scholarly journals Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Symmetry ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 889
Author(s):  
Oleg I. Kolodiazhnyi
Keyword(s):  
Organophosphorus Compounds ◽  
Biological Properties ◽  
Vital Role ◽  
Biologically Active ◽  
Phosphorus Compounds ◽  
Biochemical Processes ◽  
Metabolic Intermediates ◽  
History Of ◽  
Living Organisms ◽  
Life On Earth

Organophosphorus compounds play a vital role as nucleic acids, nucleotide coenzymes, metabolic intermediates and are involved in many biochemical processes. They are part of DNA, RNA, ATP and a number of important biological elements of living organisms. Synthetic compounds of this class have found practical application as agrochemicals, pharmaceuticals, bioregulators, and others. In recent years, a large number of phosphorus compounds containing P-O, P-N, P-C bonds have been isolated from natural sources. Many of them have shown interesting biological properties and have become the objects of intensive scientific research. Most of these compounds contain asymmetric centers, the absolute configurations of which have a significant effect on the biological properties of the products of their transformations. This area of research on natural phosphorus compounds is still little-studied, that prompted us to analyze and discuss it in our review. Moreover natural organophosphorus compounds represent interesting models for the development of new biologically active compounds, and a number of promising drugs and agrochemicals have already been obtained on their basis. The review also discusses the history of the development of ideas about the role of organophosphorus compounds and stereochemistry in the origin of life on Earth, starting from the prebiotic period, that allows us in a new way to consider this most important problem of fundamental science.

Future Disasters

2000 ◽  
Author(s):  
Robert B. Smith ◽  
Lee J. Siegel
Keyword(s):  
Hot Springs ◽  
The United States ◽  
Greater Yellowstone Ecosystem ◽  
Yellowstone Hotspot ◽  
Moisture Regimes ◽  
History Of ◽  
Greater Yellowstone ◽  
Complex Relationships ◽  
Living Organisms ◽  
Life On Earth

In 1870, the fall before Ferdinand Hayden’s celebrated exploration of Yellowstone, an Army lieutenant named Gustavus C. Doane guided a small troop into the mysterious high country. Unlike Hayden, Doane did not conduct extensive scientific studies. However, Doane was observant. He said of Yellowstone: . . . As a country for sight seers, it is without parallel. As a field for scientific research it promises great results, in the branches of Geology, Mineralogy, Botany, Zoology, and Ornithology. It is probably the greatest laboratory that nature furnishes on the surface of the globe. . . . Yellowstone’s value as a unique ecological region soon gained recognition when in 1872, it was designated as the first national park in the United States—and in the world. The complex relationships among Yellowstone’s fauna, flora, and geology helped inspire America’s budding conservation ethic, which came to fruition only a century later with widespread recognition of the tenuous interdependence of living organisms and the Earth they occupy. The idea of a greater Yellowstone ecosystem recognized that its living and geological wonders extended beyond the park’s boundaries and into a broader area. The greater Yellowstone ecosystem is defined by the subterranean yet dominant presence of the Yellowstone hotspot, the engine that ultimately drives not only the region’s geology, but also its living organisms. The Rocky Mountains, lifted upward tens of millions of years ago, were pushed perhaps 1,700 feet higher at Yellowstone during the past 2 million years by the upward-bulging hotspot. Today, a line drawn at 6,100 feet elevation roughly demarcates the boundaries of the greater Yellowstone ecosystem. The high altitude is critical in creating the temperature and moisture regimes that gave rise to Yellowstone’s biological wonders and now determine the distribution of its plants and wildlife. In addition, the incredible amount of heat rising from the hotspot is responsible for Yellowstone’s history of volcanism and its geysers and hot springs, rich with exotic microbes that branched off the evolutionary tree at a primitive stage of life on Earth. Yelllowstone’s expansive lodgepole pine forests demonstrate the interaction of the park’s biology and geology. They grow well on rhyolite lava flows that cover most of western and central Yellowstone.

scholarly journals The Chemical Synthesis of the Crinine and Haemanthamine Alkaloids: Biologically Active and Enantiomerically-Related Systems that Serve as Vehicles for Showcasing New Methodologies for Molecular Assembly

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 765
Author(s):  
Nan Hu ◽  
Lorenzo V. White ◽  
Ping Lan ◽  
Martin G. Banwell
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
Biological Properties ◽  
Molecular Assembly ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Comprehensive Survey ◽  
History Of ◽  
New Methodologies

The title alkaloids, often referred to collectively as crinines, are a prominent group of structurally distinct natural products with additional members being reported on a regular basis. As such, and because of their often notable biological properties, they have attracted attention as synthetic targets since the mid-1950s. Such efforts continue unabated and more recent studies on these alkaloids have focused on using them as vehicles for showcasing the utility of new synthetic methods. This review provides a comprehensive survey of the nearly seventy-year history of these synthetic endeavors.

scholarly journals Loliolide - the most ubiquitous lactone

2015 ◽  
Vol 11 ◽  
pp. 1-8 ◽  
Author(s):  
Małgorzata Grabarczyk ◽  
Katarzyna Wińska ◽  
Wanda Mączka ◽  
Bartłomiej Potaniec ◽  
Mirosław Anioł
Keyword(s):  
Side Effects ◽  
Folk Medicine ◽  
Biological Properties ◽  
Biologically Active ◽  
Complicated Structure ◽  
Tropical Coral ◽  
Anti Cancer ◽  
Structural Analogues ◽  
Treatment Of Diabetes ◽  
Living Organisms

The searching for biologically active compounds produced by living organisms led to the discovery of a number of compounds with more or less complicated structure. One of the simplest molecules are monoterpenoid lactones and loliolide is the most common among them. Loliolide was found in animals (insects) and plants (flowers, shrubs, trees) both terrestrial and marine, such as algae and corals. Many years of research on plants used in traditional folk medicine of different countries have led to the conclusion that this compound has a variety of biological properties such as anti-cancer, antibacterial, antifungal and antioxidant ones. Moreover, plants containing loliolide are used in alternative medicine in treatment of diabetes and depression. It is extremely interesting that this lactone also affects the behavior of ants as well as the development of certain plants (allelopathic activity). However, sometimes there are side effects as in the case of structural analogues of loliolide contributing to extinction of tropical coral.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

Philosophic Pride

2012 ◽  
Author(s):  
Christopher Brooke
Keyword(s):  
Early Modern ◽  
Political Thought ◽  
Historical Context ◽  
Vital Role ◽  
Intellectual Life ◽  
Marcus Aurelius ◽  
Hugo Grotius ◽  
History Of ◽  
Early Modern Era ◽  
Modern Era

This is the first full-scale look at the essential place of Stoicism in the foundations of modern political thought. Spanning the period from Justus Lipsius's Politics in 1589 to Jean-Jacques Rousseau's Emile in 1762, and concentrating on arguments originating from England, France, and the Netherlands, the book considers how political writers of the period engaged with the ideas of the Roman and Greek Stoics that they found in works by Cicero, Seneca, Epictetus, and Marcus Aurelius. The book examines key texts in their historical context, paying special attention to the history of classical scholarship and the historiography of philosophy. The book delves into the persisting tension between Stoicism and the tradition of Augustinian anti-Stoic criticism, which held Stoicism to be a philosophy for the proud who denied their fallen condition. Concentrating on arguments in moral psychology surrounding the foundations of human sociability and self-love, the book details how the engagement with Roman Stoicism shaped early modern political philosophy and offers significant new interpretations of Lipsius and Rousseau together with fresh perspectives on the political thought of Hugo Grotius and Thomas Hobbes. The book shows how the legacy of the Stoics played a vital role in European intellectual life in the early modern era.

The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds

2019 ◽  
Vol 16 (7) ◽  
pp. 953-967 ◽  
Author(s):  
Ghodsi M. Ziarani ◽  
Fatemeh Mohajer ◽  
Razieh Moradi ◽  
Parisa Mofatehnia
Keyword(s):  
Biological Activities ◽  
Biological Properties ◽  
Biologically Active ◽  
Microtubule Assembly ◽  
Heterocyclic Molecules ◽  
Biological Perspective ◽  
Highly Active ◽  
Anti Inflammatory ◽  
High Yields ◽  
Short Time

Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I and III) and novel microtubule assembly inhibitors. It should be mentioned that spiro-pyrazole also has biological activities like cytotoxic, antimicrobial, anticonvulsant, antifungal, anticancer, anti-inflammatory, and cardiotonic activities. Objective: Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses. This review disclosed the advances in the use of urazole as the starting material in the synthesis of various biologically active molecules from 2006 to 2019. Conclusion: Compounds of urazole (1,2,4-triazolidine-3,5-dione) are the most important molecules which are highly active from the biological perspective in the pharmaceuticals as well as polymers. In summary, many protocols for preparations of the urazole derivatives from various substrates in multi-component reactions have been reported from different aromatic and aliphatic groups which have had carbonyl groups in their structures. It is noted that several catalysts have been synthesized to afford applicable molecules with urazole scaffolds. In some papers, being environmentally friendly, short time reactions and high yields are highlighted in the protocols. There is a room to synthesize new catalysts and perform new reactions by manipulating urazole to produce biologically active compounds, even producing chiral urazole component as many groups of chiral urazole compounds are important from biological perspective.

Antiviral Essential Oils Incorporated in Nanocarriers: Strategy for Prevention from COVID-19 and Future Infectious Pandemics

2020 ◽  
Vol 8 (6) ◽  
pp. 437-451
Author(s):  
Malkiet Kaur ◽  
Gayatri Devi ◽  
Manju Nagpal ◽  
Manjinder Singh ◽  
Gitika A. Dhingra ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Antiviral Activity ◽  
Essential Oils ◽  
Bacterial Infections ◽  
Biological Properties ◽  
Vital Role ◽  
Chinese Herbs ◽  
Active Constituents ◽  
Prevention And Treatment ◽  
Low Solubility

Background: Coronavirus has become a life-threatening disease and it is caused by severe acute respiratory syndrome (SARS). This new strain of coronavirus is not completely understood and to date, there is no treatment for coronavirus. Traditional ayurvedic medicines, mainly essential oils and Chinese herbs, have always played a vital role in the prevention and treatment of several epidemics and pandemics. In the meantime, guidelines of the ministry of AYUSH (Ayurveda, yoga, unani, siddha and homoepathy) include a traditional medicinal treatment for flu and fever and also recommended to boost immunity to prevent the spread of coronavirus. It is not possible to find which essential oil will offer the best level of protection. However, it is likely to assume that some essential oils are likely to offer a measurable level of defense in the same way they do with many other known viruses. Methods: Literature relevant to various essential oils having antiviral activity has been collected and compiled. Various nanocarriers of essential oils have also been stated. The database was collected using various search engines such as J-Gate, Google Scholar, Sci-Hub, PubMed, ScienceDirect, etc. Results: Essential oils contain active constituents such as phenolic compounds, terpenoids, alkaloids, phenyl propanoids, etc., which are responsible for their biological properties such as antiviral, antibacterial, antimicrobial, antioxidant activities and many more. However, the use of essential oils has always been limited due to poor solubility, solvent toxicity, volatility and low solubility. Many nanotechnology based carriers especially, liposomes, dendrimers, nanoparticles, nanoemulsion and microemulsion, etc. have been evidenced to overcome limitations associated with essential oils. Conclusion: Several essential oils possess potent antiviral activity and are characterized by fewer side effects and are safe for human use. The nanocarrier systems of these oils have proved the potential to treat viral and bacterial infections. Lay Summary: Current COVID-19 era demands traditional treatment for immunity boost up as support therapy. Traditional ayurvedic medicines, mainly essential oils and Chinese herbs, have always played a vital role in the prevention and treatment of several epidemics and pandemics. Therefore, authors have summarized various essential oils having antiviral activity in current manuscript. Various nanocarriers of essential oils have been reported. Essential oils contain active constituents such as phenolic compounds, terpenoids, alkaloids, phenyl propanoids, etc., which are responsible for their biological properties such as antiviral, antibacterial, antimicrobial, antioxidant activity. However, the use of essential oils has always been limited due to poor solubility, solvent toxicity, volatility and low solubility. Many nanotechnology based carriers especially, liposomes, dendrimers, nanoparticles, nanoemulsion and microemulsion, etc. have been evidenced to overcome limitations associated with essential oils. The nanocarrier systems of these oils have proved the potential to treat viral and bacterial infections.

Conclusion

2017 ◽  
Author(s):  
Erin Lambert
Keyword(s):  
Dutch Reformed ◽  
Christian Life ◽  
The Reformation ◽  
History Of ◽  
Life On Earth

This conclusion offers a brief commentary on the implications of song, resurrection, and belief for the broader history of the Reformation. It relates the various uses of song by Lutherans (hymn pamphlets), Anabaptists (martyr songs), Dutch Reformed exiles (psalms), and Catholics (motets) to these confessions’ ideas of belief as it concerned resurrection and their understandings of how belief was bound up with the Christian life on earth. In place of a story of the transformation of one conception of Christianity to many different conceptions, this book as a whole suggests that the Reformation might be reconceived as a much more elemental debate about the role that belief was to play in a Christian life.

The Roman Retail Revolution

2018 ◽  
Author(s):  
Steven J. R. Ellis
Keyword(s):  
Interdisciplinary Approach ◽  
Vital Role ◽  
Archaeological Material ◽  
Roman World ◽  
The Social ◽  
History Of ◽  
Food And Drink ◽  
Bodies Of Evidence ◽  
Definition Of ◽  
The University

Tabernae were ubiquitous among all Roman cities, lining the busiest streets and dominating their most crowded intersections, and in numbers not known by any other form of building. That they played a vital role in the operation of the city—indeed in the very definition of urbanization—is a point too often under-appreciated in Roman studies, or at best assumed. The Roman Retail Revolution is a thorough investigation into the social and economic worlds of the Roman shop. With a focus on food and drink outlets, and with a critical analysis of both archaeological material and textual sources, Ellis challenges many of the conventional ideas about the place of retailing in the Roman city. A new framework is forwarded, for example, to understand the motivations behind urban investment in tabernae. Their historical development is also unraveled to identify three major waves—or, revolutions—in the shaping of retail landscapes. Two new bodies of evidence underpin the volume. The first is generated from the University of Cincinnati’s recent archaeological excavations into a Pompeian neighborhood of close to twenty shop-fronts. The second comes from a field survey of the retail landscapes of more than a hundred cities from across the Roman world. The richness of this information, combined with an interdisciplinary approach to the lives of the Roman sub-elite, results in a refreshingly original look at the history of retailing and urbanism in the Roman world.

scholarly journals Isobornylchalcones as Scaffold for the Synthesis of Diarylpyrazolines with Antioxidant Activity

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3579
Author(s):  
Svetlana A. Popova ◽  
Evgenia V. Pavlova ◽  
Oksana G. Shevchenko ◽  
Irina Yu. Chukicheva ◽  
Aleksandr V. Kutchin
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
Biological Properties ◽  
High Reactivity ◽  
Biologically Active ◽  
Brain Lipids ◽  
Wide Range ◽  
Privileged Structure ◽  
Vitro Model

The pyrazoline ring is defined as a “privileged structure” in medicinal chemistry. A variety of pharmacological properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biological properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biologically active molecules. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives.

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