The Study of Efficacy of Excimer Light 308 Nanometers for Chronic Hand Dermatitis

2021 ◽  
Vol 104 (1) ◽  
pp. 32-37
Keyword(s):  
Complete Remission ◽  
Adverse Effects ◽  
Burning Sensation ◽  
Hand Dermatitis ◽  
Dermatological Disease ◽  
Significant Difference ◽  
Remission Rates ◽  
Severe Group ◽  
Melanin Index ◽  
The Mean

Background: Chronic hand dermatitis is one of the most common dermatological disease worldwide resulting from high incidence, prevalence, and recurrent rate. Nowadays, there are various kinds of treatments in chronic hand dermatitis. The previous studies only consisted of prospective non-randomized pilot study and retrospective cohort study of 308 nanometers excimer devices in chronic hand dermatitis. Objective: To study the efficacy and side effect of the excimer light 308 nanometer in chronic hand dermatitis. Materials and Methods: The researchers conducted a prospective non-randomized clinical trial to study the efficacy of 308 nanometers excimer light to treat chronic hand dermatitis. Thirty-five patients were enrolled in the eight weeks protocol. The efficacy of device was assessed by the HECSI, the PGA score, the erythema index by Mexameter MX16, and the NRS for pruritus level. In addition, the adverse effect of changing melanin index was assessed by the Mexameter MX16. The researchers also assessed the DLQI and the patient’s satisfaction score. Results: The results revealed that the mean of the HECSI, PGA, NRS, and erythema index were statistically significantly decreased after complete treatment (p<0.001). The result of subgroup analysis of percent of complete remission rates were 88.89 in mild group, 83.33 in moderate group, and 42.86 in severe group, which was statistically significant (p=0.029). In addition, the complete remission rates of pruritus were 88.89 in the mild group, 94.44 in the moderate group, and 57.14 in the severe group, and there was no statistically significant difference between the groups (p=0.21). On the other hand, the mean of melanin index demonstrated no statistically significant change in palmar and dorsal side of both hands (p=0.79, 0.57, 0.78, and 0.07, respectively). Furthermore, the DLQI was also statistically significantly improved (p<0.001), and the patients were very satisfied to the treatment. The adverse effects, which included burning sensation, skin dryness, and progressive itchiness, were observed (5.88, 5.88, and 8.82%, respectively) and spontaneously resolved within 24 hours without clinical skin change. Conclusion: The excimer light 308 nanometers is the alternative treatment of chronic hand dermatitis by reducing the severity score statistically significantly without hyperpigmentation after treatment. Mild adverse effects such as itchiness, dry skin, and burning sensation without major adverse event were observed. Keywords: Excimer light, Chronic hand dermatitis

Iron Absorption: Comparison of Oral Heme-Bound Iron with Inorganic Ferrous Sulfate.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3752-3752
Author(s):  
Dexter T. Estrada ◽  
Kenneth A. Schwartz
Keyword(s):  
Adverse Effects ◽  
Ferrous Sulfate ◽  
Serum Iron ◽  
Heme Iron ◽  
Deficiency Anemia ◽  
Bovine Blood ◽  
Fasting Serum ◽  
Baseline Serum ◽  
Significant Difference ◽  
The Mean

Abstract Oral iron supplementation is an effective method for treating iron deficiency anemia. However, current preparations of inorganic iron have significant gastrointestinal adverse effects, that sometimes prevent patients from complying with their prescribed iron. Gut absorption of heme bound iron is via a different pathway than inorganic iron. Heme-bound iron may also have fewer gastrointestinal side effects as it is present in red meat and other specially prepared foods. If it can be shown that oral heme-bound iron is absorbed as readily as oral inorganic iron, then patients who cannot tolerate inorganic iron would have a less expensive alternative to parenteral iron which is costly and can cause life-threatening risk of anaphylaxis. The purpose of this study was to determine if there is a significant difference between the oral absorption of heme-bound iron, in the form of cooked bovine blood soup, and inorganic ferrous sulfate. Ten normal adult subjects were recruited for participation in this study and informed consents were obtained. All subjects had normal baseline fasting serum iron studies and ferritin. After blood for a fasting serum iron was obtained, subjects ingested a cooked bovine blood soup, containing 18 mg of elemental heme iron. Repeat iron studies were taken 2 hours after ingestion of the heme iron preparation. After a 2 week washout period, the same 10 subjects had baseline serum iron drawn followed by ingestion of 18 mg of elemental iron in the form of inorganic ferrous sulfate elixir. Serum iron was again measured 2 hours after ingestion of ferrous sulfate. The mean increase in serum iron after ingestion of bovine blood preparation was 18.5 micrograms/dL. In comparison, the mean increase in serum iron after ingestion of ferrous sulfate was 37.9 micrograms/dL. A paired T test analysis did not show any significant difference in the increase of serum iron from baseline to 2 hours between the two iron preparations (P&gt;0.1112). No adverse effects were reported by any of the subjects after ingestion of either preparation. In conclusion, heme iron ingested in the form of a cooked bovine blood soup is well tolerated, produces increases in the concentrations of serum iron that are comparable to those produced by ferrous sulfate, and supports the principle that reasonable amounts of iron can be absorbed from heme.

scholarly journals Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

2021 ◽  
Vol 8 (1) ◽  
pp. e000522
Author(s):  
Kristina K Deonaraine ◽  
Philip M Carlucci ◽  
Andrea Fava ◽  
Jessica Li ◽  
David Wofsy ◽  
...  
Keyword(s):  
Complete Remission ◽  
Kidney Biopsy ◽  
National Institutes Of Health ◽  
New Drugs ◽  
Health Reporting ◽  
Complication Risk ◽  
Targeted Treatments ◽  
Remission Rates ◽  
The Usa ◽  
The Mean

ObjectivesIn lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.ConclusionsProcurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.

scholarly journals Results of tadalafil treatment in patients following an open nerve-sparing radical prostatectomy

2016 ◽  
Vol 88 (1) ◽  
pp. 4
Author(s):  
Erkan Hirik ◽  
Aliseydi Bozkurt ◽  
Mehmet Karabakan ◽  
Özkan Onuk ◽  
Mustafa Bahadır Can Balcı ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Adverse Effects ◽  
Erectile Function ◽  
Nerve Sparing ◽  
Ultrasound Evaluation ◽  
Significant Difference ◽  
Daily Dose ◽  
The Mean ◽  
Positive Effect

Purpose: To evaluate the effect of postoperatively administering a low daily dose of tadalafil on the erectile function of patients who underwent a nerve-sparing radical prostatectomy(NSRP) due to localized prostate cancer (PCa). Materials and Methods: Of 138 patients, who underwent NSRP due to PCa between 2012 and 2014, 55 patients who had not had pre-operative erectile dysfunction (ED) were included in the study. The mean age of the patients was 64 (54-72). On the 15th day after surgery, after ultrasound evaluation, all 55 patients started on a daily dose of 5 mg tadalafil that was continued for 2.5 months. The erectile function of patients was evaluated pre-operatively, post-operatively, and at the 3rd and 6th month after surgery using the International Index of Erectile Function (IIEF-5) test. None of the patients was treated with hormonal therapy or radiotherapy before or after surgery. Results: Three patients were excluded from the study due to the adverse effects of tadalafil and two patients elected to discontinue the treatment. Of the remaining 50 patients whose pre-operative erectile function had been found normal, at 3 months after surgery, 36 (72%) had normal erectile function; of the remaining patients in the study six (12%) presented with mild, two (4%) with moderate, and six (12%) with severe ED. Six months after surgery, 35 patients (70%) had normal erectile function while seven (14%) had mild, three (6%) moderate and five (10%) severe ED. There was no statistically significant difference between the results obtained at the 3rd and 6thmonth follow-up (p &gt; 0.05). Three patients reported adverse effects with tadalafil including flushes in 2 (3.6%) and a headache in 1 (1.8%). Conclusions: The administration of a 5 mg post-operative dose of tadalafil to patients that had undergone a bilateral NSRP was found to have a positive effect on the recovery and maintenance of erectile function. However, there is still a need to investigate a larger series of cases.

scholarly journals Efficacy of Mefenamic acid and Ginger on Pain Relief in Primary Dysmenorrhea Among Basic Sciences Students of Nepalgunj Medical College

2020 ◽  
Vol 2 (1) ◽  
pp. 4-10
Author(s):  
Ankita Singh ◽  
Bijay Aryal ◽  
Sushma Deo
Keyword(s):  
Adverse Effects ◽  
Mefenamic Acid ◽  
Similar Efficacy ◽  
Primary Dysmenorrhea ◽  
Menstrual Pain ◽  
Basic Sciences ◽  
Cross Sectional ◽  
Medical College ◽  
Significant Difference ◽  
The Mean

Introduction: Primary dysmenorrhea has been reported as the most common cause of regular absenteeism among young women. Pain affects daily activities and quality of life. The aim of the study was to compare the efficacy between mefenamic acid (Meftal) and ginger capsules (Remezy) among Basic Sciences Students of Nepalgunj Medical College (NGMC), Chisapani. Adverse effects, if any, were also observed in both Meftal and ginger groups. Methodology: This was a prospective cross-sectional study conducted from July 2018 to February 2019. Out of 104 students, 87 were suffering menstrual pain. These 87 individuals received Mefenamic acid (Meftal) 500mg twice a day for three days and the same 87 individuals, in their next month of period, took ginger capsules (Remezy) 500mg twice daily for three days. Medication was started on the first day of their menstruation. The severity of pain before and after the medication was recorded with the help of a multi-dimensional scoring system (MSS). All the data were directly entered into SPSS 20.0 and compiled, analyzed and expressed in tables and charts. Results: Out of 104, 87 (83.7%) students had experienced menstrual pain. The mean±S.D age of the students was 19.64±1.02 while the mean±S.D menarche age was 13.21±1.01. The pain severity of dysmenorrhea was significantly reduced (p<0.05) with both meftal and ginger intake in both the first and second months consecutively. However, a comparison of efficacy between the two medications showed no statistically significant difference (p>0.05). Adverse effects were found to be significantly higher in students receiving meftal tablets.     Conclusion: A high proportion of students had dysmenorrhea. Similar efficacy of ginger and meftal was observed with minimal adverse effects in ginger. Findings suggest the need for educating students on appropriate and effective management of dysmenorrhea.

scholarly journals Sociodemographic Impact and Acquaintance on Antibiotic Resistance Among Outpatients in Specialist Hospital, Malaysia

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Hanish Singh Jayasingh Chellammal ◽  
Mohamed Mansor Manan ◽  
Thayashini Kupusamy ◽  
Long Chiau Ming ◽  
Shafeeq Mohd Faizal
Keyword(s):  
Antimicrobial Resistance ◽  
Adverse Effects ◽  
Cross Sectional Study ◽  
Antibiotics Resistance ◽  
Cross Sectional ◽  
Global Issues ◽  
Validated Questionnaire ◽  
Significant Difference ◽  
The Mean ◽  
Knowledge And Attitude

INTRODUCTION: Awareness on antibiotics resistance among outpatients in hospital settings is reasonably explored and this study aimed to investigate the sociodemographic impact and the level of acquaintance towards antibiotics practice and resistance. MATERIALS AND METHODS: This cross-sectional study was conducted on 270 patients from the outpatient department of KPJ Seremban Specialist Hospital (KPJSSH), Malaysia. A pre-validated questionnaire was used to collect the data on the demographics of the patients, their knowledge, attitude, and usage of antibiotics. The study was approved by the KPJUC ethics committee (KPJUC/RMC/BPH/EC/2017/104). RESULTS: The mean age of the respondents was 36 ± 11.07 years and 50.37% of them have moderate knowledge on antibiotics. The knowledge and attitude on antibiotics usage exhibited a significant difference (p=0.001) amongst these patients in association with literacy. The results showed that the literate respondents have significant knowledge on the identification of antibiotics (p=0.021), their roles, and adverse effects (p=0.004). The attitude of the respondents towards following the prescription was significantly associated with their literacy (p=0.004). CONCLUSION: This study reveals that respondents have the least knowledge on antibiotic course compliance and termination of therapy, which could lead to antimicrobial resistance. In conclusion, inculcating the knowledge of antimicrobial resistance, adverse effects, and course compliance among the patients may help overcome the national and global issues on multi-drug-resistant diseases.

scholarly journals Effect of Celliant® armbands on grip strength in subjects with chronic wrist and elbow pain: randomized double-blind placebo-controlled trial

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Ian L. Gordon ◽  
Seth Casden ◽  
Michael R. Hamblin
Keyword(s):  
Adverse Effects ◽  
Grip Strength ◽  
Biological Effects ◽  
Controlled Trial ◽  
Percentage Increase ◽  
Ir Radiation ◽  
Elbow Pain ◽  
Content Type ◽  
Significant Difference ◽  
The Mean

Purpose This study aims to test the effects of Celliant armbands on grip strength in subjects with chronic wrist and elbow pain. Celliant® is a functional textile fabric containing minerals that emit infrared radiation (IR) in response to body heat. IR-emitting fabrics have biological effects including the reduction of pain and inflammation and the stimulation of muscle function. Design/methodology/approach A randomized placebo-controlled trial recruited 80 subjects (40 per group) with a six-month history of chronic wrist or elbow pain (carpal tunnel syndrome, epicondylitis or arthritis) to wear an armband (real Celliant or placebo fabric) on the affected wrist or elbow for two weeks. Grip strength was measured by a dynamometer before and after the two-week study. Findings For the placebo group, the mean grip strength increased from 47.95 ± 25.14 (baseline) to 51.69 ± 27.35 (final), whereas for the Celliant group, it increased from 46.3 ± 22.02 to 54.1 ± 25.97. The mean per cent increase over the two weeks was +7.8% for placebo and +16.8% for Celliant (p = 0.0372). No adverse effects was observed. Research limitations/implications Limitations include the wide variation in grip strength in the participants at baseline measurement, which meant that only the percentage increase between baseline and final measurements showed a significant difference. Moreover, no subjective measurements of pain or objective neurophysiology testes was done. Practical implications Celliant armbands are easy to wear and have not been shown to produce any adverse effects. Therefore, there appears to be no barrier to prevent widespread uptake. Social implications IR-emitting textiles have been studied for their beneficial effects, both in patients diagnosed with various disorders and also in healthy volunteers for health and wellness purposes. Although there are many types of textile technology that might be used to produce IR-emitting fabrics, including coating of the fabric with a printed layer of ceramic material, incorporating discs of mineral into the garment, the authors feel that incorporating ceramic particles into the polymer fibers from which the fabric is woven is likely to be the most efficient way of achieving the goal. Originality/value Celliant armbands appear to be effective in painful upper limb inflammatory disorders, and further studies are warranted. The mechanism of action is not completely understood, but the hypothesis that the emitted IR radiation is absorbed by nanostructured intracellular water provides some theoretical justification.

scholarly journals Invastigation of persica mouth wash versus doxepin 0.5% oral rinse for chemo-radiotherapy-induced mucositis pain in the treatment of head and neck cancers, a randomized double blind clinical trial

2020 ◽  
Author(s):  
Pegah Mahjour ◽  
Hassanali Vahedian Ardakani ◽  
Mohsen Nabi Meybodi ◽  
Masood Shabani ◽  
Farahnaz Pouyanfar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Head And Neck Cancer ◽  
Visual Analogue Scale ◽  
Head And Neck ◽  
Neck Cancer ◽  
Analogue Scale ◽  
Burning Sensation ◽  
Oral Rinse ◽  
Significant Difference ◽  
The Mean

Abstract Background: One of the common side effects of radiotherapy and chemotherapy in patients with head and neck cancer is oral mucositis. This painful complication restricts the ability to eat and drink and increases the risk of oral infections. The aim of this study was to investigate the effect of doxepin oral rinse 0.5% in comparison with persica mouthwash on reducing the pain of oral mucositis in patients with head and neck cancer after radiotherapy and chemotherapy. Methods: This clinical trial was performed on 56 patients admitted in the oncology ward of Shahid Sadoughi Hospital and Shahid Ramezanzadeh radiotherapy center in Yazd, who received more than 45 gray of radiation and had mucositis and their pain score was more than 4 on the basis of the Visual Analogue Scale (VAS). Patients were randomly divided into two groups of persica and doxepin 0.5%. The data collection tool was a questionnaire including visual analogue scale for pain, taste satisfaction and possible complications. Data were analyzed by using SPSS19 software and Chi-square test. Results: There was no significant difference between the mean score of pain in doxepin and persica groups 5,15,30, 120,240 minutes and 24 hours after taking the mouthwash; just in the doxepin group, the mean of pain reduction 60 minute after taking the mouthwash was higher than persica group (P> 0.05). There was no significant difference between the mean score of burning sensation in doxepin and persica groups30,60,120,240 minutes and 24 hours after taking the mouthwash; just in the pesica group, the mean of burning sensation reduction 5,15minutes after taking the mouthwash was lower than doxepin group The level of taste satisfaction and drowsiness in the doxepin group was significantly higher than persica group. (P >0.05) Conclusion: Persica mouthwash, like doxepin mouthwash, was effective in reducing the mucositis pain in patients and just in the doxepin group reduction in pain after 60 minutes was higher than perisca group

scholarly journals Correlation of Anterior Segment Parameters in Keratoconus Patients

2012 ◽  
Vol 1 (2) ◽  
pp. 87-91 ◽  
Author(s):  
Leonardo Torquetti
Keyword(s):  
Pearson Correlation ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Inverse Correlation ◽  
Q Value ◽  
Significant Difference ◽  
Severe Group ◽  
Corneal Asphericity ◽  
The Mean ◽  
Anterior Segment Parameters

ABSTRACT Purpose To evaluate the corneal asphericity, volume, thickness and keratometry and the correlation among these variables in keratoconus patients. Materials and methods A total of 1,071 eyes of 810 patients diagnosed with keratoconus were evaluated with a Pentacam (Oculus Optikgerate GmbH). Five groups were established according to the mean keratometry readings: Very mild [K < 44.0 diopters (D)], mild (K = 44.0-47.0D), moderate (K = 47.0-52.0D), severe (K = 52.0-60.0D) and very severe (K = 60.0 or higher). The following parameters were obtained: Anterior corneal asphericity (Q), corneal volume (CV) and thinnest corneal thickness (TCT). Results Sixty-six eyes had very mild keratoconus, 269 had mild keratoconus, 465 had moderate keratoconus, 233 had severe keratoconus and 38 had very severe keratoconus. As the severity of disease increases, there is an increment in K and CV values and reduction of Q and TCT. There was a statistically significant difference in values for all parameters, except the CV. The Pearson correlation index showed an inverse correlation between the degree of keratoconus and the asphericity (Q), i.e. the more severe the keratoconus the more negative the Q-value. Only in the very severe group there was no statistically significant correlation between K and Q. There was no correlation between severity of keratoconus and CV. There was an inverse correlation between keratoconus grade and TCT; the more advanced the disease the less the TCT value. Only in the very mild group there was no correlation between K and TCT. Conclusion The corneal asphericity and pachymetry are inversely correlated to keratometry in keratoconus patients. There is no correlation between CV and severity of keratoconus. How to cite this article Torquetti L, Ferrara G, Ferrara P. Correlation of Anterior Segment Parameters in Keratoconus Patients. Int J Kerat Ect Cor Dis 2012;1(2):87-91.

The Clinical Study of Combination of Bortezomib and Dexamethasone in Treatment of Newly Diagnosed Multiple Myeloma

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5217-5217
Author(s):  
Juan Li ◽  
Lijin Zeng
Keyword(s):  
Multiple Myeloma ◽  
Complete Remission ◽  
Adverse Effects ◽  
Overall Response Rate ◽  
Response Rate ◽  
Common Adverse Event ◽  
Control Group ◽  
Newly Diagnosed ◽  
Overall Response ◽  
Significant Difference

Abstract OBJECTIVE: To study retrospectively the response and side effects in two groups of patients with newly diagnosed multiple myeloma (MM) receiving bortezomib and dexamethasone regimen (VD) and vincristine combined with pirarubicin and dexamethasone and melphalan regimen (VADM). METHODS: Nineteen patients were enrolled in a group of VD, receiving bortezomib 1.3mg/m2 on days 1,4,8,11 and dexamethasone 20mg on days 1–4 in a 21-day cycle. Blade Standard was used to evaluate the therapeutic effect and NCI-CTC was used to assess the adverse effect. Thirty-one matched patients with newly diagnosed MM who received VADM were used as a historical control group, receiving vincristine 0.4mg/d and pirarubicin 9mg•m−2•d−1 and dexamethasone 20mg/d and melphalan 12mg/d on days 1–4, with 28 days as a cycle. RESULTS: During the median 9 months’ follow-up of patients who received VD, there were 73.7% patients(14/19)responding to the treatment, including 9 cases (47.4%) of complete remission or near complete remission. Light-chain type patients who received VD had a higher overall response rate and CR +nCR rate than that of the VADM (P&lt;0.05). The patients receiving VD who had renal inadequacy had an effective rate of 69.6% (5/6), which was similar to that of the others (69.2%, 9/13), and renal function relieve could be shown in the chemotherapy. The main adverse effects were fatigue, diarrhea, peripheral neuropathy, thrombocytopenia, and infection, with incidences of 73.8%, 68.4%, 63.2%, 31.5% and 26.3% respectively. Most of the adverse effects were mild and could be relieved by symptomatic treatments. The most common adverse event in the control group was neutropenia (83.8%), followed by infection(35.5%), vomiting (35.5%) and loss of hair(32.5%). CONCLUSION: Although there was no significant difference of overall response rate between VD and VADM, VD has higher CR +nCR rate compared with VADM. VD can be tolerant in most patients, and is also safe in patients with renal inadequacy.

scholarly journals Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy-Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Rutchaporn Taweerutchana ◽  
Natchagorn Lumlerdkij ◽  
Sathit Vannasaeng ◽  
Pravit Akarasereenont ◽  
Apiradee Sriwijitkamol
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Adverse Effects ◽  
Moringa Oleifera ◽  
Blood Pressure Reduction ◽  
Controlled Study ◽  
Significant Difference ◽  
The Mean ◽  
Diabetes Patients

Background. Studies showed effects of Moringa oleifera (MO) on lowering blood sugar levels in animal and diabetes patients. The aims of this study were to determine the effect of MO leaf capsules on glucose control in therapy-naïve type 2 diabetes mellitus (T2DM) and to evaluate its safety. Method. This was a prospective randomized placebo controlled study. Therapy-naïve T2DM was randomly assigned to receive either 8 grams per day of MO leaf capsules (MO leaf group) or placebo for 4 weeks. Clinical and laboratory characteristics were recorded at screening and at the end of 4-week study. 9-point plasma glucose was obtained before and every week during the study. Results. Thirty-two T2DM patients were enrolled. The mean age was 55 years and the mean HbA1C was 7.0%. There was no significant difference in FPG and HbA1C between groups. MO leaf group had SBP reduction by 5 mmHg as compared to baseline but this difference had no statistical significance. There were no adverse effects of MO leaf. Conclusions. Moringa oleifera leaf had no effect on glycemic control and no adverse effects in T2DM. Interestingly, this study demonstrated that MO leaf had a tendency on blood pressure reduction in T2DM, and this result needs further investigation.

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