sulfur-containing compounds spread all over the natural kingdoms. We will describe the chemistry and the biochemistry of well-known metabolites and also of the unknown and poorly studied sulfur natural products which are still in search for a biological role.

scholarly journals HING (Ferula foetida Regel): A potent Unani Herb with its descriptive parameters of pharmacognosy and pharmacology: A Review

2020 ◽  
Vol 10 (5) ◽  
pp. 362-367
Author(s):  
Rasikh Javaid ◽  
Ghazala Javed ◽  
Raheela Javaid ◽  
, Anju ◽  
Farah Ahmed ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Central Asia ◽  
Present Review ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Unani Medicine ◽  
Traditional Uses ◽  
Pharmacological Studies ◽  
Botanical Description ◽  
Biological And Pharmacological Activities

Hing (Family- Umbelliferae) or asafoetida is the latex obtained from living rootstocks or taproots of several species of Ferula, e.g. F. alliacea Boiss, F. rubricaulis Boiss, F. assafoetida Linn and F. narthex Boiss found in central Asia. Asafoetida occurs in three forms, viz Tears, Mass and Paste. Hing has shown diverse biological and pharmacological activities. It has been used in Unani Medicine (Tibb-e-Unani) and other Traditional Systems of Medicine from time immemorial and it is described as diuretic, anti-diabetic, emmenagogue etc. The present review highlights the botanical description, traditional uses, pharmacognositcal features, pharmacological properties and pharmacological studies conducted on this Medicinal plant used in Unani system of medicine. Keywords: Hing; Ferula foetida; Unani Medicine; Traditional Uses; Pharmacological Properties

Coumarin-Oxadiazole Derivatives: Synthesis and Pharmacological Properties

2020 ◽  
Vol 17 (7) ◽  
pp. 780-794
Author(s):  
Nurhayatun S. Abdul Razak ◽  
Joazaizulfazli Jamalis ◽  
Subhash Chander ◽  
Roswanira Abdul Wahab ◽  
Deepak P. Bhagwat ◽  
...  
Keyword(s):  
Natural Products ◽  
Clinical Practice ◽  
Review Paper ◽  
Biological Activities ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Oxadiazole Derivatives ◽  
The Common

Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.

scholarly journals Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth

Marine Drugs ◽  
2018 ◽  
Vol 16 (12) ◽  
pp. 485 ◽  
Author(s):  
Inês Raimundo ◽  
Sandra Silva ◽  
Rodrigo Costa ◽  
Tina Keller-Costa
Keyword(s):  
Natural Products ◽  
Genome Mining ◽  
Gene Clusters ◽  
Chemical Diversity ◽  
Chemical Structures ◽  
Novel Drugs ◽  
Blue Growth ◽  
Microbial Symbionts ◽  
Bacteria And Fungi ◽  
Near Future

Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Genome mining of 15 bacterial associates (spanning 12 genera) cultivated from Eunicella spp. resulted in the identification of 440 putative and classifiable secondary metabolite biosynthetic gene clusters (BGCs), encompassing varied terpene-, polyketide-, bacteriocin-, and nonribosomal peptide-synthase BGCs. This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. However, to extend our knowledge and foster the near-future laboratory production of bioactive compounds from (cultivatable and currently uncultivatable) octocoral symbionts, optimal blending between targeted metagenomics, DNA recombinant technologies, improved symbiont cultivation, functional genomics, and analytical chemistry are required. Such a multidisciplinary undertaking is key to achieving a sustainable response to the urgent industrial demand for novel drugs and enzyme varieties.

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