scholarly journals Uji efek ekstrak biji alpukat (Persea americana Mill.) terhadap kadar kolesterol total pada tikus wistar (Rattus norvegicus)

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Abraham T. Suhendra ◽  
Henoch Awaloei ◽  
Jane Wuisan
Keyword(s):  
Traditional Medicine ◽  
Wistar Rats ◽  
Seed Extract ◽  
Persea Americana ◽  
Blood Cholesterol ◽  
Control Group ◽  
Tropical Country ◽  
Total Blood ◽  
Total Blood Cholesterol ◽  
Avocado Seed

Abstract: Indonesia is a tropical country that has more than 1,000 kinds of medicinal plants. Medicinal plant is the use of part(s) of plants as ingredients in traditional medicine or synthetic drugs. One of the traditional medicine is avocado. Several studies have concluded that the avocado fruit and leaves can reduce total blood cholesterol levels while the seed is used in Nigeria for treating hypertension. This was an experimental study. Samples consisted of 12 male Wistar rats, divided into 4 groups (3 rats in each group). The treated groups were given propylthiouracil (PTU) for 14 days then the rats were given 125 mg/kg or 250 mg/kg of avocado seed extract for 14 days. The positive control group was given PTU 8 mg/rat for 14 days, followed by simvastatin 0.2 mg for 14 days. The negative control group was only given food and water. The results showed that the average level of total blood cholesterol in Wistar rats after treated with 125 mg/kg and 250 mg/kg avocado seed extract decreased by 18.1% and 31.2%, respectively. Conclusion: Avocado seed extract had an effect in reducing total blood cholesterol of Wistar rats.Keywords: avocado seed, total cholesterol levelAbstrak: Indonesia merupakan salah satu negara tropis yang memiliki banyak tumbuhan dimana lebih dari 1000 tumbuhan tersebut dapat digunakan sebagai tanaman obat. Tanaman obat ialah penggunaan bagian dari tanaman atau tumbuhan sebagai bahan dalam pembuatan obat tradisional maupun obat sintetik. Salah satu tanaman yang digunakan sebagai obat tradisional ialah alpukat. Beberapa penelitian mengenai tanaman alpukat menunjukkan bahwa buah dan daun dari tanaman Alpukat dapat menurunkan total kolesterol dalam darah, sedangkan biji alpukat digunakan di Nigeria sebagai pengobatan untuk hipertensi. Penelitian ini menggunakan metode eksperimental. Sampel ialah 12 ekor tikus Wistar jantan yang dibagi menjadi 4 kelompok (setiap kelompok terdiri dari 3 tikus). Kelompok-kelompok perlakuan diberikan propiltiourasil (PTU) selama 14 hari kemudian diberikan 125 mg/kg atau 250 mg/kg ekstrak biji Alpukat selama 14 hari. Kelompok kontrol positif diberikan PTU selama 14 hari kemudian diberikan simvastatin 0,20 mg/kg selama 14 hari. Kelompok kontrol negatif hanya diberikan pakan dan air. Hasil penelitian memperlihatkan rerata kadar kolesterol total tikus Wistar setelah diberikan 125 mg/kg dan 250 mg/kg ekstrak biji alpukat menurun sebesar 18,1% dan 31,2%. Simpulan: Ekstrak biji Alpukat berefek menurunkan kadar kolesterol total pada tikus Wistar.Kata kunci: biji alpukat, kadar kolesterol total

scholarly journals Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americanaMill., c.v.Hass)

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Eduardo Padilla-Camberos ◽  
Moisés Martínez-Velázquez ◽  
José Miguel Flores-Fernández ◽  
Socorro Villanueva-Rodríguez
Keyword(s):  
Acute Toxicity ◽  
Traditional Medicine ◽  
Micronucleus Test ◽  
Pharmaceutical Medicine ◽  
Micronucleus Assay ◽  
Negative Control ◽  
Seed Extract ◽  
Persea Americana ◽  
Genotoxic Activity ◽  
Avocado Seed

The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products.Persea americanaseeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract ofPersea americanawas evaluated with respect to its genotoxic potential through micronucleus assay in rodents. The frequency of micronuclei in groups of animals treated with avocado seed extract showed no differences compared to the negative control (vehicle); therefore, it is considered that the avocado seed extract showed no genotoxic activity in the micronucleus test.

scholarly journals Uji daya hambat ekstrak biji buah alpukat (Persea americana Mill.) terhadap pertumbuhan Streptococcus mutans

e-GIGI ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Anggriana H. Bujung ◽  
Heriyannis Homenta ◽  
Johanna A. Khoman
Keyword(s):  
Streptococcus Mutans ◽  
Inhibitory Effect ◽  
Seed Extract ◽  
Persea Americana ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Paper Disk ◽  
Post Test ◽  
Avocado Seed

Abstract: In addition to daily consumption, avocado is also used to treat oral diseases. Scientific studies showed that avocado seed contained flavonoids, tannins, and alkaloid which were expected to inhibit bacterial growth. This study was aimed to obtain the bacterial inhibitory effect of avocado seed (Persea americana Mill.) extract on Streptococcus mutans as the primary cause of dental caries. This was a true experimental study with the post test only control group design. This study used a modified Kirby-Bauer method with paper disk. The positive control was erythromycin and the negative control was aquadest. Avocado seeds were extracted by using maceration method with 96% ethanol. The Streptococcus mutans bacteria were obtained from pure stock of Microbiology Laboratory of Pharmacy Study Program University of Sam Ratulangi Manado. The results showed that the mean diameter of inhibition zone of avocado seed extract was 21.8 mm which was classified as very strong inhibition. Conclusion: Persea Americana Mill. seed extract had a very strong inhibitory effect on the growth of Streptococcus mutans.Keywords: avocado seed (Persea americana Mill.), Streptococcus mutans, inhibition effectAbstrak: Selain menjadi bahan konsumsi masyarakat yang lezat, ternyata alpukat telah lama dipercaya dapat mengobati penyakit di dalam rongga mulut. Di dalam buah alpukat terdapat biji yang terbukti melalui penelitian ilmiah mengandung flavonoid, alkaloid, dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk mengetahui daya hambat ekstrak biji buah alpukat (Persea americana Mill.) terhadap pertumbuhan Streptococcus mutans. Jenis penelitian ialah eksperimental murni dengan post test only control group design. Metode yang digunakan ialah modifikasi Kirby-Bauer dengan paper disk. Kontrol positif menggunakan antibiotik eritromisin dan kontrol negatif menggunakan akuades. Biji buah alpukat diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Bakteri Streptococcus mutans diambil dari stok bakteri murni Laboratorium Mikrobiologi Program Studi Farmasi Fakultas MIPA Universitas Sam Ratulangi Manado. Hasil penelitian menunjukkan diameter rerata zona hambat dari ekstrak biji buah alpukat yang terbentuk ialah 21,8 mm dan digolongkan sebagai zona hambat sangat kuat. Simpulan: Ekstrak biji buah alpukat memiliki daya hambat sangat kuat terhadap pertumbuhan Streptococcus mutans.Kata kunci: biji buah alpukat (Persea americana Mill.), Streptococcus mutans, daya hambat

scholarly journals Coconut Oil Promotes Greater Satiety and Reduces Blood Cholesterol, But Induces Obesity, Anxiety and Impaired Bone Formation in Adult Wistar Rats

2021 ◽  
Author(s):  
Ítalo Gomes Reis ◽  
Arthur Rocha-Gomes ◽  
Alexandre Alves da Silva ◽  
Mayara Rodrigues Lessa ◽  
Nísia Andrade Villela Dessimoni Pinto ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Caloric Intake ◽  
Coconut Oil ◽  
Blood Cholesterol ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Total Blood ◽  
Beneficial Effects ◽  
To Receive ◽  
Tibia Length

Background: The aim of this study was to evaluate the nutritional effects of supplementation with virgin coconut oil (VCO) in Wistar rats over a sub-chronic period (6 weeks).Methods: Twelve Wistar rats were used and randomly assigned to receive (n = 6): control - lab chow; coconut oil (CO) - lab chow with added virgin coconut oil (20%). Food and caloric intake, weight gain, food efficiency, body mass index, femur and tibia length, bone mineral composition and blood biochemistry were evaluated.Result: The CO group showed an energy intake closed to control group. Also, the supplementation with VCO generated a decrease in total blood cholesterol as compared to the control group. However, the CO group showed accumulation of fat mass, shorter femur length and anxiogenesis in relation to the control group. These results indicate few beneficial effects from the sub-chronic use of VCO and indicate that its consumption in large quantities for long periods should be questioned.

scholarly journals Uji efek perasan daging buah labu kuning (Cucurbita moschata D.) terhadap kadar kolesterol total darah tikus wistar (Rattus norvegicus)

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Lisa C. Ratulangi ◽  
Pemsi Wowor ◽  
Christi Mambo
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Negative Control ◽  
Blood Cholesterol ◽  
Control Group ◽  
Cucurbita Moschata ◽  
Fruit Pulp ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

Abstract: This study aimed to obtain the effect of pumpkin fruit pulp (Cucurbita moschata D.) juice on total blood cholesterol of wistar rats (Rattus norvegicus). This was an experimental laboratory study conducted in the Laboratory of Pharmacology and Therapy Faculty of Medicine, University of Sam Ratulangi. Samples were 10 rats with an average body weight of 150 g. Samples were divided into 5 groups, each group consisted of 2 rats: negative control group, only used standard food; propylthiouracil (PTU) treatment group; positive control group used simvastatin after PTU induced for 14 days; propylthiouracil (PTU) treatment group continued with standard food; and propylthiouracil (PTU) treatment group continued with pumpkin fruit pulp juice. Doses of the pumpkin fruit pulp juice were 0.93 g/ml/day/rat as many as 2 ml/day. The measurement of total blood cholesterol levels was on days 0, 15, and 22 by using Autocheck. Conclusion: The pumpkin fruit pulp juice had an effect in reducing total blood cholesterol levels in wistar rats.Keywords: juice of pumpkin fruit pulp, total blood cholesterol, propylthiouracil.  Abstrak: Penelitian ini bertujuan untuk mengetahui efek air perasan daging buah labu kuning (Cucurbita moschata D.) terhadap kadar kolesterol darah total pada tikus wistar (Rattus norvegicus). Jenis penelitian ini eksperimental laboratorik di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Sam Ratulangi. Subjek penelitian berupa tikus wistar jantan berjumlah 10 ekor dengan berat rata-rata 150 g yang dibagi kedalam 5 kelompok, masing-masing sebanyak 2 ekor, yaitu: kontrol negatif hanya menggunakan pakan standar; kelompok perlakuan propiltiourasil (PTU); kontrol positif menggunakan simvastatin setelah diinduksi PTU selama 14 hari; kelompok perlakuan pemberian PTU dilanjutkan dengan pakan standar; dan kelompok perlakuan pemberian PTU dilanjutkan dengan perasan daging buah labu kuning (Cucurbita moschata D.). Dosis perasan daging buah labu kuning yang diberikan 0.93 g/ml/hari/ekor sebanyak 2 ml/hari. Pengukuran kadar kolesterol darah total dilakukan pada hari ke 0, 15, dan 22 menggunakan alat pengukur Autocheck. Simpulan: Perasan daging buah labu kuning berefek menurunkan kadar kolesterol total pada tikus wistar.Kata kunci: perasan daging buah labu kuning, kolesterol total darah, propiltiourasil.

PENGARUH EKSTRAK BUAH MENGKUDU (MORINDA CITRIFOLIA) TERHADAP KADAR KOLESTEROL TOTAL DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) JANTANGALUR WISTARYANG DIBERI DIET TINGGI LEMAK

2019 ◽  
Vol 3 (1) ◽  
pp. 17-24
Author(s):  
Astrid Ika Priadna ◽  
Budiarto Adiwinoto ◽  
Fitri Handajani
Keyword(s):  
High Fat Diet ◽  
Blood Cholesterol ◽  
Control Group ◽  
High Fat ◽  
Fruit Extract ◽  
Total Blood ◽  
Experimental Animals ◽  
Cholesterol Levels ◽  
Wistar Strain ◽  
Total Blood Cholesterol

Background: High cholesterol dietinduced hypercholesterolemia. Noni fruit extracthas flavonoids which are expected to reduceblood total cholesterol levels.This study aims to determine the effect of noni fruit extract (Morinda citrifolia) on total blood cholesterol levels in wistar strain male rats (Rattus norvegicus) given a high-fat diet. Method: Experimental study using post test only control group design. A total of 24 wistar strain male rats were divided into 3 groups: negative controlgroup given standard feed; positive control group of experimental animals who were given a high-fat diet; the experimental group treated with a high-fat diet for 14 days and given noni fruit extractat a dose of 200 mg / Kg BB. On the 29th day total blood cholesterol levels were measured for all groups of experimental animals. Results: The Mann Whitney UTest showed a significant increase in total blood cholesterol levels in the positive group of experimental animals given a high-fat diet (68.13 mg/dl) compared to the negative control group of experimental animals given standard feed (51.25 mg/dl). There was a significant decrease in total blood cholesterol levels in the experimental group treated with a high-fat diet and noni fruit extract (61mg/dl) compared to the average positive control group of experimental animals given a high-fat diet (68.13 mg/dl). Conclusion: Provision of a high-fat diet in wistar strain male ratscan significantly increase total blood cholesterol levels. The administration of noni fruit extract in wistar strain male ratscan significantly reduce total blood cholesterol levels

scholarly journals EFEKTIVITAS KOMBINASI EKSTRAK DAUN SIRIH MERAH (Piper Crocatum) DAN EKSTRAK BIJI ALPUKAT (Persea americana) DALAM MENGHAMBAT PERTUMBUHAN Candida albicans

2017 ◽  
Vol 2 (2) ◽  
pp. 86 ◽  
Author(s):  
Vini Anggraini ◽  
Masfufatun Masfufatun
Keyword(s):  
Candida Albicans ◽  
Leaf Extract ◽  
Seed Extract ◽  
Persea Americana ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Betel Leaf ◽  
Post Test ◽  
Avocado Seed

Abstrak   Candida albicans merupakan salah satu mikrooganisme penyebab infeksi kandidiasis. Daun sirih merah (Piper crocatum) dan biji alpukat (Persea americana) telah diteliti dapat menghambat pertumbuhan Candida albicans. Tujuan penelitian ini adalah untuk mengetahui efektivitas kombinasi daun sirih merah (Piper crocatum) dan ekstrak biji alpukat (Persea americana) dalam menghambat pertumbuhan Candida albicans. Penelitian bersifat eksperimental laboratorium (true experiment) dengan pendekatan post test control group design only. Daun sirih merah dan biji alpukat diekstraksi secara maserasi menggunakan pelarut etanol.    Pada masing-masing ekstrak etanol dilakukan uji pendahuluan untuk mengetahui konsentrasi optimum ektrak dalam memnghambat pertumbuhan C. albicans. Daya Hambat pertumbuhan C. albicans diuji menggunakan metode difusi. Hasil penelitian menunjukkan bahwa ekstraks daun sirih merah dan biji alpukat masing-masing memiliki daya hambat terbesar pada konsentrasi 10%. Kombinasi ekstrak daun sirih merah dan ekstrak biji alpukat memiliki daya hambat yang signifikan terhadap pertumbuhan Candida albicans dibandingakan kontrol negatif, kontrol positif dan ekstrak daun sirih merah. Dengan demikian kombinasi ekstrak daun sirih dan biji aplukat etanol berpotensi sebagai antifungi dalam menghambat pertumbuhan C. albicans sehingga diharapkan bisa mengurangi prevalensi kandidiasis. Kata Kunci :    daun sirih merah,  biji alpukat, Candida albicans,                                                           Abstract Candida albicans is one of the microbialism that causes candidiasis infection. Red betel leaf (Piper crocatum) and avocado seed (Persea americana) have been studied to inhibit the growth of C. albicans. The purpose of this study was to determine the effectiveness of red betel leaf (Piper crocatum) and avocado seed extract (Persea americana) combination in inhibiting the growth of C. albicans. Research is experimental laboratory (true experiment) with post test approach control group design only. Red betel leaf and avocado seeds are extracted by maceration using ethanol solvent. In each ethanol extract, a preliminary test was performed to find out the optimum concentration of extract in inhibiting the growth of C. albicans. C. albicans growth retardant was tested using diffusion method. The results showed that the extract of red betel leaf and avocado seeds each had the greatest inhibitory concentration at 10%. The combination of red betel leaf extract and avocado seed extract have significant inhibitory effect on C. albicans growth compared to negative control, positive control and red betel leaf extract. Thus, the combination of betel leaf extract and ethanol  seed has the potential as an antifungal in inhibiting the growth of C. albicans so it is expected to reduce the prevalence of candidiasis. Keywords: red betel leaf, avocado seed, Candida albicans, 

scholarly journals EFEKTIFITAS PEMBERIAN JUS TOMAT DAN JAMBU BIJI MERAH TERHADAP PENURUNAN KOLESTEROL TOTAL PADA WANITA OVERWEIGHT

2019 ◽  
Vol 7 (2) ◽  
pp. 120-124
Author(s):  
Adelina Ayu Nugraheni ◽  
Mohammad Jaelani ◽  
Arintina Rahayuni ◽  
Pujo Semedi
Keyword(s):  
Total Cholesterol ◽  
Tomato Juice ◽  
Blood Cholesterol ◽  
Control Group ◽  
Total Blood ◽  
Control Group Design ◽  
Guava Fruit ◽  
Cholesterol Levels ◽  
Nutrition Research ◽  
Total Blood Cholesterol

Background : Women are two times have hypercholesterolemia 14.5% after menopause due to blood cholesterol levels increase because of the hormone estrogen is not formed. Drugs can be used to reduce cholesterol levels, but using drugs to reduce cholesterol levels have side effects. An alternative way that can be used in preventing a long-term increase in blood cholesterol levels and to reduce the dosage of drugs use is by using natural ingredients such as red guava fruit and tomatoes.Objective : This research aim to know the effectiveness of tomato juice and red guava juice on total cholesterol in overweight women.Method : This research was a clinical nutrition research. Type of research was true experiment research and study design was randomized pre-and post-test control group design. The tomato and red guava juice consist of  300 grams of tomatoes and red guavas, was given for 21 days to 22 respondents (11 treatments and 11 controls).In the treatment group there was lowering in total blood cholesterol and the control group with an increase in blood cholesterol levels.Result : Total Blood Cholesterol influenced by the lycopene intake and a decrease in total blood cholesterol levels in the treatment and control groups (p 0.05).Conclusion : 250 ml of tomato juice and red guava juice was given everyday within 3 weeks could reduce total cholesterol 3,01 mg/dl clinically, but not significant statistically.

Pengaruh Ekstrak Buah Mengkudu (Morinda Citrifolia) Terhadap Kadar Kolesterol Total Darah Pada Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar Yang Diberi Diet Tinggi Lemak

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Astrid Ika Priadna
Keyword(s):  
High Fat Diet ◽  
Male Rats ◽  
Blood Cholesterol ◽  
Control Group ◽  
High Fat ◽  
Fruit Extract ◽  
Total Blood ◽  
Experimental Animals ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

Background: High cholesterol diet induced hypercholesterolemia. Noni fruit extract has flavonoids which are expected to reduce blood total cholesterol levels. This study aims to determine the effect of noni fruit extract (Morinda citrifolia) on total blood cholesterol levels in wistar strain male rats (Rattus norvegicus) given a high-fat diet. Method: Experimental study using post test only control group design. A total of 24 wistar strain male rats were divided into 3 groups: negative control group given standard feed; positive control group of experimental animals who were given a high-fat diet; the experimental group treated with a high-fat diet for 14 days and given noni fruit extract at a dose of 200 mg / Kg BB. On the 29th day total blood cholesterol levels were measured for all groups of experimental animals. Results: The Mann Whitney U Test showed a significant increase in total blood cholesterol levels in the positive group of experimental animals given a high-fat diet (68.13 mg/dl) compared to the negative control group of experimental animals given standard feed (51.25 mg/dl). There was a significant decrease in total blood cholesterol levels  in the experimental group treated with a high-fat diet and noni fruit extract (61mg/dl) compared to the average positive control group of experimental animals given a high-fat diet ( 68.13 mg/dl). Conclusion: Provision of a high-fat diet in wistar strain male rats can significantly increase total blood cholesterol levels. The administration of noni fruit extract in wistar strain male rats can significantly reduce total blood cholesterol levels.

The effects of dyslipidemia on noise-induced hearing loss in a petrochemical workers in the Southwest of Iran

Work ◽  
2021 ◽  
pp. 1-8
Author(s):  
Payam Rashnoudi ◽  
Arman Amiri ◽  
Maryam Omidi ◽  
Abbas Mohammadi
Keyword(s):  
Hearing Loss ◽  
Cross Sectional Study ◽  
Blood Cholesterol ◽  
Noise Induced Hearing Loss ◽  
Total Blood ◽  
Cross Sectional ◽  
Inner Diameter ◽  
Spss Software ◽  
Southwest Of Iran ◽  
Total Blood Cholesterol

BACKGROUND: Research has shown that the decrease in the inner diameter of vessels caused by hyperlipidemia lowers the capacity for blood oxygen delivery to the cochlea. This leads to impaired cochlear metabolism and causes hearing problems. OBJECTIVE: The effects of dyslipidemia on noise-induced hearing loss in workers were examined. METHODS: This descriptive cross-sectional study was performed on 692 male employees in a petrochemical industry in the southwest of Iran exposed to 85 dB noise. Clinical audiometry and blood sample tests were used to evaluate the hearing and prevalence indices of dyslipidemia (cholesterol, triglyceride, HDL and LDL). The data were analyzed using SPSS software version 25 (p = 0.05). RESULTS: The results showed that the prevalence of dyslipidemia was 24.5%with abnormal relative triglyceride frequency of 49.5%, HDL of 28%, LDL of 33%, and total blood cholesterol level of 37.8%. There was no significant relationship between NIHL and dyslipidemia (p >  0.09). However, the major NIHL drops at different frequencies were in the individuals with dyslipidemia. The parameters age and dyslipidemia increased NIHL odds ratio (95%C.I.). by 1.130 (1.160–1.100) and 1.618 (2.418–1.082) respectively CONCLUSION: The rate of hearing loss in individuals with dyslipidemia increases at different frequencies and it leads to an increase of the OR of NIHL in individuals with dyslipidemia. We can control dyslipidemia and its effective factors. The NIHL is more common in people exposed to noise.

scholarly journals Pengaruh Pemberian Tepung Tempe terhadap Kadar Kolesterol Total Darah Mencit (Mus musculus) Hiperkolesterol

bionature ◽  
2019 ◽  
Vol 20 (2) ◽  
pp. 116
Author(s):  
Heryl Rumtal ◽  
Rosdiana Ngitung ◽  
A. Mu’nisa A. Mu’nisa
Keyword(s):  
Mus Musculus ◽  
Blood Cholesterol ◽  
Cholesterol Concentration ◽  
Total Blood ◽  
Treatment Groups ◽  
Independent Variable ◽  
The Subject ◽  
Imprinting Control Region ◽  
Total Blood Cholesterol ◽  
Research Show

Abstract. This research is experimental which aims to determine the effect of giving Tempe Flour to total blood cholesterol concentration of hypercholesterol mice (Mus musculus). The independent variable of this research Tempe Flour while the dependent variable is the total blood cholesterol concentration of mice (Mus musculus). The subject of this research is 25 male ICR strain (Imprinting Control Region) mice with 3 months age divided 5 treatment groups which are normal group, hypercholesterol group, giving of tempe flour at dose of 10 g / day / BB (P1), 20 g / days / BB (P2) and 25 g / day / BB (P3). Tempe flour is given after the giving of cholesterol feed. All mices blood cholesterol concentration were check after the time of treatment. The result is analyz by using ANOVA with Ducan test. The result of this research show that the giving of Tempe Flour affected the decrease of blood cholesterol concentration of mice (Mus musculus) in dose of 10 g/day/BB,20 g/day/BB and 25 g/day/BB. Dose of 25 g/day/BB showed an effective dose for lowering cholesterol in the research.   Keywords: tempe flour, cholesterol, hypercholesterol, mencit (Mus musculus)

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