THE INFLUENCE OF THE STORAGE CONDITIONS OF RAW MATERIALS  ON THE PRESERVATION OF THE PROPERTIES OF THE FUR SEMI-FINISHED PRODUCT

This article deals with the problem of preserving the properties of a semi-finished fur product under the influence of a biological factor during the storage of raw materials. The characteristic features of the biodegradation of untreated rabbit skins during storage at elevated temperature and relative humidity are identified and described. A complex characteristic of a semi-finished fur product developed from raw materials of various degrees of microbiological spoilage is given. The author offers a point scale of assessment dynamics of the processes of destruction of fur raw materials and a point assessment of the organoleptic indicators of the semi-finished product was developed. As a result of comprehensive studies, it was found that the degree of damage to the fur raw materials being processed affects the decrease in the stability of the structure and strength properties of the finished semi-finished product.

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Stability of extemporaneously prepared rosuvastatin oral suspension

American Journal of Health-System Pharmacy ◽

10.2146/ajhp160235 ◽

2017 ◽

Vol 74 (19) ◽

pp. 1579-1583 ◽

Cited By ~ 2

Author(s):

Abdel Naser Zaid ◽

Rania Shtayah ◽

Ayman Qadumi ◽

Mashour Ghanem ◽

Rawan Qedan ◽

...

Keyword(s):

Relative Humidity ◽

High Performance ◽

Room Temperature ◽

Microbial Contamination ◽

Active Pharmaceutical Ingredient ◽

Storage Conditions ◽

Dissolution Profile ◽

Stability Studies ◽

Organoleptic Properties ◽

The Stability

Abstract Purpose The stability of an extemporaneously prepared rosuvastatin suspension stored over 30 days under various storage conditions was evaluated. Methods Rosuvastatin suspension was extemporaneously prepared using commercial rosuvastatin tablets as the source of active pharmaceutical ingredient. The organoleptic properties, dissolution profile, and stability of the formulation were investigated. For the stability studies, samples of the suspension were stored under 2 storage conditions, room temperature (25 °C and 60% relative humidity) and accelerated stability chambers (40 °C and 75% relative humidity). Viscosity, pH, organoleptic properties, and microbial contamination were evaluated according to the approved specifications. High-performance liquid chromatography was used for the analysis and quantification of rosuvastatin in selected samples. Microbiological investigations were also conducted. Results The prepared suspension showed acceptable organoleptic properties. It showed complete release of rosuvastatin within 15 minutes. The pH of the suspension was 9.8, which remained unchanged during the stability studies. The microbiological investigations demonstrated that the preparation was free of any microbial contamination. In addition, the suspension showed stability within at least the period of use of a 100-mL rosuvastatin bottle. Conclusion Extemporaneously prepared rosuvastatin 20-mg/mL suspension was stable for 30 days when stored at room temperature.

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Effect of Sunlight, Moisture, Temperature and Ultraviolet Radiation on the Quality Control Parameters of Ciprofloxacin Tablet Formulation

International Journal of Drug Delivery ◽

10.5138/09750215.1928 ◽

2016 ◽

Vol 8 (3) ◽

pp. 99 ◽

Cited By ~ 1

Author(s):

Kenneth Ezealisiji ◽

Angenlina Pepple ◽

Catherine Stanley

Keyword(s):

Relative Humidity ◽

Uv Light ◽

Physical Stability ◽

Accelerated Aging ◽

Storage Conditions ◽

Dissolution Behavior ◽

Ciprofloxacin Hydrochloride ◽

Label Claim ◽

Aging Conditions ◽

The Stability

This work assesses the stability and quality of Ciprofloxacin hydrochloride tablets after subjection to accelerated stability conditions of sunlight, temperature of 40±10C, 75% relative humidity, and UV light of 365 nm for 4 hours each day. This study was performed at time zero and at 4-day intervals for a period of 45 days (that is, days 0, 4, 8, 12…40, 44) according to the International Conference on Harmonization (ICH) accelerated aging conditions and the results obtained were subjected to statistical analysis. The results showed that with increasing time there was a gradual reduction in the dissolution rate with the tablets exposed to all four storage conditions failing the test on day 44 where they had less than 80 % release of the label claim. For content of Ciprofloxacin Hydrochloride, only those tablets exposed to UV light passed the test for all 44 days as they had a minimum of 96.83 % content on the 44th day. At day 0, all the tablets assayed passed this test, having a ciprofloxacin content of 99.43 %. For those tablets subjected to the other storage conditions including temperature of 40±10C, 75 % relative humidity and sunlight, they had ciprofloxacin content of 70.22 %, 71.50 %, and 78.36 % respectively. The results further, indicated that the storage conditions used in the study had a greater impact on the dissolution behavior and content of the Ciprofloxacin tablets than they did on the physical stability (hardness, uniformity of weight, disintegration).

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Stability test for mastitis reagent ad us. vet.

Biotechnology in Animal Husbandry ◽

10.2298/bah1302399v ◽

2013 ◽

Vol 29 (2) ◽

pp. 399-404

Author(s):

V. Vukovic ◽

M. Vicentijevic ◽

N. Plavsa

Keyword(s):

Relative Humidity ◽

Shelf Life ◽

Ph Value ◽

Storage Conditions ◽

Stability Test ◽

Initial State ◽

The Stability

In the stability test of the mastitis reagent ad us.vet., as the finished product, three production series were tested in quantities of 500 ml of the sample, under appropriate storage conditions. For the testing, the appropriate uniformity of temperature and relative humidity was provided. Also, the procedure of the stability test was determined, which included the initial state, then every three months until the end of the first trial and a final testing at the end of shelf life (0, 3, 6, 9, 12 and 18 months). Of the tested parameters the following were included: appearance, pH value of the solution, dry residue (in %) and microbiological purity.

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Water Sorption and Mechanical Properties of Starch/Chitosan Nanoparticle Films

Journal of Nanomaterials ◽

10.1155/2019/3843949 ◽

2019 ◽

Vol 2019 ◽

pp. 1-12 ◽

Cited By ~ 5

Author(s):

Siti H. Othman ◽

Nurul R. A. Kechik ◽

Ruzanna A. Shapi’i ◽

Rosnita A. Talib ◽

Intan S. M. A. Tawakkal

Keyword(s):

Mechanical Properties ◽

Relative Humidity ◽

Water Sorption ◽

Food Packaging ◽

High Water ◽

Storage Conditions ◽

Sorption Behavior ◽

Sorption Data ◽

Chitosan Nanoparticle ◽

The Stability

The usage of biopolymer as food packaging material has been limited due to high water sorption and poor mechanical properties of the biopolymer. Thus, this study is aimed at improving the water sorption and mechanical properties of biopolymer particularly starch films by incorporation of a natural filler particularly chitosan nanoparticle (CNP) and investigating the properties of starch/CNP films at different storage conditions (relative humidity: 23, 50, and 75%; temperature: 4, 30, and 40°C). The water sorption behavior and isotherms of the films were investigated by fitting the water sorption data to the Peleg model and Guggenheim, Anderson, and de Boer model. Both the models were well fitted to the experimental data, thus proving the reliability of water sorption behavior prediction. It was found that different storage conditions of the films significantly affected the mechanical properties of the films due to the sensitivity of the films towards moisture. Water sorption and mechanical properties of the films were best improved at relative humidity of 23% and temperature of 30°C. The water sorption and mechanical properties of the films are worth to be investigated because the properties affected the stability, shelf life, and application of the films in the food packaging field.

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Development of an Orodispersible Film Containing Stabilized Influenza Vaccine

Pharmaceutics ◽

10.3390/pharmaceutics12030245 ◽

2020 ◽

Vol 12 (3) ◽

pp. 245 ◽

Cited By ~ 1

Author(s):

Yu Tian ◽

Yoshita C. Bhide ◽

Herman J. Woerdenbag ◽

Anke L. W. Huckriede ◽

Henderik W. Frijlink ◽

...

Keyword(s):

Relative Humidity ◽

Oral Cavity ◽

Influenza Virus Vaccine ◽

Storage Conditions ◽

Hemagglutination Activity ◽

Promising Alternative ◽

Improved Stability ◽

The Stability ◽

Subsequent Storage ◽

Excellent Stability

Most influenza vaccines are administered via injection, which is considered as user-unfriendly. Vaccination via oral cavity using an orodispersible film (ODF) might be a promising alternative. To maintain the antigenicity of the vaccine during preparation and subsequent storage of these ODFs, sugars such as trehalose and pullulan can be employed as stabilizing excipients for the antigens. In this study, first, β-galactosidase was used as a model antigen. Solutions containing β-galactosidase and sugar (trehalose or trehalose/pullulan blends) were pipetted onto plain ODFs and then either air- or vacuum-dried. Subsequently, sugar ratios yielding the highest β-galactosidase stability were used to prepare ODFs containing H5N1 whole inactivated influenza virus vaccine (WIV). The stability of the H5N1 hemagglutinin was assessed by measuring its hemagglutination activity. Overall, various compositions of trehalose and pullulan successfully stabilized β-galactosidase and WIV in ODFs. WIV incorporated in ODFs showed excellent stability even at challenging storage conditions (60 °C/0% relative humidity or 30 °C/56% relative humidity) for 4 weeks. Except for sugars, the polymeric component of ODFs, i.e., hypromellose, possibly improved stability of WIV as well. In conclusion, ODFs may be suitable for delivering of WIV to the oral cavity and can possibly serve as an alternative for injections.

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Microencapsulation Preservation of the Stability and Efficacy of Citrus Grandis Oil-Based Repellent Formulation against Aedes aegypti during Storage

Molecules ◽

10.3390/molecules26123599 ◽

2021 ◽

Vol 26 (12) ◽

pp. 3599

Author(s):

Norashiqin Misni ◽

Zurainee Mohamed Nor ◽

Rohani Ahmad ◽

Nur Raihana Ithnin ◽

Ngah Zasmy Unyah

Keyword(s):

Relative Humidity ◽

Essential Oil ◽

Zeta Potential ◽

Aedes Aegypti ◽

Essential Oils ◽

Ph Value ◽

Physical Stability ◽

Storage Conditions ◽

Mosquito Repellent ◽

The Stability

Essential oils have been widely used as an active ingredient in mosquito repellent products. However, essential oils are highly unstable and prone to degradation when exposed to the environment during storage. Microencapsulation techniques help to maintain the stability of molecules in essential oils that are sensitive to environmental stress, and therefore improve shelf life. In this study, the physical stability and efficacy of a repellent formulation consisting of encapsulated Citrus grandis essential oil (CGEO) were evaluated under different storage conditions over a 12-month period by comparing the formulation with a non-encapsulated formulation. The formulations were both stored under two different storage conditions, i.e., 25 ± 2 °C/60% ± 5% relative humidity (RH) and 40 ± 2 °C/75% RH ± 5%, for 12 months. Droplet size, zeta potential, and pH value were measured after 1, 6, and 12 months of storage to determine their stability. For the study of efficacy, each formulation was tested against Aedes aegypti under laboratory conditions. We found that the microencapsulated formulation’s physical characteristics showed insignificant changes as compared with the non-encapsulated formulation during storage. The microencapsulated formulation demonstrated better repellent effects, sustaining high protection (>80%) for 4 more hours of exposure after 12 months of storage as compared with the non-encapsulated formulation that demonstrated high protection for only an hour post application. Microencapsulation helped to preserve the stability of the formulation, which resulted in high protection being maintained for over 12 months of storage.

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Stability of clonidine hydrochloride in an oral powder form compounded for pediatric patients in Japan

Journal of Pharmaceutical Health Care and Sciences ◽

10.1186/s40780-021-00214-x ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Jumpei Saito ◽

Takehisa Hanawa ◽

Takahiro Matsumoto ◽

Nozomi Yoshikawa ◽

Tsutomu Harada ◽

...

Keyword(s):

Relative Humidity ◽

Pediatric Patients ◽

Storage Conditions ◽

Drug Dissolution ◽

Powder Form ◽

X Ray Diffraction ◽

Oral Clonidine ◽

Clonidine Hydrochloride ◽

Array Detection ◽

The Stability

Abstract Background Clonidine hydrochloride is used to treat sedative agent withdrawals, malignant hypertension, and anesthesia complications. Clonidine is also prescribed off-label to pediatric patients at a dose of 1 μg/kg. The commercially available enteral form of clonidine, Catapres® tablets, is often compounded into a powder form by pharmacists to achieve dosage adjustments for administration to pediatric patients. However, the stability and quality of compounded clonidine powder have not been verified. The objectives of this study were to formulate a 0.2 mg/g oral clonidine hydrochloride powder and assess the stability and physical properties of this compounded product in storage. Methods A 0.2 mg/g clonidine powder was prepared by adding lactose monohydrate to crushed and filtrated clonidine tablets. The powder was stored in polycarbonate amber bottles or coated paper packages laminated with cellophane and polyethylene. The stability of clonidine at 25 °C ± 2 °C and 60% ± 5% relative humidity was examined over a 120-d period in “bottle (closed),” “bottle (in use),” and “laminated paper” storage conditions. Drug dissolution and powder X-ray diffraction analysis were conducted to assess physicochemical stabilities. Validated liquid chromatography-diode array detection was used to detect and quantify clonidine and its degradation product, 2,6-dichloroaniline (2,6-DCA). Results Clonidine content was maintained between 90.0 and 110.0% of the initial contents in all packaging and storage conditions. After 120 d of storage, 2,6-DCA was not detected, and no crystallographic and dissolution changes were observed. Conclusions Compounded clonidine powder stability was maintained for 120 d at 25 °C ± 2 °C and 60% ± 5% relative humidity. This information may contribute to the management of clonidine compounded powder in community and hospital pharmacies in Japan.

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FORMULATION AND DEVELOPMENT OF FAST DISSOLVING TABLET OF METOCLOPRAMIDE: AN ANTI-EMETIC DRUG

Journal of Biomedical and Pharmaceutical Research ◽

10.32553/jbpr.v8i6.699 ◽

2019 ◽

Vol 8 (6) ◽

Author(s):

Avilash Carpenter ◽

M.K. Gupta ◽

Neetesh Kumar Jain ◽

Urvashi Sharma ◽

Rahul Sisodiya

Keyword(s):

Mechanical Strength ◽

Standard Procedure ◽

Flow Property ◽

Storage Conditions ◽

Angle Of Repose ◽

Dissolution Time ◽

Disintegration Time ◽

Powder Blend ◽

Standard Curve ◽

The Stability

Aim: The main of the study is to formulate and develop orally disintegrating fast dissolving tablet of Metoclopramide hydrochloride. Material & Methods: Before formulation and development of selected drug, the standard curve in buffer was prepared and absorbance at selected maxima was taken. Then two different disintegrating agents were selected and drug was mixed with disintegrating agents in different ratio. Various Preformulation parameters and evaluation of tablet i.e. disintegration time, dissolution time, friability, hardness, thickness were measured by standard procedure. Result & Discussion: The angle of repose for all the batches prepared. The values were found to be in the range of 30.46 to 36.45, which indicates good flow property for the powder blend according to the USP. The bulk density and tapped density for all the batches varied from 0.49 to 0.54 g/mL and 0.66 to 0.73, respectively. Carr’s index values were found to be in the range of 23.33 to 25.88, which is satisfactory for the powders as well as implies that the blends have good compressibility. Hausner ratio values obtained were in the range of 1.22 to 1.36, which shows a passable flow property for the powder blend based on the USP. The results for tablet thickness and height for all batches was found to range from 4.45 to 4.72 mm and 3.67 to 3.69 mm, respectively. Hardness or breaking force of tablets for all batches was found to range from 32.8 to 36.2 N. Tablet formulations must show good mechanical strength with sufficient hardness in order to handle shipping and transportation. Friability values for all the formulations were found to be in the range of 0.22 % to 0.30 %. Conclusion: Orally disintegrating tablets were compressed in order to have sufficient mechanical strength and integrity to withstand handling, shipping and transportation. The formulation was shown to have a rapid disintegration time that complied with the USP (less than one minute). The data obtained from the stability studies indicated that the orally disintegrating mini-tablets of MTH were stable under different environmental storage conditions. Keywords: Formulation & Development, Fast Dissolving Tablet, Metoclopramide, Anti-Emetic Drug, Oral Disintegrating Tablet

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FUNDAMENTAL CAPITAL FINANCING OF PRODUCTION

Innovation in the economy ◽

10.26739/2181-9491-2020-8-8 ◽

2020 ◽

Vol 8 (3) ◽

pp. 74-78

Author(s):

Farrux Zulfiyev ◽

Keyword(s):

Raw Materials ◽

Economic Reforms ◽

Equity Financing ◽

Capital Financing ◽

The Republic ◽

The Stability

This article is based on the principles of shared financing of the production of raw materials. The article is aimed at financing the production of capital on the basis of equity in order to further strengthen the stability of economic reforms in the republic. At the same time, the essence of equity financing, the risks associated with it, and the efficiency of raw materials are covered

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