The situation of antibiotic use for diarrhea treatment on pediatric inpatient at Pediatrics - Kien Giang General Hospital in 2019-2020

2020 ◽  
pp. 15-24
Author(s):  
Nhon Tran Van ◽  
Mai Do Van ◽  
Hien Ha Minh
Keyword(s):  
General Hospital ◽  
Blood Cells ◽  
Antibiotic Prescription ◽  
White Blood Cells ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Loose Stool ◽  
Cross Sectional ◽  
Watery Stool ◽  
Pediatric Inpatient

Background: To survey for evaluation the use of antibiotic for diarrhea treatment on pediatric inpatient in compliance with MOH, WHO or treatment regimen. Objectives: (1) To describe the situation of antibiotic use for diarrhea treatment and (2) to determine factors that affected on indication of antibiotic for pediatric inpatient under 15 years at Kien Giang General Hospital in 2019. Subjects and methods: A cross-sectional study on 251 medical records of pediatric inpatients who treated by one of any drug from 01/2019 to 12/2019. Results: one antibiotic was prescribed in 71.7% in comparison with 17.1% on two antibiotics. The antibiotic prescription was based on the results of blood test including examinations of white blood cells (WBC), the percentage of neutrophils (Neu%) and/or C-reactive protein (CRP) (59.4%), stool with white blood cells and/or red blood cells (1.6%), high fever without causes (27.9%), watery stool (86.3%), loose stool with blood (100%), loose stool (97.9%). The most used antibiotics are ceftriaxone (53.4%), ciprofloxacin (12.4%). Duration of antibiotic use is 5 days in median. Conclusion: The rate of antibiotic prescription that met MOH and WHO guidelines was 88.3% in comparison with 11.7% of non-conformance. The compliance prescriptions based on antibiogram were 77.8%, non-compliance were 22.5%. The compliance dosage refered to guideline was 86.4%, non-conpliance was 2.4%. The duration of hospitalization and neutrophil are factors that affected the use of antibiotics (p < 0.05). Keywords: diarrhea, pediatric inpatient, antibiotic, Pediatrics-Kien Giang General Hospital

Associations between white blood cells count and obesity in apparently healthy young adults

2020 ◽  
Vol 50 (6) ◽  
pp. 1013-1019
Author(s):  
Fatemeh Ghannadiasl
Keyword(s):  
Young Adults ◽  
Cardiovascular Diseases ◽  
Blood Cells ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
The Body ◽  
Sectional Study ◽  
Cross Sectional ◽  
Content Type ◽  
Apparently Healthy

Purpose The elevated white blood cells (WBCs) count has been reported to be a predictor of cardiovascular diseases, diabetes, hypertension and metabolic syndrome. This study aims to determine the associations between WBCs count and obesity in apparently healthy young adults. Design/methodology/approach In this cross-sectional study, the authors evaluated the body mass index (BMI) in 392 apparently healthy young adults of both sexes. The WBCs count was measured using standard counter techniques. The inclusion criteria were the agreement to participate in the study, between 18 and 25 years of age, lack of self-reported diseases such as cardiovascular diseases, hypertension, kidney and infectious diseases. Findings According to the BMI classification, underweight and overweight or obesity were observed in 14.58 and 11.48 per cent of young adults, respectively. The mean WBC was 6.5 ± 1.5 (×10³ cells/µL). Higher values of WBCs were found in women than in men (p = 0.02). The young adults with higher BMI had a higher WBCs count. There was a positive correlation between WBCs count and weight and BMI (r = 0.19 and r = 0.22, p < 0.001, respectively). Research limitations/implications This research was a cross-sectional study. Future studies are suggested using longitudinal studies to examine more relationships between obesity and WBCs count in apparently healthy young adults. Practical implications The results of this study provide evidence for weight management in this age group to reduce diseases associated with increased WBCs count. Originality/value The WBCs count was related to increasing levels of BMI per cent 2 C even in the normal range.

scholarly journals STAT3 methylation in white blood cells as a novel sensitive biomarker for the toxic effect of low-dose benzene exposure

2016 ◽  
Vol 5 (3) ◽  
pp. 800-807 ◽  
Author(s):  
Di Liu ◽  
Yujiao Chen ◽  
Pengling Sun ◽  
Wenlin Bai ◽  
Ai Gao
Keyword(s):  
Dna Methylation ◽  
Toxic Effect ◽  
Health Effects ◽  
Blood Cells ◽  
Low Dose ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Benzene Exposure

A cross-sectional study was conducted in a sample of 571 workers to explore the toxic effect and early sensitive biomarker of the health effects of low-dose benzene exposure (LDBE), as well as the correlation between DNA methylation and the toxic effect of LDBE.

RESEARCH ON CLINICAL MANIFESTATIONS AND AEROBIC BACTERIA OF QUINSY IN HUE CENTRAL HOSPITAL AND HUE UNIVERSITY HOSPITAL

2012 ◽  
pp. 85-91
Author(s):  
Kim Tri Truong ◽  
Tu The Nguyen ◽  
Lam Phuoc Vo
Keyword(s):  
Antibiotic Prescription ◽  
White Blood Cells ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Aerobic Bacteria ◽  
Sectional Study ◽  
Central Hospital ◽  
Cross Sectional ◽  
Bacteria Culture

Objectives: To identify the paraclinical and clinical mannifestations, aerobic bacteria and antibiogramme of quinsy. Materials and methods: Cross-sectional study was conducted upon 37 patients with quinsy at Hue Central hospital and Hue University Hospital. Results: Clinical and paraclinical symtoms: odynophagy 100%, dysphagy 91.9%. Having treatment with antibiotics before hospitalization 67.6%. White blood cells >15.109/l (54.1%). Positive bacteria culture is 48.6% in which streptococcus α hemolytic 57.9%, staphylococcus aureus 10.5%, streptococcus pneumoniae 10.5%. Antibiogramme: Sensitization: Gentamycin 100%, vancomycin 100%, cefuroxim 100%, ciprofloxacin 80%.Resistance: Erythromycin 60%, ampicillin 41.7%, cefalexin 40%, tetracyclin 40%, ceftriaxon 30.8%.Consclusions: The priority of antibiotic prescription for quinsy should be based on the frequency of bacteria found in bacteria culture and depending on antibiogramme to choose appropriate antibiotics.

ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE REGARDING ANTIBIOTICS MISUSE AMONG THE PUBLIC IN SAUDI ARABIA

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Khaled Hassan
Keyword(s):  
Bacterial Resistance ◽  
Antibiotic Prescription ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Antibiotics Resistance ◽  
Upper Respiratory Tract ◽  
Cross Sectional ◽  
The Public ◽  
Improper Use ◽  
Self Administered Questionnaire

Background: improper use of antibiotics lead to one of the serious problems of bacterial resistance. Aim: to assess the frequency of antibiotic use and to obtain information about antibiotic prescription, in two centers in Northern Lima, Peru. Methods: it is cross sectional study using a self-administered questionnaire. Results: 1961surveys were considered, Two thirds received antibiotics in the last year, to obtain these drugs, were prescribed by a physician, most of physicians agreed in the importance of inadequate use of antibiotics and 85.1%prescribed antibiotics more than once every day. Internet is a useful resource of information as suggested by physicians to develop educative programs about use of antibiotics. Conclusions: No enough knowledge about adequate use of antibiotics in the community, three quarters would go to hospital if they presented upper respiratory tract symptoms and half received an antibiotic prescription by the physician, if physicians prescribed antibiotics more than once every day, it leads to resistance. Keywords: Knowledge, attitudes, practices, antibiotics, resistance

Procalcitonin and White Blood Cells as an Infection Marker in Children with Diabetic Ketoacidosis

2021 ◽  
Vol 70 (12) ◽  
pp. 260-264
Author(s):  
Nur Rochmah ◽  
Muhammad Faizi ◽  
Yudhi Kurniawan ◽  
Latifatu Choirunisa ◽  
Anang Endaryanto ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Blood Cells ◽  
Characteristic Curve ◽  
White Blood Cells ◽  
Insulin Dependent Diabetes Mellitus ◽  
Cross Sectional Study ◽  
Dependent Diabetes Mellitus ◽  
Cross Sectional ◽  
Insulin Dependent ◽  
Infection Marker

Introduction: Diabetic ketoacidosis (DKA), an acute complication of type 1 (insulin dependent) diabetes mellitus (T1DM), can be precipitated by infection. Procalcitonin (PCT) is an accurate marker of bacteremia, sepsis, and inflammation, however white blood cells (WBC) are still often used by clinicians. We aimed to analyze PCT levels and WBC counts in children with DKA.Methods: A cross-sectional study was conducted in Dr. Soetomo General Hospital, Surabaya, Indonesia, between 2015 and 2019. T1DM and DKA diagnosis was based on the International Society for Pediatric and Adolescent Diabetes. PCT levels and WBC counts were measured in samples from patients with and without DKA, and were compared using the Mann-Whitney test.Results: A total of 41 samples were included, with 15 samples (36.6%) from children with DKA, and 26 (63.4%) from children without DKA. PCT levels and WBC counts were significantly higher in those with DKA (p<0.001). The receiver operating characteristic curve analysis of WBC was lower than PCT (0.849 vs. 0.982). PCT had a higher sensitivity and spesificity as an infection marker than WBC (93.3 vs. 86.7; 92.3 vs. 88.5, respectively).Conclusion: PCT is a better infection marker in children with DKA than WBC  

RESEARCH ON CLINICAL MANIFESTATIONS AND AEROBIC BACTERIA OF ACUTE TONSILITIS IN HUE CENTRAL HOSPITAL AND HUE UNIVERSITY HOSPITAL

2012 ◽  
pp. 30-37
Author(s):  
Kim Tri Truong ◽  
Tu The Nguyen ◽  
Lam Phuoc Vo
Keyword(s):  
Antibiotic Prescription ◽  
White Blood Cells ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Aerobic Bacteria ◽  
Central Hospital ◽  
Cross Sectional ◽  
Group A ◽  
Bacteria Culture

Objective: To study the paraclinical and clinical mannifestations, aerobic bacteria and antibiogramme of acute tonsilitis. Materials and method: A cross-sectional study was conducted upon 34 patients with acute tonsilitis at Hue Central hospital and of Hue University Hospital. Results: Clinical and paraclinical characteristics: odynophagy 94.1%, tonsillar hyperaemia 88.2%. Having treatment with antibiotics before hospitalization 50%. White blood cells >10-15.109/l (58.8%). Positive bacteria culture is 67.6% in which streptococcus β hemolytic group (A) 25%, streptococcus α hemolytic 25%, hemophilus influenzae 25%. Antibiogramme: Sensitization: gentamycin 100%, cefuroxim 100%, ceftriaxone 93.8%, cefalexin 90.9%, vancomycin 86.7%; Resistance: Tetracyclin 85.7%, erythromycin 69.2%, ofloxacin 42.9%, ampicillin 33.3%, ciprofloxacin 33.3%. Consclusions: The priority of antibiotic prescription for acute tonsilitis should be based on the frequency of bacteria found in bacteria culture and depending on antibiogramme to choose appropriate antibiotics.

scholarly journals Assessment of Antibiotic Utilization Pattern in Treatment of Acute Diarrhoea Diseases in Bishoftu General Hospital, Oromia Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Selamawit Tulu ◽  
Tarekegne Tadesse ◽  
Addisu Alemayehu Gube
Keyword(s):  
General Hospital ◽  
Acute Diarrhoea ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Children Under Five ◽  
Under Five ◽  
Adults And Children ◽  
Diarrhoeal Diseases ◽  
Bacterial Type

Background. Majority of acute diarrhoeal diseases are self-limiting and do not require routine treatment. Treatment with empirical antimicrobials is recommended only for dysenteric and invasive bacterial diarrhoea. Irrational use of antibiotics in treatment of acute diarrhoea is common in clinical practice worldwide. This study was carried out to assess the pattern of antibiotic use for acute diarrhoeal diseases in Bishoftu General Hospital, East Shewa Ethiopia. Methods and Materials. Institution based cross-sectional study was conducted from April 1 to April 30, 2016. Data were collected retrospectively from patients treated for diarrhoeal diseases from January 2015 to December 2015 using structured questionnaires and entered into SPSS (IBM 20) and descriptive statistics was carried out. Results. Among the 303 patients, 51.2% were males and 48.8% were females. Of them, 62% were children under five years. Two hundred sixty three (86.8%) patients received eight different types of antibiotics and cotrimoxazole (178 patients, 58.7%) was the most prescribed antibiotics, followed by ciprofloxacin (33, 10.9%) and amoxicillin (14, 4.6%). Based on the presence of blood in stools, 14.5% of cases were of invasive bacterial type. According to the recommendations of WHO, the rate of overuse of antibiotics was 72.3%. Conclusion. This study revealed that there was high overuse of antibiotics for both adults and children under five with acute diarrhoea in Bishoftu General Hospital. And Cotrimoxazole was the most prescribed antibiotic.

scholarly journals Establishment of Hematological Reference intervals for healthy Children in Elobied City, Sudan

2021 ◽  
Vol 2 (4) ◽  
pp. 24-31
Author(s):  
Tarig Osman Khalafallah Ahmed ◽  
Malaz Elfatih Abd-elkareem Ahmed ◽  
Ream Elzain Abdelgadir ◽  
Hiba Awadelkareem Osman Fadl ◽  
Assad MA. Babker
Keyword(s):  
Blood Cells ◽  
Hematological Parameters ◽  
Venous Blood ◽  
White Blood Cells ◽  
Reference Interval ◽  
Cross Sectional Study ◽  
Reference Intervals ◽  
Healthy Population ◽  
Healthy Children ◽  
Cross Sectional

Hemogram Reference intervals are established since a healthy population is critical to accurately interpret laboratory tests, which include Hemoglobin estimation, Red blood cells count and indices, White blood cells count and differential in addition to Platelets count. This study aims to establish the reference interval of the complete hemogram amongst healthy Sudanese children in Elobied city, Sudan. A descriptive cross-sectional study  included 354 healthy children, aged between 3 to 17 years, who were categorized into three groups according to age. A questionnaire was fulfilled, EDTA anti-coagulated venous blood sample was collected from each child then the complete hemogram was performed automated hematological analyzer (Sysmex Xp 300), Finally, Data was analyzed by a software program (SPSS version 21). The hematological reference intervals for healthy children [Hb g/dl, HCT%, RBCs count x106μL, MCV/fL ,MCH /pg., MCHC g/dl ,WBCs count x10³/μL, Neutrophil count%, Eosinophil count %, Basophile count %, lymphocyte count ,Monocytes count%, RDW CV and PLTs count×10³/μL] are [(12.4±1.2),(37±4),(5.0 ±0.4), (82±5.0), (26±3.0), (32±3.0) ,(7.0±2.0) (47±10), (1±0.1) ,(0±0),(45± 10),(7 ± 4), (13±1.8) &(227±91)] respectively. The hematological RI for healthy children in Elobied was established in this study to be representative of this population, there was a significant gender-based difference in all the evaluated hematological parameters, they were found to be higher in males than in females except for basophil (%). Finally, the results of this study would shed a light on the importance of establishing RI for the children population in Elobied.

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