scholarly journals Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Sensors ◽  
2020 ◽  
Vol 20 (20) ◽  
pp. 5820
Author(s):  
Zhenzhou Deng ◽  
Yushan Deng ◽  
Guandong Chen

Positron emission tomography (PET) has a wide range of applications in the treatment and prevention of major diseases owing to its high sensitivity and excellent resolution. However, there is still much room for optimization in the readout circuit and fast pulse sampling to further improve the performance of the PET scanner. In this work, a LIGHTENING® PET detector using a 13 × 13 lutetium-yttrium oxyorthosilicate (LYSO) crystal array read out by a 6 × 6 silicon photomultiplier (SiPM) array was developed. A novel sampling method, referred to as the dual time interval (DTI) method, is therefore proposed to realize digital acquisition of fast scintillation pulse. A semi-cut light guide was designed, which greatly improves the resolution of the edge region of the crystal array. The obtained flood histogram shown that all the 13 × 13 crystal pixels can be clearly discriminated. The optimum operating conditions for the detector were obtained by comparing the flood histogram quality under different experimental conditions. An average energy resolution (FWHM) of 14.3% and coincidence timing resolution (FWHM) of 972 ps were measured. The experimental results demonstrated that the LIGHTENING® PET detector achieves extremely high resolution which is suitable for the development of a high performance time-of-flight PET scanner.

Geosciences ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 60
Author(s):  
Viacheslav Glinskikh ◽  
Oleg Nechaev ◽  
Igor Mikhaylov ◽  
Kirill Danilovskiy ◽  
Vladimir Olenchenko

This paper is dedicated to the topical problem of examining permafrost’s state and the processes of its geocryological changes by means of geophysical methods. To monitor the cryolithozone, we proposed and scientifically substantiated a new technique of pulsed electromagnetic cross-well sounding. Based on the vector finite-element method, we created a mathematical model of the cross-well sounding process with a pulsed source in a three-dimensional spatially heterogeneous medium. A high-performance parallel computing algorithm was developed and verified. Through realistic geoelectric models of permafrost with a talik under a highway, constructed following the results of electrotomography field data interpretation, we numerically simulated the pulsed sounding on the computing resources of the Siberian Supercomputer Center of SB RAS. The simulation results suggest the proposed system of pulsed electromagnetic cross-well monitoring to be characterized by a high sensitivity to the presence and dimensions of the talik. The devised approach can be oriented to addressing a wide range of issues related to monitoring permafrost rocks under civil and industrial facilities, buildings, and constructions.


Metals ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 877 ◽  
Author(s):  
Vagner Gobbi ◽  
Silvio Gobbi ◽  
Danieli Reis ◽  
Jorge Ferreira ◽  
José Araújo ◽  
...  

Superalloys are used primarily for the aerospace, automotive, and petrochemical industries. These applications require materials with high creep resistance. In this work, evaluation of creep resistance and microstructural characterization were carried out at two new nickel intermediate content alloys for application in aerospace industry and in high performance valves for automotive applications (alloys VAT 32 and VAT 36). The alloys are based on a high nickel chromium austenitic matrix with dispersion of intermetallic L12 and phases containing different (Nb,Ti)C carbides. Creep tests were performed at constant load, in the temperature range of 675–750 °C and stress range of 500–600 MPa. Microstructural characterization and failure analysis of fractured surfaces of crept samples were carried out with optical and scanning electron microscopy with EDS. Phases were identified by Rietveld refinement. The results showed that the superalloy VAT 32 has higher creep resistance than the VAT 36. The superior creep resistance of the alloy VAT 32 is related to its higher fraction of carbides (Nb,Ti)C and intermetallic L12 provided by the amount of carbon, titanium, and niobium in its chemical composition and subsequent heat treatment. During creep deformation these precipitates produce anchoring effect of grain boundaries, hindering relative slide between grains and therefore inhibiting crack formation. These volume defects act also as obstacles to dislocation slip and climb, decreasing the creep rate. Failure analysis of surface fractures of crept samples showed intergranular failure mechanism at crack origin for both alloys VAT 36 and VAT 32. Intergranular fracture involves nucleation, growth, and subsequent binding of voids. The final fractured portion showed transgranular ductile failure, with dimples of different shapes, generated by the formation and coalescence of microcavities with dissimilar shape and sizes. The occurrence of a given creep mechanism depends on the test conditions. At creep tests of VAT 32 and VAT 36, for lower stresses and higher temperature, possible dislocation climb over carbides and precipitates would prevail. For higher stresses and intermediate temperatures shear mechanisms involving stacking faults presumably occur over a wide range of experimental conditions.


1993 ◽  
Vol 28 (1) ◽  
pp. 16-24 ◽  
Author(s):  
R. Vieira ◽  
M. Aldegunde

The determination of serotonin (5-HT), N-acetylserotonin (NAS) and 5-hydroxy-3-indoleacetic acid (5-HIAA) in single brains of two acridids (Paracinema tricolor and Oedipoda caerulescens) was accomplished using a HPLC method combined with amperometric detection. A hydrodynamic voltammetry approach was used to assess the identity of each peak by comparing the voltammograms of standards and those of samples. The analytical method gave satisfactory reproducibility and sensitivity, and detected levels of 5-HT, NAS and 5-HIAA as low as 29, 55 and 10 fmol, respectively. This high sensitivity together with the simplicity of sample processing make the present analytical method suitable for a wide range of studies concerning indoleamine analyses in the insect nervous system. In both acridids, 5-HT showed the largest quantities, while its derivatives occurred in extremely low amounts. The results suggest that N-acetylation of 5-HT is quantitatively preferred to oxidative deamination in both species (NAS levels were 4-fold those of 5-HIAA). The relative importance of each catabolic pathway is discussed as related to physiological and genetic aspects.


Author(s):  
Yun-Hsiang Sun ◽  
Tao Chen ◽  
Cyrus Shafai

This work proposes a simple but general experimental approach including the rig design and measurement procedure to carry out a wide range of experiments required for identifying parameters for LuGre dynamic friction model. The design choice is based on accuracy of the estimated friction and flexibility in terms of changing contact conditions. The experimental results allow a complete LuGre model, which facilitates, but not limited to, other advanced friction modeling and high performance controller design if needed. In addition, several well-known dynamic friction features (varying break-away force, friction lag and presliding) are successfully demonstrated by our rig, which indicates the adequacy of our approach for capturing highly sophisticated and dynamic friction behavior over a wide range of operating conditions. The proposed set-up and the produced experimental data are believed to greatly facilitate the development of advanced friction compensation and modeling in friction affected mechanisms.


2014 ◽  
Vol 496-500 ◽  
pp. 1825-1829 ◽  
Author(s):  
Ehsan Rohani ◽  
Jing Wei Xu ◽  
Gwan Choi ◽  
Mi Lu

Manufacturing and operation of wireless systems require a practical solution for achieving low-power and high-performance when using advance communication apparatus such as that using multiple-input and multiple-output (MIMO). Often algorithm solutions achieve very high performance but over only in a narrow range of operating parameters. This paper presents a hardware design of MIMO detection that allows real-time switching between various algorithms and detection effort to achieve high performance over the wide-range of signal to noise ratio (SNR) found in realistic operating conditions. We illustrate a design with over 80% reduction in detection power that satisfies the required quality of service (QoS) in SNRs (Eb/No) as low as 8.7 dB.


2021 ◽  
Author(s):  
Christian Hunley ◽  
Md Mohsin ◽  
Marcelo Marucho

We present an interactive Mathematica notebook that characterizes the electrical impulses along actin filaments in both muscle and non-muscle cells for a wide range of physiological and pathological conditions. The program is based on a multi-scale (atomic → monomer → filament) approach capable of accounting for the atomistic details of a protein molecular structure, its biological environment, and their impact on the travel distance, velocity, and attenuation of monovalent ionic wave packets propagating along microfilaments. The interactive component allows investigators to conduct original research by choosing the experimental conditions (intracellular Vs in vitro), nucleotide state (ATP Vs ADP), actin isoform (alpha, gamma, beta, and muscle or non-muscle cell), as well as, a conformation model that covers a variety of mutants and wild-type (the control) actin filament. The simplicity of the theoretical formulation and the high performance of the Mathematica software enable the analysis of multiple conditions without computational restrictions. These studies may provide an unprecedented molecular understanding of why and how age, inheritance, and disease conditions induce dysfunctions in the biophysical mechanisms underlying the propagation of electrical signals along actin filaments.


Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3465
Author(s):  
Jianli Cui ◽  
Xueli Nan ◽  
Guirong Shao ◽  
Huixia Sun

Researchers are showing an increasing interest in high-performance flexible pressure sensors owing to their potential uses in wearable electronics, bionic skin, and human–machine interactions, etc. However, the vast majority of these flexible pressure sensors require extensive nano-architectural design, which both complicates their manufacturing and is time-consuming. Thus, a low-cost technology which can be applied on a large scale is highly desirable for the manufacture of flexible pressure-sensitive materials that have a high sensitivity over a wide range of pressures. This work is based on the use of a three-dimensional elastic porous carbon nanotubes (CNTs) sponge as the conductive layer to fabricate a novel flexible piezoresistive sensor. The synthesis of a CNTs sponge was achieved by chemical vapor deposition, the basic underlying principle governing the sensing behavior of the CNTs sponge-based pressure sensor and was illustrated by employing in situ scanning electron microscopy. The CNTs sponge-based sensor has a quick response time of ~105 ms, a high sensitivity extending across a broad pressure range (less than 10 kPa for 809 kPa−1) and possesses an outstanding permanence over 4,000 cycles. Furthermore, a 16-pixel wireless sensor system was designed and a series of applications have been demonstrated. Its potential applications in the visualizing pressure distribution and an example of human–machine communication were also demonstrated.


2021 ◽  
Author(s):  
Antonio Ruiz ◽  
Xun Cao ◽  
Yizhong Huang ◽  
Kwang-Leong Choy

Abstract The detection of ions is essential for a wide range of applications including biomedical diagnosis, and environmental monitoring among others. However, current ion sensors are based on thick sensing films (typically 100 µm), requiring time-consuming preparations, and have a thermodynamic limit to their sensitivity of 59 mV.Log[C]-1. Such configuration hinders the development of high-performance ion sensors due to the inherent limitations of the bulk diffusion of ions inside sensors. Consequently, they cannot be applied for high-precision applications that require high sensitivity. Furthermore, the research of anion monitoring is hampered due to the limited availability of molecular receptors with acceptable performances. We overcome such limitations by using a 300 nm nanostructured sensing film based on a novel nanoporous ion imprinted core-shell silica/gold nanoparticulate sensing film. The novel sensing film was highly selective towards chloride ions when compared to other anions such as nitrate, sulphate and carbonate. Moreover, this nanostructured sensing film exhibited above 3-fold higher sensitivity (-186.4 mV.Log[C]-1) towards chloride ions when compared to commercial devices. Such breakthrough has led to the fabrication of the smallest and most sensitive reported anion sensor working on open circuit potentiometry, with an exceptional selectivity towards chloride ions.


2021 ◽  
Vol 895 (1) ◽  
pp. 012002
Author(s):  
V S Alekseev ◽  
R S Seryi

Abstract Currently sluice washing devices are the most common in alluvial gold mining. Their use provides a sufficiently high performance, relatively low power consumption, and acceptable recovery of valuable components. The theoretical provisions of traditional hydraulics make it possible to determine all the main parameters of the movement of particles of rocks and gold in the pulp, however, in real operating conditions of the sluice box, their actual values will differ greatly from the calculated ones, especially if there are solid fractions in the pulp with a particle size of more than 20 mm. This is explained by significant fluctuations in the values of the surface, average and bottom velocities of the two-phase flow, vertical pulsation velocity in conditions of constrained movement of the different fractional composition of rocks. The article presents the results of experimental studies to identify the dependence of the distance traveled by an individual gold particle and host rocks in a two-phase flow through a sluice, the bottom of which is lined with trapping coatings, on the design and technological parameters of the flushing device. The mathematical model for determining this distance formed the basis of the Gold Enriching program. The program allows, in a wide range of initial data, to determine the zones of concentration of gold of a certain size at the sluice boxes.


2020 ◽  
Vol 20 (2) ◽  
pp. 148-154
Author(s):  
Mohamed Hakam ◽  
Wael Hashima ◽  
Ibrahim Elhawary ◽  
Adel Elgeiheini

AbstractWoven and nonwoven fabrics present filtration efficiency higher than other air filtration media. Fabrics are selected according to air flow conditions and particle characteristics. The majority of air filtration media are nonwoven fabrics because of their cost, but they need high filtration area for high efficiency. Modified construction of woven fabric introduces high performance in air filtration and decreases filter size, which tends to have better competition abilities. The designed fabrics have considerable thickness and suitable pore characteristics by applying roving instead of weft yarns. Four factors (roving count and their turns per inch, picks per inch and fabric designs) were varied in order to study the effect of these factors on their performance in filtration. Optimum operating conditions for a determined range of air permeability and pore size were obtained.


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