scholarly journals The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview

Vaccines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1345
Author(s):  
Bruna Aparecida Souza Machado ◽  
Katharine Valéria Saraiva Hodel ◽  
Larissa Moraes dos Santos Fonseca ◽  
Luís Alberto Brêda Mascarenhas ◽  
Leone Peter Correia da Silva Andrade ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Vaccine Development ◽  
Research Field ◽  
Related Protein ◽  
Relevant Research ◽  
Cell Mediated Immune Response ◽  
The World ◽  
Mrna Technology ◽  
New Vaccines ◽  
Fight Against Cancer

In recent years, vaccine development using ribonucleic acid (RNA) has become the most promising and studied approach to produce safe and effective new vaccines, not only for prophylaxis but also as a treatment. The use of messenger RNA (mRNA) as an immunogenic has several advantages to vaccine development compared to other platforms, such as lower coast, the absence of cell cultures, and the possibility to combine different targets. During the COVID-19 pandemic, the use of mRNA as a vaccine became more relevant; two out of the four most widely applied vaccines against COVID-19 in the world are based on this platform. However, even though it presents advantages for vaccine application, mRNA technology faces several pivotal challenges to improve mRNA stability, delivery, and the potential to generate the related protein needed to induce a humoral- and T-cell-mediated immune response. The application of mRNA to vaccine development emerged as a powerful tool to fight against cancer and non-infectious and infectious diseases, for example, and represents a relevant research field for future decades. Based on these advantages, this review emphasizes mRNA and self-amplifying RNA (saRNA) for vaccine development, mainly to fight against COVID-19, together with the challenges related to this approach.

scholarly journals Synthetic Messenger RNA-Based Vaccines: From Scorn to Hype

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 270
Author(s):  
Steve Pascolo
Keyword(s):  
Messenger Rna ◽  
Neutralizing Antibodies ◽  
Low Dose ◽  
Safety Data ◽  
Viral Proteins ◽  
Efficacy And Safety ◽  
The Third ◽  
The World ◽  
Synthetic Mrna ◽  
New Vaccines

In the race for a vaccine against SARS-CoV-2, the synthetic mRNA format has been shown to be the fastest one and proved to be safe and highly efficient, even at the very low dose of a few µg per injection. The mRNA vaccines are not new: vaccines that are based on attenuated mRNA viruses, such as Mumps, Measles, and Rubella, immunize by delivering their mRNAs into the cells of the vaccinated individual, who produces the viral proteins that then prime the immune response. Synthetic mRNA in liposomes can be seen as a modern, more refined, and thereby a safer version of those live attenuated RNA viruses. The anti-COVID-19 mRNA vaccine (coding the SARS-CoV-2 spike protein) is the third synthetic RNA therapeutic being approved. It follows the aptamer Macugen® (which neutralizes VEGF) and the siRNA Onpattro® (which destroys the transthyretin-coding mRNA). Remarkably, the 30 µg of mRNA that are contained in the first approved anti-COVID-19 vaccine are sufficient for generating high levels of neutralizing antibodies against the virus in all injected volunteers (including participants over 65 years old). The efficacy and safety data are stunning. The distribution of these vaccines throughout the world will bring a halt to the coronavirus pandemic.

The chronicle of COVID-19: possible strategies to curb the pandemic

2020 ◽  
Vol 27 ◽  
Author(s):  
Rajesh Kumar ◽  
Seetha Harilal ◽  
Abdullah G. Al-Sehemi ◽  
Githa Elizabeth Mathew ◽  
Simone Carradori ◽  
...  
Keyword(s):  
Life Cycle ◽  
Research And Development ◽  
Vaccine Development ◽  
Therapeutic Strategies ◽  
Antiviral Drugs ◽  
Limited Data ◽  
Social Distancing ◽  
The World ◽  
Novel Virus ◽  
Day By Day

: COVID-19, an epidemic that emerged in Wuhan, has become a pandemic affecting worldwide and is in a rapidly evolving condition. Day by day, the confirmed cases and deaths are increasing many folds. SARS-CoV-2 is a novel virus; therefore, limited data are available to curb the disease. Epidemiological approaches, isolation, quarantine, social distancing, lockdown, and curfew are being employed to halt the spread of the disease. Individual and joint efforts all over the world are producing a wealth of data and information which are expected to produce therapeutic strategies against COVID-19. Current research focuses on the utilization of antiviral drugs, repurposing strategies, vaccine development as well as basic to advanced research about the organism and the infection. The review focuses on the life cycle, targets, and possible therapeutic strategies, which can lead to further research and development of COVID-19 therapy.

scholarly journals Growth Promotion or Osmotic Stress Response: How SNF1-Related Protein Kinase 2 (SnRK2) Kinases Are Activated and Manage Intracellular Signaling in Plants

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1443
Author(s):  
Yoshiaki Kamiyama ◽  
Sotaro Katagiri ◽  
Taishi Umezawa
Keyword(s):  
Protein Kinase ◽  
Plant Growth ◽  
Osmotic Stress ◽  
Protein Function ◽  
Intracellular Signaling ◽  
Growth Promotion ◽  
Research Field ◽  
Dependent Manner ◽  
Related Protein ◽  
Wide Range

Reversible phosphorylation is a major mechanism for regulating protein function and controls a wide range of cellular functions including responses to external stimuli. The plant-specific SNF1-related protein kinase 2s (SnRK2s) function as central regulators of plant growth and development, as well as tolerance to multiple abiotic stresses. Although the activity of SnRK2s is tightly regulated in a phytohormone abscisic acid (ABA)-dependent manner, recent investigations have revealed that SnRK2s can be activated by group B Raf-like protein kinases independently of ABA. Furthermore, evidence is accumulating that SnRK2s modulate plant growth through regulation of target of rapamycin (TOR) signaling. Here, we summarize recent advances in knowledge of how SnRK2s mediate plant growth and osmotic stress signaling and discuss future challenges in this research field.

Latin learning and instruction as a research field

2019 ◽  
Vol 18 (1-2) ◽  
pp. 35-59
Author(s):  
Suzanne Adema
Keyword(s):  
Second Language Acquisition ◽  
Language Acquisition ◽  
Child Development ◽  
Text Comprehension ◽  
Research Field ◽  
Relevant Research ◽  
Translation Research ◽  
Research Fields ◽  
Dictionary Use ◽  
Learning And Instruction

Abstract Empirical research on the learning and instruction of Latin is still scarce. In this article, relevant research is surveyed, along with publications that report experiences of classics teachers or provide teaching suggestions. An overview is presented of where to find publications on the learning and instruction of Latin, as well as a brief introduction to several relevant research methods. The article is organized by reference to various research fields relevant to the learning and instruction of Latin. These fields are classics and Latin linguistics, second language acquisition, vocabulary acquisition and dictionary use, reading and text comprehension, translation research and pedagogy, child development and psychology.

scholarly journals SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Nikolaos C. Kyriakidis ◽  
Andrés López-Cortés ◽  
Eduardo Vásconez González ◽  
Alejandra Barreto Grimaldos ◽  
Esteban Ortiz Prado
Keyword(s):  
Neutralizing Antibodies ◽  
Large Scale ◽  
Vaccine Development ◽  
Rna Virus ◽  
Protein S ◽  
Effective Vaccine ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
Advantages And Disadvantages ◽  
The World

AbstractThe new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.

3D Technology – Additive Manufacturing Applications and Prospects (Vol. 24, No. 9, Full Issue)

2020 ◽  
Vol 24 (09) ◽  
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Environmental Impact ◽  
Real World ◽  
Vaccine Development ◽  
Health Screening ◽  
Wide Range ◽  
The World ◽  
Real World Applications ◽  
Manufacturing Applications

For the month of September 2020, APBN dives into the world of 3D printing and its wide range of real-world applications. Keeping our focus on the topic of the year, the COVID-19 pandemic, we explore the environmental impact of the global outbreak as well as gain insight to the top 5 vaccine platforms used in vaccine development. Discover more about technological advancements and how it is assisting innovation in geriatric health screening.

Computer Supported Product Development Through Integration of CAD, Rapid Prototyping and 3D-Digitizing Helps the Productivity of Former East German Companies

1996 ◽  
Author(s):  
Karl-H. Grote ◽  
Christiane Beyer
Keyword(s):  
Product Development ◽  
Rapid Prototyping ◽  
Development Process ◽  
Complex Problem ◽  
Life Cycles ◽  
Research Field ◽  
Product Development Process ◽  
Process Chain ◽  
The World ◽  
3D Digitizing

Abstract In socialistic countries, customer satisfaction and the market conditions were not of high priority: Some selected parts of the market products were of satisfactory costs and quality to customers. Quality and costs of a product decide on its success in the world-wide market. The wishes and expectations of the customer for a high-quality and low-priced product continue to grow, however, with the desire for faster availability of this product. The customer determines also the delivery time and other competitive factors as the durability of the product. At present the trend goes towards shorter product life cycles, which in turn requires reduced time spent on the product development. With these complex market requirements and growing diversity of the products the engineer faces new challenges in his development tasks. It can be paraphrased as follows: In reduced lifecycles a quality-assured and advantageous product has to be developed despite increasing complexity of the design and demands for reduction of material used, manpower and monetary spending. For the solution of this complex problem the following suggestions are tested and implemented: • Structured design process for the development process, • Simultaneous work where ever possible during the development stages, • Employment of modern resources for the product development, • Use of information technology and • Implementation of rapid prototyping for models and in secondary manufacturing processes. An important research field at the Department of Mechanical Engineering Design at the Otto-von-Guericke-University Magdeburg is research and further development of productive procedures and tools for the realization of a computer integrated product development process. This process includes the effective application of technologies to produce the prototypes for presentation, producibility analysis and production. Of particular interest is the closed process chain (loop) from Solid Modeling via Rapid Prototyping and 3D-Digitizing where the entry point of this process chain depends on the needs of the application or particular interest of the innovating company. Information for faster and more competitive preparation, verification and Re-Engineering of existing and established products, which have to be adjusted to the world-market needs, will be made available. The results of this applied research offer opportunities to display new developed products for the lagging industries in the former East Germany, and furthermore arranging for necessary venture capital to produce the product, to gain information about possible suppliers and manufacturing opportunities in order to minimize the investors’ risks of an enterprise.

SARS-CoV-2: Molecular biology and therapeutic target.

Coronaviruses ◽  
2021 ◽  
Vol 02 ◽  
Author(s):  
Vivek Pandey ◽  
Ankita Pathak ◽  
Mohammad Shahar Yar ◽  
Yuba Raj Pokharel
Keyword(s):  
Viral Genome ◽  
Vaccine Development ◽  
Viral Proteins ◽  
Current Review ◽  
The World ◽  
Spanish Flu ◽  
Repurposed Drugs ◽  
Key Features ◽  
Economic Infrastructure ◽  
Viral Outbreak

: A century after the outbreak of the Spanish flu, the world is suffering with another pandemic on because of the coronavirus. The virus took a toll of more than millions of lives worldwide and still continues to affect the health and socio-economic infrastructure all over the world. The study explores the epidemiology, etiology and transmission of the virus and its phylogenetic relationship with SARS and MERS coronavirus responsible for 2002 and 2012 viral outbreak. Highlights about the key features of the viral genome and essential viral proteins responsible for viral life cycle, evading host immune response, and viral immunopathology with therapeutics from “Recovery” and “Solidarity” trials, are major concern of the current review. The review culminated with a discussion on different classes of front-runners vaccines and their efficacy. An overall understanding of essential viral proteins and their role in pathogenesis, repurposed drugs and vaccine development is the rationale of the present review.

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