scholarly journals Effect of Chitosan and Aloe Vera Extract Concentrations on the Physicochemical Properties of Chitosan Biofilms

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1187
Author(s):  
Cristiana M. P. Yoshida ◽  
Murilo S. Pacheco ◽  
Mariana A. de Moraes ◽  
Patrícia S. Lopes ◽  
Patrícia Severino ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Chronic Wounds ◽  
Healing Process ◽  
Aloe Vera ◽  
Water Vapor Permeability ◽  
Vapor Permeability ◽  
Aloe Barbadensis ◽  
Casting Technique ◽  
Color Parameters ◽  
Chitosan Films

Chitosan films have been extensively studied as dressings in formulations for the treatment of chronic wounds. The incorporation of aloe vera (Aloe barbadensis Miller) into chitosan dressings could potentialize the healing process since aloe vera shows several pharmacological activities. This work aimed to evaluate the effect of aloe vera and chitosan concentrations on the physicochemical properties of the developed films. The films were obtained by casting technique and characterized with respect to their color parameters, morphology, barrier and mechanical properties, and thermal analysis. Results showed that the presence of aloe vera modified the films′ color parameters, changed barrier properties, increased fluid handling capacity (FHC), and decreased water-vapor permeability (WVP). The reduced elongation at break resulted in more rigid films. Aloe vera concentration did not significantly change film properties, but the presence of this gel increased the films′ stability at temperatures below 200 °C, showing similar behavior as chitosan films above 400 °C. The results suggest a crosslinking/complexation between chitosan and aloe vera, which combine appropriate physicochemical properties for application as wound dressing materials.

scholarly journals Characterization of compisote edible films from aloe vera gel, beeswax and chitosan

10.5219/1177 ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 854-862 ◽  
Author(s):  
Usman Amin ◽  
Muhammad Azam Khan ◽  
Muhammad Ehtasham Akram ◽  
Abdel Rahman Mohammad Said Al-Tawaha ◽  
Alexey Laishevtcev ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Water Vapor ◽  
Food Packaging ◽  
Aloe Vera ◽  
Water Vapor Permeability ◽  
Edible Films ◽  
Vapor Permeability ◽  
Casting Technique ◽  
Edible Packaging ◽  
Superior Mechanical Properties

Environmental consciousness as well as individual’s demand for ready to eat food, recently, has changed the trends in food packaging leading to the development of biodegradable and edible packaging. Emulsified edible films have better transparency, superior mechanical properties and provide barriers to water and other atmospheric gases. Edible films if not consumed, biodegrad chemically. In present study, edible films were, initially, prepared using Chitosan and Aloe vera at different concentrations. Films were then subjected to physical and mechanical testing. Films with 20% Aloe vera had low thickness as compared to films with no Aloe vera. These films also had superior mechanical properties and lower water vapor permeability. Films with 20% Aloe vera were, then, selected and beeswax was dispersed in Chitosan-Aloe vera solution at concentration upto 2.0% followed by film preparation through casting technique. Thickness and water vapor permeability were observed to be improved with increase in concentration of beeswax. Tensile strength of edible films was also improved 1.3 times when concentration of beeswax increased from 0.5 to 2.0%. Percentage elongation decreased with increase in beeswax concentration in the emulsified films. No change in particle size was observed with change in concentration of beeswax. Emulsions were also stable at room temperatures. Decrease in transparency of emulsified edible films was observed with increase in beeswax content in the emulsified films. In addition, cost analysis of the films proved them reasonable to be used as an alternate of synthetic packaging materials.

scholarly journals Made in Germany: A Quality Indicator Not Only in the Automobile Industry But Also When It Comes to Skin Replacement: How an Automobile Textile Research Institute Developed a New Skin Substitute

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 143
Author(s):  
Herbert Leopold Haller ◽  
Matthias Rapp ◽  
Daniel Popp ◽  
Sebastian Philipp Nischwitz ◽  
Lars Peter Kamolz
Keyword(s):  
Wound Healing ◽  
Automobile Industry ◽  
Chronic Wounds ◽  
Water Vapor Permeability ◽  
Healing Time ◽  
Development Cooperation ◽  
Skin Substitute ◽  
Vapor Permeability ◽  
Clinical Use ◽  
Research Institute

Successful research and development cooperation between a textile research institute, the German Federal Ministry of Education and Research via the Center for Biomaterials and Organ Substitutes, the University of Tübingen, and the Burn Center of Marienhospital, Stuttgart, Germany, led to the development of a fully synthetic resorbable temporary epidermal skin substitute for the treatment of burns, burn-like syndromes, donor areas, and chronic wounds. This article describes the demands of the product and the steps that were taken to meet these requirements. The material choice was based on the degradation and full resorption of polylactides to lactic acid and its salts. The structure and morphology of the physical, biological, and degradation properties were selected to increase the angiogenetic abilities, fibroblasts, and extracellular matrix generation. Water vapor permeability and plasticity were adapted for clinical use. The available scientific literature was screened for the use of this product. A clinical application demonstrated pain relief paired with a reduced workload, fast wound healing with a low infection rate, and good cosmetic results. A better understanding of the product’s degradation process explained the reduction in systemic oxidative stress shown in clinical investigations compared to other dressings, positively affecting wound healing time and reducing the total area requiring skin grafts. Today, the product is in clinical use in 37 countries. This article describes its development, the indications for product growth over time, and the scientific foundation of treatments.

scholarly journals Chitosan Films Obtained from Brachystola magna (Girard) and Its Evaluation on Quality Attributes in Sausages during Storage

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1782
Author(s):  
Juan Manuel Tirado-Gallegos ◽  
Paul Baruk Zamudio-Flores ◽  
Miguel Espino-Díaz ◽  
René Salgado-Delgado ◽  
Gilber Vela-Gutiérrez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Lipid Oxidation ◽  
Meat Products ◽  
Water Vapor Permeability ◽  
Good Alternative ◽  
Quality Attributes ◽  
Vapor Permeability ◽  
Biodegradable Films ◽  
Molecular Weights ◽  
Chitosan Films

High molecular weight chitosan (≈322 kDa) was obtained from chitin isolated from Brachystola magna (Girard) to produced biodegradable films. Their physicochemical, mechanical and water vapor permeability (WVP) properties were compared against commercial chitosan films with different molecular weights. Brachystola magna chitosan films (CFBM) exhibited similar physicochemical and mechanical characteristics to those of commercial chitosans. The CFBM films presented lower WVP values (10.01 × 10−11 g/m s Pa) than commercial chitosans films (from 16.06 × 10−11 to 64.30 × 10−11 g/m s Pa). Frankfurt-type sausages were covered with chitosan films and stored in refrigerated conditions (4 °C). Their quality attributes (color, weight loss, pH, moisture, texture and lipid oxidation) were evaluated at 0, 5, 10, 15 and 20 days. Sausages covered with CFMB films presented the lowest weight loss (from 1.24 to 2.38%). A higher increase in hardness (from 22.32 to 30.63 N) was observed in sausages covered with CFMB films. Compared with other films and the control (uncovered sausages), CFMB films delay pH reduction. Moreover, this film presents the lower lipid oxidation level (0.10 malonaldehyde mg/sample kg). Thus, chitosan of B. magna could be a good alternative as packaging material for meat products with high-fat content.

scholarly journals Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 961
Author(s):  
Sibusiso Alven ◽  
Vuyolwethu Khwaza ◽  
Opeoluwa O. Oyedeji ◽  
Blessing A. Aderibigbe
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Mechanical Performance ◽  
Healing Process ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Wound Management ◽  
Wound Healing Process ◽  
Treatment Of Wounds

The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

scholarly journals Silk derived formulations for accelerated wound healing in diabetic mice

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10232
Author(s):  
Muniba Tariq ◽  
Hafiz Muhammad Tahir ◽  
Samima Asad Butt ◽  
Shaukat Ali ◽  
Asma Bashir Ahmad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Chronic Wounds ◽  
Histological Analysis ◽  
Healing Process ◽  
Aloe Vera ◽  
Wound Contraction ◽  
Wound Dressings ◽  
Control Group ◽  
Diabetic Mice

Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

Effect of different drying procedures on physicochemical properties and flow behavior of Aloe vera ( Aloe barbadensis Miller) gel

LWT ◽  
2016 ◽  
Vol 74 ◽  
pp. 378-386 ◽  
Author(s):  
R. Minjares-Fuentes ◽  
A. Femenia ◽  
F. Comas-Serra ◽  
C. Rosselló ◽  
V.M. Rodríguez-González ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Flow Behavior ◽  
Aloe Vera ◽  
Aloe Barbadensis ◽  
Drying Procedures

Improved mechanical, physical and biological properties of chitosan films using Aloe vera and electrospun PVA nanofibers for wound dressing applications

2019 ◽  
pp. 152808371986693 ◽  
Author(s):  
Shirin Rafieian ◽  
Hamid Mahdavi ◽  
Mir Esmaeil Masoumi
Keyword(s):  
Mechanical Properties ◽  
Wound Dressing ◽  
Aloe Vera ◽  
Composite Layer ◽  
Synthetic Polymers ◽  
Biological Properties ◽  
Vapor Permeability ◽  
Natural Polymers ◽  
Simple Method ◽  
Chitosan Films

Natural polymers such as chitosan and Aloe vera are widely used in novel wound dressings due to their biocompatibility and biodegradability. A problem associated with these polymers is their poor mechanical behavior. Efforts have been made to improve the mechanical properties by mixing synthetic polymers such as PVA, but the role of chitosan and Aloe vera in the final dressing is dimmed. The techniques are also time-consuming and costly and there is still a need for an acceptable and affordable wound dressing which can be made through easily accessible techniques. A new but very simple method is introduced in this work for incorporating PVA nanofibers with Aloe vera-containing chitosan films. Using this method the levels of Aloe vera and chitosan in the system can be optimized at higher scales while benefiting from PVA best mechanical properties as a composite layer. Higher amounts of Aloe vera and chitosan in the system lead to lower product costs and more biocompability. The biological properties of films were examined through cell cytotoxicity and antibacterial tests and compared with Atomic force microscopy results. Physical and mechanical properties of films containing PVA nanofibers were characterized by water vapor permeability, swelling ratio, and tensile tests. The morphology of fibers before and after applying on the films was also observed by scanning electron microscopy. According to the results, this combination of natural and synthetic polymers has led to an affordable, biocompatible, and flexible film for wound dressing applications.

Study of Diffusion and Water Vapor Permeability in Chitosan Films and Chitosan Emulsified Films

2012 ◽  
Vol 326-328 ◽  
pp. 170-175 ◽  
Author(s):  
Arlete Barbosa dos Reis ◽  
Cristiana Maria Pedroso Yoshida ◽  
Vera Solange Oliveira Farias ◽  
Wilton Pereira Silva
Keyword(s):  
Water Vapor ◽  
Lipid Analysis ◽  
Water Vapor Permeability ◽  
Vapor Permeability ◽  
Oxygen Barrier ◽  
Water Vapor Barrier ◽  
Industry Waste ◽  
Diffusive Permeability ◽  
Hydrophobic Compound ◽  
Chitosan Films

Chitosan is an abundant, natural polysaccaride obtained from fishing industry waste and films of chitosan also provide an efficient oxygen barrier. However, they are a poor water vapor barrier, which can be improved by incorporation of a hydrophobic compound, forming a emulsified film. Chitosan films were produced with the addition of palmitic acid lipid analysis and then the process in parallel with the diffusive permeability to water vapor. The objective of this work was to characterize the diffusion and water vapor permeability behavior of chitosan films and chitosan emulsified films.

scholarly journals A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 200 ◽  
Author(s):  
Francisco Alexandrino-Junior ◽  
Kattya Gyselle de Holanda e Silva ◽  
Marjorie Caroline Liberato Cavalcanti Freire ◽  
Viviane de Oliveira Freitas Lione ◽  
Elisama Azevedo Cardoso ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Topical Treatment ◽  
Healing Process ◽  
Water Vapor Permeability ◽  
Vero Cells ◽  
Poly Vinyl Alcohol ◽  
Vapor Permeability ◽  
Secondary Infections ◽  
Leishmania Spp

Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL.

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