scholarly journals Ранний - средний голоцен северного Сахалина

2021 ◽  
pp. 50-65
Author(s):  
Yu. A. Mikishin ◽  
◽  
I. G. Gvozdeva ◽  
Keyword(s):  
Late Phase ◽  
Climatic Conditions ◽  
Humid Climate ◽  
Maximum Expansion ◽  
Atlantic Period ◽  
Radiocarbon Data ◽  
Coniferous Tree Species ◽  
Glacial Time ◽  
Birch Forests

New palynological and radiocarbon data obtained from sections of two ancient peatbogs permitted to specify the landscape and climatic changes in the nature of the first half of the Holocene on the southern outskirts of North Sakhalin. The Early Holocene was generally colder and drier in comparison with modern climatic conditions. The vegetation cover was dominated by larch/birch forests with the shrub birch undergrowth. In the middle of the Boreal Period (9000-8400 yrs. BP / 10,100-9300 Cal. yrs. BP), the climate became significantly warmer and slightly wetter, yet remaining drier than the modern one. Birch forests with the presence of broad-leaved and dark coniferous tree species were widespread. In the initial phase of the Atlantic Period (probably 7800-7500 yrs. BP / 8800-8300 Cal. yrs. BP), in the climatic conditions warmer and much more humid than modern ones, the first expansion of spruce/fir forests occurred. The second half of the early and first half of the middle phase of the Atlantic Period (7500-6500 yrs. BP / 8300-7400 Cal. yrs. BP) were distinguished by decreased humidity and further warming of the climate, which resulted in dominating birch forests, subordinate spruce/fir taiga, and a lot of deciduous forests. There were two cold episodes at the beginning and in the middle of this stage. The first of them, about 7300 yrs. BP / 8100 Cal. yrs. BP, was dry and provided the return of birch/larch forests. The second, about 7100 yrs. BP / 7900 Cal. yrs. BP, had a more humid climate, which caused an increase in the role of dark coniferous taiga and a weakening of birch forests. In the second half of the middle and, possibly, the beginning of the late phase of the period (probably 6500-5400 yrs. BP / 7400-6200 Cal. yrs. BP), spruce/fir forests with participation of broad-leaved tree spread. They developed in a warmer and more humid climate, similar to the current climate in the south of the Sakhalin Island and close to the optimal climatic conditions of the post-glacial time. The middle of the Late Atlantic Period, about 5300 yrs. BP / 6100 Cal. yrs. BP, was marked by the second, maximum expansion of spruce/ fir forests, due to the onset of the cool and, possibly, the wettest episode in the Middle Holocene.

scholarly journals Characteristics of Phomopsis juglandina (Sacc.) Hohn. Associated with Dieback of Walnut in the Climatic Conditions of Southern Romania

Agronomy ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 46
Author(s):  
Cristina Mihaescu ◽  
Daniel Dunea ◽  
Adrian Gheorghe Bășa ◽  
Loredana Neagu Frasin
Keyword(s):  
Growth Temperature ◽  
Potential Evapotranspiration ◽  
Optimal Growth ◽  
Climatic Conditions ◽  
Cultural Characteristics ◽  
Optimal Growth Temperature ◽  
Conidial State ◽  
Optimal Ph

Phomopsis juglandina (Sacc.) Höhn., which is the conidial state of Diaporthe juglandina (Fuckel) Nitschke, and the main pathogen causing the dieback of branches and twigs of walnut was recently detected in many orchards from Romania. The symptomatological, morphological, ultrastructural, and cultural characteristics, as well as the pathogenicity of an isolate of this lignicolous fungus, were described and illustrated. The optimum periods for infection, under the conditions prevailing in Southern Romania, mainly occur in the spring (April) and autumn months (late September-beginning of October). Strong inverse correlations (p < 0.001) were found between potential evapotranspiration and lesion lengths on walnut branches in 2019. The pathogen forms two types of phialospores: alpha and beta; the role of beta phialospores is not well known in pathogenesis. In Vitro, the optimal growth temperature of mycelial hyphae was in the range of 22–26 °C, and the optimal pH is 4.4–7. This pathogen should be monitored continuously due to its potential for damaging infestations of intensive plantations.

scholarly journals Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior

2021 ◽  
Author(s):  
Young-Min Han ◽  
Min Sun Kim ◽  
Juyeong Jo ◽  
Daiha Shin ◽  
Seung-Hae Kwon ◽  
...  
Keyword(s):  
Inhibitory Action ◽  
Time Course ◽  
Molecular Mechanisms ◽  
Late Phase ◽  
Fine Tuning ◽  
Dependent Manner ◽  
Middle Phase ◽  
Temporal Shift

AbstractThe fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via anti-inflammatory actions exerted by the glucocorticoid receptor (GR). However, technical limitations have restricted our understanding of how GR is involved in the dynamics of NFκB in vivo. In this study, we used an improved lentiviral-based reporter to elucidate the time course of NFκB and GR activities during behavioral changes from sickness to depression induced by a systemic lipopolysaccharide challenge. The trajectory of NFκB activity established a behavioral basis for the NFκB signal transition involved in three phases, sickness-early-phase, normal-middle-phase, and depressive-like-late-phase. The temporal shift in brain GR activity was differentially involved in the transition of NFκB signals during the normal and depressive-like phases. The middle-phase GR effectively inhibited NFκB in a glucocorticoid-dependent manner, but the late-phase GR had no inhibitory action. Furthermore, we revealed the cryptic role of basal GR activity in the early NFκB signal transition, as evidenced by the fact that blocking GR activity with RU486 led to early depressive-like episodes through the emergence of the brain NFκB activity. These results highlight the inhibitory action of GR on NFκB by the basal and activated hypothalamic-pituitary-adrenal (HPA)-axis during body-to-brain inflammatory spread, providing clues about molecular mechanisms underlying systemic inflammation caused by such as COVID-19 infection, leading to depression.

scholarly journals Role of glaciers in watershed hydrology: a preliminary study of a "Himalayan catchment"

2010 ◽  
Vol 4 (1) ◽  
pp. 115-128 ◽  
Author(s):  
R. J. Thayyen ◽  
J. T. Gergan
Keyword(s):  
Mass Balance ◽  
River Flow ◽  
Initial Increase ◽  
Glacier Mass Balance ◽  
Mountain Range ◽  
Humid Climate ◽  
Flow Response ◽  
Sustainable Water Resources Management ◽  
South West Monsoon

Abstract. A large number of Himalayan glacier catchments are under the influence of humid climate with snowfall in winter (November–April) and south-west monsoon in summer (June–September) dominating the regional hydrology. Such catchments are defined as "Himalayan catchment", where the glacier meltwater contributes to the river flow during the period of annual high flows produced by the monsoon. The winter snow dominated Alpine catchments of the Kashmir and Karakoram region and cold-arid regions of the Ladakh mountain range are the other major glacio-hydrological regimes identified in the region. Factors influencing the river flow variations in a "Himalayan catchment" were studied in a micro-scale glacier catchment in the Garhwal Himalaya, covering an area of 77.8 km2. Three hydrometric stations were established at different altitudes along the Din Gad stream and discharge was monitored during the summer ablation period from 1998 to 2004, with an exception in 2002. These data have been analysed along with winter/summer precipitation, temperature and mass balance data of the Dokriani glacier to study the role of glacier and precipitation in determining runoff variations along the stream continuum from the glacier snout to 2360 m a.s.l. The study shows that the inter-annual runoff variation in a "Himalayan catchment" is linked with precipitation rather than mass balance changes of the glacier. This study also indicates that the warming induced an initial increase of glacier runoff and subsequent decline as suggested by the IPCC (2007) is restricted to the glacier degradation-derived component in a precipitation dominant Himalayan catchment and cannot be translated as river flow response. The preliminary assessment suggests that the "Himalayan catchment" could experience higher river flows and positive glacier mass balance regime together in association with strong monsoon. The important role of glaciers in this precipitation dominant system is to augment stream runoff during the years of low summer discharge. This paper intends to highlight the importance of creating credible knowledge on the Himalayan cryospheric processes to develop a more representative global view on river flow response to cryospheric changes and locally sustainable water resources management strategies.

HAS PSYCHOLOGIC MALNUTRITION TAKEN THE PLACE OF RICKETS AND SCURVY IN CONTEMPORARY PEDIATRIC PRACTICE?

PEDIATRICS ◽  
1963 ◽  
Vol 31 (6) ◽  
pp. 909-918
Author(s):  
Nathan B. Talbot
Keyword(s):  
Sixteenth Century ◽  
Lemon Juice ◽  
Climatic Conditions ◽  
Northern Europe ◽  
Scientific Medicine ◽  
Pediatric Practice ◽  
Therapeutic Value ◽  
High Prevalence ◽  
The Baltic

WHILE MEDICAL HISTORIANS cannot provide us with accurate statistics concerning the incidence of rickets and scurvy in centuries past, they leave little room for doubt about the high prevalence of these disorders prior to the advent of modern scientific medicine. Thus, Castiglione has written that in the sixteenth century scurvy raged throughout northern Europe, in Scandinavia, on the shores of the Baltic, and in the interior of Germany. It is interesting to note, however, that Jacques Cartier, whose sailors had been ravaged by scurvy, learned in 1536 from the Indians that the malady could be cured by juices of the almeda tree. This was 200 years before James Lind demonstrated the curative effects of lemon juice in his treatise on scurvy published in 1753 and almost 400 years before ascorbic acid, which was isolated by Szent-Gyorgi in 1928, was recognized to be vitamin C by Waugh and King in 1932. Rickets, likewise, was occurring in a large portion of children prior to the discovery of the existence of vitamin D by Hess, Steinbock, and Windaus in 1918, of its therapeutic value by Mellanby in 1919, of the equivalent role of sunlight by Hess in 1921, and of the chemical composition of the vitamins by Windaus in 1922. But 200 years earlier Friedrick Hoffman had the answer to the control of this disease almost in hand. He attached much importance to climatic conditions as a factor in rickets, noting that if anything is specially powerful in producing this affliction, it is a surrounding atmosphere of cold foggy air. He cited as striking evidence of this the famous emporium of England, London, which he found to be specially apt to produce and foster this disease.

Robustness of HPHC Reduction in THS 2.2 Aerosol Relative to 3R4F Reference Cigarette Smoke under Extreme Climatic Conditions

2021 ◽  
Vol 30 (3) ◽  
pp. 109-126
Author(s):  
Laurent Poget ◽  
Catherine Goujon ◽  
Samuel Kleinhans ◽  
Serge Maeder ◽  
Jean-Pierre Schaller
Keyword(s):  
Cigarette Smoke ◽  
Heating System ◽  
Tobacco Product ◽  
Climatic Conditions ◽  
Mainstream Smoke ◽  
Humid Climate ◽  
Experimental Conditions ◽  
Puff Volume ◽  
Temperature And Humidity ◽  
Health Canada

Summary In order to assess robustness for the reduction of harmful and potentially harmful constituent (HPHC) levels generated by the Tobacco Heating System 2.2 (THS 2.2), a heated tobacco product, we compared the aerosol of this product with mainstream smoke from the 3R4F reference cigarette under different conditions of temperature and humidity. The desired climatic conditions were achieved by using an air-conditioning system coupled with the smoking-machine housing. Two extreme climatic conditions were selected, representing a “Hot and Dry” climate (30 °C and 35% relative humidity RH) and a “Hot and Very Humid” climate (30 °C and 75% RH). In addition, aerosol and smoke were generated using the standard conditions recognized for smoking-machine analyses of tobacco products (22 °C and 60% RH), which were close to the climatic conditions defined for “Subtropical and Mediterranean” environments (25 °C and 60% RH). The experimental conditions were chosen to simulate the use of THS 2.2 and cigarettes under extreme conditions of temperature and humidity. HeatSticks and cigarettes taken from freshly opened packs were subjected to short-term conditioning from two to a few more days under the same experimental conditions. We analyzed 54 HPHCs in THS 2.2 aerosol and 3R4F cigarette smoke, generated in accordance with the Health Canada Intense (HCI) standard, using modified temperature and humidity conditions for sample conditioning and machine-smoking experiments. We used a volume-adjusted approach for comparing HPHC reductions across the different climatic conditions investigated. Although a single puffing regimen was used, the total puff volume recorded for the 3R4F cigarette smoke varied due to the influence of temperature and humidity on combustion rate, which justified the use of a volume-adjusted approach. Volume-adjusted yields were derived from HPHC yields expressed in mass-per-tobacco stick normalized per total puff volume. The results indicated that, regardless of the considered climatic conditions, the HPHC levels investigated in THS 2.2 aerosol were reduced by at least 90%, on average, when compared with the concentrations in 3R4F cigarette mainstream smoke. This confirmed the robustness in performance for THS 2.2 to deliver reduced levels of HPHCs under the extreme climatic conditions investigated in this study. In order to further characterize the robustness of these reductions, the lowest reduction performance achieved for individual HPHCs across all climatic conditions was used to define the threshold for a robust reduction. The majority of the 54 HPHCs investigated in THS 2.2 aerosol showed more than 90% reduction. Calculations derived from nicotine-adjusted yields also confirmed robust reductions for all investigated HPHCs. The small differences in absolute reduction between the volume- and nicotine-adjusted approaches were predominantly attributed to a combination of the differences in both nominal nicotine deliveries and total puff volumes between THS 2.2 and 3R4F cigarettes; however, this did not influence the determination of robustness. Our findings confirm the value of this approach for assessing the robustness of a product’s performance under different climatic conditions.

On Approaches to Taking into Account the Risks of Changing Climatic Conditions when Planning and Implementing Oil and Gas Projects

2021 ◽  
Vol 18 (1) ◽  
pp. 52-65
Author(s):  
P. N. Mikheev
Keyword(s):  
Climate Change ◽  
Oil And Gas ◽  
Oil And Gas Industry ◽  
Climatic Conditions ◽  
Qualitative Assessment ◽  
Physical Factors ◽  
Gas Industry ◽  
Climate Risks ◽  
The Impact

The article discusses issues related to the impact of climate change on the objects of the oil and gas industry. The main trends in climate change on a global and regional (on the territory of Russian Federation) scale are outlined. Possible approaches to the identification and assessment of climate risks are discussed. The role of climatic risks as physical factors at various stages of development and implementation of oil and gas projects is shown. Based on the example of oil and gas facilities in the Tomsk region, a qualitative assessment of the level of potential risk from a weather and climatic perspective is given. Approaches to creating a risk management and adaptation system to climate change are presented.

scholarly journals ROLE OF EFFECTIVE PROJECT MANAGEMENT IN REDUCING DRUG DEVELOPMENT COST

2017 ◽  
Vol 10 (3) ◽  
pp. 53
Author(s):  
Faisal B A Zaidi ◽  
Salma Ahmed ◽  
Munish Makkad
Keyword(s):  
Project Management ◽  
Drug Development ◽  
Site Selection ◽  
Late Phase ◽  
Critical Role ◽  
Project Manager ◽  
Development Cost ◽  
The Cost ◽  
Patient Enrollment

ABSTRACTPharmaceuticals are passing through the difficult phase due to increasing numbers of patents expiry along with increasing cost of drug development.Protocol design, regulatory cycle time, site selection, patient enrollment and monitoring are some of the cost contributing elements for late phaseclinical trials. This paper applies the principles of project management and suggests means to reduce the cost of late phase drug development. It alsothrows light on the critical role that a project manager can play in overall drug development process.Keywords: Cost of drug development, Effective project management, Reduction in cost of drug development.

scholarly journals Klimazeugen des periglazialen Dauerfrostbodens in Mittel- und Westeuropa: Ein Beitrag zur Rekonstruktion des Klimas der Glaziale des quartären Eiszeitalters

1960 ◽  
Vol 11 (1) ◽  
pp. 121-141 ◽  
Author(s):  
Karlheinz Kaiser
Keyword(s):  
Western Europe ◽  
Younger Dryas ◽  
Climatic Conditions ◽  
Border Zone ◽  
Patterned Ground ◽  
A Value ◽  
Outer Appearance ◽  
Glacial Periods ◽  
Glacial Time ◽  
Temperature Depression

Abstract. Certain periglacial phenomena (ice-wedges, cryoturbations, patterned ground, pingos) are critically investigated with respect to their outer appearance as well as to the causes of their formation, but especially how far they might be used as indicators of an old permafrost. The results for Central and Western Europe have been mapped according to our actual status of knowledge. The attempts hitherto made to reconstruct the climate of the Quaternary glacial periods, have been thoroughly checked. A new calculation of the maximum diminution of Pleistocene temperature gives a value of 15—16° C (bottom temperature) in Central and Western Europe. For the Younger Dryas we still have to expect a temperature depression of 11—12° C. Both values have been found by comparing mean annual temperatures in the border-zone of permafrost at the high-glacial time and during the Younger Dryas with the actual temperatures. This is true on the premise that the active permafrost area can be limited by the — 2° C annual isotherme, both under actual as well as under glacial climatic conditions.

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