scholarly journals Effect of 8 weeks high-intensity interval training (HIIT) with and without caloric restriction on gene expression of myocardial Bax and Bcl2 in mice

2021 ◽  
Vol 43 (1) ◽  
pp. 124-133
Author(s):  
Mohammadreza Zarali ◽  
Zaher Etemad ◽  
Kamal Azizbeigi ◽  
Pouran Karimi
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Caloric Restriction ◽  
High Intensity ◽  
Interval Training ◽  
Training Group ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Interval Exercise ◽  
High Intensity Interval

Background: Apoptosis is the physiological cell death that in natural conditions leads to the elimination of old, damaged, waste, and harmful cells. The aim of this study was the effect of eight weeks of high-intensity interval training (HIIT) with and without caloric restriction on gene expression of myocardial Bax and Bcl2 in mice. Methods: Present study was an experimental multi-group design with a control group conducted on 30 two-month old male mice. Subjects were divided into five homogenous groups including base control, control, caloric restriction, interval exercise training, and caloric restriction + interval exercise training. Training groups participated in interval exercise training five sessions per week for 8 weeks. The level of gene expression of myocardial Bax and Bcl2 was evaluated by real-time PCR. Data were analyzed using the one-way ANOVA at the level of (P<0.05). Results: The results showed that the training group had a significant increase in gene expression of myocardial Bcl2 in comparison with caloric restriction + exercise training (P<0.05) and a significant decrease in gene expression of myocardial Bax compared to the caloric restriction group (P<0.05). Also, exercise training and exercise training + caloric restriction significantly increased the gene expression of myocardial Bcl2 and significantly decreased Bax/Bcl2 ratio compared to caloric restriction, base control, and control (P< 0.05). Conclusion: It seems that high-intensity interval training without caloric restriction would provide a suitable environment for increasing the integrity of the mitochondrial membrane of myocardial cells and possibly apoptosis.

scholarly journals Effect of 8 Weeks of High Intensity Interval Training (HIIT) With and Without Calorie Restriction on Gene Expression of Caspase-3 and Caspase-9 Proteins in Male Rats

2020 ◽  
Vol 23 (3) ◽  
pp. 300-313
Author(s):  
Mohammadreza Zarali ◽  
◽  
Zaher Etemad ◽  
Kamal Azizbeigi ◽  
Pouran Karimi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Caloric Restriction ◽  
High Intensity ◽  
Caspase 3 ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Interval Exercise ◽  
High Intensity Interval ◽  
And Control

Background and Aim Apoptosis or programmed death is active biological process and reversible that the balance between growth and cell death in various tissues, particularly myocardial tissue is essential role. The aim of this study was the effect of 8 weeks High Intensity Interval Training (HIIT) with and without food restriction on gene expression of Caspase 3 and 9 in rats. Methods & Materials: This study was experimental multi group design with control group which conducted on 30 rats with two months old male. Subjects were divided in to five homogenous groups including base control, control, caloric restriction, interval exercise training and caloric restriction+interval exercise training. Training groups five sessions in weeks were participated in interval exercise training for 8 weeks. The level of gene expression of the proteins Caspase 3 and 9 was evaluated by Real Time-PCR. Dates were analyzed using the 1-way ANOVA at the level of (P<0.05). Ethical Considerations: The protocol of this study was approved by the Medical Committee of Sanandaj University of Medical Sciences (Code: IR.MYK.REC.1397.5022). Results: The results showed that the training group had a significant decrease in gene expression of Caspase 3 in comparison with caloric restriction+exercise training (P<0.05). Also, exercise training and exercise training+caloric restriction significantly decrease in the gene expression of Caspase 9 compared to caloric restriction, base control and control (P<0.05) and significantly decrease in the gene expression of Caspase 3 compared to base control and control (P<0.05). Conclusion: According to the results, it seems that high intensity interval training with and without calorie restriction provides the necessary adaptations to inhibit or stop apoptosis induced by aerobic exercise. 

scholarly journals The Cognitive Effectiveness of High-Intensity Interval Training (HIIT) for Individuals of Methamphetamine Dependent: A Study Protocol for a Randomized Controlled Trial

2021 ◽  
Author(s):  
Menglu Shen ◽  
Suyong Yang ◽  
Songting Lu ◽  
Dong Zhu
Keyword(s):  
High Intensity ◽  
Mixed Model ◽  
Interval Training ◽  
Training Group ◽  
Moderate Intensity ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Short Period ◽  
High Intensity Interval

Abstract IntroductionCognitive deficit is a common syndrome of methamphetamine (MA) dependence, it relates to decision-making, control ability, and social functioning. High-Intensity Interval Training (HIIT) is a training technique that requests people to work out at full intensity during a short period. A number of studies have already shown the potential effects of HIIT on cognitive roles. A number of studies have already shown the potential effects of HIIT on cognitive function. The purpose of this trial is to evaluate the cognitive effects of HIIT on the individuals of MA dependent. Methods and analysis240 individuals of MA dependent are randomly assigned to High-intensity Interval Training group (HIIT), Moderate-intensity Continuous Training group (MICT) and Control group (CON) respectively. HIIT consists of a 24-minute exercise of high-intensity interval training on a treadmill. MICT consists of a 1-hour body-mind exercise. CON remains their traditional intervention. The experimental period will be 12 months, with 3 interventions weekly for the first 6 months and follow-up for the next 6 months. All subjects will be given both physical and cognitive tests at baseline, after intervention and follow-up. The cognitive performances will be compared by a mixed-model analysis for repeated-measures.DiscussionHIIT training may reduce illicit drug cravings among individuals of MA dependent, it indicates that HIIT has better effect on cognitive functions such as memory and executive function for individuals of MA dependent.Trial RegistrationChiCTR, ChiCTR2000032492, Registered on Aril 30, 2020, Prospective registration, http://www.chictr.org.cn/edit.aspx?pid=52127&htm=4.

The Effect of High-Intensity Interval Training on GLP-1, Appetite, and Weight in Obese Rats

2021 ◽  
Vol 20 (3) ◽  
pp. 290-299
Author(s):  
Mohammad Hosein Sepehri ◽  
Javad Nemati ◽  
Maryam Koushkie Jahromi ◽  
Mohammad Hadi Eskandari ◽  
Farhad Daryanoosh ◽  
...  
Keyword(s):  
High Intensity ◽  
Repeated Measures ◽  
Interval Training ◽  
Training Group ◽  
Control Group ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
High Caloric Diet ◽  
And Control ◽  
High Calorie

Background and Objectives: Appetite is an essential factor in obesity. The present study aimed to evaluate the effect of High-Intensity Interval Training (HIIT) on GLP-1, appetite, and weight of obese mice while maintaining a high caloric diet. Subjects and Methods A total of 24 C57BL/6 mice with a Mean±SD weight of 20.7±1 g were selected. After implementing a high caloric dieting and making them fat (Mean±SD weight: 30.95±3.23 g), they were divided into two groups of training and control. A high caloric diet was maintained for both groups (training and control) until the end of the experiment, while the training group performed HIIT for 8 weeks. Every session of HIIT included 30 minutes of exercise with a progressive intensity of 50% to 60% in low-intensity intervals and 80% to 90% in high-intensity intervals. The independent t test and analysis of variance with repeated measures were used for data analysis. Results Findings of the study indicated that GLP-1 increased significantly in the HIIT training group compared to the control group (P<0.05). In the HIIT group, body weight was significantly higher (P<0.001), and food intake was significantly lower (P<0.001) than those in the control group. Conclusion When consuming high-calorie food, HIIT training can probably cause weight loss through reducing appetite mediated by increasing GLP-1

scholarly journals Effects of Exercise Training on Anabolic and Catabolic Hormones with Advanced Age: A Systematic Review

2021 ◽  
Author(s):  
Hassane Zouhal ◽  
Ayyappan Jayavel ◽  
Kamalanathan Parasuraman ◽  
Lawrence D. Hayes ◽  
Claire Tourny ◽  
...  
Keyword(s):  
Systematic Review ◽  
Exercise Training ◽  
High Intensity ◽  
Aerobic Training ◽  
Training Programs ◽  
Interval Training ◽  
Sex Hormone Binding Globulin ◽  
High Intensity Interval Training ◽  
Interval Exercise ◽  
High Intensity Interval

Abstract Background Ageing is accompanied by decreases in physical capacity and physiological regulatory mechanisms including altered hormonal regulation compared with age-matched sedentary people. The potential benefits of exercise in restoring such altered hormone production and secretion compared to age-matched physically inactive individuals who are ageing remains unclear. Objectives The aim of this systematic review was to summarise the findings of exercise training in modulating levels of ostensibly anabolic and catabolic hormones in adults aged > 40 years. Methods We searched the following electronic databases (to July 2021) without a period limit: Cochrane Library, PubMed, Science Direct, Scopus, SPORTDiscus and Web of Science. Additionally, a manual search for published studies in Google Scholar was conducted for analysis of the ‘grey literature’ (information produced outside of traditional commercial or academic publishing and distribution channels). The initial search used the terms ‘ageing’ OR ‘advanced age’ OR ‘old people’ OR ‘older’ OR elderly’ AND ‘anabolic hormones’ OR ‘catabolic hormones’ OR ‘steroid hormones’ OR ‘sex hormones’ OR ‘testosterone’ OR ‘cortisol’ OR ‘insulin’ OR ‘insulin-like growth factor-1’ OR ‘IGF-1’ OR ‘sex hormone-binding globulin’ OR ‘SHBG’ OR ‘growth hormone’ OR ‘hGH’ OR ‘dehydroepiandrosterone’ OR ‘DHEA’ OR ‘dehydroepiandrosterone sulfate (DHEA-S)’ AND ‘exercise training’ OR ‘endurance training’ OR ‘resistance training’ OR ‘ strength training’ OR ‘weight-lifting’ OR ‘high-intensity interval training’ OR ‘high-intensity interval exercise’ OR ‘high-intensity intermittent training’ OR ‘high-intensity intermittent exercise’ OR ‘interval aerobic training’ OR ‘interval aerobic exercise’ OR ‘intermittent aerobic training’ OR ‘intermittent aerobic exercise’ OR ‘high-intensity training’ OR ‘high-intensity exercise’ OR ‘sprint interval training’ OR ‘sprint interval exercise’ OR ‘combined exercise training’ OR ‘anaerobic training’. Only eligible full texts in English or French were considered for analysis. Results Our search identified 484 records, which led to 33 studies for inclusion in the analysis. Different exercise training programs were used with nine studies using endurance training programs, ten studies examining the effects of high-intensity interval training, and 14 studies investigating the effects of resistance training. Most training programs lasted ≥ 2 weeks. Studies, regardless of the design, duration or intensity of exercise training, reported increases in testosterone, sex hormone-binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), human growth hormone (hGH) or dehydroepiandrosterone (DHEA) (effect size: 0.19 < d < 3.37, small to very large) in both older males and females. However, there was no consensus on the effects of exercise on changes in cortisol and insulin in older adults. Conclusion In conclusion, findings from this systematic review suggest that exercise training increases basal levels of testosterone, IGF-1, SHBG, hGH and DHEA in both male and females over 40 years of age. The increases in blood levels of these hormones were independent of the mode, duration and intensity of the training programs. However, the effects of long-term exercise training on cortisol and insulin levels in elderly people are less clear.

Effects of high-intensity interval training and flaxseed oil supplement on learning, memory and immobility: relationship with BDNF and TrkB genes

2020 ◽  
pp. 1-12
Author(s):  
S. Rahmati-Ahmadabad ◽  
M.-A. Azarbayjani ◽  
D.R. Broom ◽  
M. Nasehi
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Executive Functions ◽  
High Intensity ◽  
Interval Training ◽  
Flaxseed Oil ◽  
High Intensity Interval Training ◽  
Positive Effects ◽  
High Intensity Interval ◽  
Positive Effect

This study examined the independent and combined effects of high-intensity interval training (HIIT) and flaxseed oil supplementation on cognitive/executive functions in middle-aged rats. Hippocampal neurotropic brain factor (BDNF) and tyrosine kinase receptor B (TrkB) gene expression were also measured. Animals were randomly divided into groups including no exercise control and saline (CS), no exercise control and flaxseed oil supplement (CF), exercise training-and saline (TS) and exercise training and flaxseed oil supplement (TF). The training groups undertook a program of HIIT (10 weeks, five sessions per week) and the supplement groups received flaxseed oil supplement (300 mg/kg). The results showed that HIIT and flaxseed oil supplementation independently had positive effects on memory and learning (P<0.05). HIIT and flaxseed oil independently decreased immobility behaviour and increased hippocampal BDNF and TrkB genes expression (P<0.05). HIIT and flaxseed oil combination had a greater effect on some variables (hippocampal TrkB gene expression, memory and immobility) compared to each intervention alone (P<0.05). In conclusion, HIIT and flaxseed oil can independently improve cognitive/executive functions. In addition, HIIT had a greater positive effect than flaxseed oil supplementation on memory and immobility. The combination of HIIT and flaxseed oil supplement had a more positive effect compared to each intervention alone on memory, and immobility. Hippocampal BDNF gene expression did not significantly differ in the combination or independent groups. Thus, future work is needed on several other genes in different segments of the brain to find the additive-mechanisms involved in memory and immobility regulation and younger and older species of rat should be examined.

scholarly journals Pengaruh High Intensity Interval Training Terhadap Cardiorespiratory Pada Remaja

2019 ◽  
Vol 8 (2) ◽  
pp. 169-176
Author(s):  
Yoga Handita Windiastoni ◽  
Nurul Fithriati Haritsah
Keyword(s):  
Cardiorespiratory Fitness ◽  
High Intensity ◽  
Interval Training ◽  
Training Group ◽  
T Test ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Significant Difference ◽  
Post Test ◽  
High Intensity Interval

Background: Cardiorespiratory fitness in adolescence affects the level of fitness and determinants of health levels in old age. School adolescents who have low physical activity need easy, efficient and effective physical training to increase cardiorespiratry fitness, namely high intensity interval training. Objective: to determine the effect of high intensity interval training on cardiorespitatory fitness training in adolescents. Subjects: 60 high school students (men n = 21, women n = 39) aged 15-19 years who met the study criteria and were divided into 2 groups, a high intensity interval training group and a control group by jogging. Method: quasi experimental with pre-test and post-test one group design with control group. The instrument used in this study was a 20m shuttle run test. Analysis: normality test with Kolmogorov-Smirnov, then parametric test with paired sample t-test and parametric difference test with independent sample t-test. Results: VO2max pre-test and post-test high intensity interval training group obtained p value = 0,000 (p <0.05) which showed there were significant differences before and after treatment. The results of the post-test different test between the control and treatment groups showed that the value of p = 0,000 (p <0.05) showed that there was a significant difference between the high intensity interval training group and the control group and the results of the different mean mean were greater in the high intensity interval training group. after and before treatment. Conclusion: high intensity interval training can increase cardiorespiratory fitness in adolescents according to the results of VO2max values.

High intensity interval training reduces systemic inflammation in post-PCI patients

2011 ◽  
Vol 18 (6) ◽  
pp. 850-857 ◽  
Author(s):  
Peter Scott Munk ◽  
Unni Mathilde Breland ◽  
Pål Aukrust ◽  
Thor Ueland ◽  
Jan Terje Kvaløy ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Exercise Training ◽  
Stable Angina ◽  
High Intensity ◽  
Inflammatory Markers ◽  
Cell Activation ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Endothelial Cell Activation ◽  
High Intensity Interval

Background: Increased plasma levels of inflammatory markers and markers of endothelial cell activation have been associated with increased risk for cardiovascular events. Exercise training may lower the risk for coronary heart disease by attenuating inflammation and improving endothelial function. The objective of this study was to evaluate effects of regular high-intensity exercise training on a wide range of markers of inflammation and endothelial cell activation. Materials and methods: Consecutively, 40 patients were prospectively randomized to a 6 months supervised high-intensity interval training programme or to a control group following successful percutaneous coronary intervention (PCI). Blood samples of 36 patients with stable angina, drawn at baseline (before PCI) and at 6 months, were analysed. Late luminal loss was measured at 6 months using quantitative coronary angiography. Results: At 6 months, levels of the inflammatory markers interleukin (IL)-6 and IL-8 were reduced and levels of the anti-inflammatory cytokine IL-10 increased in the training group only. The decrease in IL-6 and C-reactive protein levels were significantly correlated with the decrease in luminal loss following PCI. In contrast to these anti-inflammatory effects, training had no effect on markers of platelet-mediated inflammation, and the effect of training on markers on endothelial cell activation were rather complex showing attenuating (von Willebrand factor) and enhancing (E-selectin and vascular cell adhesion molecule 1) effects. Conclusions: Regular exercise training in stable angina patients following PCI may attenuate some, but not all, inflammatory pathways, potentially contributing to the beneficial effects of exercise training on restenosis.

High-intensity interval training improves interventricular synchrony and strain under hypoxic stress in sedentary males

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y.C Huang ◽  
J.S Wang
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
Control Group ◽  
Funding Source ◽  
Peak Strain ◽  
High Intensity Interval Training ◽  
The Difference ◽  
High Intensity Interval ◽  
Longitudinal Strains

Abstract Background Interventricular interactions in increased RV afterload such as hypoxia stress, which affects both synchrony and function in an in-series effect as well as a parallel effect arising from leftward septal shift. Improved myocardial contractility is a critical circulatory adaptation to exercise training, however, the types of exercise that can improve interventricular synchrony under hypoxic environment have not yet been established. Purpose This study investigates how high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) influence on the interventricular synchrony in response to normobaric hypoxia in sedentary men. Methods Fifty-four sedentary males were randomized to perform HIIT (3-minute intervals at 40% and 80% VO2peak, n=18), MICT (sustained 60% VO2peak, n=18) for 30 minutes/day, 5 days/week for 6 weeks and the control group (CTL, n=18). Synchrony measurements at apical 4-chamber view including (1) intra-delay, the difference in time to peak strain (TS) between segmental septal-to-lateral ventricular or atrial walls, and (2) inter-delay, the difference in TS between RV or RA free wall and LV or LA lateral wall. The data were acquired by 2-dimensional speckle tracking echocardiography at rest under hypoxic condition (12% FIO2, simulated an altitude of 4,500 m) before and after the interventions. Results HIIT had significantly elevated radial and longitudinal strains in both LA and LV (p&lt;0.05). As the results showed, HIIT was superior than MICT in improvement of longitudinal intra-delay of LV; furthermore, only HIIT simultaneously ameliorated both radial and longitudinal synchrony at apex. Although the HIIT enhanced intraventricular synchrony in both motions, whereas the interventricular synchrony deteriorated at radial motion. In atrium synchrony, although both groups augmented the intra-LA synchrony, however, only HIIT reduced the inter-delay between LA and RA at the roof motion. LV end-systolic volume (ESV) significantly correlated with the longitudinal inter-delay of ventricle (r=−0.53, p&lt;0.05), whereas the LV end-diastolic volume (EDV) correlated with the inter-delay of atrium in roof motion (r=0.40, p&lt;0.05). Conclusion We found differences between HIIT and MICT in segmental intra- and inter- synchrony. HIIT enhanced both ventricular or atrial synchrony, and further increased the EDV coupled with decreased ESV. These findings give new insight into cardiac adaptation to difference endurance training and the long-term impact of such changes warrants future study in cardiac diseases. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National Science Council of Taiwan

scholarly journals The Effects of the Combination of High-Intensity Interval Training with 3D-Multiple Object Tracking Task on Perceptual-Cognitive Performance: A Randomized Controlled Intervention Trial

2021 ◽  
Vol 18 (9) ◽  
pp. 4862
Author(s):  
Soo-Yong Park ◽  
Thomas Jürgen Klotzbier ◽  
Nadja Schott
Keyword(s):  
Object Tracking ◽  
Cognitive Performance ◽  
High Intensity ◽  
Interval Training ◽  
Multiple Object Tracking ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Multiple Object ◽  
Post Test ◽  
High Intensity Interval

The ability to process goal-related visual information while ignoring goal-irrelevant information is essential for the human attention system. The study aimed to investigate how perceptual–cognitive performance was affected during high-intensity interval training (HIIT) using a 3D-multiple object tracking (3D-MOT) task called Neurotracker (NT). In an experimental design, 42 healthy adults (age M = 23.3 SD = 2.94, VO2max 52.8 ± 5.66 mL·kg−1·min−1) were randomly assigned to an intervention (HIIT + NT, NT, HIIT) or control group. NT performance (20 trials per session) was measured pre-and post-test (at 5, 15, and 25 min while running on the treadmill). The participants trained twice a week for a 4-week intervention period. There was a significant interaction effect between pre/post-test and groups regarding perceptual-cognitive performance, indicating similar enhancements in the HIIT + NT and the NT group during exercise. HIIT influences physical fitness but did not show any impact on perceptual–cognitive performance. Due to the specific NT task characteristics, improved physical abilities may not directly impact sport-specific perceptual-cognitive performance. Our findings suggest that training resulted in substantial task-specific gains. Therefore, combination training may be proposed as a training program to improve perceptual–cognitive, and physical performance in a time-efficient way.

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